iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.00e-09	36.7	229	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+  ++ ++ lpC+H+fh +C+  w         +++CP+Cr
   Q: 229  CPVCKEDYtvEEKVRQLPCNHFFHSSCIVPW------LELHDTCPVCR 270
           ********99566******************......**********8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEASAAGAD AGSAVAAHRF FCHFCKGEVN PKLPEYICPR CESGFIEEVT DDSSFLGGGG 60
SRTDNSTATH FAELWDHLDH TMFLQDFRPF LSSNPLDQDN RANERGHQTH TDFWGPSRPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGGGGAG GGACCGCCGG CCGCCCTTTC GGACATCCTC CGCAGAGGCG AAAAATGGCG 60
GAGGCCTCGG CGGCGGGGGC GGACGCGGGC TCCGCTGTCG CCGCGCACCG TTTCTTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000079	Aegilops tauschii	29.96	9.00e-26	110.00
IUUC-Aml-002035	Ailuropoda melanoleuca	95.49	2.00e-158	551.00
IUUC-Apl-003694	Anas platyrhynchos	70.24	1.00e-90	325.00
IUUC-Ath-006961	Arabidopsis thaliana	30.50	1.00e-22	100.00
IUUC-Ate-010398	Aspergillus terreus	38.66	4.00e-18	86.30
IUUC-Ame-011898	Astyanax mexicanus	53.33	1.00e-75	276.00
IUUC-Bgr-012144	Blumeria graminis	37.14	6.00e-18	85.50
IUUC-Bta-013190	Bos taurus	82.99	4.00e-131	460.00
IUUC-Bci-013958	Botrytis cinerea	36.19	3.00e-17	83.60
IUUC-Bdi-014806	Brachypodium distachyon	26.60	7.00e-24	104.00
IUUC-Bol-016085	Brassica oleracea	32.27	3.00e-29	122.00
IUUC-Bra-016939	Brassica rapa	31.67	6.00e-29	121.00
IUUC-Cja-020001	Callithrix jacchus	91.32	2.00e-151	528.00
IUUC-Cfa-020882	Canis familiaris	95.47	1.00e-157	548.00
IUUC-Cpo-021690	Cavia porcellus	87.55	2.00e-117	415.00
IUUC-Csa-024004	Chlorocebus sabaeus	94.10	2.00e-148	518.00
IUUC-Cho-024643	Choloepus hoffmanni	92.55	5.00e-80	290.00
IUUC-Cin-025452	Ciona intestinalis	41.18	3.00e-19	87.40
IUUC-Csv-025892	Ciona savignyi	38.10	6.00e-22	96.30
IUUC-Dre-027515	Danio rerio	58.36	2.00e-84	305.00
IUUC-Dno-029010	Dasypus novemcinctus	95.14	6.00e-158	549.00
IUUC-Dor-030147	Dipodomys ordii	85.61	4.00e-136	477.00
IUUC-Dse-031376	Dothistroma septosporum	34.53	1.00e-17	84.30
IUUC-Dme-031601	Drosophila melanogaster	55.56	2.00e-35	142.00
IUUC-Ete-032392	Echinops telfairi	91.30	7.00e-79	286.00
IUUC-Eca-033803	Equus caballus	95.20	5.00e-146	509.00
IUUC-Eeu-034831	Erinaceus europaeus	77.13	5.00e-100	357.00
IUUC-Fca-036192	Felis catus	94.44	3.00e-165	573.00
IUUC-Gmo-039513	Gadus morhua	58.81	2.00e-91	328.00
IUUC-Gga-040282	Gallus gallus	77.35	8.00e-78	282.00
IUUC-Gac-041784	Gasterosteus aculeatus	59.12	6.00e-91	327.00
IUUC-Ggo-044873	Gorilla gorilla	93.75	9.00e-148	515.00
IUUC-Hsa-045780	Homo sapiens	93.40	8.00e-148	516.00
IUUC-Itr-048142	Ictidomys tridecemlineatus	93.73	3.00e-141	494.00
IUUC-Lch-050673	Latimeria chalumnae	77.51	1.00e-132	465.00
IUUC-Laf-054384	Loxodonta africana	93.06	2.00e-142	498.00
IUUC-Mcc-055137	Macaca mulatta	94.10	2.00e-148	518.00
IUUC-Meu-056635	Macropus eugenii	88.56	1.00e-118	418.00
IUUC-Mtr-058295	Medicago truncatula	41.94	2.00e-21	96.30
IUUC-Mla-058832	Melampsora laricipopulina	45.57	2.00e-14	72.00
IUUC-Mmr-060631	Microcebus murinus	97.22	9.00e-170	588.00
IUUC-Mdo-062489	Monodelphis domestica	89.58	3.00e-133	467.00
IUUC-Mmu-064196	Mus musculus	99.65	3.00e-174	603.00
IUUC-Mpu-066575	Mustela putorius furo	95.49	2.00e-166	577.00
IUUC-Mlu-067024	Myotis lucifugus	89.30	6.00e-146	509.00
IUUC-Ncr-068908	Neurospora crassa	31.51	4.00e-18	86.30
IUUC-Nle-069348	Nomascus leucogenys	92.36	5.00e-144	503.00
IUUC-Opr-070812	Ochotona princeps	87.50	8.00e-151	525.00
IUUC-Ont-072555	Oreochromis niloticus	60.69	4.00e-87	314.00
IUUC-Ocu-074691	Oryctolagus cuniculus	95.83	3.00e-155	540.00
IUUC-Ola-087047	Oryzias latipes	62.07	4.00e-99	353.00
IUUC-Oga-089111	Otolemur garnettii	95.16	8.00e-151	526.00
IUUC-Oar-089999	Ovis aries	83.33	7.00e-132	463.00
IUUC-Ptr-091473	Pan troglodytes	93.40	2.00e-147	514.00
IUUC-Pan-092618	Papio anubis	81.25	6.00e-120	423.00
IUUC-Psi-093930	Pelodiscus sinensis	83.10	4.00e-119	420.00
IUUC-Pma-094530	Petromyzon marinus	50.57	3.00e-64	238.00
IUUC-Pno-094903	Phaeosphaeria nodorum	41.03	7.00e-18	85.10
IUUC-Pfo-096461	Poecilia formosa	69.70	3.00e-65	241.00
IUUC-Pab-098466	Pongo abelii	94.10	1.00e-148	518.00
IUUC-Pop-100026	Populus trichocarpa	30.23	2.00e-25	109.00
IUUC-Pca-100550	Procavia capensis	76.04	1.00e-116	412.00
IUUC-Pva-102881	Pteropus vampyrus	92.71	1.00e-153	535.00
IUUC-Sha-107616	Sarcophilus harrisii	89.67	1.00e-120	425.00
IUUC-Sja-107922	Schizosaccharomyces japonicus	45.19	4.00e-23	102.00
IUUC-Spo-108354	Schizosaccharomyces pombe	34.18	8.00e-25	108.00
IUUC-Smo-109522	Selaginella moellendorffii	51.43	4.00e-20	89.00
IUUC-Sly-111262	Solanum lycopersicum	29.84	3.00e-25	108.00
IUUC-Stu-112897	Solanum tuberosum	30.23	2.00e-24	106.00
IUUC-Sar-113319	Sorex araneus	72.22	9.00e-63	233.00
IUUC-Sre-115230	Sporisorium reilianum	38.79	5.00e-18	85.90
IUUC-Ssc-115917	Sus scrofa	84.72	2.00e-137	481.00
IUUC-Tgu-117105	Taeniopygia guttata	90.55	2.00e-67	246.00
IUUC-Tsy-119630	Tarsius syrichta	85.26	1.00e-141	495.00
IUUC-Tni-120265	Tetraodon nigroviridis	64.14	3.00e-104	371.00
IUUC-Tca-120938	Theobroma cacao	40.65	7.00e-21	94.70
IUUC-Tre-122013	Trichoderma reesei	35.58	5.00e-16	79.30
IUUC-Tvi-122598	Trichoderma virens	36.45	2.00e-16	80.50
IUUC-Tur-125986	Triticum urartu	29.57	2.00e-24	107.00
IUUC-Tme-127143	Tuber melanosporum	46.85	4.00e-28	118.00
IUUC-Tbe-127794	Tupaia belangeri	73.71	3.00e-104	370.00
IUUC-Ttr-129117	Tursiops truncatus	82.99	5.00e-126	443.00
IUUC-Uma-129414	Ustilago maydis	35.83	2.00e-17	84.30
IUUC-Vpa-130755	Vicugna pacos	81.18	2.00e-118	418.00
IUUC-Xtr-132520	Xenopus tropicalis	74.82	4.00e-100	357.00
IUUC-Xma-133074	Xiphophorus maculatus	69.09	8.00e-65	240.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence