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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046634
UUCD1 version UUC-HoS-01145
Ensembl Protein ID ENSP00000382382.2
UniProt Accession Q96K76; B3KXF5; E9PM46; Q658U0; Q86Y73; Q8TEP6; Q9BWI0; Q9NWN1; UBP47_HUMAN
Genbank Protein ID BAA91348.1; BAB55063.1; BAG54467.1; AAH00226.2; AAH47044.2; BAB84902.1; CAH56337.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 47; Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47
Genbank Nucleotide ID AK000734; AK027362; AK092290; AC104383; BC047044; BC071559; AL832991
Gene Name USP47
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170242.17 ENST00000339865.9 ENSP00000339957.5
ENSG00000170242.17 ENST00000527733.5 ENSP00000433146.1
ENSG00000170242.17 ENST00000399455.2 ENSP00000382382.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12401499
Classification
Family E-value Score Start End
DUB/USP 4.00e-75 254.8 188 562
Active Site
Position(s) Description Evidence
197 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
503 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           +Gl N+  tCY+NS+LQ+L+++pe+r++l +    +++e++ ++p +++  +lq+lf  l++skk+a++++++++++++ ++e    +q+D+
   Q: 188  VGLVNQAMTCYLNSLLQTLFMTPEFRNALYK---WEFEESE-EDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE--AWQQHDV 273
           6******************************...5555443.5899*********************************9998..9****** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke.etk 183
           qE++++++d+le++                           k++++ +li++l+qg+lk+ ++clec+ +  r ++ ld++l ++    +++
   Q: 274  QELCRVMFDALEQKW--------------------------KQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGsSQA 339
           ***************..........................678999*************************************95540456 PP
   S: 184  keslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke. 274
             s++++L++f ++e l+g n+y+ce+ckkk++a+k l++ ++P  L+l+LkRf f+ ++++r+k+n++++fp+eLd+s f   ++ek+ + 
   Q: 340  FASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQt 431
           78******************************************************************************999977766667 PP
   S: 275  ....................................................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDsk 313
                                                               + +YeL++v+vHsGs+ +GHY+a++k+ +++ W+ f+D++
   Q: 432  esctdsgaenegschsdqmsndfsnddgvdegicletnsgtekisksgleknSLIYELFSVMVHSGSAAGGHYYACIKSFSDEqWYSFNDQH 523
           8888888888888889999999999999999999999999999999999999***************************65555******** PP
   S: 314  Vtevkeeevleetg................staYvlfYk 336
           V+ +++e++++++g                ++aY+l+Y+
   Q: 524  VSRITQEDIKKTHGgssgsrgyyssafassTNAYMLIYR 562
           ***********888************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
 Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Protein Sequence
(Fasta)
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI 60
TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046634|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGGGGAAA AGAACGTCAG GAGAGTGAAC GGGAGCAAAT AAAACGCTGT CCATTCTGAC 60
TGGAAGGGCC AGAGCCGTGT CTAAGGGCGG GGGCCGGGAG GTGGCCCGCG GTGGTGTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046634|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0071987--F:WD40-repeat domain binding
GO:0006284--P:base-excision repair
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0030307--P:positive regulation of cell growth
GO:0016579--P:protein deubiquitination
GO:0042493--P:response to drug
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:55031
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002228 Ailuropoda melanoleuca 96.37 0.00e+00 2540.00
IUUC-Apl-003486 Anas platyrhynchos 90.38 0.00e+00 2363.00
IUUC-Aca-005061 Anolis carolinensis 88.08 0.00e+00 2405.00
IUUC-Ame-011206 Astyanax mexicanus 80.23 0.00e+00 2107.00
IUUC-Bta-012942 Bos taurus 97.08 0.00e+00 2577.00
IUUC-Cel-018600 Caenorhabditis elegans 37.62 3.00e-123 437.00
IUUC-Cja-018950 Callithrix jacchus 99.45 0.00e+00 2407.00
IUUC-Cfa-020299 Canis familiaris 98.44 0.00e+00 2560.00
IUUC-Cpo-021943 Cavia porcellus 97.43 0.00e+00 2544.00
IUUC-Csa-023285 Chlorocebus sabaeus 98.25 0.00e+00 2568.00
IUUC-Cho-025006 Choloepus hoffmanni 89.34 0.00e+00 2196.00
IUUC-Cin-025145 Ciona intestinalis 41.54 0.00e+00 731.00
IUUC-Csv-025839 Ciona savignyi 49.62 4.00e-166 579.00
IUUC-Dre-027959 Danio rerio 80.58 0.00e+00 2065.00
IUUC-Dno-030023 Dasypus novemcinctus 94.84 0.00e+00 2440.00
IUUC-Dor-030994 Dipodomys ordii 97.53 0.00e+00 962.00
IUUC-Dme-031604 Drosophila melanogaster 49.39 4.00e-148 520.00
IUUC-Ete-032596 Echinops telfairi 81.19 0.00e+00 1308.00
IUUC-Eca-033913 Equus caballus 98.02 0.00e+00 2583.00
IUUC-Eeu-034518 Erinaceus europaeus 90.03 0.00e+00 2142.00
IUUC-Fca-035997 Felis catus 97.82 0.00e+00 2584.00
IUUC-Fal-037088 Ficedula albicollis 89.81 0.00e+00 2103.00
IUUC-Gmo-038920 Gadus morhua 77.22 0.00e+00 2015.00
IUUC-Gga-040953 Gallus gallus 89.39 0.00e+00 2377.00
IUUC-Gac-042400 Gasterosteus aculeatus 79.13 0.00e+00 2048.00
IUUC-Ggo-044820 Gorilla gorilla 97.10 0.00e+00 2509.00
IUUC-Lch-050440 Latimeria chalumnae 86.03 0.00e+00 2314.00
IUUC-Loc-051904 Lepisosteus oculatus 84.50 0.00e+00 2239.00
IUUC-Laf-053760 Loxodonta africana 96.88 0.00e+00 2605.00
IUUC-Mcc-054637 Macaca mulatta 99.71 0.00e+00 2624.00
IUUC-Meu-056904 Macropus eugenii 95.49 0.00e+00 1692.00
IUUC-Mga-059556 Meleagris gallopavo 88.77 0.00e+00 2334.00
IUUC-Mmr-061192 Microcebus murinus 98.91 0.00e+00 2602.00
IUUC-Mdo-061929 Monodelphis domestica 95.56 0.00e+00 2542.00
IUUC-Mmu-063726 Mus musculus 94.55 0.00e+00 2547.00
IUUC-Mpu-066014 Mustela putorius furo 98.36 0.00e+00 2545.00
IUUC-Mlu-067232 Myotis lucifugus 97.44 0.00e+00 2549.00
IUUC-Nle-069619 Nomascus leucogenys 98.25 0.00e+00 2566.00
IUUC-Opr-070224 Ochotona princeps 93.27 0.00e+00 1142.00
IUUC-Ont-071384 Oreochromis niloticus 80.52 0.00e+00 2091.00
IUUC-Oan-073208 Ornithorhynchus anatinus 88.82 0.00e+00 2382.00
IUUC-Ocu-074285 Oryctolagus cuniculus 98.33 0.00e+00 2588.00
IUUC-Ola-087051 Oryzias latipes 79.03 0.00e+00 2006.00
IUUC-Oga-088928 Otolemur garnettii 98.31 0.00e+00 2566.00
IUUC-Oar-090215 Ovis aries 97.73 0.00e+00 2586.00
IUUC-Ptr-091035 Pan troglodytes 99.71 0.00e+00 2622.00
IUUC-Pan-092377 Papio anubis 99.27 0.00e+00 2578.00
IUUC-Pfo-096722 Poecilia formosa 79.74 0.00e+00 2067.00
IUUC-Pab-098723 Pongo abelii 99.56 0.00e+00 2620.00
IUUC-Pca-100105 Procavia capensis 92.73 0.00e+00 2358.00
IUUC-Pva-102514 Pteropus vampyrus 98.54 0.00e+00 959.00
IUUC-Rno-105384 Rattus norvegicus 95.71 0.00e+00 2514.00
IUUC-Sha-106982 Sarcophilus harrisii 92.00 0.00e+00 2485.00
IUUC-Sar-113723 Sorex araneus 86.90 0.00e+00 933.00
IUUC-Ssc-115671 Sus scrofa 97.88 0.00e+00 2046.00
IUUC-Tgu-116722 Taeniopygia guttata 88.42 0.00e+00 2318.00
IUUC-Tru-118380 Takifugu rubripes 77.38 0.00e+00 2066.00
IUUC-Tsy-119646 Tarsius syrichta 91.85 0.00e+00 2352.00
IUUC-Tni-120762 Tetraodon nigroviridis 77.85 0.00e+00 2078.00
IUUC-Tbe-127861 Tupaia belangeri 95.76 0.00e+00 2370.00
IUUC-Ttr-129254 Tursiops truncatus 92.05 0.00e+00 1452.00
IUUC-Vpa-130141 Vicugna pacos 98.41 0.00e+00 1191.00
IUUC-Xtr-132700 Xenopus tropicalis 81.81 0.00e+00 2197.00
Created Date 25-Jun-2017

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