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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063576
Ensembl Protein ID ENSMUSP00000057527.7
UniProt Accession Q62441; Q9JKQ9; TLE4_MOUSE
Genbank Protein ID AAF43203.1; AAC97070.1
Protein Name Transducin-like enhancer protein 4; Grg-4; Groucho-related protein 4
Genbank Nucleotide ID AF229633; U61363
Gene Name Tle4; Grg4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024642.16 ENSMUST00000052011.13 ENSMUSP00000057527.7
ENSMUSG00000024642.16 ENSMUST00000167776.2 ENSMUSP00000126249.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.80e-22 78.2 617 655
UBD/Beta-Prp 6.50e-40 138.3 485 655
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 617  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 655
           8***********999*********************998 PP
   

   UBD/Beta-Prp
   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 485  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 572
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 573  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 655
           88888888999*********************************9.********************************997443 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
Protein Sequence
(Fasta)
MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063576|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGCGCGTT GTTAGAGCTG TTCCGAGCGG GCGTTCGGCT GTTGGCTGCC TTCTTCCCCC 60
TCTTACACAC TCGTGTATTA TTTTGAGGTG GTGTTCGCAG AGTTTGAAAG AGAATTTTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063576|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0070491--F:repressing transcription factor binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG mmu:21888
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003434 Anas platyrhynchos 87.92 0.00e+00 1127.00
IUUC-Aca-005279 Anolis carolinensis 98.97 0.00e+00 1335.00
IUUC-Bta-012646 Bos taurus 98.71 0.00e+00 1365.00
IUUC-Cel-018361 Caenorhabditis elegans 58.99 2.00e-122 432.00
IUUC-Cja-019079 Callithrix jacchus 99.35 0.00e+00 1409.00
IUUC-Cfa-020987 Canis familiaris 99.07 0.00e+00 1354.00
IUUC-Cpo-021606 Cavia porcellus 97.26 0.00e+00 1322.00
IUUC-Csa-023445 Chlorocebus sabaeus 99.74 0.00e+00 1382.00
IUUC-Cho-024590 Choloepus hoffmanni 85.45 0.00e+00 1212.00
IUUC-Csv-026174 Ciona savignyi 58.67 7.00e-164 571.00
IUUC-Dno-028979 Dasypus novemcinctus 99.32 0.00e+00 1334.00
IUUC-Dor-030533 Dipodomys ordii 94.87 0.00e+00 1163.00
IUUC-Dme-031576 Drosophila melanogaster 86.03 0.00e+00 665.00
IUUC-Ete-032887 Echinops telfairi 86.04 0.00e+00 1226.00
IUUC-Eca-034397 Equus caballus 99.04 0.00e+00 1271.00
IUUC-Eeu-035237 Erinaceus europaeus 86.38 0.00e+00 1160.00
IUUC-Fca-036030 Felis catus 99.21 0.00e+00 1369.00
IUUC-Fal-037460 Ficedula albicollis 99.08 0.00e+00 1345.00
IUUC-Gga-040416 Gallus gallus 99.35 0.00e+00 1376.00
IUUC-Ggo-045633 Gorilla gorilla 95.57 0.00e+00 1348.00
IUUC-Hsa-046461 Homo sapiens 95.65 0.00e+00 1381.00
IUUC-Itr-048974 Ictidomys tridecemlineatus 99.61 0.00e+00 1377.00
IUUC-Lch-049943 Latimeria chalumnae 95.87 0.00e+00 1239.00
IUUC-Loc-052835 Lepisosteus oculatus 95.49 0.00e+00 1276.00
IUUC-Laf-053425 Loxodonta africana 99.60 0.00e+00 1377.00
IUUC-Mcc-055766 Macaca mulatta 95.78 0.00e+00 1383.00
IUUC-Mmr-061317 Microcebus murinus 96.25 0.00e+00 1384.00
IUUC-Mdo-062956 Monodelphis domestica 98.71 0.00e+00 1364.00
IUUC-Mpu-066410 Mustela putorius furo 99.44 0.00e+00 1277.00
IUUC-Mlu-067456 Myotis lucifugus 97.30 0.00e+00 1295.00
IUUC-Nle-069495 Nomascus leucogenys 99.74 0.00e+00 1350.00
IUUC-Ont-071419 Oreochromis niloticus 85.84 0.00e+00 1186.00
IUUC-Oan-072842 Ornithorhynchus anatinus 95.72 0.00e+00 1353.00
IUUC-Ocu-074453 Oryctolagus cuniculus 98.32 0.00e+00 1357.00
IUUC-Ola-087090 Oryzias latipes 85.44 0.00e+00 1195.00
IUUC-Oga-087939 Otolemur garnettii 99.48 0.00e+00 1376.00
IUUC-Oar-090347 Ovis aries 98.88 0.00e+00 1247.00
IUUC-Ptr-091048 Pan troglodytes 99.74 0.00e+00 1382.00
IUUC-Pan-091973 Papio anubis 95.08 0.00e+00 1326.00
IUUC-Pma-094452 Petromyzon marinus 81.18 0.00e+00 932.00
IUUC-Pfo-097518 Poecilia formosa 84.72 0.00e+00 1139.00
IUUC-Pab-097539 Pongo abelii 95.42 0.00e+00 1251.00
IUUC-Pva-103037 Pteropus vampyrus 93.16 0.00e+00 1365.00
IUUC-Rno-105314 Rattus norvegicus 100.00 0.00e+00 1304.00
IUUC-Ssc-116408 Sus scrofa 98.84 0.00e+00 1394.00
IUUC-Tgu-117068 Taeniopygia guttata 98.27 0.00e+00 1338.00
IUUC-Tru-118782 Takifugu rubripes 82.72 0.00e+00 1144.00
IUUC-Tsy-118884 Tarsius syrichta 85.97 0.00e+00 1087.00
IUUC-Tni-120404 Tetraodon nigroviridis 84.21 0.00e+00 1185.00
IUUC-Tbe-128013 Tupaia belangeri 91.49 0.00e+00 1274.00
IUUC-Vpa-130577 Vicugna pacos 90.40 0.00e+00 715.00
IUUC-Xtr-132974 Xenopus tropicalis 96.27 0.00e+00 1288.00
Created Date 25-Jun-2017

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