iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000069678.10	ENSMUST00000165164.8	ENSMUSP00000130614.2
ENSMUSG00000069678.10	ENSMUST00000176027.7	ENSMUSP00000135664.1
ENSMUSG00000069678.10	ENSMUST00000176089.1	ENSMUSP00000135268.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/RAWUL	1.30e-24	87.7	169	253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsklkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk.kegpLvLqYr 86
           +sl+Le+l+s k+k++++l++ky+rcs r++V+hl+++l+++l+l+++ +v+ll+++evL d++t++++ +  +w  k +pL+LqY+
   Q: 169  LSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQL-WLSRWFgKPSPLLLQYS 253
           58**********************************************.********************.*****9999*******5 PP

Organism

Mus musculus

Functional Description
(View)

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (By similarity).

Protein Sequence
(Fasta)

MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI 60
TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCTCCCA GACTTCGCGA GCCCGGAAAA AACTCCCGCG GCGCAGACGG GAGAAGGCCC 60
GCGGCTGGGA CGCAGCTCCG CAACGCGGAC GCCGCAGCGG AGCAGGACTG CACTGTATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0008022--F:protein C-terminus binding
GO:0008270--F:zinc ion binding
GO:0035518--P:histone H2A monoubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:69837

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002099	Ailuropoda melanoleuca	98.46	3.00e-143	500.00
IUUC-Atr-002463	Amborella trichopoda	41.46	4.00e-12	65.90
IUUC-Aca-004475	Anolis carolinensis	71.20	9.00e-73	265.00
IUUC-Ame-011787	Astyanax mexicanus	79.77	2.00e-123	434.00
IUUC-Bta-012404	Bos taurus	98.07	2.00e-142	498.00
IUUC-Cja-019959	Callithrix jacchus	98.07	5.00e-143	499.00
IUUC-Cfa-021067	Canis familiaris	98.46	3.00e-143	500.00
IUUC-Cpo-021935	Cavia porcellus	98.07	1.00e-142	498.00
IUUC-Csa-023876	Chlorocebus sabaeus	98.46	6.00e-143	499.00
IUUC-Cin-025434	Ciona intestinalis	44.84	3.00e-52	198.00
IUUC-Csv-026203	Ciona savignyi	46.26	8.00e-50	189.00
IUUC-Dre-027690	Danio rerio	79.77	5.00e-124	436.00
IUUC-Dno-029852	Dasypus novemcinctus	98.84	2.00e-143	501.00
IUUC-Dor-030923	Dipodomys ordii	98.46	1.00e-152	531.00
IUUC-Eca-033830	Equus caballus	99.19	6.00e-136	476.00
IUUC-Eeu-034879	Erinaceus europaeus	74.49	1.00e-101	362.00
IUUC-Fca-036120	Felis catus	98.46	3.00e-143	500.00
IUUC-Fal-036629	Ficedula albicollis	82.96	1.00e-101	362.00
IUUC-Gmo-039075	Gadus morhua	76.08	4.00e-117	414.00
IUUC-Gga-040955	Gallus gallus	83.14	1.00e-130	458.00
IUUC-Gac-042588	Gasterosteus aculeatus	79.38	9.00e-112	395.00
IUUC-Ggo-045205	Gorilla gorilla	98.07	8.00e-143	499.00
IUUC-Hsa-046271	Homo sapiens	98.07	8.00e-143	499.00
IUUC-Itr-048922	Ictidomys tridecemlineatus	98.84	2.00e-143	501.00
IUUC-Lpe-051490	Leersia perrieri	44.29	1.00e-11	64.70
IUUC-Loc-052395	Lepisosteus oculatus	82.28	7.00e-116	409.00
IUUC-Laf-054374	Loxodonta africana	97.57	5.00e-135	473.00
IUUC-Mcc-055839	Macaca mulatta	98.46	6.00e-143	499.00
IUUC-Meu-056254	Macropus eugenii	81.15	2.00e-105	374.00
IUUC-Mmr-061131	Microcebus murinus	98.46	3.00e-143	500.00
IUUC-Mdo-062849	Monodelphis domestica	92.43	7.00e-132	462.00
IUUC-Mac-065443	Musa acuminata	41.46	1.00e-11	63.90
IUUC-Mpu-066111	Mustela putorius furo	98.46	2.00e-143	501.00
IUUC-Mlu-067503	Myotis lucifugus	96.93	3.00e-140	490.00
IUUC-Nle-069996	Nomascus leucogenys	98.46	6.00e-143	499.00
IUUC-Ont-071986	Oreochromis niloticus	77.52	5.00e-115	406.00
IUUC-Ocu-073943	Oryctolagus cuniculus	98.84	2.00e-143	501.00
IUUC-Oba-075928	Oryza barthii	43.66	2.00e-11	63.50
IUUC-Ogl-077158	Oryza glaberrima	43.66	2.00e-11	63.50
IUUC-Ogu-078857	Oryza glumaepatula	43.66	2.00e-11	63.50
IUUC-Oin-080071	Oryza indica	43.66	3.00e-11	63.20
IUUC-Olo-080821	Oryza longistaminata	43.66	2.00e-11	63.50
IUUC-Ome-081413	Oryza meridionalis	43.66	3.00e-11	63.20
IUUC-Oni-082240	Oryza nivara	43.66	3.00e-11	63.20
IUUC-Oru-084344	Oryza rufipogon	43.66	2.00e-11	63.50
IUUC-Ola-086932	Oryzias latipes	75.76	5.00e-88	316.00
IUUC-Oga-089144	Otolemur garnettii	98.07	1.00e-142	498.00
IUUC-Oar-089550	Ovis aries	98.07	2.00e-142	498.00
IUUC-Ptr-091118	Pan troglodytes	98.07	8.00e-143	499.00
IUUC-Pan-092208	Papio anubis	98.46	6.00e-143	499.00
IUUC-Pma-094218	Petromyzon marinus	69.02	4.00e-95	340.00
IUUC-Ppa-095811	Physcomitrella patens	48.33	5.00e-10	59.30
IUUC-Pfo-096815	Poecilia formosa	76.26	3.00e-115	407.00
IUUC-Pab-098575	Pongo abelii	98.46	6.00e-143	499.00
IUUC-Pca-100587	Procavia capensis	96.72	2.00e-130	457.00
IUUC-Ppe-102026	Prunus persica	41.46	3.00e-13	69.30
IUUC-Pva-102656	Pteropus vampyrus	93.05	5.00e-132	462.00
IUUC-Rno-105780	Rattus norvegicus	100.00	2.00e-144	504.00
IUUC-Sha-106983	Sarcophilus harrisii	87.94	4.00e-92	330.00
IUUC-Sit-110796	Setaria italica	42.25	1.00e-10	60.80
IUUC-Sly-111519	Solanum lycopersicum	46.34	2.00e-13	70.10
IUUC-Stu-112366	Solanum tuberosum	46.34	2.00e-13	70.50
IUUC-Sar-113694	Sorex araneus	98.45	2.00e-73	266.00
IUUC-Sbi-114697	Sorghum bicolor	43.66	1.00e-10	61.20
IUUC-Ssc-115319	Sus scrofa	95.75	8.00e-149	519.00
IUUC-Tru-118337	Takifugu rubripes	79.46	7.00e-121	426.00
IUUC-Tsy-119461	Tarsius syrichta	94.52	3.00e-69	253.00
IUUC-Tni-120608	Tetraodon nigroviridis	78.31	2.00e-116	411.00
IUUC-Tca-121851	Theobroma cacao	40.23	1.00e-11	64.30
IUUC-Ttr-129127	Tursiops truncatus	98.46	3.00e-143	500.00
IUUC-Vpa-130033	Vicugna pacos	67.98	7.00e-80	289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence