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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045839
UUCD1 version UUC-HoS-00356
Ensembl Protein ID ENSP00000453801.1
UniProt Accession Q9GZS3; D3DW84; Q6IA22; Q7Z4X4; WDR61_HUMAN
Genbank Protein ID AAG31639.1; AAP97225.1; AAP97249.1; BAB14986.1; CAG33614.1; EAW99174.1; EAW99175.1; AAH10080.1
Protein Name WD repeat-containing protein 61; Meiotic recombination REC14 protein homolog; SKI8 homolog; WD repeat-containing protein 61, N-terminally processed
Genbank Nucleotide ID AF309553; AF100786; AF127799; AK024754; CR457333; CH471136; CH471136; BC010080
Gene Name WDR61
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140395.8 ENST00000558453.5 ENSP00000453118.1
ENSG00000140395.8 ENST00000560807.5 ENSP00000455689.1
ENSG00000140395.8 ENST00000558311.5 ENSP00000453801.1
ENSG00000140395.8 ENST00000558459.5 ENSP00000453024.1
ENSG00000140395.8 ENST00000559848.1 ENSP00000453589.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-44 149.1 230 269
UBD/Beta-Prp 1.90e-74 252.2 12 303
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+++v  +af +d t++vs+s D+++kvWD+ t +++++
   Q: 230  GHASWVLNVAFcPDdTHFVSSSSDKSVKVWDVGTRTCVHT 269
           8***********777*****************99999875 PP
   

   UBD/Beta-Prp
   S: 6    kghhksvitcvkf....spdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           +++h++ i +v++    +++++ ++tgs d+ +kvw+++++ l   +sl+gh+ +v +v++s++ +i +++s D++i++wdl++gk++ ++ 
   Q: 12   EQAHDDAIWSVAWgtnkKENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID 103
           567788888899998888999********************99999********************************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsv 183
           +   ++++l+fsp++++l++G+h+  ++++ +e+g++ +  l+ + +++ +++++pdg++l+sG+ D++++++d++tgkll+tl+g h  ++
   Q: 104  AGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEY-SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG-HAMPI 193
           ***************************************.*********************************************9.***** PP
   S: 184  yslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsf 275
           +sl+f+++++ lv++s+dg++k++d+q+ +   tl gh ++v+ v+f+p+d+++vs ssD+s+++Wd+ ++++++t+  h+++v+ v++ + 
   Q: 194  RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKY-NG 284
           *****************************************************************************************.99 PP
   S: 276  gdnvlvlgsedskvniwkl 294
           +++++v++++d++++i+++
   Q: 285  NGSKIVSVGDDQEIHIYDC 303
           9****************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
 Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
Protein Sequence
(Fasta)
MTNQYGILFK QEQAHDDAIW SVAWGTNKKE NSETVVTGSL DDLVKVWKWR DERLDLQWSL 60
EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK SIDAGPVDAW TLAFSPDSQY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045839|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAATTTCCAA CTACCACTCC TCTGGAAGCA GGACCTGGCT TCCTCCCTCC TCTCTCCGCC 60
CACCCTCGTC GGCGTCTGCC CCGCGCCCGC CATAGCGACG GCAACGGGCG CTGCGGAGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045839|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0055087--C:Ski complex
GO:0035327--C:transcriptionally active chromatin
GO:0043928--P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0080182--P:histone H3-K4 trimethylation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2001162--P:positive regulation of histone H3-K79 methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway
KEGG hsa:80349
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000774 Aegilops tauschii 33.93 1.00e-47 183.00
IUUC-Aml-002245 Ailuropoda melanoleuca 98.69 5.00e-168 583.00
IUUC-Atr-003142 Amborella trichopoda 51.55 2.00e-38 152.00
IUUC-Apl-003179 Anas platyrhynchos 91.15 2.00e-157 548.00
IUUC-Aca-004880 Anolis carolinensis 88.20 3.00e-157 547.00
IUUC-Aly-005956 Arabidopsis lyrata 37.82 1.00e-55 209.00
IUUC-Ath-007230 Arabidopsis thaliana 37.50 2.00e-51 196.00
IUUC-Acl-008297 Aspergillus clavatus 28.88 6.00e-25 108.00
IUUC-Ang-009702 Aspergillus niger 29.90 8.00e-30 124.00
IUUC-Ame-011511 Astyanax mexicanus 83.71 8.00e-149 519.00
IUUC-Bgr-012189 Blumeria graminis 30.82 1.00e-28 120.00
IUUC-Bta-012936 Bos taurus 99.02 2.00e-168 584.00
IUUC-Bdi-015020 Brachypodium distachyon 37.59 4.00e-47 181.00
IUUC-Bol-016345 Brassica oleracea 38.46 1.00e-56 213.00
IUUC-Bra-017323 Brassica rapa 38.46 7.00e-57 214.00
IUUC-Cja-019961 Callithrix jacchus 100.00 8.00e-170 589.00
IUUC-Cfa-020862 Canis familiaris 98.36 3.00e-167 580.00
IUUC-Cpo-021356 Cavia porcellus 99.01 7.00e-166 576.00
IUUC-Cre-022602 Chlamydomonas reinhardtii 41.58 2.00e-57 216.00
IUUC-Csa-024067 Chlorocebus sabaeus 99.67 4.00e-169 587.00
IUUC-Cho-024421 Choloepus hoffmanni 83.84 9.00e-83 299.00
IUUC-Cin-025261 Ciona intestinalis 64.59 5.00e-116 410.00
IUUC-Cgl-026446 Colletotrichum gloeosporioides 28.30 1.00e-28 120.00
IUUC-Cne-026846 Cryptococcus neoformans 29.45 7.00e-25 108.00
IUUC-Dre-027706 Danio rerio 65.57 7.00e-110 390.00
IUUC-Dno-029084 Dasypus novemcinctus 99.02 1.00e-167 582.00
IUUC-Dor-030353 Dipodomys ordii 83.33 1.00e-123 435.00
IUUC-Dse-031348 Dothistroma septosporum 29.08 2.00e-26 112.00
IUUC-Dme-031836 Drosophila melanogaster 52.31 9.00e-88 317.00
IUUC-Ete-032261 Echinops telfairi 96.39 2.00e-162 564.00
IUUC-Eca-034231 Equus caballus 91.48 3.00e-153 534.00
IUUC-Eeu-034828 Erinaceus europaeus 97.94 3.00e-157 547.00
IUUC-Fca-036569 Felis catus 99.02 7.00e-168 582.00
IUUC-Fal-037469 Ficedula albicollis 93.11 2.00e-161 561.00
IUUC-Fox-038047 Fusarium oxysporum 33.00 4.00e-29 122.00
IUUC-Gmo-039579 Gadus morhua 83.61 8.00e-146 509.00
IUUC-Gga-040808 Gallus gallus 93.49 6.00e-154 536.00
IUUC-Gac-042100 Gasterosteus aculeatus 83.93 5.00e-147 513.00
IUUC-Gma-044408 Glycine max 40.94 8.00e-60 223.00
IUUC-Ggo-045227 Gorilla gorilla 100.00 8.00e-170 589.00
IUUC-Hvu-047591 Hordeum vulgare 37.97 1.00e-49 190.00
IUUC-Itr-048741 Ictidomys tridecemlineatus 99.67 4.00e-169 587.00
IUUC-Lch-049549 Latimeria chalumnae 83.61 8.00e-147 512.00
IUUC-Lpe-050746 Leersia perrieri 38.59 4.00e-48 184.00
IUUC-Loc-052540 Lepisosteus oculatus 86.56 2.00e-148 518.00
IUUC-Lma-052992 Leptosphaeria maculans 28.14 4.00e-27 115.00
IUUC-Laf-053907 Loxodonta africana 99.67 4.00e-169 587.00
IUUC-Mcc-055828 Macaca mulatta 93.54 1.00e-165 575.00
IUUC-Meu-056075 Macropus eugenii 94.51 4.00e-135 473.00
IUUC-Mtr-057728 Medicago truncatula 40.71 2.00e-56 213.00
IUUC-Mga-059872 Meleagris gallopavo 93.44 5.00e-162 563.00
IUUC-Mvi-060564 Microbotryum violaceum 32.11 1.00e-29 124.00
IUUC-Mmr-060985 Microcebus murinus 99.66 4.00e-161 560.00
IUUC-Mdo-062758 Monodelphis domestica 90.46 1.00e-158 551.00
IUUC-Mmu-063580 Mus musculus 97.38 2.00e-166 578.00
IUUC-Mac-064880 Musa acuminata 40.19 7.00e-58 217.00
IUUC-Mpu-066577 Mustela putorius furo 98.03 2.00e-166 578.00
IUUC-Nle-069573 Nomascus leucogenys 100.00 8.00e-170 589.00
IUUC-Opr-070216 Ochotona princeps 97.67 2.00e-164 571.00
IUUC-Ont-071981 Oreochromis niloticus 85.25 9.00e-150 522.00
IUUC-Oan-073223 Ornithorhynchus anatinus 93.94 1.00e-107 381.00
IUUC-Ocu-074199 Oryctolagus cuniculus 84.92 2.00e-139 488.00
IUUC-Oba-075255 Oryza barthii 40.00 1.00e-41 163.00
IUUC-Obr-076168 Oryza brachyantha 47.20 1.00e-35 143.00
IUUC-Ogl-077777 Oryza glaberrima 38.39 8.00e-49 187.00
IUUC-Ogu-078780 Oryza glumaepatula 38.39 8.00e-49 187.00
IUUC-Oin-079228 Oryza indica 38.39 2.00e-51 196.00
IUUC-Olo-080617 Oryza longistaminata 45.77 3.00e-29 120.00
IUUC-Ome-081421 Oryza meridionalis 38.39 5.00e-48 184.00
IUUC-Oni-082997 Oryza nivara 38.39 2.00e-51 196.00
IUUC-Opu-083931 Oryza punctata 38.71 8.00e-49 187.00
IUUC-Oru-084645 Oryza rufipogon 38.39 8.00e-49 187.00
IUUC-Osa-085842 Oryza sativa 38.39 2.00e-51 196.00
IUUC-Ola-086696 Oryzias latipes 84.92 1.00e-145 508.00
IUUC-Olu-087643 Ostreococcus lucimarinus 39.91 1.00e-41 162.00
IUUC-Oga-088272 Otolemur garnettii 97.70 3.00e-165 573.00
IUUC-Oar-089416 Ovis aries 99.02 2.00e-168 584.00
IUUC-Ptr-090944 Pan troglodytes 100.00 8.00e-170 589.00
IUUC-Pan-091861 Papio anubis 100.00 8.00e-170 589.00
IUUC-Psi-093750 Pelodiscus sinensis 93.77 4.00e-161 560.00
IUUC-Pma-094608 Petromyzon marinus 79.68 5.00e-135 473.00
IUUC-Pno-094832 Phaeosphaeria nodorum 32.59 3.00e-26 112.00
IUUC-Ppa-095737 Physcomitrella patens 40.38 1.00e-56 213.00
IUUC-Pfo-096479 Poecilia formosa 85.90 8.00e-144 503.00
IUUC-Pab-098179 Pongo abelii 100.00 8.00e-170 589.00
IUUC-Pop-099532 Populus trichocarpa 40.91 4.00e-56 211.00
IUUC-Pca-100664 Procavia capensis 76.45 8.00e-106 376.00
IUUC-Ppe-102056 Prunus persica 40.26 5.00e-58 218.00
IUUC-Pva-102859 Pteropus vampyrus 99.02 6.00e-168 583.00
IUUC-Pte-104236 Pyrenophora teres 35.56 2.00e-25 109.00
IUUC-Rno-105826 Rattus norvegicus 97.05 8.00e-166 575.00
IUUC-Sha-106660 Sarcophilus harrisii 92.03 9.00e-153 532.00
IUUC-Sja-107800 Schizosaccharomyces japonicus 33.22 6.00e-36 144.00
IUUC-Spo-108244 Schizosaccharomyces pombe 31.39 4.00e-35 141.00
IUUC-Smo-109234 Selaginella moellendorffii 42.81 5.00e-61 228.00
IUUC-Sit-110048 Setaria italica 36.86 1.00e-40 160.00
IUUC-Sly-111618 Solanum lycopersicum 38.46 4.00e-52 198.00
IUUC-Stu-112543 Solanum tuberosum 38.78 3.00e-55 209.00
IUUC-Sar-113743 Sorex araneus 78.36 4.00e-130 457.00
IUUC-Sbi-114309 Sorghum bicolor 38.57 8.00e-42 164.00
IUUC-Ssc-115560 Sus scrofa 93.44 4.00e-155 540.00
IUUC-Tgu-117300 Taeniopygia guttata 93.44 8.00e-162 562.00
IUUC-Tru-117933 Takifugu rubripes 84.59 4.00e-149 520.00
IUUC-Tsy-119574 Tarsius syrichta 88.85 3.00e-145 507.00
IUUC-Tni-120191 Tetraodon nigroviridis 87.34 7.00e-113 399.00
IUUC-Tca-120983 Theobroma cacao 40.13 2.00e-57 216.00
IUUC-Tae-124056 Triticum aestivum 36.16 1.00e-49 190.00
IUUC-Tur-126711 Triticum urartu 36.05 1.00e-48 186.00
IUUC-Tme-127066 Tuber melanosporum 33.83 6.00e-34 138.00
IUUC-Tbe-127802 Tupaia belangeri 99.02 7.00e-168 582.00
IUUC-Ttr-128861 Tursiops truncatus 98.11 2.00e-56 212.00
IUUC-Vda-129720 Verticillium dahliae 29.27 7.00e-23 101.00
IUUC-Vpa-130618 Vicugna pacos 95.55 1.00e-135 475.00
IUUC-Vvi-130981 Vitis vinifera 40.38 9.00e-56 210.00
IUUC-Xtr-132460 Xenopus tropicalis 85.90 7.00e-146 509.00
IUUC-Xma-134154 Xiphophorus maculatus 85.90 6.00e-144 503.00
IUUC-Yli-134554 Yarrowia lipolytica 27.90 4.00e-20 92.00
Created Date 25-Jun-2017

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