iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000055371.17	ENSMUST00000102759.7	ENSMUSP00000099820.1
ENSMUSG00000055371.17	ENSMUST00000127316.7	ENSMUSP00000121898.1
ENSMUSG00000055371.17	ENSMUST00000155516.1	ENSMUSP00000119203.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	BioGRID	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11406394; 12551915
UBD/Alpha-Helix/VHS	VHS	11406394; 12551915

Classification

Family	E-value	Score	Start	End
UBD/SH3	1.70e-16	61.0	204	257
UBD/Alpha-Helix/VHS	1.80e-55	187.6	16	144
UBD/Alpha-Helix/UIM	0.0006	20.7	165	183

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            ++v++lyd+ea++d+eLt+k+G+ ++v+  ++ d++W++g  e +   GlfP+nFv+
   Q: 204  ARRVRALYDFEAVEDNELTFKHGELITVL--DDSDANWWQG--ENHRGTGLFPSNFVT 257
           5789*************************..99********..89999********97 PP

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           at+e++t+edw+li++icd +++t +gakd+l+a++kr+n+k phval+aLtlL++cv+nCgk+fh+ev+s+d+++e+r+++kn+++pk
   Q: 16   ATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIKNKAHPK 104
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v+eKlk+l+v+W++e++++p++sli+a+ik++keeG++fp
   Q: 105  VCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGVTFP 144
           ***************************************8 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +Ede++++A++lSlqE+ +
   Q: 165  KEDEDIAKAIELSLQEQKQ 183
           69**************976 PP

Organism

Mus musculus

Functional Description
(View)

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).

Protein Sequence
(Fasta)

MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDRVGSTP SGAKDCLKAI MKRVNHKVPH 60
VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRSVIKNK AHPKVCEKLK SLMVEWSEEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGGTGGGG CTGGAGCCGC GGCGGCCGGG CGCCGGACAG GCAGGCGCGC GCAGGGCAGG 60
CACGGCGGCG GAAGTGAAGG CACCGCTGGG CCAAGCCGTC TAGGAAGCCG CGGCGGGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport

Interpro

IPR008942--ENTH_VHS
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom

PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS

Pfam

PF00018--SH3_1
PF02809--UIM
PF00790--VHS

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3
SM00726--UIM
SM00288--VHS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0006886--P:intracellular protein transport

KEGG

mmu:56324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002079	Ailuropoda melanoleuca	82.41	0.00e+00	852.00
IUUC-Apl-003548	Anas platyrhynchos	74.12	0.00e+00	716.00
IUUC-Aca-004991	Anolis carolinensis	73.06	0.00e+00	662.00
IUUC-Ago-007874	Ashbya gossypii	25.06	1.00e-29	124.00
IUUC-Acl-008046	Aspergillus clavatus	27.13	3.00e-35	143.00
IUUC-Afl-008621	Aspergillus flavus	26.95	1.00e-38	154.00
IUUC-Afu-008826	Aspergillus fumigatus	26.80	5.00e-32	132.00
IUUC-Ani-009419	Aspergillus nidulans	28.09	5.00e-38	152.00
IUUC-Ang-009580	Aspergillus niger	28.28	1.00e-37	151.00
IUUC-Ate-010532	Aspergillus terreus	27.43	2.00e-37	150.00
IUUC-Ame-011913	Astyanax mexicanus	58.00	3.00e-157	548.00
IUUC-Bgr-012113	Blumeria graminis	28.57	3.00e-40	160.00
IUUC-Bta-013115	Bos taurus	79.63	3.00e-162	564.00
IUUC-Bci-013955	Botrytis cinerea	32.23	3.00e-35	143.00
IUUC-Cja-018846	Callithrix jacchus	83.90	0.00e+00	912.00
IUUC-Cfa-020589	Canis familiaris	84.57	0.00e+00	855.00
IUUC-Cpo-021460	Cavia porcellus	80.65	0.00e+00	843.00
IUUC-Csa-023912	Chlorocebus sabaeus	86.48	0.00e+00	934.00
IUUC-Cho-024297	Choloepus hoffmanni	84.54	0.00e+00	865.00
IUUC-Cgl-026648	Colletotrichum gloeosporioides	28.65	6.00e-40	159.00
IUUC-Cne-027007	Cryptococcus neoformans	31.69	4.00e-17	83.60
IUUC-Cme-027127	Cyanidioschyzon merolae	28.83	4.60e-01	30.80
IUUC-Dre-027454	Danio rerio	58.85	1.00e-159	556.00
IUUC-Dno-029182	Dasypus novemcinctus	84.57	0.00e+00	910.00
IUUC-Dor-030949	Dipodomys ordii	78.84	0.00e+00	697.00
IUUC-Dse-031527	Dothistroma septosporum	32.43	6.00e-35	142.00
IUUC-Eca-033544	Equus caballus	85.28	0.00e+00	830.00
IUUC-Eeu-035224	Erinaceus europaeus	74.29	0.00e+00	760.00
IUUC-Fca-035958	Felis catus	85.52	0.00e+00	899.00
IUUC-Fal-037193	Ficedula albicollis	67.24	0.00e+00	649.00
IUUC-Fox-037748	Fusarium oxysporum	33.83	1.00e-38	154.00
IUUC-Ggr-040048	Gaeumannomyces graminis	28.07	1.00e-38	154.00
IUUC-Gga-041158	Gallus gallus	71.54	0.00e+00	708.00
IUUC-Ggo-044661	Gorilla gorilla	82.17	0.00e+00	862.00
IUUC-Hsa-046959	Homo sapiens	86.48	0.00e+00	934.00
IUUC-Itr-048399	Ictidomys tridecemlineatus	90.81	0.00e+00	724.00
IUUC-Lch-050505	Latimeria chalumnae	66.86	0.00e+00	678.00
IUUC-Loc-051737	Lepisosteus oculatus	60.90	5.00e-172	597.00
IUUC-Laf-053943	Loxodonta africana	85.14	0.00e+00	920.00
IUUC-Mcc-055609	Macaca mulatta	86.48	0.00e+00	934.00
IUUC-Meu-056575	Macropus eugenii	61.22	3.00e-163	568.00
IUUC-Mor-056972	Magnaporthe oryzae	30.88	3.00e-35	143.00
IUUC-Mpo-057476	Magnaporthe poae	28.00	4.00e-39	156.00
IUUC-Mla-059162	Melampsora laricipopulina	30.92	4.00e-23	103.00
IUUC-Mga-059462	Meleagris gallopavo	71.73	0.00e+00	702.00
IUUC-Mvi-060560	Microbotryum violaceum	24.17	5.00e-27	116.00
IUUC-Mmr-061756	Microcebus murinus	70.45	0.00e+00	649.00
IUUC-Mdo-062314	Monodelphis domestica	81.94	0.00e+00	875.00
IUUC-Mpu-066320	Mustela putorius furo	84.71	0.00e+00	822.00
IUUC-Mlu-067472	Myotis lucifugus	83.30	0.00e+00	875.00
IUUC-Nfi-068568	Neosartorya fischeri	27.91	2.00e-34	140.00
IUUC-Ncr-068765	Neurospora crassa	26.89	5.00e-39	156.00
IUUC-Nle-070035	Nomascus leucogenys	84.19	0.00e+00	906.00
IUUC-Opr-070584	Ochotona princeps	65.33	0.00e+00	658.00
IUUC-Ont-072419	Oreochromis niloticus	59.45	3.00e-159	555.00
IUUC-Oan-072727	Ornithorhynchus anatinus	77.18	2.00e-141	495.00
IUUC-Ocu-074576	Oryctolagus cuniculus	78.72	0.00e+00	838.00
IUUC-Oga-089079	Otolemur garnettii	67.69	0.00e+00	654.00
IUUC-Oar-089306	Ovis aries	84.44	0.00e+00	870.00
IUUC-Ptr-090536	Pan troglodytes	86.29	0.00e+00	932.00
IUUC-Pan-092172	Papio anubis	86.12	0.00e+00	926.00
IUUC-Psi-094026	Pelodiscus sinensis	71.17	0.00e+00	660.00
IUUC-Pno-094911	Phaeosphaeria nodorum	32.47	3.00e-37	149.00
IUUC-Pfo-096200	Poecilia formosa	58.73	2.00e-155	542.00
IUUC-Pab-098151	Pongo abelii	87.03	0.00e+00	915.00
IUUC-Pca-100361	Procavia capensis	63.60	4.00e-178	617.00
IUUC-Pva-103093	Pteropus vampyrus	85.90	0.00e+00	887.00
IUUC-Rno-105275	Rattus norvegicus	91.97	0.00e+00	959.00
IUUC-Sce-106209	Saccharomyces cerevisiae	27.00	6.00e-25	108.00
IUUC-Sha-107090	Sarcophilus harrisii	77.53	0.00e+00	831.00
IUUC-Sja-107859	Schizosaccharomyces japonicus	29.02	5.00e-31	128.00
IUUC-Spo-108333	Schizosaccharomyces pombe	31.84	3.00e-29	122.00
IUUC-Ssl-108525	Sclerotinia sclerotiorum	27.20	1.00e-34	141.00
IUUC-Sar-113125	Sorex araneus	75.95	0.00e+00	768.00
IUUC-Sre-115010	Sporisorium reilianum	38.57	2.00e-21	97.40
IUUC-Ssc-116366	Sus scrofa	84.18	0.00e+00	832.00
IUUC-Tgu-117414	Taeniopygia guttata	75.72	0.00e+00	684.00
IUUC-Tru-117683	Takifugu rubripes	54.55	4.00e-148	518.00
IUUC-Tsy-119199	Tarsius syrichta	85.90	0.00e+00	927.00
IUUC-Tni-120765	Tetraodon nigroviridis	64.69	1.00e-145	509.00
IUUC-Tre-122061	Trichoderma reesei	26.27	7.00e-36	145.00
IUUC-Tbe-127343	Tupaia belangeri	80.93	0.00e+00	659.00
IUUC-Ttr-128960	Tursiops truncatus	84.89	0.00e+00	858.00
IUUC-Uma-129613	Ustilago maydis	39.29	8.00e-22	98.60
IUUC-Vda-129759	Verticillium dahliae	31.29	4.00e-36	146.00
IUUC-Vpa-130600	Vicugna pacos	80.46	0.00e+00	825.00
IUUC-Xtr-132472	Xenopus tropicalis	66.27	0.00e+00	666.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence