iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000150991.14	ENST00000536769.1	ENSP00000441543.1
ENSG00000150991.14	ENST00000538617.5	ENSP00000443053.1
ENSG00000150991.14	ENST00000546120.2	ENSP00000438394.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Drug and target
DrugBank	PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/NEDD8	0	1182.2	609	684
ULD/UDP/UBQ/UBQ_PIM	3.20e-263	852.1	609	681

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           m+i+vktLtgk+i++e+e+sdtie++k+++++keGiPP+qqrli+aGkqled++t++dyn++k+s+LhLvL+LrGG
   Q: 609  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 684
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m+++vktl+gk+++lev+++dt+e++K+ki+++ g+pp+qq+LI+aGk+L+D +tLs+++i+++s++hlv++ 
   Q: 609  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL 681
           99********************************************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Protein Sequence
(Fasta)

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGCTGGGC CTCTGTCCCT TCTCCATTGG TGCCAGCTCT GAAGCAATCT TTTCTGGGGC 60
GCCTGCAAAG GACGGATCTG TGGGTGGAAC GAACTGAAAA CGGATCCAGT GACTCATCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0030666--C:endocytic vesicle membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005741--C:mitochondrial outer membrane
GO:0043209--C:myelin sheath
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0002020--F:protease binding
GO:0003723--F:RNA binding
GO:0000187--P:activation of MAPK activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0044267--P:cellular protein metabolic process
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0016197--P:endosomal transport
GO:0035635--P:entry of bacterium into host cell
GO:0038128--P:ERBB2 signaling pathway
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0070911--P:global genome nucleotide-excision repair
GO:0005978--P:glycogen biosynthetic process
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0036297--P:interstrand cross-link repair
GO:0075733--P:intracellular transport of virus
GO:0034220--P:ion transmembrane transport
GO:0007254--P:JNK cascade
GO:0016236--P:macroautophagy
GO:0000165--P:MAPK cascade
GO:0061024--P:membrane organization
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0038061--P:NIK/NF-kappaB signaling
GO:0007219--P:Notch signaling pathway
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0006297--P:nucleotide-excision repair, DNA gap filling
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0006457--P:protein folding
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043488--P:regulation of mRNA stability
GO:0060544--P:regulation of necroptotic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0032479--P:regulation of type I interferon production
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0019985--P:translesion synthesis
GO:0055085--P:transmembrane transport
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0010992--P:ubiquitin homeostasis
GO:0019058--P:viral life cycle
GO:0019068--P:virion assembly
GO:0016055--P:Wnt signaling pathway
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:7316

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003614	Anas platyrhynchos	99.64	8.00e-157	545.00
IUUC-Aca-004901	Anolis carolinensis	99.74	0.00e+00	752.00
IUUC-Aly-006562	Arabidopsis lyrata	92.48	0.00e+00	976.00
IUUC-Ath-006600	Arabidopsis thaliana	96.05	0.00e+00	870.00
IUUC-Ago-007937	Ashbya gossypii	96.05	0.00e+00	725.00
IUUC-Acl-008108	Aspergillus clavatus	95.74	1.00e-167	582.00
IUUC-Afl-008740	Aspergillus flavus	96.05	2.00e-167	581.00
IUUC-Afu-009031	Aspergillus fumigatus	92.68	5.00e-165	573.00
IUUC-Ani-009444	Aspergillus nidulans	96.05	2.00e-166	578.00
IUUC-Ang-009646	Aspergillus niger	96.05	3.00e-166	577.00
IUUC-Aor-009964	Aspergillus oryzae	96.05	2.00e-167	581.00
IUUC-Ate-010298	Aspergillus terreus	96.05	2.00e-167	581.00
IUUC-Ame-011696	Astyanax mexicanus	97.63	0.00e+00	729.00
IUUC-Bta-012771	Bos taurus	99.67	8.00e-174	602.00
IUUC-Bci-013832	Botrytis cinerea	97.37	6.00e-169	586.00
IUUC-Bdi-015013	Brachypodium distachyon	96.05	0.00e+00	726.00
IUUC-Bol-015598	Brassica oleracea	96.05	0.00e+00	870.00
IUUC-Cel-018571	Caenorhabditis elegans	98.54	0.00e+00	1326.00
IUUC-Cja-019812	Callithrix jacchus	100.00	0.00e+00	754.00
IUUC-Cfa-020579	Canis familiaris	100.00	0.00e+00	753.00
IUUC-Cin-025600	Ciona intestinalis	96.06	0.00e+00	730.00
IUUC-Csv-026265	Ciona savignyi	94.32	0.00e+00	1284.00
IUUC-Cne-026938	Cryptococcus neoformans	97.37	0.00e+00	877.00
IUUC-Dre-028641	Danio rerio	100.00	0.00e+00	1199.00
IUUC-Dno-029812	Dasypus novemcinctus	100.00	0.00e+00	753.00
IUUC-Dme-031690	Drosophila melanogaster	99.85	0.00e+00	1349.00
IUUC-Fal-036678	Ficedula albicollis	100.00	2.00e-173	601.00
IUUC-Fso-038454	Fusarium solani	95.72	4.00e-167	580.00
IUUC-Ggr-040118	Gaeumannomyces graminis	96.05	3.00e-167	580.00
IUUC-Gga-041058	Gallus gallus	100.00	1.00e-173	602.00
IUUC-Gac-042568	Gasterosteus aculeatus	99.34	0.00e+00	1190.00
IUUC-Gma-043881	Glycine max	96.05	0.00e+00	1015.00
IUUC-Ggo-044799	Gorilla gorilla	99.74	0.00e+00	750.00
IUUC-Hvu-047805	Hordeum vulgare	34.31	5.00e-39	154.00
IUUC-Itr-048563	Ictidomys tridecemlineatus	95.60	9.00e-45	171.00
IUUC-Kpa-049199	Komagataella pastoris	96.05	1.00e-167	582.00
IUUC-Lpe-050731	Leersia perrieri	34.74	9.00e-43	167.00
IUUC-Lma-053015	Leptosphaeria maculans	94.84	1.00e-167	582.00
IUUC-Laf-053548	Loxodonta africana	100.00	0.00e+00	753.00
IUUC-Mcc-055561	Macaca mulatta	100.00	0.00e+00	1198.00
IUUC-Mor-056991	Magnaporthe oryzae	96.05	3.00e-167	580.00
IUUC-Mpo-057384	Magnaporthe poae	96.05	3.00e-167	580.00
IUUC-Mtr-058240	Medicago truncatula	96.05	0.00e+00	1304.00
IUUC-Mla-058957	Melampsora laricipopulina	95.86	0.00e+00	1013.00
IUUC-Mdo-062630	Monodelphis domestica	100.00	0.00e+00	1052.00
IUUC-Mmu-063593	Mus musculus	99.85	0.00e+00	1350.00
IUUC-Mpu-066106	Mustela putorius furo	83.61	2.00e-138	484.00
IUUC-Mlu-068100	Myotis lucifugus	100.00	3.00e-174	603.00
IUUC-Nfi-068475	Neosartorya fischeri	95.74	1.00e-167	582.00
IUUC-Ncr-068770	Neurospora crassa	96.05	8.00e-166	575.00
IUUC-Nle-069526	Nomascus leucogenys	100.00	3.00e-174	603.00
IUUC-Oan-073470	Ornithorhynchus anatinus	99.74	0.00e+00	752.00
IUUC-Oba-075152	Oryza barthii	34.31	2.00e-41	163.00
IUUC-Obr-076236	Oryza brachyantha	96.05	0.00e+00	870.00
IUUC-Ogl-077274	Oryza glaberrima	90.53	0.00e+00	672.00
IUUC-Oin-079920	Oryza indica	96.05	0.00e+00	1015.00
IUUC-Olo-080418	Oryza longistaminata	34.35	3.00e-30	125.00
IUUC-Ome-081397	Oryza meridionalis	34.10	8.00e-41	160.00
IUUC-Oni-082299	Oryza nivara	33.77	2.00e-40	159.00
IUUC-Opu-083917	Oryza punctata	29.38	2.00e-29	124.00
IUUC-Osa-085789	Oryza sativa	96.05	0.00e+00	1015.00
IUUC-Ola-087192	Oryzias latipes	95.34	0.00e+00	1178.00
IUUC-Olu-087888	Ostreococcus lucimarinus	95.80	0.00e+00	727.00
IUUC-Oar-089386	Ovis aries	95.04	0.00e+00	973.00
IUUC-Ptr-091261	Pan troglodytes	100.00	0.00e+00	753.00
IUUC-Pan-092134	Papio anubis	100.00	0.00e+00	902.00
IUUC-Psi-093239	Pelodiscus sinensis	77.63	0.00e+00	648.00
IUUC-Pma-094556	Petromyzon marinus	99.01	0.00e+00	790.00
IUUC-Ppa-095548	Physcomitrella patens	94.74	0.00e+00	999.00
IUUC-Pfo-096371	Poecilia formosa	95.44	3.00e-130	457.00
IUUC-Pab-097884	Pongo abelii	100.00	0.00e+00	1200.00
IUUC-Pop-099396	Populus trichocarpa	96.05	0.00e+00	726.00
IUUC-Pca-100992	Procavia capensis	100.00	0.00e+00	687.00
IUUC-Ppe-102064	Prunus persica	95.84	0.00e+00	872.00
IUUC-Pgr-103301	Puccinia graminis	95.89	0.00e+00	1160.00
IUUC-Ptt-103710	Puccinia triticina	96.05	9.00e-168	582.00
IUUC-Rno-105199	Rattus norvegicus	99.85	0.00e+00	1350.00
IUUC-Sce-106142	Saccharomyces cerevisiae	96.05	0.00e+00	725.00
IUUC-Sha-106780	Sarcophilus harrisii	99.02	9.00e-171	592.00
IUUC-Sja-107825	Schizosaccharomyces japonicus	96.05	0.00e+00	725.00
IUUC-Spo-108219	Schizosaccharomyces pombe	95.80	0.00e+00	725.00
IUUC-Ssl-108565	Sclerotinia sclerotiorum	97.04	5.00e-168	583.00
IUUC-Smo-109259	Selaginella moellendorffii	94.60	0.00e+00	1285.00
IUUC-Sit-109965	Setaria italica	96.05	0.00e+00	1015.00
IUUC-Sly-111224	Solanum lycopersicum	96.05	0.00e+00	1015.00
IUUC-Stu-112256	Solanum tuberosum	96.05	0.00e+00	1014.00
IUUC-Sbi-114776	Sorghum bicolor	95.98	0.00e+00	856.00
IUUC-Ssc-115672	Sus scrofa	99.62	0.00e+00	1045.00
IUUC-Tgu-116620	Taeniopygia guttata	95.86	8.00e-155	539.00
IUUC-Tca-120959	Theobroma cacao	95.83	0.00e+00	869.00
IUUC-Tre-122012	Trichoderma reesei	96.05	3.00e-167	580.00
IUUC-Tvi-122369	Trichoderma virens	96.05	3.00e-167	580.00
IUUC-Tae-123654	Triticum aestivum	96.05	0.00e+00	870.00
IUUC-Tur-126025	Triticum urartu	96.05	0.00e+00	1014.00
IUUC-Tme-126952	Tuber melanosporum	96.07	3.00e-167	580.00
IUUC-Ttr-128311	Tursiops truncatus	99.56	0.00e+00	898.00
IUUC-Uma-129417	Ustilago maydis	97.37	0.00e+00	877.00
IUUC-Vvi-130874	Vitis vinifera	86.54	0.00e+00	1146.00
IUUC-Xtr-132052	Xenopus tropicalis	99.38	0.00e+00	1257.00
IUUC-Yli-134420	Yarrowia lipolytica	96.05	0.00e+00	869.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence