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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046114
UUCD1 version UUC-HoS-00355
Ensembl Protein ID ENSP00000261015.3
UniProt Accession Q9GZL7; B3KPA9; Q96HU0; Q9NV80; Q9NYI8; WDR12_HUMAN
Genbank Protein ID AAF60355.1; BAA91875.1; BAB14242.1; BAB14243.1; BAG51621.1; AAH08082.1
Protein Name Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Genbank Nucleotide ID AF242546; AK001743; AK022781; AK022782; AK056092; BC008082
Gene Name WDR12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138442.9 ENST00000261015.4 ENSP00000261015.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-42 143.7 341 376
UBD/Beta-Prp 4.90e-46 158.9 246 412
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNIVKLWDTRSCK 376
           **********9533678**************99876 PP
   

   UBD/Beta-Prp
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktgkll 172
           t+++++tl+gh + v s+ +s   + + s+s+d tirvwd+e+g+  + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g+l+
   Q: 246  TRTPIVTLSGHMEAVSSVLWSD-AEEICSASWDHTIRVWDVESGSLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDGSLV 334
           67899****************9.99**********************9.***987.99**************************54456666 PP
   S: 173  rtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
               t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 335  SLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           644366.************9889*****************54566****************9.999********998765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAQLQTRFYT DNKKYAVDDV PFSIPAASEI ADLSNIINKL LKDKNEFHKH VEFDFLIKGQ 60
FLRMPLDKHM EMENISSEEV VEIEYVEKYT APQPEQCMFH DDWISSIKGA EEWILTGSYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046114|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGATTTAC CCAGCCGTTG GGCGGCAGCT GTTCAATGGT CGCGTAGGCT GGGGATGGGC 60
GGGGTGACCT GAAGCCCCGC CCCAGCATAC CTGCGCAGCC GCAGTCGACA GGCTCTGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046114|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0006364--P:rRNA processing
KEGG hsa:55759
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000532 Aegilops tauschii 33.02 2.00e-56 213.00
IUUC-Aml-001997 Ailuropoda melanoleuca 96.83 0.00e+00 746.00
IUUC-Atr-002544 Amborella trichopoda 33.33 3.00e-55 209.00
IUUC-Apl-003981 Anas platyrhynchos 87.23 0.00e+00 645.00
IUUC-Aca-004370 Anolis carolinensis 84.94 0.00e+00 698.00
IUUC-Aly-006455 Arabidopsis lyrata 34.73 4.00e-58 218.00
IUUC-Ath-006669 Arabidopsis thaliana 34.15 4.00e-54 205.00
IUUC-Ago-007864 Ashbya gossypii 29.93 2.00e-36 146.00
IUUC-Acl-008177 Aspergillus clavatus 29.95 4.00e-37 149.00
IUUC-Afl-008617 Aspergillus flavus 29.74 5.00e-36 145.00
IUUC-Afu-008752 Aspergillus fumigatus 28.54 2.00e-33 137.00
IUUC-Ani-009136 Aspergillus nidulans 30.26 3.00e-36 146.00
IUUC-Ang-009701 Aspergillus niger 28.46 5.00e-34 139.00
IUUC-Aor-009884 Aspergillus oryzae 29.74 5.00e-36 145.00
IUUC-Ate-010472 Aspergillus terreus 29.88 5.00e-21 95.10
IUUC-Ame-011432 Astyanax mexicanus 76.12 0.00e+00 649.00
IUUC-Bgr-012218 Blumeria graminis 28.61 1.00e-32 134.00
IUUC-Bta-012829 Bos taurus 95.98 0.00e+00 771.00
IUUC-Bci-013953 Botrytis cinerea 30.36 4.00e-35 142.00
IUUC-Bdi-014351 Brachypodium distachyon 35.55 3.00e-55 209.00
IUUC-Bol-016514 Brassica oleracea 33.81 3.00e-53 202.00
IUUC-Bra-017876 Brassica rapa 33.74 8.00e-56 211.00
IUUC-Cel-018569 Caenorhabditis elegans 31.62 2.00e-46 179.00
IUUC-Cja-019468 Callithrix jacchus 98.11 0.00e+00 766.00
IUUC-Cfa-020471 Canis familiaris 95.04 0.00e+00 742.00
IUUC-Cpo-022260 Cavia porcellus 95.98 0.00e+00 757.00
IUUC-Cre-022614 Chlamydomonas reinhardtii 30.96 5.00e-39 155.00
IUUC-Csa-023989 Chlorocebus sabaeus 99.05 0.00e+00 775.00
IUUC-Cho-024426 Choloepus hoffmanni 92.38 2.00e-158 552.00
IUUC-Cin-025789 Ciona intestinalis 43.65 9.00e-97 347.00
IUUC-Cne-027063 Cryptococcus neoformans 24.34 1.00e-21 97.80
IUUC-Dre-027907 Danio rerio 77.07 0.00e+00 665.00
IUUC-Dno-029225 Dasypus novemcinctus 94.56 0.00e+00 762.00
IUUC-Dor-031082 Dipodomys ordii 78.25 1.00e-167 582.00
IUUC-Dse-031308 Dothistroma septosporum 28.05 9.00e-36 144.00
IUUC-Dme-032189 Drosophila melanogaster 41.75 6.00e-92 331.00
IUUC-Ete-032247 Echinops telfairi 88.18 0.00e+00 704.00
IUUC-Eca-034285 Equus caballus 95.98 0.00e+00 770.00
IUUC-Eeu-035322 Erinaceus europaeus 85.18 0.00e+00 642.00
IUUC-Fca-036114 Felis catus 95.51 0.00e+00 768.00
IUUC-Fal-036891 Ficedula albicollis 86.44 2.00e-173 601.00
IUUC-Fox-037965 Fusarium oxysporum 25.59 3.00e-34 139.00
IUUC-Fso-038244 Fusarium solani 26.64 1.00e-33 137.00
IUUC-Gmo-039040 Gadus morhua 75.65 0.00e+00 666.00
IUUC-Gga-040610 Gallus gallus 83.92 0.00e+00 707.00
IUUC-Gac-042117 Gasterosteus aculeatus 74.70 0.00e+00 644.00
IUUC-Gma-043146 Glycine max 37.17 3.00e-65 242.00
IUUC-Ggo-045179 Gorilla gorilla 99.29 0.00e+00 772.00
IUUC-Hvu-047331 Hordeum vulgare 33.59 6.00e-52 197.00
IUUC-Itr-048275 Ictidomys tridecemlineatus 95.98 0.00e+00 769.00
IUUC-Kpa-049304 Komagataella pastoris 28.67 2.00e-40 160.00
IUUC-Lch-050655 Latimeria chalumnae 77.61 1.00e-142 499.00
IUUC-Lpe-051675 Leersia perrieri 34.84 1.00e-57 217.00
IUUC-Loc-052868 Lepisosteus oculatus 80.14 0.00e+00 662.00
IUUC-Lma-053258 Leptosphaeria maculans 27.03 7.00e-32 133.00
IUUC-Laf-053993 Loxodonta africana 94.56 0.00e+00 767.00
IUUC-Mcc-055128 Macaca mulatta 79.91 7.00e-174 603.00
IUUC-Meu-056501 Macropus eugenii 78.55 2.00e-160 558.00
IUUC-Mor-057114 Magnaporthe oryzae 26.48 3.00e-26 113.00
IUUC-Mtr-058367 Medicago truncatula 36.45 4.00e-59 222.00
IUUC-Mla-059107 Melampsora laricipopulina 27.43 1.00e-28 121.00
IUUC-Mga-059745 Meleagris gallopavo 81.88 0.00e+00 681.00
IUUC-Mvi-060362 Microbotryum violaceum 29.85 3.00e-35 143.00
IUUC-Mdo-062257 Monodelphis domestica 85.68 0.00e+00 715.00
IUUC-Mmu-063546 Mus musculus 93.85 0.00e+00 759.00
IUUC-Mac-065540 Musa acuminata 34.44 2.00e-54 206.00
IUUC-Mpu-066284 Mustela putorius furo 96.93 0.00e+00 777.00
IUUC-Mlu-067241 Myotis lucifugus 95.98 0.00e+00 772.00
IUUC-Nfi-068260 Neosartorya fischeri 28.29 2.00e-35 143.00
IUUC-Ncr-068719 Neurospora crassa 26.58 3.00e-27 116.00
IUUC-Nle-068981 Nomascus leucogenys 99.29 0.00e+00 758.00
IUUC-Opr-071218 Ochotona princeps 87.44 0.00e+00 668.00
IUUC-Ont-071646 Oreochromis niloticus 77.35 0.00e+00 666.00
IUUC-Oan-073453 Ornithorhynchus anatinus 88.89 0.00e+00 750.00
IUUC-Ocu-074008 Oryctolagus cuniculus 96.69 0.00e+00 776.00
IUUC-Oba-075712 Oryza barthii 30.53 6.00e-41 161.00
IUUC-Obr-076721 Oryza brachyantha 34.29 2.00e-57 216.00
IUUC-Ogl-077229 Oryza glaberrima 34.37 1.00e-56 214.00
IUUC-Ogu-078977 Oryza glumaepatula 30.53 3.00e-41 162.00
IUUC-Oin-079683 Oryza indica 34.37 8.00e-57 214.00
IUUC-Olo-080291 Oryza longistaminata 30.30 5.00e-28 118.00
IUUC-Ome-081834 Oryza meridionalis 34.61 9.00e-58 218.00
IUUC-Oni-082507 Oryza nivara 33.25 7.00e-53 201.00
IUUC-Opu-083396 Oryza punctata 34.61 6.00e-58 218.00
IUUC-Oru-085220 Oryza rufipogon 33.81 2.00e-52 199.00
IUUC-Osa-085767 Oryza sativa 34.37 8.00e-57 214.00
IUUC-Ola-087420 Oryzias latipes 77.54 0.00e+00 665.00
IUUC-Olu-087740 Ostreococcus lucimarinus 27.88 4.00e-35 142.00
IUUC-Oga-088264 Otolemur garnettii 96.22 0.00e+00 756.00
IUUC-Oar-089335 Ovis aries 95.51 0.00e+00 767.00
IUUC-Ptr-091320 Pan troglodytes 100.00 0.00e+00 778.00
IUUC-Pan-092833 Papio anubis 98.58 0.00e+00 770.00
IUUC-Psi-093504 Pelodiscus sinensis 87.23 0.00e+00 727.00
IUUC-Pma-094189 Petromyzon marinus 68.63 2.00e-169 588.00
IUUC-Pno-094929 Phaeosphaeria nodorum 26.91 1.00e-33 137.00
IUUC-Ppa-095429 Physcomitrella patens 35.61 8.00e-65 241.00
IUUC-Pfo-096337 Poecilia formosa 75.18 0.00e+00 666.00
IUUC-Pab-097571 Pongo abelii 99.53 0.00e+00 776.00
IUUC-Pop-099977 Populus trichocarpa 35.82 6.00e-63 234.00
IUUC-Pca-100394 Procavia capensis 88.51 0.00e+00 664.00
IUUC-Ppe-101848 Prunus persica 35.58 2.00e-59 223.00
IUUC-Pva-102921 Pteropus vampyrus 94.74 6.00e-114 404.00
IUUC-Pgr-103637 Puccinia graminis 28.60 7.00e-34 138.00
IUUC-Ptt-103781 Puccinia triticina 28.60 9.00e-34 138.00
IUUC-Pte-104135 Pyrenophora teres 26.07 1.00e-32 135.00
IUUC-Pyt-104609 Pyrenophora triticirepentis 25.93 1.00e-31 130.00
IUUC-Rno-105114 Rattus norvegicus 93.38 0.00e+00 757.00
IUUC-Sce-106401 Saccharomyces cerevisiae 29.07 6.00e-38 152.00
IUUC-Sha-107122 Sarcophilus harrisii 86.13 0.00e+00 685.00
IUUC-Sja-107766 Schizosaccharomyces japonicus 32.24 1.00e-48 187.00
IUUC-Spo-108134 Schizosaccharomyces pombe 29.82 2.00e-39 156.00
IUUC-Ssl-108398 Sclerotinia sclerotiorum 28.26 5.00e-36 145.00
IUUC-Smo-108720 Selaginella moellendorffii 33.10 6.00e-57 214.00
IUUC-Sit-110311 Setaria italica 35.55 1.00e-55 210.00
IUUC-Sly-111023 Solanum lycopersicum 32.52 5.00e-53 201.00
IUUC-Stu-112778 Solanum tuberosum 35.56 1.00e-59 223.00
IUUC-Sar-113596 Sorex araneus 78.49 7.00e-174 603.00
IUUC-Sbi-114193 Sorghum bicolor 34.96 7.00e-57 214.00
IUUC-Sre-115002 Sporisorium reilianum 25.00 8.00e-11 62.00
IUUC-Ssc-116066 Sus scrofa 96.22 0.00e+00 769.00
IUUC-Tgu-117048 Taeniopygia guttata 85.11 0.00e+00 636.00
IUUC-Tsy-119573 Tarsius syrichta 62.92 1.00e-131 462.00
IUUC-Tni-119820 Tetraodon nigroviridis 76.01 0.00e+00 665.00
IUUC-Tca-121605 Theobroma cacao 36.30 3.00e-60 225.00
IUUC-Tre-121947 Trichoderma reesei 26.28 8.00e-34 138.00
IUUC-Tvi-122481 Trichoderma virens 26.50 3.00e-35 142.00
IUUC-Tae-125861 Triticum aestivum 33.25 2.00e-56 213.00
IUUC-Tur-126586 Triticum urartu 33.85 3.00e-54 205.00
IUUC-Tme-126900 Tuber melanosporum 32.15 1.00e-48 187.00
IUUC-Tbe-127736 Tupaia belangeri 73.12 4.00e-152 531.00
IUUC-Ttr-129041 Tursiops truncatus 83.69 0.00e+00 656.00
IUUC-Vpa-130260 Vicugna pacos 96.69 0.00e+00 775.00
IUUC-Vvi-131009 Vitis vinifera 35.48 7.00e-60 224.00
IUUC-Xtr-132083 Xenopus tropicalis 81.56 0.00e+00 671.00
IUUC-Xma-133094 Xiphophorus maculatus 74.47 0.00e+00 660.00
IUUC-Yli-134531 Yarrowia lipolytica 23.25 2.00e-18 87.40
IUUC-Zma-135509 Zea mays 33.57 2.00e-57 216.00
Created Date 25-Jun-2017

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