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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063560
UUCD1 version UUC-MuM-00461
Ensembl Protein ID ENSMUSP00000038137.4
UniProt Accession Q5U4D9; THOC6_MOUSE
Genbank Protein ID AAH85131.1; AAH89551.1
Protein Name THO complex subunit 6 homolog; WD repeat-containing protein 58
Genbank Nucleotide ID BC085131; BC089551
Gene Name Thoc6; Wdr58
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041319.13 ENSMUST00000047436.10 ENSMUSP00000038137.4
ENSMUSG00000041319.13 ENSMUST00000115489.7 ENSMUSP00000111152.1
ENSMUSG00000041319.13 ENSMUST00000115490.7 ENSMUSP00000111153.1
ENSMUSG00000041319.13 ENSMUST00000135259.1 ENSMUSP00000119920.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-11 44.3 166 202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvl 35
           gHtd ++cla+   ++ ++sG+ Dg +++WDlr  + 
   Q: 166  GHTDYIHCLALreRSPEVLSGGEDGAVRLWDLRIAKE 202
           8**********98559***************986655 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity).
 Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development (By similarity).
Protein Sequence
(Fasta)
MEHAAPLAVP LGQAEVFQAL QRLHMTIFSQ SVSPCGKFLA AGNNYGQIAI FSLSAALSSE 60
AKEESKKPVV VFHAHDGPVY SMVSTDRHLL SAGDGEVKGW LWAEILKKGC KELWRRQPPY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063560|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCACTGGAGA CGTTTTACGC AGGCGCGGAA GACAGGAATC AGGTTAGAGG TTAGAAGGCG 60
GGACAGGTCG GCGCGGTGGG GGAGGGGATC CGGCGTGGCT GGATAGTTCT GGGCGCTTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063560|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005622--C:intracellular
GO:0016604--C:nuclear body
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000347--C:THO complex
GO:0000445--C:THO complex part of transcription export complex
GO:0000346--C:transcription export complex
GO:0003723--F:RNA binding
GO:0006915--P:apoptotic process
GO:0007417--P:central nervous system development
GO:0006406--P:mRNA export from nucleus
GO:0006397--P:mRNA processing
GO:0043066--P:negative regulation of apoptotic process
GO:0008380--P:RNA splicing
GO:0046784--P:viral mRNA export from host cell nucleus
KEGG mmu:386612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001101 Aegilops tauschii 29.84 6.00e-29 121.00
IUUC-Aml-001693 Ailuropoda melanoleuca 95.89 2.00e-179 621.00
IUUC-Atr-002699 Amborella trichopoda 29.20 6.00e-22 98.20
IUUC-Aca-004231 Anolis carolinensis 70.03 1.00e-125 442.00
IUUC-Aly-006385 Arabidopsis lyrata 30.03 1.00e-28 120.00
IUUC-Ath-006723 Arabidopsis thaliana 30.03 9.00e-29 120.00
IUUC-Ame-010813 Astyanax mexicanus 63.26 2.00e-86 311.00
IUUC-Bta-013458 Bos taurus 94.72 1.00e-175 608.00
IUUC-Bdi-014935 Brachypodium distachyon 29.44 8.00e-29 121.00
IUUC-Bol-015442 Brassica oleracea 29.75 5.00e-28 118.00
IUUC-Bra-017807 Brassica rapa 31.29 9.00e-29 120.00
IUUC-Cja-019061 Callithrix jacchus 94.74 3.00e-176 610.00
IUUC-Cfa-021146 Canis familiaris 94.72 6.00e-177 612.00
IUUC-Cpo-022512 Cavia porcellus 94.72 4.00e-178 616.00
IUUC-Csa-023055 Chlorocebus sabaeus 94.72 6.00e-178 616.00
IUUC-Cho-024693 Choloepus hoffmanni 96.37 3.00e-99 353.00
IUUC-Cin-025181 Ciona intestinalis 35.09 2.00e-55 209.00
IUUC-Csv-025852 Ciona savignyi 36.28 4.00e-50 191.00
IUUC-Dre-028221 Danio rerio 59.63 8.00e-117 413.00
IUUC-Dno-029200 Dasypus novemcinctus 89.95 7.00e-87 312.00
IUUC-Dor-030863 Dipodomys ordii 92.96 4.00e-174 603.00
IUUC-Dme-032016 Drosophila melanogaster 30.82 5.00e-37 148.00
IUUC-Eca-034363 Equus caballus 95.31 2.00e-178 618.00
IUUC-Fca-036546 Felis catus 95.01 9.00e-177 612.00
IUUC-Gmo-038513 Gadus morhua 57.76 8.00e-107 380.00
IUUC-Gac-042606 Gasterosteus aculeatus 56.83 2.00e-110 391.00
IUUC-Gma-043171 Glycine max 28.19 3.00e-31 129.00
IUUC-Ggo-044877 Gorilla gorilla 95.89 2.00e-179 621.00
IUUC-Hsa-045813 Homo sapiens 95.31 3.00e-179 620.00
IUUC-Hvu-047782 Hordeum vulgare 31.08 2.00e-19 89.00
IUUC-Itr-047876 Ictidomys tridecemlineatus 95.31 6.00e-179 619.00
IUUC-Lch-049506 Latimeria chalumnae 63.53 4.00e-118 417.00
IUUC-Lpe-051203 Leersia perrieri 29.83 6.00e-24 105.00
IUUC-Loc-052451 Lepisosteus oculatus 52.48 8.00e-89 320.00
IUUC-Laf-053864 Loxodonta africana 93.55 7.00e-175 606.00
IUUC-Mcc-055705 Macaca mulatta 87.43 4.00e-151 527.00
IUUC-Meu-055926 Macropus eugenii 89.91 2.00e-154 538.00
IUUC-Mtr-058556 Medicago truncatula 28.82 2.00e-31 129.00
IUUC-Mmr-060836 Microcebus murinus 95.01 9.00e-179 619.00
IUUC-Mdo-062534 Monodelphis domestica 90.21 4.00e-154 537.00
IUUC-Mac-065134 Musa acuminata 28.63 4.00e-26 112.00
IUUC-Mpu-066031 Mustela putorius furo 95.89 4.00e-179 620.00
IUUC-Mlu-068051 Myotis lucifugus 91.50 1.00e-168 585.00
IUUC-Nle-069080 Nomascus leucogenys 94.72 1.00e-177 615.00
IUUC-Opr-070787 Ochotona princeps 90.03 1.00e-165 575.00
IUUC-Ont-071952 Oreochromis niloticus 55.28 1.00e-108 386.00
IUUC-Oan-073334 Ornithorhynchus anatinus 85.38 3.00e-117 414.00
IUUC-Oba-075175 Oryza barthii 30.39 1.00e-24 107.00
IUUC-Obr-076393 Oryza brachyantha 30.94 1.00e-24 107.00
IUUC-Ogl-077603 Oryza glaberrima 35.59 3.00e-18 85.50
IUUC-Ogu-078211 Oryza glumaepatula 30.39 1.00e-24 107.00
IUUC-Oin-079554 Oryza indica 30.39 5.00e-25 108.00
IUUC-Olo-080922 Oryza longistaminata 30.56 1.00e-22 100.00
IUUC-Ome-081127 Oryza meridionalis 23.76 1.00e-11 64.70
IUUC-Oni-082376 Oryza nivara 30.39 1.00e-24 107.00
IUUC-Opu-083163 Oryza punctata 29.83 3.00e-24 105.00
IUUC-Oru-084311 Oryza rufipogon 30.39 1.00e-24 107.00
IUUC-Osa-085762 Oryza sativa 35.59 4.00e-18 85.10
IUUC-Oga-088804 Otolemur garnettii 93.84 2.00e-177 614.00
IUUC-Oar-090095 Ovis aries 94.72 5.00e-176 610.00
IUUC-Ptr-090731 Pan troglodytes 95.60 3.00e-179 620.00
IUUC-Pan-092595 Papio anubis 95.32 3.00e-177 613.00
IUUC-Psi-093866 Pelodiscus sinensis 69.93 7.00e-117 413.00
IUUC-Pma-094236 Petromyzon marinus 58.95 3.00e-114 404.00
IUUC-Pfo-096095 Poecilia formosa 56.52 1.00e-105 375.00
IUUC-Pab-098385 Pongo abelii 95.31 1.00e-178 618.00
IUUC-Pop-099433 Populus trichocarpa 27.24 1.00e-28 120.00
IUUC-Pca-101119 Procavia capensis 94.98 6.00e-116 410.00
IUUC-Ppe-101677 Prunus persica 28.63 2.00e-26 113.00
IUUC-Pva-102726 Pteropus vampyrus 94.13 1.00e-176 612.00
IUUC-Rno-105576 Rattus norvegicus 98.53 0.00e+00 640.00
IUUC-Sha-106774 Sarcophilus harrisii 90.52 2.00e-155 541.00
IUUC-Sit-109988 Setaria italica 28.23 1.00e-26 114.00
IUUC-Sly-110864 Solanum lycopersicum 29.37 9.00e-28 117.00
IUUC-Sar-113060 Sorex araneus 86.31 3.00e-126 444.00
IUUC-Sbi-114699 Sorghum bicolor 29.12 1.00e-27 117.00
IUUC-Ssc-116445 Sus scrofa 95.01 3.00e-178 617.00
IUUC-Tru-117834 Takifugu rubripes 58.07 1.00e-112 399.00
IUUC-Tni-119651 Tetraodon nigroviridis 57.45 4.00e-112 397.00
IUUC-Tca-121318 Theobroma cacao 27.42 5.00e-27 115.00
IUUC-Tae-124184 Triticum aestivum 29.84 6.00e-29 121.00
IUUC-Tur-126226 Triticum urartu 30.39 1.00e-25 110.00
IUUC-Tbe-128079 Tupaia belangeri 81.27 8.00e-107 379.00
IUUC-Ttr-128391 Tursiops truncatus 90.35 4.00e-165 573.00
IUUC-Vvi-131148 Vitis vinifera 27.02 5.00e-24 105.00
IUUC-Xtr-132743 Xenopus tropicalis 62.02 3.00e-117 414.00
IUUC-Xma-133722 Xiphophorus maculatus 56.83 2.00e-110 392.00
Created Date 25-Jun-2017

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