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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046270
Ensembl Protein ID ENSP00000309597.3
UniProt Accession Q16584; B4DS76; Q53H00; Q59F06; Q6P2G4; M3K11_HUMAN
Genbank Protein ID AAA19647.1; AAA59859.1; BAD92892.1; BAG61538.1; BAH14403.1; BAD96501.1; AAH11263.1; AAH64543.1
Protein Name Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
Genbank Nucleotide ID U07747; L32976; AB209655; AK299609; AK316032; AK222781; AP001362; BC064543
Gene Name MAP3K11; MLK3; PTK1; SPRK
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000173327.7 ENST00000309100.7 ENSP00000309597.3
ENSG00000173327.7 ENST00000524848.5 ENSP00000431506.1
ENSG00000173327.7 ENST00000526293.1 ENSP00000435970.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.10e-14 54.9 47 102
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvkelegkrGlfPenFvek 61
            +l+dye++ +deL l+kGd v+v+      + degW+ g  +  g+ G+fP+n+v +
   Q: 47   TALFDYEPSGQDELALRKGDRVEVLsrdAAISGDEGWWAG--QVGGQVGIFPSNYVSR 102
           69***********************66555689*******..7************975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
 Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Protein Sequence
(Fasta)
MEPLKSLFLK SPLGSWNGSG SGGGGGGGGG RPEGSPKAAG YANPVWTALF DYEPSGQDEL 60
ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046270|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GATTTCGCTC CCAGCGGCGT CTACTTCCGG GTCAGAGCTC AGACCTAGGG TGTAGAGAAC 60
AACCTTCCGT AACAGGCAGG AATAGTCGAA ATAGGATAGC GTCGTCTTTC TTAAAGTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046270|UBD,SH3|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00220--S_TKc
SM00326--SH3
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0004706--F:JUN kinase kinase kinase activity
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0042803--F:protein homodimerization activity
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007257--P:activation of JUN kinase activity
GO:0000187--P:activation of MAPK activity
GO:0008219--P:cell death
GO:0008283--P:cell proliferation
GO:0007254--P:JNK cascade
GO:0007017--P:microtubule-based process
GO:0043065--P:positive regulation of apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0043507--P:positive regulation of JUN kinase activity
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0046777--P:protein autophosphorylation
GO:0006468--P:protein phosphorylation
KEGG hsa:4296
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002080 Ailuropoda melanoleuca 93.45 0.00e+00 1038.00
IUUC-Ame-011785 Astyanax mexicanus 70.00 0.00e+00 709.00
IUUC-Bta-012372 Bos taurus 97.47 0.00e+00 1060.00
IUUC-Bol-015857 Brassica oleracea 32.84 6.00e-27 115.00
IUUC-Cja-019543 Callithrix jacchus 93.27 0.00e+00 1146.00
IUUC-Cfa-020080 Canis familiaris 97.39 0.00e+00 1003.00
IUUC-Cpo-022478 Cavia porcellus 92.58 0.00e+00 1161.00
IUUC-Csa-023280 Chlorocebus sabaeus 99.49 0.00e+00 1009.00
IUUC-Dno-030074 Dasypus novemcinctus 90.67 0.00e+00 1243.00
IUUC-Dor-030866 Dipodomys ordii 94.35 0.00e+00 1178.00
IUUC-Eca-033782 Equus caballus 96.96 3.00e-171 595.00
IUUC-Fca-035440 Felis catus 96.68 0.00e+00 1041.00
IUUC-Gac-042299 Gasterosteus aculeatus 61.99 0.00e+00 703.00
IUUC-Ggo-044795 Gorilla gorilla 99.41 0.00e+00 1261.00
IUUC-Itr-048561 Ictidomys tridecemlineatus 95.05 0.00e+00 1163.00
IUUC-Lch-049724 Latimeria chalumnae 63.17 0.00e+00 696.00
IUUC-Meu-056762 Macropus eugenii 90.58 0.00e+00 750.00
IUUC-Mdo-062929 Monodelphis domestica 83.03 0.00e+00 1153.00
IUUC-Mmu-063196 Mus musculus 94.12 0.00e+00 1181.00
IUUC-Mpu-066569 Mustela putorius furo 96.83 0.00e+00 1071.00
IUUC-Mlu-067815 Myotis lucifugus 92.66 0.00e+00 1138.00
IUUC-Ont-071274 Oreochromis niloticus 72.92 0.00e+00 713.00
IUUC-Ocu-074842 Oryctolagus cuniculus 93.03 0.00e+00 1191.00
IUUC-Olo-080520 Oryza longistaminata 31.79 1.00e-22 102.00
IUUC-Ome-081788 Oryza meridionalis 29.52 7.00e-31 129.00
IUUC-Oga-088038 Otolemur garnettii 95.40 0.00e+00 1204.00
IUUC-Oar-089467 Ovis aries 90.38 0.00e+00 1106.00
IUUC-Ptr-090955 Pan troglodytes 99.41 0.00e+00 1292.00
IUUC-Pan-091695 Papio anubis 98.47 0.00e+00 1274.00
IUUC-Psi-093760 Pelodiscus sinensis 75.41 0.00e+00 895.00
IUUC-Pfo-096248 Poecilia formosa 58.80 0.00e+00 700.00
IUUC-Pab-097966 Pongo abelii 99.41 0.00e+00 1293.00
IUUC-Pca-100802 Procavia capensis 98.35 3.00e-100 359.00
IUUC-Pva-102546 Pteropus vampyrus 93.76 0.00e+00 1153.00
IUUC-Rno-104963 Rattus norvegicus 93.54 0.00e+00 1251.00
IUUC-Sha-107470 Sarcophilus harrisii 78.86 0.00e+00 1078.00
IUUC-Tni-120577 Tetraodon nigroviridis 61.09 0.00e+00 707.00
IUUC-Ttr-129146 Tursiops truncatus 93.06 0.00e+00 1069.00
Created Date 25-Jun-2017

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