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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046826
UUCD1 version UUC-HoS-01008
Ensembl Protein ID ENSP00000292616.5
UniProt Accession Q9UFC0; A8K4K2; B2R9G2; Q8N0T9; Q8WV43; Q96GJ2; LRWD1_HUMAN
Genbank Protein ID BAF83656.1; BAG36509.1; CAB61382.2; EAW50250.1; AAH09436.1; AAH18769.1; AAH30547.1
Protein Name Leucine-rich repeat and WD repeat-containing protein 1; Centromere protein 33; Origin recognition complex-associated protein
Genbank Nucleotide ID AK290967; AK313771; AL133057; AC093668; BC009436; BC018769; BC030547
Gene Name LRWD1; CENP-33; ORCA
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161036.11 ENST00000292616.9 ENSP00000292616.5
ENSG00000161036.11 ENST00000464107.5 ENSP00000418204.1
ENSG00000161036.11 ENST00000476270.1 ENSP00000417913.1
ENSG00000161036.11 ENST00000485808.5 ENSP00000420729.1
ENSG00000161036.11 ENST00000468175.1 ENSP00000420373.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.30e-07 30.8 391 421
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWD 29
           H+  +  l+f   ++t+l ++s+D+ i +WD
   Q: 391  HKKAIATLCFspaHETHLFTASYDKRIILWD 421
           888899999*98666**************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
 Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Protein Sequence
(Fasta)
MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE 60
TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR 120
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Protein Fasta Sequence


>IUUC-Hsa-046826|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTTCCTTCC GGTCGTTAAC GCCCACGGGC TCGCGCGGCG CCGCCTCCTG GGCTCAGTTA 60
CCGCGGACGC CAGTGCCGGG CTCCAGGAGA CGCAGGGCGA CGCCACACGC CGGGGTGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046826|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0235--DNA replication
KW-0995--Kinetochore
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR025875--Leu-rich_rpt_4
IPR003591--Leu-rich_rpt_typical-subtyp
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS51450--LRR
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12799--LRR_4
SMART

SM00369--LRR_TYP
SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005815--C:microtubule organizing center
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005721--C:pericentric heterochromatin
GO:0031933--C:telomeric heterochromatin
GO:0003682--F:chromatin binding
GO:0008327--F:methyl-CpG binding
GO:0035064--F:methylated histone binding
GO:0006325--P:chromatin organization
GO:0016569--P:covalent chromatin modification
GO:0006270--P:DNA replication initiation
GO:0071169--P:establishment of protein localization to chromatin
KEGG hsa:222229
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001948 Ailuropoda melanoleuca 84.76 0.00e+00 680.00
IUUC-Bta-012858 Bos taurus 79.51 0.00e+00 1000.00
IUUC-Cja-019702 Callithrix jacchus 95.21 0.00e+00 1165.00
IUUC-Cfa-020910 Canis familiaris 87.38 0.00e+00 1078.00
IUUC-Cpo-022523 Cavia porcellus 82.52 0.00e+00 1082.00
IUUC-Csa-023359 Chlorocebus sabaeus 96.91 0.00e+00 1224.00
IUUC-Dno-029426 Dasypus novemcinctus 87.06 0.00e+00 1063.00
IUUC-Dor-030654 Dipodomys ordii 81.15 0.00e+00 823.00
IUUC-Eca-034035 Equus caballus 88.54 0.00e+00 1090.00
IUUC-Eeu-034711 Erinaceus europaeus 76.43 8.00e-171 593.00
IUUC-Gmo-039096 Gadus morhua 39.13 5.00e-79 288.00
IUUC-Ggo-044714 Gorilla gorilla 99.69 0.00e+00 1214.00
IUUC-Laf-054449 Loxodonta africana 85.67 0.00e+00 1071.00
IUUC-Mcc-055193 Macaca mulatta 97.53 0.00e+00 1191.00
IUUC-Mmr-061572 Microcebus murinus 88.54 0.00e+00 1118.00
IUUC-Mmu-063240 Mus musculus 77.66 0.00e+00 952.00
IUUC-Mpu-066295 Mustela putorius furo 87.37 0.00e+00 1079.00
IUUC-Mlu-067766 Myotis lucifugus 86.15 0.00e+00 1084.00
IUUC-Nle-069200 Nomascus leucogenys 94.75 0.00e+00 1112.00
IUUC-Ola-086965 Oryzias latipes 39.35 2.00e-87 317.00
IUUC-Oga-088411 Otolemur garnettii 82.03 0.00e+00 1091.00
IUUC-Oar-089415 Ovis aries 80.59 0.00e+00 949.00
IUUC-Ptr-090663 Pan troglodytes 99.69 0.00e+00 1214.00
IUUC-Pan-092467 Papio anubis 95.53 0.00e+00 1159.00
IUUC-Pab-098479 Pongo abelii 97.53 0.00e+00 1198.00
IUUC-Pca-101023 Procavia capensis 75.39 0.00e+00 884.00
IUUC-Pva-102812 Pteropus vampyrus 83.59 0.00e+00 1050.00
IUUC-Rno-105469 Rattus norvegicus 78.21 0.00e+00 971.00
IUUC-Ssc-115884 Sus scrofa 87.06 0.00e+00 1107.00
IUUC-Tbe-127247 Tupaia belangeri 89.27 4.00e-139 488.00
IUUC-Ttr-128723 Tursiops truncatus 86.07 0.00e+00 1074.00
Created Date 25-Jun-2017

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