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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063846
UUCD1 version UUC-MuM-00586
Ensembl Protein ID ENSMUSP00000037978.4
UniProt Accession Q80WG7; Q7TNM1; TRI36_MOUSE
Genbank Protein ID BAC76066.1; AAP51209.1; AAH58106.1
Protein Name E3 ubiquitin-protein ligase Trim36; Acrosome RBCC protein; Haprin; RING-type E3 ubiquitin transferase TRIM36; Tripartite motif-containing protein 36
Genbank Nucleotide ID AB103063; AY251389; BC058106
Gene Name Trim36
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033949.11 ENSMUST00000167364.7 ENSMUSP00000129771.1
ENSMUSG00000033949.11 ENSMUST00000037011.4 ENSMUSP00000037978.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.90e-06 29.4 33 118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw............pglknssskefr..............................CPlC 45
           C+ C+e f + pl+lpC+H  +++C++ +             +++n+ss++ r                              CP C
   Q: 33   CPACKELFTH-PLILPCQHSVCHKCVKELllslddsfndvaSDSSNQSSPRLRltspsmdkidkinrpgwkrnsltprpttfpCPGC 118
           ********99.**************98888888999888886666666666668888888888888888888888888888889988 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Protein Sequence
(Fasta)
MSESEEISEF GYIMELLAKG KVTIKNIEKE LICPACKELF THPLILPCQH SVCHKCVKEL 60
LLSLDDSFND VASDSSNQSS PRLRLTSPSM DKIDKINRPG WKRNSLTPRP TTFPCPGCEH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063846|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTTCCGTTA GCTGGCGCTG GCCAGCCTGG TGCAGCTAGG GCCTGGGAGG CTGGACAAGA 60
CTGCCCGGGT CCTCCTGGGC CTGCATCCCA CACGGCCCCG CCCTCAGCTT TCTCCTCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063846|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027726--Trim36
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00336--BBOX
SM00184--RING
Gene Ontology

GO:0001669--C:acrosomal vesicle
GO:0070062--C:extracellular exosome
GO:0015630--C:microtubule cytoskeleton
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007340--P:acrosome reaction
GO:0001578--P:microtubule bundle formation
GO:0051726--P:regulation of cell cycle
KEGG mmu:28105
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002038 Ailuropoda melanoleuca 92.71 0.00e+00 1406.00
IUUC-Apl-003863 Anas platyrhynchos 74.58 0.00e+00 1059.00
IUUC-Aca-005003 Anolis carolinensis 76.69 0.00e+00 1177.00
IUUC-Ame-011283 Astyanax mexicanus 64.33 0.00e+00 918.00
IUUC-Bta-013517 Bos taurus 93.00 0.00e+00 1415.00
IUUC-Cja-019181 Callithrix jacchus 92.87 0.00e+00 1415.00
IUUC-Cfa-020375 Canis familiaris 93.12 0.00e+00 1409.00
IUUC-Cpo-021827 Cavia porcellus 90.26 0.00e+00 1366.00
IUUC-Csa-023819 Chlorocebus sabaeus 92.66 0.00e+00 1368.00
IUUC-Cho-024602 Choloepus hoffmanni 92.70 0.00e+00 1236.00
IUUC-Dre-028570 Danio rerio 61.56 0.00e+00 901.00
IUUC-Dno-029385 Dasypus novemcinctus 91.89 0.00e+00 1360.00
IUUC-Ete-032498 Echinops telfairi 90.51 0.00e+00 1351.00
IUUC-Eca-034142 Equus caballus 91.77 0.00e+00 1401.00
IUUC-Eeu-034756 Erinaceus europaeus 85.47 2.00e-145 509.00
IUUC-Fca-035508 Felis catus 92.51 0.00e+00 1365.00
IUUC-Fal-037617 Ficedula albicollis 71.84 0.00e+00 1119.00
IUUC-Gmo-038943 Gadus morhua 61.36 0.00e+00 771.00
IUUC-Gac-041330 Gasterosteus aculeatus 60.57 0.00e+00 782.00
IUUC-Ggo-045308 Gorilla gorilla 91.91 0.00e+00 1400.00
IUUC-Hsa-046810 Homo sapiens 92.46 0.00e+00 1408.00
IUUC-Lch-050382 Latimeria chalumnae 68.33 0.00e+00 1008.00
IUUC-Loc-051809 Lepisosteus oculatus 61.44 0.00e+00 869.00
IUUC-Laf-054251 Loxodonta africana 92.05 0.00e+00 1354.00
IUUC-Mcc-054735 Macaca mulatta 92.87 0.00e+00 1410.00
IUUC-Meu-056861 Macropus eugenii 82.26 0.00e+00 1037.00
IUUC-Mmr-061266 Microcebus murinus 93.14 0.00e+00 1415.00
IUUC-Mdo-061996 Monodelphis domestica 85.91 0.00e+00 1315.00
IUUC-Mpu-065916 Mustela putorius furo 92.85 0.00e+00 1406.00
IUUC-Mlu-067753 Myotis lucifugus 87.11 0.00e+00 1342.00
IUUC-Nle-068991 Nomascus leucogenys 91.77 0.00e+00 1392.00
IUUC-Opr-070512 Ochotona princeps 88.40 0.00e+00 1118.00
IUUC-Ont-072641 Oreochromis niloticus 61.58 0.00e+00 918.00
IUUC-Oan-072998 Ornithorhynchus anatinus 72.25 0.00e+00 1083.00
IUUC-Ocu-074891 Oryctolagus cuniculus 87.70 0.00e+00 1232.00
IUUC-Ola-086318 Oryzias latipes 61.79 0.00e+00 766.00
IUUC-Oga-088089 Otolemur garnettii 91.95 0.00e+00 1358.00
IUUC-Oar-089836 Ovis aries 92.59 0.00e+00 1407.00
IUUC-Ptr-091083 Pan troglodytes 92.04 0.00e+00 1402.00
IUUC-Pan-092310 Papio anubis 91.36 0.00e+00 1383.00
IUUC-Psi-093663 Pelodiscus sinensis 79.01 0.00e+00 1214.00
IUUC-Pfo-096697 Poecilia formosa 62.89 0.00e+00 899.00
IUUC-Pab-098766 Pongo abelii 89.07 0.00e+00 683.00
IUUC-Pca-100938 Procavia capensis 83.90 0.00e+00 725.00
IUUC-Pva-102799 Pteropus vampyrus 92.58 0.00e+00 1004.00
IUUC-Rno-105823 Rattus norvegicus 98.90 0.00e+00 1509.00
IUUC-Sha-106921 Sarcophilus harrisii 85.91 0.00e+00 1342.00
IUUC-Sar-113002 Sorex araneus 77.18 0.00e+00 883.00
IUUC-Ssc-115356 Sus scrofa 92.46 0.00e+00 1432.00
IUUC-Tgu-117350 Taeniopygia guttata 70.27 0.00e+00 1043.00
IUUC-Tru-117786 Takifugu rubripes 61.91 0.00e+00 915.00
IUUC-Tsy-119009 Tarsius syrichta 91.91 0.00e+00 1373.00
IUUC-Tni-119753 Tetraodon nigroviridis 61.22 0.00e+00 912.00
IUUC-Ttr-128842 Tursiops truncatus 92.98 0.00e+00 1405.00
IUUC-Vpa-130330 Vicugna pacos 92.94 0.00e+00 1400.00
IUUC-Xtr-132760 Xenopus tropicalis 68.29 0.00e+00 1045.00
Created Date 25-Jun-2017

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