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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063501
Ensembl Protein ID ENSMUSP00000023666.4
UniProt Accession Q9D0N7; CAF1B_MOUSE
Genbank Protein ID BAB27490.1; AAH13532.1
Protein Name Chromatin assembly factor 1 subunit B; Chromatin assembly factor I p60 subunit
Genbank Nucleotide ID AK011243; BC013532
Gene Name Chaf1b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022945.11 ENSMUST00000023666.10 ENSMUSP00000023666.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-19 70.9 127 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH ++v+++++ +d +l+ s+s D+t+ +WD+++g 
   Q: 127  GHLEDVYDICWaTDgNLMTSASVDNTVIIWDVSKGQ 162
           89**********998****************99886 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity).
 Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity).
Protein Sequence
(Fasta)
MKVITCEIAW HNKEPVYSLD FQHGATWKIH RLASAGVDTA VRIWKLERGP DGKAIVEFLS 60
NLARHTKAVN VVRFSPTGEI LASGGDDAVI LLWKMNDSKE PEQIAFQDEE EAQLNKENWT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063501|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGACCGGAG GCGTGGCCTG CGGCGCGCGG GAAGCTGCGG GCTGTGGCGG CCCCGGGTGG 60
ACCGAGTTAC TGCAGGTAGG TTTGCTGATA CCCGGCTTCC GCGCTTCTGA CCTGGGTTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063501|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR029129--CAF1_p60_C
IPR001632--Gprotein_B
IPR002469--Peptidase_S9B_N
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF15512--CAF-1_p60_C
PF00400--WD40
PRINTS

PR00319--GPROTEINB
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0005829--C:cytosol
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0042393--F:histone binding
GO:0007049--P:cell cycle
GO:0031497--P:chromatin assembly
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006334--P:nucleosome assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:110749
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000474 Aegilops tauschii 40.35 9.00e-81 294.00
IUUC-Aml-001755 Ailuropoda melanoleuca 80.28 0.00e+00 887.00
IUUC-Atr-002674 Amborella trichopoda 40.49 4.00e-84 305.00
IUUC-Apl-003701 Anas platyrhynchos 71.45 0.00e+00 810.00
IUUC-Aca-004692 Anolis carolinensis 70.61 0.00e+00 769.00
IUUC-Aly-006286 Arabidopsis lyrata 41.49 2.00e-85 309.00
IUUC-Ath-007683 Arabidopsis thaliana 40.48 7.00e-85 307.00
IUUC-Ago-007940 Ashbya gossypii 32.69 2.00e-64 239.00
IUUC-Acl-008070 Aspergillus clavatus 41.59 5.00e-42 166.00
IUUC-Afl-008414 Aspergillus flavus 39.91 2.00e-41 164.00
IUUC-Afu-009046 Aspergillus fumigatus 34.10 7.00e-28 119.00
IUUC-Ani-009399 Aspergillus nidulans 41.98 3.00e-41 163.00
IUUC-Ang-009650 Aspergillus niger 38.74 4.00e-39 156.00
IUUC-Aor-009937 Aspergillus oryzae 39.91 3.00e-41 163.00
IUUC-Ate-010505 Aspergillus terreus 31.78 2.00e-26 113.00
IUUC-Ame-011094 Astyanax mexicanus 63.35 0.00e+00 667.00
IUUC-Bgr-012005 Blumeria graminis 40.65 3.00e-38 153.00
IUUC-Bta-013423 Bos taurus 82.92 0.00e+00 863.00
IUUC-Bci-013847 Botrytis cinerea 39.81 1.00e-38 154.00
IUUC-Bdi-014860 Brachypodium distachyon 42.33 2.00e-80 293.00
IUUC-Bol-016603 Brassica oleracea 35.62 1.00e-82 300.00
IUUC-Bra-017175 Brassica rapa 40.39 7.00e-79 287.00
IUUC-Cel-018272 Caenorhabditis elegans 33.17 6.00e-54 204.00
IUUC-Cja-019558 Callithrix jacchus 81.47 0.00e+00 884.00
IUUC-Cfa-020900 Canis familiaris 76.67 0.00e+00 858.00
IUUC-Cpo-022054 Cavia porcellus 74.20 0.00e+00 791.00
IUUC-Csa-023850 Chlorocebus sabaeus 82.33 0.00e+00 916.00
IUUC-Cho-024510 Choloepus hoffmanni 80.97 1.00e-138 486.00
IUUC-Cin-025178 Ciona intestinalis 47.25 5.00e-108 384.00
IUUC-Csv-025885 Ciona savignyi 46.94 7.00e-35 139.00
IUUC-Cgl-026572 Colletotrichum gloeosporioides 42.77 1.00e-35 145.00
IUUC-Cne-027015 Cryptococcus neoformans 34.00 6.00e-36 145.00
IUUC-Cme-027136 Cyanidioschyzon merolae 30.00 1.00e-57 217.00
IUUC-Dre-027879 Danio rerio 64.00 0.00e+00 652.00
IUUC-Dno-029335 Dasypus novemcinctus 82.89 0.00e+00 934.00
IUUC-Dor-030520 Dipodomys ordii 66.08 0.00e+00 672.00
IUUC-Dse-031566 Dothistroma septosporum 39.44 3.00e-40 160.00
IUUC-Dme-031838 Drosophila melanogaster 46.85 4.00e-108 385.00
IUUC-Eca-033563 Equus caballus 81.10 0.00e+00 924.00
IUUC-Fca-036052 Felis catus 78.62 0.00e+00 866.00
IUUC-Fal-037080 Ficedula albicollis 72.46 0.00e+00 797.00
IUUC-Fox-038022 Fusarium oxysporum 40.85 2.00e-39 157.00
IUUC-Fso-038115 Fusarium solani 41.31 2.00e-38 154.00
IUUC-Gmo-039461 Gadus morhua 70.93 3.00e-138 484.00
IUUC-Ggr-040100 Gaeumannomyces graminis 40.28 4.00e-39 156.00
IUUC-Gga-041133 Gallus gallus 71.15 0.00e+00 797.00
IUUC-Gac-041769 Gasterosteus aculeatus 65.74 0.00e+00 682.00
IUUC-Gma-043070 Glycine max 40.25 3.00e-92 332.00
IUUC-Ggo-044561 Gorilla gorilla 82.22 0.00e+00 908.00
IUUC-Hsa-046150 Homo sapiens 82.51 0.00e+00 915.00
IUUC-Hvu-047792 Hordeum vulgare 39.66 5.00e-51 194.00
IUUC-Itr-048630 Ictidomys tridecemlineatus 85.05 0.00e+00 887.00
IUUC-Kpa-049397 Komagataella pastoris 38.50 6.00e-83 301.00
IUUC-Lch-050365 Latimeria chalumnae 52.85 1.00e-142 499.00
IUUC-Lpe-050875 Leersia perrieri 39.60 1.00e-79 290.00
IUUC-Loc-052770 Lepisosteus oculatus 68.53 0.00e+00 692.00
IUUC-Lma-053291 Leptosphaeria maculans 39.44 2.00e-40 160.00
IUUC-Laf-053505 Loxodonta africana 83.25 0.00e+00 961.00
IUUC-Mcc-054803 Macaca mulatta 82.51 0.00e+00 916.00
IUUC-Meu-056578 Macropus eugenii 67.84 0.00e+00 743.00
IUUC-Mor-057211 Magnaporthe oryzae 40.09 1.00e-37 151.00
IUUC-Mpo-057411 Magnaporthe poae 39.81 3.00e-38 153.00
IUUC-Mtr-058066 Medicago truncatula 41.13 7.00e-91 328.00
IUUC-Mga-059735 Meleagris gallopavo 71.45 0.00e+00 808.00
IUUC-Mvi-060288 Microbotryum violaceum 29.48 8.00e-31 129.00
IUUC-Mmr-061343 Microcebus murinus 82.45 0.00e+00 946.00
IUUC-Mdo-062065 Monodelphis domestica 76.34 0.00e+00 836.00
IUUC-Mac-064864 Musa acuminata 38.63 1.00e-80 293.00
IUUC-Mpu-066549 Mustela putorius furo 77.95 0.00e+00 852.00
IUUC-Mlu-067121 Myotis lucifugus 74.38 0.00e+00 807.00
IUUC-Nfi-068462 Neosartorya fischeri 42.06 2.00e-42 167.00
IUUC-Ncr-068838 Neurospora crassa 38.32 3.00e-39 156.00
IUUC-Nle-069854 Nomascus leucogenys 82.86 0.00e+00 910.00
IUUC-Opr-070803 Ochotona princeps 74.34 0.00e+00 823.00
IUUC-Ont-071642 Oreochromis niloticus 65.27 0.00e+00 671.00
IUUC-Oan-073675 Ornithorhynchus anatinus 74.28 0.00e+00 811.00
IUUC-Ocu-073863 Oryctolagus cuniculus 88.43 0.00e+00 734.00
IUUC-Oba-075682 Oryza barthii 40.10 1.00e-76 280.00
IUUC-Obr-076039 Oryza brachyantha 41.48 2.00e-82 300.00
IUUC-Ogu-078021 Oryza glumaepatula 41.09 2.00e-81 296.00
IUUC-Oin-079908 Oryza indica 36.71 8.00e-62 231.00
IUUC-Olo-081063 Oryza longistaminata 41.09 2.00e-81 296.00
IUUC-Ome-081930 Oryza meridionalis 41.09 3.00e-81 295.00
IUUC-Oni-082547 Oryza nivara 40.84 1.00e-81 296.00
IUUC-Opu-084089 Oryza punctata 40.59 1.00e-78 287.00
IUUC-Oru-084844 Oryza rufipogon 41.09 3.00e-81 295.00
IUUC-Osa-085582 Oryza sativa 41.09 3.00e-81 295.00
IUUC-Ola-087187 Oryzias latipes 64.01 0.00e+00 674.00
IUUC-Olu-087792 Ostreococcus lucimarinus 37.41 4.00e-75 275.00
IUUC-Oga-088390 Otolemur garnettii 79.96 0.00e+00 924.00
IUUC-Oar-089740 Ovis aries 81.12 0.00e+00 827.00
IUUC-Ptr-091581 Pan troglodytes 82.69 0.00e+00 917.00
IUUC-Pan-092258 Papio anubis 75.44 0.00e+00 827.00
IUUC-Psi-093761 Pelodiscus sinensis 75.05 0.00e+00 829.00
IUUC-Ppa-095428 Physcomitrella patens 40.28 1.00e-90 327.00
IUUC-Pfo-097357 Poecilia formosa 65.80 0.00e+00 672.00
IUUC-Pab-098520 Pongo abelii 81.98 0.00e+00 912.00
IUUC-Pop-099331 Populus trichocarpa 36.70 1.00e-86 313.00
IUUC-Ppe-101548 Prunus persica 39.28 1.00e-83 303.00
IUUC-Pva-103243 Pteropus vampyrus 79.43 0.00e+00 805.00
IUUC-Pgr-103591 Puccinia graminis 32.47 2.00e-33 137.00
IUUC-Pte-104247 Pyrenophora teres 40.19 2.00e-40 160.00
IUUC-Pyt-104641 Pyrenophora triticirepentis 40.19 3.00e-40 160.00
IUUC-Rno-105202 Rattus norvegicus 91.94 0.00e+00 1016.00
IUUC-Sce-106250 Saccharomyces cerevisiae 33.69 3.00e-72 265.00
IUUC-Sha-107036 Sarcophilus harrisii 80.07 0.00e+00 885.00
IUUC-Sja-107912 Schizosaccharomyces japonicus 36.38 9.00e-77 280.00
IUUC-Spo-108050 Schizosaccharomyces pombe 33.97 6.00e-71 261.00
IUUC-Ssl-108607 Sclerotinia sclerotiorum 37.86 6.00e-39 155.00
IUUC-Sit-109838 Setaria italica 41.67 3.00e-82 298.00
IUUC-Sly-110872 Solanum lycopersicum 39.05 3.00e-82 299.00
IUUC-Stu-111933 Solanum tuberosum 38.57 6.00e-80 291.00
IUUC-Sbi-114587 Sorghum bicolor 36.87 8.00e-83 301.00
IUUC-Ssc-115462 Sus scrofa 80.92 0.00e+00 903.00
IUUC-Tgu-117186 Taeniopygia guttata 71.67 0.00e+00 768.00
IUUC-Tru-118310 Takifugu rubripes 64.61 0.00e+00 671.00
IUUC-Tsy-118927 Tarsius syrichta 74.74 0.00e+00 676.00
IUUC-Tni-120832 Tetraodon nigroviridis 65.34 0.00e+00 651.00
IUUC-Tca-121584 Theobroma cacao 37.81 1.00e-85 310.00
IUUC-Tre-122140 Trichoderma reesei 39.72 1.00e-38 154.00
IUUC-Tvi-122663 Trichoderma virens 41.12 5.00e-39 156.00
IUUC-Tae-123476 Triticum aestivum 40.35 9.00e-81 294.00
IUUC-Tur-126239 Triticum urartu 40.35 6.00e-81 295.00
IUUC-Tme-127108 Tuber melanosporum 39.06 5.00e-79 288.00
IUUC-Ttr-129010 Tursiops truncatus 80.21 0.00e+00 886.00
IUUC-Vda-129825 Verticillium dahliae 41.51 4.00e-40 159.00
IUUC-Vpa-130374 Vicugna pacos 75.57 1.00e-96 347.00
IUUC-Vvi-131136 Vitis vinifera 40.34 4.00e-84 305.00
IUUC-Xtr-132141 Xenopus tropicalis 75.06 0.00e+00 710.00
IUUC-Xma-133980 Xiphophorus maculatus 75.25 0.00e+00 666.00
IUUC-Yli-134457 Yarrowia lipolytica 37.95 8.00e-37 148.00
IUUC-Zma-135321 Zea mays 37.40 5.00e-83 301.00
Created Date 25-Jun-2017

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