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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064128
Ensembl Protein ID ENSMUSP00000144001.1
UniProt Accession Q04736; YES_MOUSE
Genbank Protein ID CAA47909.1; AAH10594.1; AAA40020.1
Protein Name Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes
Genbank Nucleotide ID X67677; BC010594; L25762
Gene Name Yes1; Yes
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000014932.15 ENSMUST00000202543.3 ENSMUSP00000144001.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-14 55.1 94 149
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 94   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKSGYIPSNYVVPAD 149
           789***********************..8999**********************9875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity).
 Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity).
Protein Sequence
(Fasta)
MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV NFNSLSMTPF 60
GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120
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Protein Fasta Sequence


>IUUC-Mmu-064128|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGAGGAGA GAGGGAGGCC GCGGGGTGCG GGCGTCCGGG AGTTCCCTCC TCCTCAAGTA 60
AAGCGTCCCG GGCCGGCTGC GCCGCCGTCG CTGCCTCCTG GCGCCCCGCG ACCTGGAGGT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064128|UBD,SH3|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005815--C:microtubule organizing center
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0044325--F:ion channel binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG mmu:22612
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002374 Ailuropoda melanoleuca 96.68 0.00e+00 1054.00
IUUC-Apl-004032 Anas platyrhynchos 91.31 0.00e+00 1009.00
IUUC-Aca-004255 Anolis carolinensis 91.50 0.00e+00 1028.00
IUUC-Ame-010954 Astyanax mexicanus 85.19 0.00e+00 961.00
IUUC-Bta-013503 Bos taurus 96.30 0.00e+00 1025.00
IUUC-Cja-019694 Callithrix jacchus 95.03 0.00e+00 1031.00
IUUC-Cfa-020402 Canis familiaris 96.86 0.00e+00 1060.00
IUUC-Cpo-022506 Cavia porcellus 95.01 0.00e+00 1041.00
IUUC-Csa-023713 Chlorocebus sabaeus 95.76 0.00e+00 1037.00
IUUC-Csv-026029 Ciona savignyi 62.08 0.00e+00 629.00
IUUC-Dre-027978 Danio rerio 84.18 0.00e+00 932.00
IUUC-Dno-029897 Dasypus novemcinctus 94.54 0.00e+00 919.00
IUUC-Dor-030202 Dipodomys ordii 97.35 0.00e+00 926.00
IUUC-Eca-034157 Equus caballus 96.12 0.00e+00 1053.00
IUUC-Eeu-034950 Erinaceus europaeus 91.48 3.00e-176 610.00
IUUC-Fca-036233 Felis catus 96.67 0.00e+00 1079.00
IUUC-Fal-037461 Ficedula albicollis 91.50 0.00e+00 1026.00
IUUC-Gmo-038929 Gadus morhua 81.79 0.00e+00 896.00
IUUC-Gga-041107 Gallus gallus 90.94 0.00e+00 1009.00
IUUC-Gac-042321 Gasterosteus aculeatus 83.61 0.00e+00 932.00
IUUC-Ggo-044597 Gorilla gorilla 75.46 0.00e+00 790.00
IUUC-Hsa-047010 Homo sapiens 95.95 0.00e+00 1048.00
IUUC-Lch-050239 Latimeria chalumnae 88.54 0.00e+00 1003.00
IUUC-Loc-052314 Lepisosteus oculatus 86.79 0.00e+00 934.00
IUUC-Laf-053517 Loxodonta africana 95.93 0.00e+00 1025.00
IUUC-Mcc-055626 Macaca mulatta 95.76 0.00e+00 1037.00
IUUC-Mga-059310 Meleagris gallopavo 90.94 0.00e+00 1009.00
IUUC-Mmr-061652 Microcebus murinus 95.38 0.00e+00 1038.00
IUUC-Mdo-062963 Monodelphis domestica 90.76 0.00e+00 1021.00
IUUC-Mpu-065906 Mustela putorius furo 96.86 0.00e+00 1060.00
IUUC-Mlu-067035 Myotis lucifugus 95.59 0.00e+00 1045.00
IUUC-Nle-069041 Nomascus leucogenys 91.90 0.00e+00 988.00
IUUC-Opr-070299 Ochotona princeps 86.51 0.00e+00 914.00
IUUC-Ont-072337 Oreochromis niloticus 84.46 0.00e+00 947.00
IUUC-Oan-072997 Ornithorhynchus anatinus 97.14 0.00e+00 932.00
IUUC-Ocu-074171 Oryctolagus cuniculus 96.12 0.00e+00 1054.00
IUUC-Oba-075994 Oryza barthii 34.48 8.00e-21 95.90
IUUC-Ogl-077331 Oryza glaberrima 34.98 4.00e-23 103.00
IUUC-Ogu-078962 Oryza glumaepatula 34.98 4.00e-23 103.00
IUUC-Ola-086619 Oryzias latipes 83.73 0.00e+00 947.00
IUUC-Oga-087957 Otolemur garnettii 94.27 0.00e+00 1020.00
IUUC-Oar-089670 Ovis aries 94.45 0.00e+00 1017.00
IUUC-Ptr-091352 Pan troglodytes 95.95 0.00e+00 1048.00
IUUC-Pan-092202 Papio anubis 95.76 0.00e+00 1037.00
IUUC-Psi-093310 Pelodiscus sinensis 90.94 0.00e+00 1018.00
IUUC-Pma-094232 Petromyzon marinus 87.74 0.00e+00 863.00
IUUC-Pfo-096137 Poecilia formosa 83.57 0.00e+00 935.00
IUUC-Pab-098301 Pongo abelii 98.97 0.00e+00 968.00
IUUC-Pva-102592 Pteropus vampyrus 91.87 0.00e+00 993.00
IUUC-Rno-105544 Rattus norvegicus 97.60 0.00e+00 1043.00
IUUC-Sar-113364 Sorex araneus 92.05 0.00e+00 975.00
IUUC-Tgu-117380 Taeniopygia guttata 91.50 0.00e+00 1026.00
IUUC-Tru-117594 Takifugu rubripes 84.06 0.00e+00 939.00
IUUC-Tni-120433 Tetraodon nigroviridis 84.09 0.00e+00 935.00
IUUC-Ttr-128893 Tursiops truncatus 96.30 0.00e+00 1056.00
IUUC-Vpa-130060 Vicugna pacos 96.67 0.00e+00 1045.00
IUUC-Xtr-132322 Xenopus tropicalis 89.46 0.00e+00 1002.00
Created Date 25-Jun-2017

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