iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.10e-06	28.0	18	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++C  ++++++ v  CgH f+ +Clq +     +s + f+CP 
   Q: 18   CPLCGKPMREPVQVSTCGHRFCDTCLQEF-----LSEGVFKCPE 56
           ********99888888**********999.....89*******6 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP 60
LDYAKIYPDP ELEVQVLGLA IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV VPCPNRCPAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCCCGA GCGAGGCGCG CGGGCTGTGG GGCCGCCGCG TGCCCGGCCC CGCTCGCCCG 60
TGCCCGGCGC CCGCCCGCCA TGCCCGGCTT CGACTACAAG TTCCTGGAGA AGCCCAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027138--TRAF4
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0046330--P:positive regulation of JNK cascade
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0042981--P:regulation of apoptotic process
GO:0007585--P:respiratory gaseous exchange
GO:0030323--P:respiratory tube development

KEGG

rno:303285

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000797	Aegilops tauschii	42.25	3.00e-08	53.10
IUUC-Aml-001287	Ailuropoda melanoleuca	95.74	0.00e+00	894.00
IUUC-Ame-011530	Astyanax mexicanus	77.87	0.00e+00	777.00
IUUC-Bta-013582	Bos taurus	97.66	0.00e+00	918.00
IUUC-Cfa-020133	Canis familiaris	91.28	0.00e+00	847.00
IUUC-Cpo-022021	Cavia porcellus	97.45	0.00e+00	917.00
IUUC-Csa-023199	Chlorocebus sabaeus	97.45	0.00e+00	917.00
IUUC-Dre-028193	Danio rerio	77.23	0.00e+00	773.00
IUUC-Dno-028917	Dasypus novemcinctus	97.66	0.00e+00	917.00
IUUC-Ete-032433	Echinops telfairi	95.96	0.00e+00	904.00
IUUC-Fca-036155	Felis catus	96.81	0.00e+00	912.00
IUUC-Gmo-038860	Gadus morhua	77.23	0.00e+00	770.00
IUUC-Gga-041052	Gallus gallus	81.70	0.00e+00	835.00
IUUC-Gac-041489	Gasterosteus aculeatus	77.02	0.00e+00	769.00
IUUC-Gma-042951	Glycine max	25.98	1.00e-07	51.20
IUUC-Ggo-044996	Gorilla gorilla	96.81	0.00e+00	912.00
IUUC-Hsa-046252	Homo sapiens	97.02	0.00e+00	915.00
IUUC-Hvu-047127	Hordeum vulgare	38.03	2.00e-07	49.70
IUUC-Itr-048232	Ictidomys tridecemlineatus	98.09	0.00e+00	922.00
IUUC-Kpa-049340	Komagataella pastoris	26.46	2.00e-15	77.40
IUUC-Loc-052312	Lepisosteus oculatus	77.49	0.00e+00	772.00
IUUC-Lma-053014	Leptosphaeria maculans	22.22	1.00e-12	67.80
IUUC-Laf-054376	Loxodonta africana	97.87	0.00e+00	920.00
IUUC-Mcc-055684	Macaca mulatta	97.45	0.00e+00	917.00
IUUC-Mmr-061198	Microcebus murinus	97.87	0.00e+00	918.00
IUUC-Mdo-062585	Monodelphis domestica	87.87	0.00e+00	838.00
IUUC-Mmu-064303	Mus musculus	99.79	0.00e+00	936.00
IUUC-Mac-064529	Musa acuminata	28.80	7.00e-10	58.20
IUUC-Mpu-066854	Mustela putorius furo	96.81	0.00e+00	913.00
IUUC-Nle-070098	Nomascus leucogenys	95.74	0.00e+00	902.00
IUUC-Ont-071518	Oreochromis niloticus	77.19	0.00e+00	769.00
IUUC-Ocu-073841	Oryctolagus cuniculus	97.66	0.00e+00	918.00
IUUC-Ola-086674	Oryzias latipes	76.97	0.00e+00	768.00
IUUC-Oga-088510	Otolemur garnettii	97.23	0.00e+00	915.00
IUUC-Oar-089225	Ovis aries	93.83	0.00e+00	874.00
IUUC-Pan-092725	Papio anubis	97.45	0.00e+00	917.00
IUUC-Pfo-096341	Poecilia formosa	76.76	0.00e+00	768.00
IUUC-Ppe-101708	Prunus persica	29.37	1.00e-06	49.30
IUUC-Pva-103131	Pteropus vampyrus	97.71	9.00e-142	496.00
IUUC-Sly-111800	Solanum lycopersicum	30.00	8.00e-06	47.00
IUUC-Tru-117602	Takifugu rubripes	77.66	0.00e+00	778.00
IUUC-Tur-126067	Triticum urartu	42.25	2.00e-08	53.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence