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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046901
Ensembl Protein ID ENSP00000385751.2
UniProt Accession Q7KZI7; Q15449; Q15524; Q5XGA3; Q68A18; Q96HB3; Q96RG0; MARK2_HUMAN
Genbank Protein ID CAA66229.1; BAD37141.1; AAP36006.1; AAH08771.2; AAH84540.1; AAK82368.1; CAA80914.1
Protein Name Serine/threonine-protein kinase MARK2; ELKL motif kinase 1; MAP/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b
Genbank Nucleotide ID X97630; AB188493; BT007342; AP003780; BC084540; AF387638; Z25427
Gene Name MARK2; EMK1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000072518.20 ENST00000508192.5 ENSP00000425765.1
ENSG00000072518.20 ENST00000361128.9 ENSP00000355091.5
ENSG00000072518.20 ENST00000350490.11 ENSP00000294247.9
ENSG00000072518.20 ENST00000502399.7 ENSP00000423452.3
ENSG00000072518.20 ENST00000543674.1 ENSP00000444859.1
ENSG00000072518.20 ENST00000512060.1 ENSP00000423844.1
ENSG00000072518.20 ENST00000425897.2 ENSP00000415494.2
ENSG00000072518.20 ENST00000402010.6 ENSP00000385751.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
circBasecircRNADbCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 16803889
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
 Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Protein Sequence
(Fasta)
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG 60
KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046901|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
AAACAGAGCC GAAGCTTCGT CTTCGGAATC GAGGAGGAGA GCGCGTCCCC GGGGTTTACC 60
TTCTTCGGCT GTTTCCGGAA TTCACCCGTA GTCTGTGGCC GGGAGGAGAA GGCGCGCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046901|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0418--Kinase
KW-0446--Lipid-binding
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0879--Wnt signaling pathway
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
SM00165--UBA
Gene Ontology

GO:0005884--C:actin filament
GO:0016328--C:lateral plasma membrane
GO:0016020--C:membrane
GO:0097427--C:microtubule bundle
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0045296--F:cadherin binding
GO:0008289--F:lipid binding
GO:0000287--F:magnesium ion binding
GO:0030295--F:protein kinase activator activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0003723--F:RNA binding
GO:0050321--F:tau-protein kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0030010--P:establishment of cell polarity
GO:0045197--P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0035556--P:intracellular signal transduction
GO:0000226--P:microtubule cytoskeleton organization
GO:0051646--P:mitochondrion localization
GO:0000422--P:mitophagy
GO:0001764--P:neuron migration
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0010976--P:positive regulation of neuron projection development
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
GO:0050770--P:regulation of axonogenesis
GO:0051493--P:regulation of cytoskeleton organization
GO:0016055--P:Wnt signaling pathway
KEGG hsa:2011
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-004803 Anolis carolinensis 85.93 0.00e+00 1330.00
IUUC-Ame-011854 Astyanax mexicanus 71.61 0.00e+00 1063.00
IUUC-Cel-018198 Caenorhabditis elegans 74.19 3.00e-160 560.00
IUUC-Cja-019475 Callithrix jacchus 97.80 0.00e+00 1525.00
IUUC-Cfa-020356 Canis familiaris 98.45 0.00e+00 1540.00
IUUC-Cgl-026480 Colletotrichum gloeosporioides 43.01 2.00e-69 258.00
IUUC-Dre-028467 Danio rerio 71.48 0.00e+00 1066.00
IUUC-Dno-029653 Dasypus novemcinctus 98.44 0.00e+00 1535.00
IUUC-Dor-030743 Dipodomys ordii 99.60 0.00e+00 1527.00
IUUC-Ete-032528 Echinops telfairi 96.92 0.00e+00 1253.00
IUUC-Eca-033799 Equus caballus 98.69 0.00e+00 1515.00
IUUC-Eeu-034949 Erinaceus europaeus 97.45 0.00e+00 955.00
IUUC-Fca-035596 Felis catus 98.60 0.00e+00 1577.00
IUUC-Gac-042044 Gasterosteus aculeatus 71.88 0.00e+00 1039.00
IUUC-Lch-049551 Latimeria chalumnae 81.69 0.00e+00 1240.00
IUUC-Loc-051934 Lepisosteus oculatus 68.63 0.00e+00 986.00
IUUC-Mcc-055104 Macaca mulatta 99.87 0.00e+00 1594.00
IUUC-Meu-056525 Macropus eugenii 96.95 0.00e+00 1490.00
IUUC-Mmr-060697 Microcebus murinus 99.11 0.00e+00 1584.00
IUUC-Mmu-063467 Mus musculus 97.94 0.00e+00 1507.00
IUUC-Mpu-066665 Mustela putorius furo 98.31 0.00e+00 1536.00
IUUC-Opr-070302 Ochotona princeps 97.08 0.00e+00 1540.00
IUUC-Ont-071386 Oreochromis niloticus 70.13 0.00e+00 981.00
IUUC-Pan-092847 Papio anubis 99.87 0.00e+00 1594.00
IUUC-Pva-103239 Pteropus vampyrus 98.41 0.00e+00 1499.00
IUUC-Pgr-103687 Puccinia graminis 46.18 1.00e-70 261.00
IUUC-Ssc-116439 Sus scrofa 93.97 0.00e+00 992.00
IUUC-Tme-127019 Tuber melanosporum 41.31 2.00e-69 257.00
Created Date 25-Jun-2017

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