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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045920
UUCD1 version UUC-HoS-01156
Ensembl Protein ID ENSP00000296257.5
UniProt Accession Q9HC62; B4DQ42; Q8IW97; Q96SR2; Q9P2L5; SENP2_HUMAN
Genbank Protein ID AAG15309.2; BAA92569.2; BAB55222.1; BAG60804.1; AAH40609.1; CAD39043.1
Protein Name Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Sentrin/SUMO-specific protease SENP2
Genbank Nucleotide ID AF151697; AB037752; AK027599; AK298628; AC016961; AL834380
Gene Name SENP2; KIAA1331
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163904.12 ENST00000430355.5 ENSP00000399156.1
ENSG00000163904.12 ENST00000296257.9 ENSP00000296257.5
ENSG00000163904.12 ENST00000453532.5 ENSP00000393197.1
ENSG00000163904.12 ENST00000439684.5 ENSP00000390229.1
ENSG00000163904.12 ENST00000413407.5 ENSP00000388893.1
ENSG00000163904.12 ENST00000458551.1 ENSP00000408114.1
ENSG00000163904.12 ENST00000444509.1 ENSP00000399201.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 15824120; 20417598; 20637912
Classification
Family E-value Score Start End
DUB/ULP 1.50e-54 186.5 396 558
Active Site
Position(s) Description Evidence
548 Nucleophile N/A
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslavvcf 93
            +t+ d+++L++ ++lnD++i+fy++ l++e+ kk+ ++ +h+fs+ffy klk+ ++++vk+wt+ v+lfe+++i+vpi++++HWsl+v+++
   Q: 396  RITRGDIQTLKNYHWLNDEVINFYMN-LLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDL 486
           699***********************.999************************************************************** PP
   S: 94   kkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk...vpqQkNssDCGvyvlqyves 163
           +kk++ +lDS+ g++ ++++++l +yl++e+k+k++ +++  ++ ++++k   +pqQ N+sDCG++ ++y+++
   Q: 487  RKKCLKYLDSM-GQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKpheIPQQLNGSDCGMFTCKYADY 558
           ***********.********************************998888889*****************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620).
Protein Sequence
(Fasta)
MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK 60
NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS NSSSCELTGS GSWNNMLKLG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045920|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATAAGGATCT TCTTGGAGAA CTGGGGCATC TGATTGGAAC ACCTGCGAAA GCTTAAGCGA 60
TGAGGTTGTG CCCCTCTTGC AGTACAAGGC TGCAAATTAT CCAAGCCAAG GGCAGAAATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045920|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
Interpro

IPR003653--Peptidase_C48_C
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0005654--C:nucleoplasm
GO:0016605--C:PML body
GO:0004175--F:endopeptidase activity
GO:0070139--F:SUMO-specific endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0009950--P:dorsal/ventral axis specification
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0060711--P:labyrinthine layer development
GO:0051028--P:mRNA transport
GO:0035562--P:negative regulation of chromatin binding
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0032091--P:negative regulation of protein binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001934--P:positive regulation of protein phosphorylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0031648--P:protein destabilization
GO:0016926--P:protein desumoylation
GO:0016925--P:protein sumoylation
GO:0015031--P:protein transport
GO:0032875--P:regulation of DNA endoreduplication
GO:2000045--P:regulation of G1/S transition of mitotic cell cycle
GO:0030111--P:regulation of Wnt signaling pathway
GO:0060712--P:spongiotrophoblast layer development
GO:0060707--P:trophoblast giant cell differentiation
GO:0016055--P:Wnt signaling pathway
KEGG hsa:59343
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001512 Ailuropoda melanoleuca 92.20 0.00e+00 1062.00
IUUC-Apl-003602 Anas platyrhynchos 50.12 9.00e-113 400.00
IUUC-Aca-004819 Anolis carolinensis 61.92 5.00e-101 361.00
IUUC-Afl-008417 Aspergillus flavus 30.30 2.00e-30 128.00
IUUC-Aor-010104 Aspergillus oryzae 32.04 2.00e-29 122.00
IUUC-Ame-011519 Astyanax mexicanus 35.26 4.00e-76 279.00
IUUC-Bta-013157 Bos taurus 91.00 0.00e+00 1056.00
IUUC-Cja-018720 Callithrix jacchus 96.61 0.00e+00 1118.00
IUUC-Cfa-020805 Canis familiaris 93.22 0.00e+00 1072.00
IUUC-Cpo-021808 Cavia porcellus 89.47 0.00e+00 1039.00
IUUC-Cre-022877 Chlamydomonas reinhardtii 31.49 5.00e-19 87.00
IUUC-Cho-024783 Choloepus hoffmanni 67.03 0.00e+00 632.00
IUUC-Cgl-026530 Colletotrichum gloeosporioides 25.22 1.00e-14 75.90
IUUC-Dno-028882 Dasypus novemcinctus 92.70 0.00e+00 1077.00
IUUC-Dor-030693 Dipodomys ordii 70.63 0.00e+00 729.00
IUUC-Ete-032724 Echinops telfairi 77.63 0.00e+00 876.00
IUUC-Eca-034052 Equus caballus 92.53 0.00e+00 1071.00
IUUC-Eeu-034465 Erinaceus europaeus 89.51 0.00e+00 943.00
IUUC-Fca-036319 Felis catus 93.22 0.00e+00 1078.00
IUUC-Fal-037347 Ficedula albicollis 55.95 2.00e-85 308.00
IUUC-Gga-041045 Gallus gallus 62.96 8.00e-99 354.00
IUUC-Gma-043405 Glycine max 37.41 1.00e-36 147.00
IUUC-Ggo-044694 Gorilla gorilla 90.83 0.00e+00 1022.00
IUUC-Hvu-047684 Hordeum vulgare 45.22 4.00e-44 172.00
IUUC-Itr-048799 Ictidomys tridecemlineatus 93.21 0.00e+00 1084.00
IUUC-Lch-049790 Latimeria chalumnae 63.25 2.00e-88 318.00
IUUC-Lma-052978 Leptosphaeria maculans 34.18 1.00e-20 95.10
IUUC-Laf-053368 Loxodonta africana 90.66 0.00e+00 1052.00
IUUC-Mcc-055057 Macaca mulatta 97.96 0.00e+00 1129.00
IUUC-Meu-056435 Macropus eugenii 56.25 0.00e+00 635.00
IUUC-Mtr-058391 Medicago truncatula 37.66 1.00e-36 147.00
IUUC-Mmr-061684 Microcebus murinus 94.57 0.00e+00 1102.00
IUUC-Mdo-062858 Monodelphis domestica 69.50 1.00e-135 476.00
IUUC-Mmu-063498 Mus musculus 85.93 0.00e+00 976.00
IUUC-Mpu-066611 Mustela putorius furo 89.78 0.00e+00 1015.00
IUUC-Mlu-067118 Myotis lucifugus 87.90 0.00e+00 1076.00
IUUC-Ncr-068706 Neurospora crassa 29.91 1.00e-16 82.40
IUUC-Nle-069443 Nomascus leucogenys 98.81 0.00e+00 1137.00
IUUC-Opr-070806 Ochotona princeps 80.00 0.00e+00 902.00
IUUC-Oan-073590 Ornithorhynchus anatinus 55.12 4.00e-80 291.00
IUUC-Ocu-073901 Oryctolagus cuniculus 91.36 0.00e+00 1074.00
IUUC-Oga-089135 Otolemur garnettii 94.91 0.00e+00 1097.00
IUUC-Oar-089942 Ovis aries 91.34 0.00e+00 1065.00
IUUC-Ptr-090705 Pan troglodytes 99.15 0.00e+00 1144.00
IUUC-Pan-092887 Papio anubis 96.95 0.00e+00 919.00
IUUC-Psi-093140 Pelodiscus sinensis 51.66 8.00e-143 500.00
IUUC-Pno-094805 Phaeosphaeria nodorum 34.81 9.00e-22 99.40
IUUC-Pab-098511 Pongo abelii 98.29 1.00e-161 563.00
IUUC-Pca-100253 Procavia capensis 63.73 0.00e+00 636.00
IUUC-Ppe-101189 Prunus persica 41.08 5.00e-34 138.00
IUUC-Pva-103179 Pteropus vampyrus 89.98 0.00e+00 1033.00
IUUC-Pte-104020 Pyrenophora teres 32.70 4.00e-18 87.00
IUUC-Pyt-104575 Pyrenophora triticirepentis 31.65 6.00e-19 89.70
IUUC-Rno-105258 Rattus norvegicus 86.95 0.00e+00 972.00
IUUC-Sha-107397 Sarcophilus harrisii 40.28 1.00e-100 360.00
IUUC-Sit-110193 Setaria italica 42.48 1.00e-43 171.00
IUUC-Stu-112651 Solanum tuberosum 37.39 3.00e-36 146.00
IUUC-Sar-113372 Sorex araneus 89.65 0.00e+00 909.00
IUUC-Sbi-114067 Sorghum bicolor 42.29 8.00e-44 171.00
IUUC-Ssc-115700 Sus scrofa 89.86 0.00e+00 1019.00
IUUC-Tgu-117433 Taeniopygia guttata 61.23 3.00e-85 307.00
IUUC-Tsy-118960 Tarsius syrichta 83.40 0.00e+00 831.00
IUUC-Tae-125765 Triticum aestivum 43.29 2.00e-44 173.00
IUUC-Tur-126817 Triticum urartu 43.72 2.00e-44 173.00
IUUC-Tbe-127893 Tupaia belangeri 66.08 0.00e+00 660.00
IUUC-Ttr-128910 Tursiops truncatus 92.43 0.00e+00 991.00
IUUC-Vda-129779 Verticillium dahliae 24.08 2.00e-10 61.60
IUUC-Vpa-130290 Vicugna pacos 93.04 0.00e+00 1090.00
IUUC-Zma-135913 Zea mays 41.41 9.00e-43 167.00
Created Date 25-Jun-2017

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