iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.30e-09	37.4	22	85
E3 adaptor/Cullin RING/DCX/DWD	2.80e-06	28.6	429	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 4    ilvvggeeffahkivLaas.SsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkld 66
            l+vgg++f++ + +L+    s+F++l+++  +  +++++ + i+ ++p+vf  +l+Fl+t++ld
   Q: 22   HLNVGGKRFSTSRQTLTWIpDSFFSSLLSGRIStLKDETGAIFID-RDPTVFAPILNFLRTKELD 85
           69****************99*************9999********.*****************98 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd.tllvsGsdDgtikvWDlrtg 33
           H ++vt + +s+ +l+++++d++ ++ W+++++
   Q: 429  HRSPVTKIMLSEkHLISVCADNNHVRTWSVTRF 461
           99******9988566677888888*****9976 PP

Organism

Mus musculus

Functional Description
(View)

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation (PubMed:21830225).

Protein Sequence
(Fasta)

MAVATTAVEG VPSRGAPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET 60
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QVREELDRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGGGGTC TATGCACACC CGGAAGTGGG TGCGAGCCGG CCGGCTTGCG GGGGGGTGGG 60
GCTATGGCCG TCGCGACGAC TGCAGTGGAG GGGGTCCCGA GTCGGGGAGC ACCCGGGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50097--BTB
PS00678--WD_REPEATS_1

Pfam

PF02214--BTB_2

SMART

SM00225--BTB
SM00320--WD40

Gene Ontology

GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0051260--P:protein homooligomerization

KEGG

mmu:192192

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002379	Ailuropoda melanoleuca	91.34	0.00e+00	1126.00
IUUC-Aca-004906	Anolis carolinensis	73.12	0.00e+00	957.00
IUUC-Ath-006820	Arabidopsis thaliana	38.54	5.00e-09	55.80
IUUC-Afl-008395	Aspergillus flavus	26.80	9.00e-05	41.60
IUUC-Ame-011252	Astyanax mexicanus	68.30	0.00e+00	869.00
IUUC-Bta-012690	Bos taurus	93.44	0.00e+00	1148.00
IUUC-Bci-013656	Botrytis cinerea	37.96	4.00e-10	58.20
IUUC-Cja-018763	Callithrix jacchus	92.05	0.00e+00	1281.00
IUUC-Cfa-020543	Canis familiaris	94.62	0.00e+00	1142.00
IUUC-Cpo-021962	Cavia porcellus	89.77	0.00e+00	1177.00
IUUC-Dre-027729	Danio rerio	74.04	0.00e+00	960.00
IUUC-Dno-028972	Dasypus novemcinctus	88.80	0.00e+00	1073.00
IUUC-Dor-030553	Dipodomys ordii	92.21	0.00e+00	1103.00
IUUC-Dme-031935	Drosophila melanogaster	50.60	0.00e+00	662.00
IUUC-Eca-033315	Equus caballus	93.57	0.00e+00	1137.00
IUUC-Eeu-035311	Erinaceus europaeus	88.33	0.00e+00	977.00
IUUC-Fca-036552	Felis catus	92.90	0.00e+00	1163.00
IUUC-Fso-038119	Fusarium solani	33.70	5.00e-06	45.80
IUUC-Gmo-039368	Gadus morhua	74.25	0.00e+00	897.00
IUUC-Gac-041846	Gasterosteus aculeatus	67.84	0.00e+00	938.00
IUUC-Ggo-045623	Gorilla gorilla	72.61	0.00e+00	867.00
IUUC-Hsa-045915	Homo sapiens	92.79	0.00e+00	1268.00
IUUC-Itr-048663	Ictidomys tridecemlineatus	95.57	0.00e+00	1166.00
IUUC-Loc-051959	Lepisosteus oculatus	69.73	0.00e+00	976.00
IUUC-Laf-054452	Loxodonta africana	84.43	0.00e+00	1006.00
IUUC-Mcc-055544	Macaca mulatta	93.07	0.00e+00	1226.00
IUUC-Meu-056159	Macropus eugenii	88.28	0.00e+00	1045.00
IUUC-Mmr-061709	Microcebus murinus	93.75	0.00e+00	1179.00
IUUC-Mdo-062553	Monodelphis domestica	82.16	0.00e+00	1048.00
IUUC-Mpu-066614	Mustela putorius furo	93.57	0.00e+00	1140.00
IUUC-Nle-069872	Nomascus leucogenys	88.40	0.00e+00	1162.00
IUUC-Opr-070600	Ochotona princeps	81.68	0.00e+00	962.00
IUUC-Ont-071375	Oreochromis niloticus	73.98	0.00e+00	942.00
IUUC-Oga-088526	Otolemur garnettii	93.47	0.00e+00	1193.00
IUUC-Oar-089898	Ovis aries	92.02	0.00e+00	1144.00
IUUC-Ptr-091353	Pan troglodytes	88.83	0.00e+00	1195.00
IUUC-Pan-091730	Papio anubis	93.42	0.00e+00	1214.00
IUUC-Pfo-097224	Poecilia formosa	66.80	0.00e+00	950.00
IUUC-Pab-098142	Pongo abelii	89.75	0.00e+00	1177.00
IUUC-Pca-100847	Procavia capensis	82.53	0.00e+00	957.00
IUUC-Pva-102652	Pteropus vampyrus	94.17	0.00e+00	1167.00
IUUC-Rno-104907	Rattus norvegicus	97.30	0.00e+00	1314.00
IUUC-Stu-112405	Solanum tuberosum	39.18	2.00e-10	60.50
IUUC-Sar-113577	Sorex araneus	81.05	0.00e+00	924.00
IUUC-Tru-118507	Takifugu rubripes	71.82	0.00e+00	967.00
IUUC-Tni-120814	Tetraodon nigroviridis	70.06	0.00e+00	936.00
IUUC-Tre-121919	Trichoderma reesei	30.51	4.00e-06	46.20
IUUC-Tvi-122427	Trichoderma virens	33.00	4.00e-06	46.20
IUUC-Xtr-132155	Xenopus tropicalis	70.68	0.00e+00	961.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence