iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	miRecords	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	20436459

Classification

Family	E-value	Score	Start	End
DUB/UCH	4.90e-141	470.1	43	471

Active Site

Position(s)	Description	Evidence
131	Nucleophile	ECO:0000305}
213	Proton donor	ECO:0000250}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCaty 102
           +++wleLesdPglftll++dfg++++ qvee+y+L++      +e+ +g+++lF+++e+r+++rk+ +t+++++v+de++i++iffa+qv++NsCat+
   Q: 43   ADGWLELESDPGLFTLLLKDFGCHDV-QVEEVYDLQKP-----IESPYGFIFLFRWIEERRARRKIVETTAEIFVKDEEAISSIFFAQQVVPNSCATH 134
           489***********************.********874.....59***************************************************** PP
   S: 103  AllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqy..tkeafhfvsyvningrlyeldglkp 198
           Allsvllnc++++l+lG+tlsrlk++tk++spenk+la+gn+++l+c+hns+a++++r++ er+++  +++  t eafhfvs+v+ing+l+eldglkp
   Q: 135  ALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAIGNTPELACAHNSHAMPQARRRLERTGAGVSSCrfTGEAFHFVSFVPINGQLFELDGLKP 232
           *********************************************************************999************************** PP
   S: 199  fPldlgkkketeelkdklkvvraflerikllesde.irfnllaivadrrviktlrlnvlkid.................................... 259
           +P+++g ++++e+++dk+++v+  +er+++++ ++ irfnl+a+v+drr+++t++l++l+++                                    
   Q: 233  YPMNHGGWEDSEDWTDKFRRVM--AERLGIATGEQdIRFNLMAVVPDRRIAITHKLKMLRTNqaivsgtlqkllkadeqgesgngdsqrpdtpttlle 328
           **********************..*********999************************************************************** PP
   S: 260  ......keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevre...fgvnegrlakq...... 342
                 ++L++Llk++++e++ +e++l+de+++r++fk+d++rRt+nyd+fic+f+++la++g+l +lv+++++++++   +g++ +r++kq      
   Q: 329  psaftaRDLQSLLKNLDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVSQHLLPSKKvsgQGAA-NRISKQsttasa 425
           *******************************************************************************999988.************ PP
   S: 343  .............................rkqgrekkirplkrkrk 359
                                        +++gr++k r+++rkrk
   Q: 426  ggstaagtastpktqqqqaaaakngkspsKTPGRRRKGRNKCRKRK 471
           ********************************************98 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MNAAGGGSGA QAAAVAAGNN SLSHNALLST ASGATTMPMA QLADGWLELE SDPGLFTLLL 60
KDFGCHDVQV EEVYDLQKPI ESPYGFIFLF RWIEERRARR KIVETTAEIF VKDEEAISSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTATTGAAA TTTACGTGAT CCTGTGAATG GCTAAGGCAG ATAAGAGGAA GCGCAAAAAA 60
CTATTTTGGT CCAAATCGGT AATATTTTTA TATTTAAAAT GAATTGGGGA CAGAAGATAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006342--P:chromatin silencing
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0007385--P:specification of segmental identity, abdomen
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG8445

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	59.29	1.00e-89	323.00
IUUC-Aca-004836	Anolis carolinensis	59.77	2.00e-87	316.00
IUUC-Ame-011946	Astyanax mexicanus	60.55	1.00e-95	343.00
IUUC-Bta-013131	Bos taurus	55.85	2.00e-79	289.00
IUUC-Cja-019599	Callithrix jacchus	61.19	3.00e-90	325.00
IUUC-Cfa-021003	Canis familiaris	59.29	2.00e-89	323.00
IUUC-Cpo-022143	Cavia porcellus	61.19	4.00e-90	325.00
IUUC-Csa-023477	Chlorocebus sabaeus	61.19	3.00e-90	325.00
IUUC-Cho-024734	Choloepus hoffmanni	64.00	1.00e-22	101.00
IUUC-Csv-025842	Ciona savignyi	44.73	3.00e-85	308.00
IUUC-Dre-027793	Danio rerio	56.62	6.00e-93	334.00
IUUC-Dno-029253	Dasypus novemcinctus	60.15	4.00e-85	308.00
IUUC-Dor-030891	Dipodomys ordii	52.61	2.00e-71	263.00
IUUC-Ete-032646	Echinops telfairi	58.33	4.00e-72	265.00
IUUC-Eca-033805	Equus caballus	61.19	5.00e-90	324.00
IUUC-Eeu-035216	Erinaceus europaeus	58.56	9.00e-33	134.00
IUUC-Fca-035611	Felis catus	58.46	2.00e-84	306.00
IUUC-Fal-037186	Ficedula albicollis	62.50	7.00e-65	241.00
IUUC-Gmo-038824	Gadus morhua	62.64	2.00e-93	335.00
IUUC-Gga-040875	Gallus gallus	62.31	1.00e-94	340.00
IUUC-Gac-042226	Gasterosteus aculeatus	59.38	4.00e-94	338.00
IUUC-Ggo-045122	Gorilla gorilla	61.19	3.00e-90	325.00
IUUC-Hsa-045882	Homo sapiens	60.82	1.00e-89	323.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	61.19	5.00e-90	324.00
IUUC-Lch-049960	Latimeria chalumnae	50.52	1.00e-70	260.00
IUUC-Loc-052408	Lepisosteus oculatus	63.06	2.00e-94	338.00
IUUC-Laf-054187	Loxodonta africana	62.03	3.00e-93	335.00
IUUC-Mcc-055273	Macaca mulatta	58.58	1.00e-82	300.00
IUUC-Meu-056267	Macropus eugenii	59.16	3.00e-84	305.00
IUUC-Mga-059958	Meleagris gallopavo	61.15	6.00e-89	319.00
IUUC-Mmr-061280	Microcebus murinus	61.19	5.00e-90	324.00
IUUC-Mdo-062625	Monodelphis domestica	61.94	8.00e-94	337.00
IUUC-Mmu-063853	Mus musculus	61.19	4.00e-90	325.00
IUUC-Mlu-067771	Myotis lucifugus	60.82	4.00e-90	325.00
IUUC-Opr-070741	Ochotona princeps	59.01	9.00e-91	327.00
IUUC-Ont-072172	Oreochromis niloticus	62.64	3.00e-94	338.00
IUUC-Oan-073167	Ornithorhynchus anatinus	62.03	1.00e-93	336.00
IUUC-Ocu-074176	Oryctolagus cuniculus	61.19	2.00e-89	322.00
IUUC-Ola-087203	Oryzias latipes	54.11	2.00e-100	358.00
IUUC-Oga-089153	Otolemur garnettii	59.09	2.00e-84	306.00
IUUC-Oar-090008	Ovis aries	61.19	3.00e-90	325.00
IUUC-Ptr-091234	Pan troglodytes	61.19	2.00e-90	325.00
IUUC-Pan-092005	Papio anubis	61.19	3.00e-90	325.00
IUUC-Psi-093995	Pelodiscus sinensis	59.16	2.00e-86	312.00
IUUC-Pfo-097418	Poecilia formosa	62.26	4.00e-93	335.00
IUUC-Pab-098267	Pongo abelii	61.19	2.00e-90	325.00
IUUC-Pca-101084	Procavia capensis	62.03	3.00e-93	335.00
IUUC-Pva-102292	Pteropus vampyrus	60.82	2.00e-89	323.00
IUUC-Rno-105251	Rattus norvegicus	58.36	3.00e-87	315.00
IUUC-Sha-107100	Sarcophilus harrisii	59.92	3.00e-87	315.00
IUUC-Sar-113559	Sorex araneus	59.46	7.00e-71	261.00
IUUC-Ssc-115688	Sus scrofa	60.45	1.00e-89	323.00
IUUC-Tgu-117424	Taeniopygia guttata	57.19	1.00e-88	320.00
IUUC-Tru-118585	Takifugu rubripes	63.02	5.00e-95	341.00
IUUC-Tsy-119299	Tarsius syrichta	48.28	4.00e-59	221.00
IUUC-Tni-120808	Tetraodon nigroviridis	63.02	5.00e-95	341.00
IUUC-Tbe-127705	Tupaia belangeri	59.70	3.00e-82	297.00
IUUC-Ttr-128225	Tursiops truncatus	61.19	3.00e-90	325.00
IUUC-Vpa-130193	Vicugna pacos	46.90	2.00e-48	186.00
IUUC-Xtr-132449	Xenopus tropicalis	59.46	5.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence