iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	17599067

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	2.70e-06	28.3	309	384

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL..eddktLady.glkdgstihllek 72
           ++++v sl+++  +++ +++++t a++ e ++k+++i +  q Liy+G+ L  e ++  +++ + ++++ i+++ +
   Q: 309  MVIHVFSLQHMtAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLvlELGRLAQHFpKTTEENPIFVTSR 384
           689***********************************************98899999999999999999998866 PP

Organism

Mus musculus

Functional Description
(View)

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity.

Protein Sequence
(Fasta)

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLYAVKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGGTCACGT GCTCCGTGGC CCGGGCTGGC GAAGCCGGAA GTAGCCTGGG GCGCGAGAAG 60
GCCCGGGAGC CGCGGGCTGT ACGCGGCGGA CACTCGCGGG GTAAGAGGGG CGGGCGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0051--Antiviral defense
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0003676--F:nucleic acid binding
GO:0051219--F:phosphoprotein binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0002218--P:activation of innate immune response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0051607--P:defense response to virus
GO:0044565--P:dendritic cell proliferation
GO:0045087--P:innate immune response
GO:0010629--P:negative regulation of gene expression
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0032728--P:positive regulation of interferon-beta production
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1904417--P:positive regulation of xenophagy

KEGG

mmu:56480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001638	Ailuropoda melanoleuca	94.24	0.00e+00	1459.00
IUUC-Apl-004028	Anas platyrhynchos	86.42	0.00e+00	1349.00
IUUC-Aca-004998	Anolis carolinensis	81.76	0.00e+00	1283.00
IUUC-Ame-011617	Astyanax mexicanus	70.07	0.00e+00	1054.00
IUUC-Bta-012799	Bos taurus	93.69	0.00e+00	1453.00
IUUC-Cja-019357	Callithrix jacchus	94.11	0.00e+00	1455.00
IUUC-Cfa-020309	Canis familiaris	93.42	0.00e+00	1449.00
IUUC-Cpo-022062	Cavia porcellus	93.14	0.00e+00	1439.00
IUUC-Csa-023517	Chlorocebus sabaeus	94.10	0.00e+00	1460.00
IUUC-Cho-025037	Choloepus hoffmanni	91.31	0.00e+00	960.00
IUUC-Cin-025580	Ciona intestinalis	39.80	8.00e-149	521.00
IUUC-Csv-025818	Ciona savignyi	40.23	9.00e-143	501.00
IUUC-Dre-027527	Danio rerio	71.25	0.00e+00	1077.00
IUUC-Dno-029475	Dasypus novemcinctus	82.47	0.00e+00	1108.00
IUUC-Dme-031698	Drosophila melanogaster	41.39	1.00e-132	466.00
IUUC-Ete-033090	Echinops telfairi	81.07	0.00e+00	1210.00
IUUC-Eca-033996	Equus caballus	92.46	0.00e+00	1439.00
IUUC-Eeu-035082	Erinaceus europaeus	85.36	0.00e+00	848.00
IUUC-Fca-035921	Felis catus	90.71	0.00e+00	1396.00
IUUC-Fal-037406	Ficedula albicollis	86.15	0.00e+00	1350.00
IUUC-Gmo-038721	Gadus morhua	71.05	0.00e+00	1048.00
IUUC-Gga-041234	Gallus gallus	85.60	0.00e+00	1345.00
IUUC-Gac-042315	Gasterosteus aculeatus	71.86	0.00e+00	1069.00
IUUC-Ggo-044885	Gorilla gorilla	87.79	0.00e+00	1343.00
IUUC-Hsa-046847	Homo sapiens	94.10	0.00e+00	1459.00
IUUC-Itr-047906	Ictidomys tridecemlineatus	92.79	0.00e+00	1437.00
IUUC-Lch-049731	Latimeria chalumnae	54.48	0.00e+00	774.00
IUUC-Loc-051879	Lepisosteus oculatus	72.66	0.00e+00	1103.00
IUUC-Laf-054232	Loxodonta africana	92.33	0.00e+00	1435.00
IUUC-Mcc-055447	Macaca mulatta	94.24	0.00e+00	1461.00
IUUC-Meu-056138	Macropus eugenii	95.17	0.00e+00	676.00
IUUC-Mga-059460	Meleagris gallopavo	84.54	0.00e+00	1316.00
IUUC-Mmr-061445	Microcebus murinus	94.38	0.00e+00	1459.00
IUUC-Mpu-066834	Mustela putorius furo	94.38	0.00e+00	1462.00
IUUC-Mlu-068006	Myotis lucifugus	91.64	0.00e+00	1392.00
IUUC-Nle-069280	Nomascus leucogenys	93.83	0.00e+00	1459.00
IUUC-Opr-070728	Ochotona princeps	86.52	0.00e+00	1177.00
IUUC-Ont-071621	Oreochromis niloticus	72.60	0.00e+00	1085.00
IUUC-Oan-073162	Ornithorhynchus anatinus	90.14	0.00e+00	1351.00
IUUC-Ocu-074787	Oryctolagus cuniculus	94.11	0.00e+00	1457.00
IUUC-Ola-086737	Oryzias latipes	33.04	9.00e-28	119.00
IUUC-Oga-088764	Otolemur garnettii	93.55	0.00e+00	1446.00
IUUC-Oar-090333	Ovis aries	93.42	0.00e+00	1446.00
IUUC-Ptr-090568	Pan troglodytes	93.83	0.00e+00	1456.00
IUUC-Pan-091979	Papio anubis	93.98	0.00e+00	1452.00
IUUC-Psi-093336	Pelodiscus sinensis	85.73	0.00e+00	1328.00
IUUC-Pma-094200	Petromyzon marinus	42.96	2.00e-171	595.00
IUUC-Pfo-096354	Poecilia formosa	72.00	0.00e+00	1078.00
IUUC-Pab-098499	Pongo abelii	93.96	0.00e+00	1459.00
IUUC-Pva-102454	Pteropus vampyrus	92.73	0.00e+00	1418.00
IUUC-Rno-105595	Rattus norvegicus	97.53	0.00e+00	1465.00
IUUC-Sha-106864	Sarcophilus harrisii	91.53	0.00e+00	1425.00
IUUC-Sar-113728	Sorex araneus	85.43	0.00e+00	1239.00
IUUC-Tgu-117200	Taeniopygia guttata	84.84	0.00e+00	1332.00
IUUC-Tsy-119017	Tarsius syrichta	94.67	0.00e+00	1081.00
IUUC-Tni-120724	Tetraodon nigroviridis	71.07	0.00e+00	1072.00
IUUC-Tbe-127887	Tupaia belangeri	84.30	0.00e+00	1021.00
IUUC-Ttr-129111	Tursiops truncatus	86.42	0.00e+00	1315.00
IUUC-Vpa-130724	Vicugna pacos	94.24	0.00e+00	1458.00
IUUC-Xtr-132091	Xenopus tropicalis	75.38	0.00e+00	1178.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence