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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064303
UUCD1 version UUC-MuM-00475
Ensembl Protein ID ENSMUSP00000017530.3
UniProt Accession Q61382; Q8BHD9; TRAF4_MOUSE
Genbank Protein ID CAA63103.1; AAF44757.1; BAC28928.1; BAC30729.1; BAC35582.1; CAI24336.1; EDL12913.1
Protein Name TNF receptor-associated factor 4; Cysteine-rich motif associated to RING and Traf domains protein 1
Genbank Nucleotide ID X92346; AF233449; AK035056; AK040877; AK053900; AL591070; CH466596
Gene Name Traf4; Cart1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000017386.10 ENSMUST00000017530.3 ENSMUSP00000017530.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.20e-06 28.0 18 56
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++C  ++++++ v  CgH f+ +Clq +     +s + f+CP 
   Q: 18   CPLCGKPMREPVQVSTCGHRFCDTCLQEF-----LSEGVFKCPE 56
           ********99888888**********999.....89*******6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (By similarity). Required for normal skeleton development, and for normal development of the respiratory tract.
 Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (By similarity). Required for normal skeleton development, and for normal development of the respiratory tract.
Protein Sequence
(Fasta)
MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP 60
LDYAKIYPDP ELEVQVLGLA IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV VPCPNRCPAK 120
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Protein Fasta Sequence


>IUUC-Mmu-064303|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CTCTTCCGGC GGGCGGGGTT GCGGACCCGG GCCGGTCTCG GCCGCCAGTC GGCGCCGCCC 60
GCAGCCGGGA AACGCGGCCC GAGCGAGGCG CGGGCTGTGG GGCCGCCGCG TGCCCGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064303|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0796--Tight junction
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027138--TRAF4
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF
PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF
Pfam

PF00097--zf-C3HC4
PF02176--zf-TRAF
SMART

SM00061--MATH
SM00184--RING
Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0050699--F:WW domain binding
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0045860--P:positive regulation of protein kinase activity
GO:0042981--P:regulation of apoptotic process
GO:0007585--P:respiratory gaseous exchange
GO:0030323--P:respiratory tube development
KEGG mmu:22032
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000797 Aegilops tauschii 42.25 3.00e-08 53.10
IUUC-Aml-001287 Ailuropoda melanoleuca 95.52 0.00e+00 894.00
IUUC-Aly-006415 Arabidopsis lyrata 30.69 1.00e-06 48.10
IUUC-Ath-007062 Arabidopsis thaliana 30.69 1.00e-06 48.10
IUUC-Ame-011530 Astyanax mexicanus 77.66 0.00e+00 776.00
IUUC-Bta-013582 Bos taurus 97.45 0.00e+00 917.00
IUUC-Cfa-020133 Canis familiaris 91.06 0.00e+00 846.00
IUUC-Cpo-022021 Cavia porcellus 97.23 0.00e+00 917.00
IUUC-Csa-023199 Chlorocebus sabaeus 97.23 0.00e+00 917.00
IUUC-Dre-028193 Danio rerio 77.02 0.00e+00 773.00
IUUC-Dno-028917 Dasypus novemcinctus 97.45 0.00e+00 917.00
IUUC-Ete-032433 Echinops telfairi 95.74 0.00e+00 903.00
IUUC-Fca-036155 Felis catus 96.60 0.00e+00 912.00
IUUC-Gmo-038860 Gadus morhua 77.02 0.00e+00 769.00
IUUC-Gga-041052 Gallus gallus 81.49 0.00e+00 835.00
IUUC-Gac-041489 Gasterosteus aculeatus 76.81 0.00e+00 768.00
IUUC-Ggo-044996 Gorilla gorilla 96.60 0.00e+00 912.00
IUUC-Hsa-046252 Homo sapiens 96.81 0.00e+00 915.00
IUUC-Hvu-047127 Hordeum vulgare 38.03 3.00e-07 49.70
IUUC-Itr-048232 Ictidomys tridecemlineatus 97.87 0.00e+00 922.00
IUUC-Kpa-049340 Komagataella pastoris 26.46 2.00e-15 77.40
IUUC-Loc-052312 Lepisosteus oculatus 77.28 0.00e+00 771.00
IUUC-Lma-053014 Leptosphaeria maculans 22.22 1.00e-12 67.80
IUUC-Laf-054376 Loxodonta africana 97.66 0.00e+00 920.00
IUUC-Mcc-055684 Macaca mulatta 97.23 0.00e+00 917.00
IUUC-Mmr-061198 Microcebus murinus 97.66 0.00e+00 918.00
IUUC-Mdo-062585 Monodelphis domestica 87.66 0.00e+00 837.00
IUUC-Mac-064529 Musa acuminata 28.80 7.00e-10 58.20
IUUC-Mpu-066854 Mustela putorius furo 96.60 0.00e+00 913.00
IUUC-Nle-070098 Nomascus leucogenys 95.53 0.00e+00 902.00
IUUC-Ont-071518 Oreochromis niloticus 76.97 0.00e+00 769.00
IUUC-Ocu-073841 Oryctolagus cuniculus 97.45 0.00e+00 918.00
IUUC-Ola-086674 Oryzias latipes 76.76 0.00e+00 767.00
IUUC-Oga-088510 Otolemur garnettii 97.02 0.00e+00 914.00
IUUC-Oar-089225 Ovis aries 93.62 0.00e+00 874.00
IUUC-Pan-092725 Papio anubis 97.23 0.00e+00 917.00
IUUC-Pfo-096341 Poecilia formosa 76.55 0.00e+00 767.00
IUUC-Ppe-101708 Prunus persica 29.37 1.00e-06 49.30
IUUC-Pva-103131 Pteropus vampyrus 97.33 1.00e-141 496.00
IUUC-Rno-105996 Rattus norvegicus 99.79 0.00e+00 936.00
IUUC-Sly-111800 Solanum lycopersicum 30.00 8.00e-06 47.00
IUUC-Tru-117602 Takifugu rubripes 77.45 0.00e+00 778.00
IUUC-Tur-126067 Triticum urartu 42.25 2.00e-08 53.50
Created Date 25-Jun-2017

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