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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105767
Ensembl Protein ID ENSRNOP00000072691.1
UniProt Accession A0A0G2K3L8; A0A0G2K3L8_RAT
Genbank Protein ID ENSRNOP00000072691
Protein Name WD repeat and FYVE domain-containing 1
Genbank Nucleotide ID AABR07068142
Gene Name Wdfy1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000015080.7 ENSRNOT00000088963.1 ENSRNOP00000072691.1
ENSRNOG00000015080.7 ENSRNOT00000063834.1 ENSRNOP00000062993.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.40e-18 65.1 240 271
UBD/Beta-Prp 4.60e-41 141.3 20 272
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH d+v +l++   ++ lvs+s Dg i vW++
   Q: 240  GHHDRVQSLCYlqLTRQLVSCSADGGIAVWNM 271
           899*******9884489*************97 PP
   

   UBD/Beta-Prp
   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdvtt.gkllrsl.sgheaevtavkfspdgkilvtgseD....rtikvw....dlst 83
           ++gh+++v      +p+++ ++t+s+d+ti+vw  ++ g++  s+     ++ +a+ +++d+  +v +++D    +    +    d+++
   Q: 20   IEGHQDAVTA-ALLIPKEDGVITASEDRTIRVWLKRDsGQYWPSIyHTMASPCSAMAYHHDS-RRVFVGQDngavM---EFhvseDFNK 103
           5677776666.555699****************666515666666355667899*******8.8999999985333...334669999* PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl. 171
              + t+ +h+++v ++ fs   +++vs++hd+ +    +++g  l       +++ +c++++ d++  + G + +++ l +l+++++ 
   Q: 104  MNFIKTYPAHQNRVSAIVFSLAAEWVVSTGHDKCVSWMCTRSGNMLG--RHFFSSWASCLQYDLDTQHAFVGDYSGQITLLKLEQNSCs 190
           ************************************99999999997..777899****************************999885 PP
   S: 172  .lrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
            ++tl+g h++s+ +l +d+ ++ l sg+ d+++++wd+  ++     l+gh d v+s+  ++ +  lvs+s+Dg i +W+++
   Q: 191  vITTLKG-HEGSIACLWWDPIQRLLFSGASDNSIIMWDIGgRKGRTLLLQGHHDRVQSLCYLQLTRQLVSCSADGGIAVWNMD 272
           5788888.*******************************9855557889*******************************654 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW 60
PSIYHTMASP CSAMAYHHDS RRVFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105767|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCGGTCAG CTGATGGGCC GCCCGCGGGG GAGGCCGCGG CTCGAACATG GCGGCCGAGA 60
TCCACTCCAG GCCGCAGAGC AGCCGCCCGG TGCTGCTGAG CAAGATTGAG GGCCACCAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105767|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00064--FYVE
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0005545--F:1-phosphatidylinositol binding
GO:0046872--F:metal ion binding
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001526 Ailuropoda melanoleuca 95.29 0.00e+00 814.00
IUUC-Apl-003661 Anas platyrhynchos 90.16 0.00e+00 723.00
IUUC-Aca-005225 Anolis carolinensis 90.44 0.00e+00 784.00
IUUC-Ame-011044 Astyanax mexicanus 77.51 0.00e+00 665.00
IUUC-Bta-012602 Bos taurus 96.83 0.00e+00 844.00
IUUC-Cja-019529 Callithrix jacchus 95.85 0.00e+00 841.00
IUUC-Cfa-020512 Canis familiaris 95.63 0.00e+00 745.00
IUUC-Cpo-022239 Cavia porcellus 93.66 0.00e+00 815.00
IUUC-Csa-023535 Chlorocebus sabaeus 95.06 0.00e+00 702.00
IUUC-Cho-024858 Choloepus hoffmanni 78.29 0.00e+00 649.00
IUUC-Dre-028520 Danio rerio 80.39 0.00e+00 689.00
IUUC-Dno-030005 Dasypus novemcinctus 97.32 0.00e+00 845.00
IUUC-Dor-030500 Dipodomys ordii 95.64 4.00e-176 609.00
IUUC-Ete-032870 Echinops telfairi 79.55 9.00e-146 509.00
IUUC-Eca-033284 Equus caballus 93.92 0.00e+00 808.00
IUUC-Fca-036212 Felis catus 96.98 0.00e+00 754.00
IUUC-Fal-037595 Ficedula albicollis 90.93 0.00e+00 809.00
IUUC-Gmo-038664 Gadus morhua 82.06 0.00e+00 734.00
IUUC-Gga-040400 Gallus gallus 90.93 0.00e+00 806.00
IUUC-Gac-041434 Gasterosteus aculeatus 82.60 0.00e+00 738.00
IUUC-Hsa-045884 Homo sapiens 97.07 0.00e+00 846.00
IUUC-Itr-048815 Ictidomys tridecemlineatus 97.48 0.00e+00 660.00
IUUC-Lch-049995 Latimeria chalumnae 87.07 0.00e+00 778.00
IUUC-Loc-052075 Lepisosteus oculatus 85.68 0.00e+00 755.00
IUUC-Laf-054345 Loxodonta africana 95.85 0.00e+00 840.00
IUUC-Mcc-055293 Macaca mulatta 95.61 0.00e+00 834.00
IUUC-Mga-059585 Meleagris gallopavo 89.59 0.00e+00 720.00
IUUC-Mmr-061268 Microcebus murinus 97.07 0.00e+00 848.00
IUUC-Mdo-061857 Monodelphis domestica 93.14 0.00e+00 818.00
IUUC-Mmu-063789 Mus musculus 98.78 0.00e+00 854.00
IUUC-Mpu-066391 Mustela putorius furo 97.80 0.00e+00 845.00
IUUC-Mlu-067636 Myotis lucifugus 95.34 0.00e+00 745.00
IUUC-Nle-068974 Nomascus leucogenys 96.34 0.00e+00 842.00
IUUC-Opr-070553 Ochotona princeps 83.66 0.00e+00 702.00
IUUC-Oan-073659 Ornithorhynchus anatinus 93.57 0.00e+00 690.00
IUUC-Ocu-074034 Oryctolagus cuniculus 97.07 0.00e+00 844.00
IUUC-Ola-087030 Oryzias latipes 82.35 0.00e+00 738.00
IUUC-Oga-087962 Otolemur garnettii 96.71 0.00e+00 756.00
IUUC-Oar-089377 Ovis aries 96.83 0.00e+00 844.00
IUUC-Ptr-090728 Pan troglodytes 96.59 0.00e+00 843.00
IUUC-Pan-092130 Papio anubis 95.37 0.00e+00 833.00
IUUC-Psi-093886 Pelodiscus sinensis 90.91 0.00e+00 728.00
IUUC-Pfo-097254 Poecilia formosa 83.90 0.00e+00 745.00
IUUC-Pab-097594 Pongo abelii 96.83 0.00e+00 844.00
IUUC-Pca-100741 Procavia capensis 86.26 0.00e+00 652.00
IUUC-Pva-102441 Pteropus vampyrus 94.49 0.00e+00 695.00
IUUC-Sha-106731 Sarcophilus harrisii 92.29 0.00e+00 729.00
IUUC-Ssc-115316 Sus scrofa 98.10 3.00e-125 440.00
IUUC-Tgu-116691 Taeniopygia guttata 91.18 0.00e+00 809.00
IUUC-Tru-118169 Takifugu rubripes 83.58 0.00e+00 740.00
IUUC-Tsy-119047 Tarsius syrichta 83.52 0.00e+00 627.00
IUUC-Tni-120708 Tetraodon nigroviridis 83.37 0.00e+00 736.00
IUUC-Tbe-127442 Tupaia belangeri 96.98 0.00e+00 755.00
IUUC-Ttr-128779 Tursiops truncatus 85.12 0.00e+00 724.00
IUUC-Vpa-130488 Vicugna pacos 91.83 6.00e-118 416.00
IUUC-Xtr-131994 Xenopus tropicalis 80.68 0.00e+00 725.00
Created Date 25-Jun-2017

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