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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045735
UUCD1 version UUC-HoS-00447
Ensembl Protein ID ENSP00000270279.3
UniProt Accession Q9ULV8; Q8N1E5; Q9Y5Z2; Q9Y5Z3; CBLC_HUMAN
Genbank Protein ID BAA86298.1; AAD34341.1; AAD34342.1; AAH28915.1
Protein Name E3 ubiquitin-protein ligase CBL-C; RING finger protein 57; RING-type E3 ubiquitin transferase CBL-C; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C
Genbank Nucleotide ID AB028645; AF117646; AF117647; BC028915
Gene Name CBLC; CBL3; RNF57
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000142273.10 ENST00000270279.7 ENSP00000270279.3
ENSG00000142273.10 ENST00000341505.4 ENSP00000340250.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18239087; 24425877
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00028 23.0 351 390
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 351  CKICAESNKD-VKIEPCGHLLCSCCLAAW-----QHSDSQTCPFCR 390
           99********.******************.....6889999****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
 Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Protein Sequence
(Fasta)
MALAVAPWGR QWEEARALGR AVRMLQRLEE QCVDPRLSVS PPSLRDLLPR TAQLLREVAH 60
SRRAAGGGGP GGPGGSGDFL LIYLANLEAK SRQVAALLPP RGRRSANDEL FRAGSRLRRQ 120
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Protein Fasta Sequence


>IUUC-Hsa-045735|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACTCTGGGCG AGGCCGCCCC TATCCCAGCC GCACCGGTCC TTCCCGGCAC ACGCGAGGCT 60
CCCATGGCTC TGGCGGTGGC CCCGTGGGGG CGACAGTGGG AAGAGGCCCG CGCCCTGGGC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045735|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
SMART

SM00184--RING
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0001784--F:phosphotyrosine binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:23624
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002286 Ailuropoda melanoleuca 83.98 0.00e+00 649.00
IUUC-Bta-012705 Bos taurus 84.52 0.00e+00 669.00
IUUC-Cja-019179 Callithrix jacchus 89.87 0.00e+00 808.00
IUUC-Cfa-020593 Canis familiaris 79.95 0.00e+00 633.00
IUUC-Cpo-021289 Cavia porcellus 76.36 2.00e-176 612.00
IUUC-Csa-023966 Chlorocebus sabaeus 93.38 0.00e+00 770.00
IUUC-Dor-030246 Dipodomys ordii 78.03 3.00e-129 454.00
IUUC-Eca-033921 Equus caballus 71.89 1.00e-152 532.00
IUUC-Fca-035747 Felis catus 67.50 4.00e-159 554.00
IUUC-Ggo-044622 Gorilla gorilla 98.60 0.00e+00 691.00
IUUC-Itr-049001 Ictidomys tridecemlineatus 83.48 5.00e-170 590.00
IUUC-Laf-053983 Loxodonta africana 82.27 0.00e+00 680.00
IUUC-Mmr-061310 Microcebus murinus 81.97 0.00e+00 669.00
IUUC-Mmu-064155 Mus musculus 74.66 0.00e+00 650.00
IUUC-Mpu-066655 Mustela putorius furo 82.93 0.00e+00 662.00
IUUC-Mlu-067929 Myotis lucifugus 83.44 3.00e-151 527.00
IUUC-Nle-070065 Nomascus leucogenys 82.70 0.00e+00 700.00
IUUC-Ocu-074049 Oryctolagus cuniculus 77.03 5.00e-134 470.00
IUUC-Oga-087952 Otolemur garnettii 83.47 0.00e+00 741.00
IUUC-Oar-089382 Ovis aries 80.93 0.00e+00 650.00
IUUC-Ptr-090579 Pan troglodytes 83.33 1.00e-163 569.00
IUUC-Pan-092075 Papio anubis 93.67 0.00e+00 810.00
IUUC-Pab-098100 Pongo abelii 88.40 0.00e+00 770.00
IUUC-Pca-100830 Procavia capensis 79.84 7.00e-111 394.00
IUUC-Pva-102714 Pteropus vampyrus 78.04 5.00e-166 577.00
IUUC-Rno-105348 Rattus norvegicus 76.03 0.00e+00 653.00
IUUC-Sha-107138 Sarcophilus harrisii 64.69 3.00e-122 431.00
IUUC-Ssc-116424 Sus scrofa 81.88 0.00e+00 674.00
Created Date 25-Jun-2017

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