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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046713
Ensembl Protein ID ENSP00000411831.2
UniProt Accession O75037; B2RP62; B7ZMI0; Q5T4J3; KI21B_HUMAN
Genbank Protein ID BAA32294.2; EAW91328.1; AAI37282.1; AAI44558.1
Protein Name Kinesin-like protein KIF21B
Genbank Nucleotide ID AB007918; AC099756; BC137281; BC144557
Gene Name KIF21B; KIAA0449
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116852.14 ENST00000332129.6 ENSP00000328494.2
ENSG00000116852.14 ENST00000461742.6 ENSP00000433808.1
ENSG00000116852.14 ENST00000360529.9 ENSP00000353724.5
ENSG00000116852.14 ENST00000422435.2 ENSP00000411831.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.70e-31 107.1 1544 1578
UBD/Beta-Prp 3.00e-52 179.3 1411 1614
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           H+d+v++laf ++ ++l+s+++ g+ikvW+++ ++
   Q: 1544 HKDWVCALAFiPGrPMLLSACRAGVIKVWNVDNFT 1578
           ***********999****************98765 PP
   

   UBD/Beta-Prp
   S: 51   heaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp...sgdklvsGshdrtirvwdletgqclee...... 131
            e +++++ +sp+g +++ +++ +++++w+ls +++v +l+gh   v++l++ +   + d +v+Gs+d ++++++l  g+c+        
   Q: 1411 GEHQINQIALSPSG-TMLYAASGNAVRIWELSRFQPVGKLTGHIGPVMCLTVTQtasQHDLVVTGSKDHYVKMFEL--GECVTGtigpth 1497
           5667999******9.9999999***************************99999985559**************55..667765779999 PP
   S: 132  .tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
            ++ +h + + c+++++  ++l+sGs D+ ++ Wdl +++l+++   +h+d v  l+f + ++ l+s+ + g +k+w++ + + + + +g
   Q: 1498 nFEPPHYDGIECLAIQG--DILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFIPGRPMLLSACRAGVIKVWNVDNFTPIGEIKG 1585
           99999**********99..9*************************999****************************************** PP
   S: 221  htdnvksvrfspnderlvsgssDgsiriWdl 251
           h+++++ + +    +++ ++ssD  +++W++
   Q: 1586 HDSPINAICTN--AKHIFTASSDCRVKLWNY 1614
           ******77777..9***************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
 Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Protein Sequence
(Fasta)
MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ 60
EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDMATSEEEQ GIIPRAIAHL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046713|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGGTGGC TGCCGGGTGG GAGGTGTGTG CGCGTGTGCC GCGCCGTAGG GAGCGGCGGG 60
TCGCGCCGCC GGCTGTCAGC TAGCTCCGCG CCGCCGCCCG ATGGCGCGAG GAGGCGCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046713|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00225--Kinesin
PF00400--WD40
PRINTS

PR00380--KINESINHEAVY
SMART

SM00129--KISc
SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0030426--C:growth cone
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement
KEGG hsa:23046
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001279 Ailuropoda melanoleuca 96.97 0.00e+00 2842.00
IUUC-Apl-003204 Anas platyrhynchos 76.36 0.00e+00 1584.00
IUUC-Aca-004506 Anolis carolinensis 82.63 0.00e+00 1645.00
IUUC-Ame-011515 Astyanax mexicanus 76.06 0.00e+00 1469.00
IUUC-Bta-013185 Bos taurus 77.48 0.00e+00 2187.00
IUUC-Cja-018844 Callithrix jacchus 95.19 0.00e+00 2869.00
IUUC-Cfa-021187 Canis familiaris 98.05 0.00e+00 2908.00
IUUC-Cpo-022444 Cavia porcellus 94.75 0.00e+00 2860.00
IUUC-Csa-023852 Chlorocebus sabaeus 99.45 0.00e+00 2956.00
IUUC-Dre-027839 Danio rerio 75.40 0.00e+00 1449.00
IUUC-Dno-030058 Dasypus novemcinctus 93.22 0.00e+00 2782.00
IUUC-Dor-030673 Dipodomys ordii 92.79 0.00e+00 2696.00
IUUC-Ete-032705 Echinops telfairi 83.36 0.00e+00 906.00
IUUC-Eca-033885 Equus caballus 96.43 0.00e+00 2818.00
IUUC-Eeu-035338 Erinaceus europaeus 83.14 0.00e+00 2215.00
IUUC-Fca-035388 Felis catus 98.25 0.00e+00 2721.00
IUUC-Fal-037044 Ficedula albicollis 87.69 0.00e+00 2712.00
IUUC-Gmo-039034 Gadus morhua 68.55 0.00e+00 1274.00
IUUC-Gac-041328 Gasterosteus aculeatus 72.86 0.00e+00 2288.00
IUUC-Ggo-045392 Gorilla gorilla 99.27 0.00e+00 2949.00
IUUC-Itr-049068 Ictidomys tridecemlineatus 97.97 0.00e+00 1702.00
IUUC-Loc-052703 Lepisosteus oculatus 79.74 0.00e+00 2511.00
IUUC-Laf-054193 Loxodonta africana 87.29 0.00e+00 2511.00
IUUC-Mcc-055484 Macaca mulatta 97.98 0.00e+00 2914.00
IUUC-Meu-056278 Macropus eugenii 86.04 0.00e+00 1204.00
IUUC-Mga-059816 Meleagris gallopavo 84.66 0.00e+00 2594.00
IUUC-Mmr-061071 Microcebus murinus 94.00 0.00e+00 2800.00
IUUC-Mdo-062845 Monodelphis domestica 91.45 0.00e+00 2801.00
IUUC-Mmu-063967 Mus musculus 96.34 0.00e+00 2840.00
IUUC-Mpu-066448 Mustela putorius furo 96.46 0.00e+00 2892.00
IUUC-Nle-070037 Nomascus leucogenys 97.76 0.00e+00 2261.00
IUUC-Opr-070325 Ochotona princeps 92.47 0.00e+00 2675.00
IUUC-Ont-071851 Oreochromis niloticus 73.23 0.00e+00 2323.00
IUUC-Oan-073615 Ornithorhynchus anatinus 89.13 0.00e+00 2561.00
IUUC-Ocu-073855 Oryctolagus cuniculus 96.89 0.00e+00 2860.00
IUUC-Ola-086703 Oryzias latipes 72.13 0.00e+00 2294.00
IUUC-Oga-088171 Otolemur garnettii 95.50 0.00e+00 2833.00
IUUC-Oar-089693 Ovis aries 78.75 0.00e+00 1244.00
IUUC-Ptr-090535 Pan troglodytes 98.51 0.00e+00 1856.00
IUUC-Pan-091917 Papio anubis 99.35 0.00e+00 2726.00
IUUC-Psi-093752 Pelodiscus sinensis 78.56 0.00e+00 1412.00
IUUC-Pfo-096827 Poecilia formosa 70.07 0.00e+00 1359.00
IUUC-Pab-098441 Pongo abelii 99.76 0.00e+00 2979.00
IUUC-Pca-100781 Procavia capensis 95.58 0.00e+00 908.00
IUUC-Pva-103099 Pteropus vampyrus 91.92 0.00e+00 1364.00
IUUC-Rno-105872 Rattus norvegicus 96.16 0.00e+00 2885.00
IUUC-Sha-107097 Sarcophilus harrisii 89.88 0.00e+00 2668.00
IUUC-Ssc-115638 Sus scrofa 95.17 0.00e+00 2481.00
IUUC-Tgu-116504 Taeniopygia guttata 87.31 0.00e+00 1699.00
IUUC-Tru-118242 Takifugu rubripes 73.83 0.00e+00 1492.00
IUUC-Ttr-128824 Tursiops truncatus 90.29 0.00e+00 2275.00
Created Date 25-Jun-2017

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