iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0260794	FBtr0303917	FBpp0292920
FBgn0260794	FBtr0334902	FBpp0306923
FBgn0260794	FBtr0303911	FBpp0292914
FBgn0260794	FBtr0344029	FBpp0310478
FBgn0260794	FBtr0344030	FBpp0310479
FBgn0260794	FBtr0303915	FBpp0292918
FBgn0260794	FBtr0303914	FBpp0292917
FBgn0260794	FBtr0334903	FBpp0306924
FBgn0260794	FBtr0344028	FBpp0310477

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-89	298.8	2808	3140

Active Site

Position(s)	Description	Evidence
3107	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 65   p...........................ehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena... 128
           +                           +    F+flG++++ka++d+r+ldlp+s +fy+ l++++ s+   dl  v pe+ ++l  +++++   
   Q: 2808 TtttsyvhavhglfplplgkssklpqmtKAKAKFKFLGKFMAKAVMDSRMLDLPFSLPFYRWLVSEEHSIglADLMRVAPEVQNTLVRLQDLVrqr 2903
           144444444566777777777777777788999*********************************655444*******************99766 PP
   S: 129  ............esdieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplells 207
                       e+  + ++ldl  ++  ++     l+  ++ eL+ gG+++pVt  N+++Y++lv+ + l eg+++q+ea+reGf +v+p++ l+
   Q: 2904 eyilsdpnidamEKTEKIEQLDLDGCPIADLgldfvLPGHANIELCRGGRDTPVTVHNLHQYISLVTYWFLIEGVQKQFEALREGFDSVFPIQRLR 2999
           666666655555446666779999999999899999************************************************************ PP
   S: 208  lFteeelellicGe.ee.....idvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.....d 292
           +F +eele + cG+ +e     +++++l++ ++ ++g+++ds+aiq++ e+l + +++e++afLqFvTgs+rlP gGf++l p l+++rk     +
   Q: 3000 MFYPEELECVFCGSgSEqqhsrWEIKMLQESCRTDHGFHQDSQAIQYLYEILASYNRDEQRAFLQFVTGSPRLPTGGFKALTPPLTIVRKtldenQ 3095
           *************965423333567777788899**********************************************************9955 PP
   S: 293  asddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           + +d lPs++TC+nyLkLP+Yss e++++kL +A +e+  +F+ls
   Q: 3096 NPNDYLPSVMTCVNYLKLPDYSSREVMRQKLKVAANEGsMSFHLS 3140
           5669**********************************999*985 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAESVKSQSL SALTEGQHDD GGSTATSATL ANKTSGTNTT SASNHSSQRR RNNNTNSNRN 60
KSHHKNEKRN APATSGPAVS SSVDVVPATS TASATSTRRS RSQGRHSSAA ALSSKESQIP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCGTAGCA AGACGCGGTC TCACTGGTGC ACATTGTTTT CCGTCGCGTG TGAAAATTGC 60
TGAGTGTATA AAAACTGTGC ATACTTAGAG AAAACTTCTG CATTTGGTTG AAAGGTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0022008--P:neurogenesis
GO:0042753--P:positive regulation of circadian rhythm
GO:0045732--P:positive regulation of protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG42574

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001502	Ailuropoda melanoleuca	44.49	6.00e-158	551.00
IUUC-Apl-003531	Anas platyrhynchos	57.19	0.00e+00	639.00
IUUC-Ame-011761	Astyanax mexicanus	44.12	6.00e-164	571.00
IUUC-Bta-013070	Bos taurus	44.46	6.00e-157	548.00
IUUC-Cja-019046	Callithrix jacchus	44.49	1.00e-157	550.00
IUUC-Cfa-020521	Canis familiaris	44.77	1.00e-158	554.00
IUUC-Cpo-021639	Cavia porcellus	44.32	8.00e-158	551.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	38.55	2.00e-52	199.00
IUUC-Csa-023231	Chlorocebus sabaeus	44.49	1.00e-157	551.00
IUUC-Cho-024380	Choloepus hoffmanni	53.35	2.00e-113	404.00
IUUC-Cin-025482	Ciona intestinalis	51.22	7.00e-101	360.00
IUUC-Csv-026121	Ciona savignyi	55.92	2.00e-136	480.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.80	6.00e-45	176.00
IUUC-Dre-028174	Danio rerio	59.64	0.00e+00	662.00
IUUC-Dor-030939	Dipodomys ordii	51.72	6.00e-121	429.00
IUUC-Ete-032345	Echinops telfairi	44.08	7.00e-155	541.00
IUUC-Eca-033229	Equus caballus	44.49	1.00e-156	547.00
IUUC-Eeu-035205	Erinaceus europaeus	49.11	3.00e-142	499.00
IUUC-Fca-036444	Felis catus	63.02	3.00e-139	489.00
IUUC-Fal-037131	Ficedula albicollis	67.44	9.00e-162	564.00
IUUC-Gmo-039497	Gadus morhua	55.39	9.00e-172	597.00
IUUC-Gga-041021	Gallus gallus	67.44	4.00e-162	565.00
IUUC-Gac-042474	Gasterosteus aculeatus	55.88	2.00e-173	603.00
IUUC-Ggo-044855	Gorilla gorilla	44.49	9.00e-158	551.00
IUUC-Hsa-046147	Homo sapiens	44.49	2.00e-157	550.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	44.49	2.00e-157	550.00
IUUC-Lch-049818	Latimeria chalumnae	66.59	7.00e-153	535.00
IUUC-Loc-051777	Lepisosteus oculatus	59.00	0.00e+00	662.00
IUUC-Laf-053727	Loxodonta africana	44.63	2.00e-158	553.00
IUUC-Mcc-055799	Macaca mulatta	44.49	1.00e-157	550.00
IUUC-Meu-056065	Macropus eugenii	67.70	1.00e-98	355.00
IUUC-Mla-058870	Melampsora laricipopulina	40.42	3.00e-71	263.00
IUUC-Mga-059580	Meleagris gallopavo	44.80	3.00e-156	546.00
IUUC-Mmr-060816	Microcebus murinus	44.21	2.00e-156	547.00
IUUC-Mdo-062866	Monodelphis domestica	60.39	0.00e+00	697.00
IUUC-Mmu-063906	Mus musculus	44.49	9.00e-157	548.00
IUUC-Mac-065513	Musa acuminata	42.38	4.00e-61	227.00
IUUC-Mpu-066199	Mustela putorius furo	44.63	2.00e-158	553.00
IUUC-Mlu-067110	Myotis lucifugus	67.44	1.00e-155	544.00
IUUC-Nle-069410	Nomascus leucogenys	44.49	1.00e-157	551.00
IUUC-Opr-070401	Ochotona princeps	44.63	1.00e-155	544.00
IUUC-Ont-072100	Oreochromis niloticus	58.94	0.00e+00	659.00
IUUC-Oan-073121	Ornithorhynchus anatinus	67.44	5.00e-162	565.00
IUUC-Ocu-074623	Oryctolagus cuniculus	44.63	5.00e-158	551.00
IUUC-Ola-087173	Oryzias latipes	59.29	0.00e+00	664.00
IUUC-Oga-087908	Otolemur garnettii	44.63	2.00e-158	553.00
IUUC-Oar-090277	Ovis aries	44.46	3.00e-156	546.00
IUUC-Ptr-091543	Pan troglodytes	44.49	2.00e-157	550.00
IUUC-Pan-092243	Papio anubis	44.49	1.00e-157	550.00
IUUC-Psi-093150	Pelodiscus sinensis	44.80	4.00e-158	552.00
IUUC-Pfo-096267	Poecilia formosa	58.32	0.00e+00	658.00
IUUC-Pab-098072	Pongo abelii	44.49	9.00e-158	551.00
IUUC-Pca-100311	Procavia capensis	48.47	7.00e-152	531.00
IUUC-Pva-102215	Pteropus vampyrus	62.79	2.00e-137	483.00
IUUC-Pgr-103694	Puccinia graminis	40.43	3.00e-72	266.00
IUUC-Ptt-103916	Puccinia triticina	41.34	2.00e-74	274.00
IUUC-Rno-105315	Rattus norvegicus	59.68	0.00e+00	676.00
IUUC-Sha-106835	Sarcophilus harrisii	67.44	3.00e-162	566.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	38.72	6.00e-58	219.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.72	2.00e-56	214.00
IUUC-Sar-113224	Sorex araneus	61.63	2.00e-134	474.00
IUUC-Sbi-114373	Sorghum bicolor	41.67	4.00e-70	259.00
IUUC-Sre-114993	Sporisorium reilianum	37.32	1.00e-57	218.00
IUUC-Ssc-115535	Sus scrofa	44.35	5.00e-157	548.00
IUUC-Tgu-117493	Taeniopygia guttata	63.02	3.00e-146	512.00
IUUC-Tru-118669	Takifugu rubripes	55.88	7.00e-175	608.00
IUUC-Tsy-119373	Tarsius syrichta	44.35	3.00e-157	549.00
IUUC-Tni-120049	Tetraodon nigroviridis	44.88	9.00e-77	280.00
IUUC-Tbe-128149	Tupaia belangeri	71.82	5.00e-103	369.00
IUUC-Ttr-128165	Tursiops truncatus	63.02	4.00e-139	489.00
IUUC-Uma-129365	Ustilago maydis	42.33	5.00e-60	226.00
IUUC-Vpa-130678	Vicugna pacos	44.21	2.00e-156	546.00
IUUC-Xtr-132636	Xenopus tropicalis	43.59	3.00e-156	546.00
IUUC-Xma-133458	Xiphophorus maculatus	58.16	0.00e+00	656.00
IUUC-Yli-134481	Yarrowia lipolytica	37.99	3.00e-58	220.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence