iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	2.30e-50	171.8	153	340

Active Site

Position(s)	Description	Evidence
324	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC +++  +++  +l+C h fCk+C++ y+e++i +g  t+i c+a+ c  +++e+ + +l++++ + ++y+++ ++++v+++++l++
   Q: 153  CPVCASSQLGDKFY-SLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRF 241
           *****999998877.77************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp p+C+++v+ ++  +++++ c++c++ fC++C   +H++++C+ +k++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 242  CPGPNCQIIVQSSEI-SAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCA---DDSETANYISAHTKDCPKCHICIEKNGGCNHM 327
           ********9999985.899999*********************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C +Ck++fCw+C
   Q: 328  QCFNCKHDFCWMC 340
           ************* PP

Organism

Drosophila melanogaster

Functional Description
(View)

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Protein Sequence
(Fasta)

MDSDIEMDME SDNDGEYDDD YDYYNTGEDC DVERLDPKRA DPEYFEYECL TVEDIEKLLN 60
ERVEKLNTIL QITPSLAKVL LLEHQWNNVA VVEKYRQDAN ALLVTARIKP PSVAVTDTAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGAAGAACG ATATGCCCCG ATAGGTTCGG ACAAGACAAA GAACAAAATG TTCTCTGCAA 60
AAGCTGTGCT CGCTTAAAAA CGCAAAAAGT CAGTGCATCT AGTGCATTGT CAGTGGTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG5709

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001557	Ailuropoda melanoleuca	55.32	6.00e-152	529.00
IUUC-Apl-003878	Anas platyrhynchos	55.27	3.00e-151	527.00
IUUC-Aca-004865	Anolis carolinensis	55.06	1.00e-149	522.00
IUUC-Bta-012901	Bos taurus	55.21	6.00e-152	529.00
IUUC-Cel-018334	Caenorhabditis elegans	50.00	2.00e-135	474.00
IUUC-Cja-019728	Callithrix jacchus	55.21	4.00e-151	526.00
IUUC-Cfa-020953	Canis familiaris	55.32	6.00e-152	529.00
IUUC-Cpo-021445	Cavia porcellus	55.62	1.00e-151	528.00
IUUC-Csa-023769	Chlorocebus sabaeus	55.21	2.00e-150	524.00
IUUC-Cho-024650	Choloepus hoffmanni	48.85	2.00e-119	421.00
IUUC-Cin-025577	Ciona intestinalis	46.40	1.00e-124	439.00
IUUC-Csv-025849	Ciona savignyi	51.07	1.00e-105	375.00
IUUC-Dre-028490	Danio rerio	55.12	4.00e-150	523.00
IUUC-Dno-029942	Dasypus novemcinctus	55.42	3.00e-151	527.00
IUUC-Dor-030134	Dipodomys ordii	58.39	5.00e-101	360.00
IUUC-Ete-032355	Echinops telfairi	51.04	2.00e-131	461.00
IUUC-Eca-033440	Equus caballus	55.42	2.00e-151	528.00
IUUC-Eeu-035230	Erinaceus europaeus	71.24	1.00e-90	325.00
IUUC-Fca-036308	Felis catus	52.89	7.00e-140	489.00
IUUC-Fal-036974	Ficedula albicollis	55.27	3.00e-151	527.00
IUUC-Gmo-038642	Gadus morhua	54.17	2.00e-140	491.00
IUUC-Gga-041019	Gallus gallus	55.27	3.00e-151	527.00
IUUC-Gac-042014	Gasterosteus aculeatus	53.75	9.00e-145	505.00
IUUC-Ggo-045329	Gorilla gorilla	55.21	1.00e-150	525.00
IUUC-Hsa-046712	Homo sapiens	55.21	1.00e-150	525.00
IUUC-Itr-048370	Ictidomys tridecemlineatus	56.82	3.00e-143	500.00
IUUC-Lch-049584	Latimeria chalumnae	56.07	2.00e-147	514.00
IUUC-Loc-051826	Lepisosteus oculatus	46.40	1.00e-89	322.00
IUUC-Laf-054567	Loxodonta africana	55.00	4.00e-149	520.00
IUUC-Mcc-054919	Macaca mulatta	55.21	2.00e-150	524.00
IUUC-Meu-056332	Macropus eugenii	54.01	4.00e-144	503.00
IUUC-Mga-060132	Meleagris gallopavo	55.14	3.00e-151	527.00
IUUC-Mmr-061599	Microcebus murinus	54.77	9.00e-144	502.00
IUUC-Mdo-062186	Monodelphis domestica	57.08	3.00e-142	497.00
IUUC-Mmu-064271	Mus musculus	55.62	2.00e-151	528.00
IUUC-Mpu-066827	Mustela putorius furo	57.51	1.00e-142	498.00
IUUC-Mlu-067528	Myotis lucifugus	55.21	4.00e-150	523.00
IUUC-Nle-068995	Nomascus leucogenys	55.21	1.00e-150	525.00
IUUC-Opr-070518	Ochotona princeps	54.70	1.00e-148	519.00
IUUC-Ont-071650	Oreochromis niloticus	54.89	2.00e-148	518.00
IUUC-Oan-073676	Ornithorhynchus anatinus	57.27	3.00e-139	487.00
IUUC-Ocu-073761	Oryctolagus cuniculus	55.42	2.00e-151	527.00
IUUC-Ola-087204	Oryzias latipes	53.66	2.00e-145	508.00
IUUC-Oga-088098	Otolemur garnettii	55.42	2.00e-151	527.00
IUUC-Oar-089205	Ovis aries	55.21	6.00e-152	529.00
IUUC-Ptr-091514	Pan troglodytes	55.21	1.00e-150	525.00
IUUC-Pan-092493	Papio anubis	51.84	2.00e-137	481.00
IUUC-Pfo-097256	Poecilia formosa	54.58	1.00e-146	512.00
IUUC-Pab-098504	Pongo abelii	48.96	4.00e-124	437.00
IUUC-Pop-099547	Populus trichocarpa	27.71	1.00e-53	203.00
IUUC-Pca-100700	Procavia capensis	52.08	2.00e-133	468.00
IUUC-Pva-103105	Pteropus vampyrus	55.00	3.00e-148	517.00
IUUC-Rno-105289	Rattus norvegicus	55.42	2.00e-150	524.00
IUUC-Sha-107417	Sarcophilus harrisii	55.27	6.00e-148	516.00
IUUC-Ssl-108406	Sclerotinia sclerotiorum	25.82	2.00e-11	62.80
IUUC-Sar-113042	Sorex araneus	55.11	8.00e-152	529.00
IUUC-Ssc-115362	Sus scrofa	54.91	4.00e-151	527.00
IUUC-Tgu-117469	Taeniopygia guttata	53.96	3.00e-141	494.00
IUUC-Tru-117976	Takifugu rubripes	53.96	1.00e-147	515.00
IUUC-Tni-119831	Tetraodon nigroviridis	53.75	1.00e-145	508.00
IUUC-Tca-121326	Theobroma cacao	29.09	3.00e-57	215.00
IUUC-Tbe-127386	Tupaia belangeri	39.16	3.00e-66	245.00
IUUC-Ttr-128315	Tursiops truncatus	55.21	1.00e-150	525.00
IUUC-Vpa-130383	Vicugna pacos	52.19	5.00e-135	473.00
IUUC-Xtr-132945	Xenopus tropicalis	55.49	2.00e-149	521.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence