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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046913
UUCD1 version UUC-HoS-01115
Ensembl Protein ID ENSP00000381577.2
UniProt Accession Q70CQ2; A8MWD0; B3KWU9; O60316; O94834; Q3B777; Q6P6C9; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1; UBP34_HUMAN
Genbank Protein ID CAE51938.1; BAA25496.2; CAB43264.1; CAD38579.1; BAG54261.1; BAA34449.1; AAH22783.1; AAH62325.1; AAI07762.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 34; Deubiquitinating enzyme 34; Ubiquitin thioesterase 34; Ubiquitin-specific-processing protease 34
Genbank Nucleotide ID AJ586138; AB011142; AC016747; AL831918; AK125898; AB018272; BC022783; BC062325; BC107761
Gene Name USP34; KIAA0570; KIAA0729
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000115464.14 ENST00000411912.5 ENSP00000398960.1
ENSG00000115464.14 ENST00000398571.6 ENSP00000381577.2
ENSG00000115464.14 ENST00000436269.1 ENSP00000398489.1
ENSG00000115464.14 ENST00000453133.1 ENSP00000388129.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 21245847
Classification
Family E-value Score Start End
DUB/USP 4.30e-69 234.9 1894 2239
Active Site
Position(s) Description Evidence
1903 Nucleophile ECO:0000305}
2164 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+Nlg+tCY+ S++Q+L++ipe r+++++ k++e++       ++++ l +lqk+f+ l++s+ ka++pr + k+  + ++ +++ eq
   Q: 1894 VGLTNLGATCYLASTIQQLYMIPEARQAVFTaKYSEDM-------KHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQ 1976
           6******************************3444444.......4568899************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           +D  Ef++ l+ ++ee                               + k++++ lF+g ++++++ l+c++vs++ e+f+++ ++v + 
   Q: 1977 KDMTEFFTDLITKIEEMS----------------------------PELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADM 2038
           **************9977............................567899************************************** PP
   S: 180  eetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.. 267
           +     ++ ++L++ t +++leg+n+y c++c kk++aek+  +kklP++L+++ +R++f+  ++++ek+n++++fpl+Ld++p++++  
   Q: 2039 K-----NIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDfl 2123
           *.....9*********************************************************************************99 PP
   S: 268  ..............peekqkekkkYeLiavvvHsGslssGHYvayvkn.......ekgkWllfdDskVtevkeeevleetg......... 327
                         + +k++e+++Y+Li+v vH+G++++GHY++++++       +++kW+lf+D +V++ + ++  +e+          
   Q: 2124 mgkserkegfkevsDHSKDSESYEYDLIGVTVHTGTADGGHYYSFIRDivnphayKNNKWYLFNDAEVKPFDSAQLASECFggemttkty 2213
           999999999999986666667***************************99999988999******************97779******** PP
   S: 328  ...............staYvlfYkrr 338
                          ++aY+lfYkr+
   Q: 2214 dsvtdkfmdfsfektHSAYMLFYKRM 2239
           ************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
 Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
Protein Sequence
(Fasta)
MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF KEYKHLEIFN 60
QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ AEEPLNIDRE CNEGSTERQK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046913|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTCTCCCCT CCCCCCCGCC GGTCGGGATC AGTCAGTGTG ATCCGAAGCG GGGGAGGGGG 60
GGGGCGGCGG CCGAACGATG TGCGAGAACT GCGCAGACCT GGTGGAGGTG TTAAATGAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046913|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005829--C:cytosol
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG hsa:9736
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002257 Ailuropoda melanoleuca 98.41 0.00e+00 6858.00
IUUC-Apl-003284 Anas platyrhynchos 94.71 0.00e+00 6311.00
IUUC-Aca-004415 Anolis carolinensis 92.73 0.00e+00 6471.00
IUUC-Acl-008140 Aspergillus clavatus 28.62 5.00e-64 241.00
IUUC-Afl-008381 Aspergillus flavus 28.81 7.00e-64 240.00
IUUC-Afu-008857 Aspergillus fumigatus 27.21 9.00e-64 240.00
IUUC-Ani-009257 Aspergillus nidulans 28.68 3.00e-56 215.00
IUUC-Ang-009759 Aspergillus niger 27.72 1.00e-63 240.00
IUUC-Aor-009931 Aspergillus oryzae 28.81 7.00e-64 240.00
IUUC-Ate-010246 Aspergillus terreus 29.45 6.00e-53 204.00
IUUC-Ame-011219 Astyanax mexicanus 64.72 0.00e+00 2479.00
IUUC-Bgr-012195 Blumeria graminis 26.76 1.00e-64 243.00
IUUC-Bta-012989 Bos taurus 98.11 0.00e+00 6807.00
IUUC-Bci-013798 Botrytis cinerea 32.44 7.00e-58 221.00
IUUC-Cja-018974 Callithrix jacchus 97.88 0.00e+00 832.00
IUUC-Cfa-021214 Canis familiaris 98.56 0.00e+00 6867.00
IUUC-Cpo-021912 Cavia porcellus 98.15 0.00e+00 4791.00
IUUC-Csa-023658 Chlorocebus sabaeus 99.58 0.00e+00 6927.00
IUUC-Cho-024971 Choloepus hoffmanni 83.70 0.00e+00 3203.00
IUUC-Cgl-026466 Colletotrichum gloeosporioides 27.68 3.00e-63 238.00
IUUC-Dre-027428 Danio rerio 84.81 0.00e+00 4625.00
IUUC-Dno-029690 Dasypus novemcinctus 97.61 0.00e+00 6672.00
IUUC-Dor-030817 Dipodomys ordii 88.77 0.00e+00 2156.00
IUUC-Dse-031423 Dothistroma septosporum 25.05 2.00e-35 146.00
IUUC-Dme-032102 Drosophila melanogaster 54.00 0.00e+00 848.00
IUUC-Ete-032552 Echinops telfairi 93.87 0.00e+00 3003.00
IUUC-Eca-033457 Equus caballus 98.41 0.00e+00 6556.00
IUUC-Eeu-035118 Erinaceus europaeus 94.14 0.00e+00 3075.00
IUUC-Fca-036213 Felis catus 96.32 0.00e+00 5070.00
IUUC-Fal-037643 Ficedula albicollis 92.04 0.00e+00 6405.00
IUUC-Fox-037971 Fusarium oxysporum 27.27 5.00e-63 237.00
IUUC-Fso-038108 Fusarium solani 26.94 2.00e-59 226.00
IUUC-Ggr-040075 Gaeumannomyces graminis 32.63 7.00e-63 237.00
IUUC-Gga-040511 Gallus gallus 92.17 0.00e+00 6471.00
IUUC-Gac-042024 Gasterosteus aculeatus 87.93 0.00e+00 5019.00
IUUC-Ggo-044924 Gorilla gorilla 95.64 0.00e+00 6352.00
IUUC-Itr-048626 Ictidomys tridecemlineatus 98.39 0.00e+00 6862.00
IUUC-Lch-049675 Latimeria chalumnae 85.63 0.00e+00 4882.00
IUUC-Loc-052832 Lepisosteus oculatus 86.69 0.00e+00 5979.00
IUUC-Lma-053130 Leptosphaeria maculans 27.49 6.00e-61 231.00
IUUC-Laf-054169 Loxodonta africana 96.74 0.00e+00 6791.00
IUUC-Mcc-055847 Macaca mulatta 98.39 0.00e+00 6807.00
IUUC-Meu-056327 Macropus eugenii 85.38 0.00e+00 1565.00
IUUC-Mor-057152 Magnaporthe oryzae 35.14 6.00e-62 234.00
IUUC-Mpo-057310 Magnaporthe poae 26.58 2.00e-60 229.00
IUUC-Mmr-060780 Microcebus murinus 98.87 0.00e+00 6909.00
IUUC-Mdo-062308 Monodelphis domestica 92.47 0.00e+00 6164.00
IUUC-Mmu-063457 Mus musculus 96.46 0.00e+00 6771.00
IUUC-Mpu-066917 Mustela putorius furo 96.21 0.00e+00 6654.00
IUUC-Mlu-067696 Myotis lucifugus 98.07 0.00e+00 6817.00
IUUC-Nfi-068259 Neosartorya fischeri 27.21 3.00e-64 241.00
IUUC-Ncr-068911 Neurospora crassa 25.71 2.00e-59 225.00
IUUC-Nle-069586 Nomascus leucogenys 99.58 0.00e+00 6963.00
IUUC-Opr-070447 Ochotona princeps 93.93 0.00e+00 2891.00
IUUC-Ont-072396 Oreochromis niloticus 84.79 0.00e+00 5480.00
IUUC-Oan-073147 Ornithorhynchus anatinus 94.62 0.00e+00 6602.00
IUUC-Ocu-074324 Oryctolagus cuniculus 98.19 0.00e+00 6826.00
IUUC-Ola-086312 Oryzias latipes 82.18 0.00e+00 5289.00
IUUC-Oga-088878 Otolemur garnettii 98.67 0.00e+00 6882.00
IUUC-Oar-089919 Ovis aries 97.81 0.00e+00 6811.00
IUUC-Ptr-090713 Pan troglodytes 99.54 0.00e+00 6355.00
IUUC-Pan-091957 Papio anubis 99.58 0.00e+00 5161.00
IUUC-Psi-093240 Pelodiscus sinensis 93.55 0.00e+00 6516.00
IUUC-Pma-094469 Petromyzon marinus 73.05 0.00e+00 4094.00
IUUC-Pno-095059 Phaeosphaeria nodorum 29.57 2.00e-57 219.00
IUUC-Pfo-097159 Poecilia formosa 81.66 0.00e+00 5543.00
IUUC-Pab-098003 Pongo abelii 99.05 0.00e+00 6569.00
IUUC-Pca-100799 Procavia capensis 90.81 0.00e+00 1940.00
IUUC-Pva-103226 Pteropus vampyrus 93.21 0.00e+00 6427.00
IUUC-Pte-104235 Pyrenophora teres 26.71 4.00e-59 224.00
IUUC-Pyt-104803 Pyrenophora triticirepentis 27.20 9.00e-61 229.00
IUUC-Rno-105389 Rattus norvegicus 96.34 0.00e+00 5542.00
IUUC-Sha-106979 Sarcophilus harrisii 94.16 0.00e+00 6579.00
IUUC-Sar-113444 Sorex araneus 91.15 0.00e+00 5972.00
IUUC-Ssc-115815 Sus scrofa 97.46 0.00e+00 5681.00
IUUC-Tgu-117470 Taeniopygia guttata 94.02 0.00e+00 6241.00
IUUC-Tru-118543 Takifugu rubripes 82.24 0.00e+00 5375.00
IUUC-Tsy-119081 Tarsius syrichta 89.11 0.00e+00 4892.00
IUUC-Tni-120294 Tetraodon nigroviridis 81.90 1.00e-164 572.00
IUUC-Tre-122057 Trichoderma reesei 31.43 1.00e-62 236.00
IUUC-Tvi-122570 Trichoderma virens 35.62 2.00e-59 225.00
IUUC-Tme-127154 Tuber melanosporum 27.40 6.00e-60 226.00
IUUC-Tbe-127801 Tupaia belangeri 86.81 0.00e+00 3324.00
IUUC-Ttr-129262 Tursiops truncatus 93.97 0.00e+00 6499.00
IUUC-Vda-129686 Verticillium dahliae 28.06 4.00e-62 234.00
IUUC-Vpa-130484 Vicugna pacos 95.94 0.00e+00 5299.00
IUUC-Xtr-131769 Xenopus tropicalis 86.09 0.00e+00 6068.00
Created Date 25-Jun-2017

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