iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000025730.14	ENSMUST00000166146.7	ENSMUSP00000132355.1
ENSMUSG00000025730.14	ENSMUST00000167626.7	ENSMUSP00000127546.1
ENSMUSG00000025730.14	ENSMUST00000164982.7	ENSMUSP00000127868.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.70e-16	59.9	180	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++k+w ++++++SLq+LC++aI++c++ + +   dkLPLP  +k++L+++++
   Q: 180  MEKIW-RPNRVFSLQDLCCRAIVSCTPVHLI---DKLPLPVTIKSHLKSFSM 227
           67899.**********************888...***************976 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGTQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG 60
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCTGCGC GGTGCCGTGC GGGAAGCGGC GGGTGGCGGC GGCGGCAGCG GCGGCGGCGG 60
CGGCTAGGAG GCTGAGGTGA AGCTGGCGGC AGCGGGGCGG GTGCACTGGG GGCGGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR001496--SOCS_box

PROSITE

PS51419--RAB
PS50225--SOCS

Pfam

PF00071--Ras
PF07525--SOCS_box

SMART

SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005768--C:endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0019003--F:GDP binding
GO:0005525--F:GTP binding
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

mmu:224624

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001616	Ailuropoda melanoleuca	98.88	9.00e-143	499.00
IUUC-Apl-003799	Anas platyrhynchos	90.20	1.00e-129	455.00
IUUC-Ame-011203	Astyanax mexicanus	94.31	9.00e-153	532.00
IUUC-Bta-013490	Bos taurus	99.64	1.00e-151	528.00
IUUC-Cja-019990	Callithrix jacchus	98.58	7.00e-150	523.00
IUUC-Cpo-022437	Cavia porcellus	99.26	3.00e-143	500.00
IUUC-Csa-024147	Chlorocebus sabaeus	99.29	3.00e-151	527.00
IUUC-Dre-027427	Danio rerio	93.59	1.00e-152	531.00
IUUC-Dno-029998	Dasypus novemcinctus	92.37	4.00e-116	413.00
IUUC-Dor-030584	Dipodomys ordii	90.13	9.00e-109	385.00
IUUC-Dme-031810	Drosophila melanogaster	69.20	3.00e-94	337.00
IUUC-Ete-033080	Echinops telfairi	96.80	4.00e-143	500.00
IUUC-Eca-033423	Equus caballus	99.57	4.00e-126	443.00
IUUC-Eeu-034590	Erinaceus europaeus	88.84	1.00e-111	395.00
IUUC-Fca-035697	Felis catus	98.72	1.00e-121	428.00
IUUC-Fal-037070	Ficedula albicollis	98.22	8.00e-151	526.00
IUUC-Gmo-039605	Gadus morhua	92.17	2.00e-150	524.00
IUUC-Gga-040343	Gallus gallus	98.22	8.00e-151	526.00
IUUC-Gac-041833	Gasterosteus aculeatus	88.81	4.00e-144	503.00
IUUC-Ggo-045131	Gorilla gorilla	91.81	8.00e-134	469.00
IUUC-Hsa-046237	Homo sapiens	99.29	3.00e-151	527.00
IUUC-Itr-048902	Ictidomys tridecemlineatus	99.64	1.00e-151	528.00
IUUC-Lch-050193	Latimeria chalumnae	95.73	9.00e-154	535.00
IUUC-Loc-052243	Lepisosteus oculatus	93.59	1.00e-152	532.00
IUUC-Laf-054435	Loxodonta africana	97.15	2.00e-150	524.00
IUUC-Mcc-055337	Macaca mulatta	98.93	3.00e-150	524.00
IUUC-Meu-056731	Macropus eugenii	98.20	1.00e-80	292.00
IUUC-Mmr-061380	Microcebus murinus	99.28	1.00e-150	525.00
IUUC-Mdo-062438	Monodelphis domestica	98.22	8.00e-151	525.00
IUUC-Mpu-066029	Mustela putorius furo	94.02	6.00e-123	432.00
IUUC-Mlu-067741	Myotis lucifugus	99.29	4.00e-151	526.00
IUUC-Nle-069240	Nomascus leucogenys	93.24	2.00e-138	484.00
IUUC-Ont-071248	Oreochromis niloticus	93.59	3.00e-152	530.00
IUUC-Oan-073432	Ornithorhynchus anatinus	97.02	4.00e-122	430.00
IUUC-Ola-086486	Oryzias latipes	86.36	8.00e-139	486.00
IUUC-Oga-088293	Otolemur garnettii	99.29	1.00e-151	528.00
IUUC-Ptr-090720	Pan troglodytes	99.29	3.00e-151	527.00
IUUC-Pan-091732	Papio anubis	99.29	3.00e-151	527.00
IUUC-Psi-093627	Pelodiscus sinensis	96.80	6.00e-143	499.00
IUUC-Pma-094679	Petromyzon marinus	77.12	7.00e-109	386.00
IUUC-Pfo-097105	Poecilia formosa	92.53	1.00e-151	528.00
IUUC-Pab-098054	Pongo abelii	99.29	3.00e-151	527.00
IUUC-Pca-100775	Procavia capensis	97.41	8.00e-90	322.00
IUUC-Pva-102658	Pteropus vampyrus	98.93	2.00e-150	525.00
IUUC-Rno-105303	Rattus norvegicus	100.00	1.00e-151	528.00
IUUC-Sha-106536	Sarcophilus harrisii	98.22	8.00e-151	525.00
IUUC-Tgu-116858	Taeniopygia guttata	99.48	1.00e-114	404.00
IUUC-Tru-118264	Takifugu rubripes	76.49	7.00e-139	486.00
IUUC-Tni-120350	Tetraodon nigroviridis	92.53	8.00e-151	526.00
IUUC-Ttr-129236	Tursiops truncatus	99.29	3.00e-153	534.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence