iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035621.13	ENSMUST00000099492.9	ENSMUSP00000097091.3
ENSMUSG00000035621.13	ENSMUST00000042057.11	ENSMUSP00000046967.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	6.20e-09	36.7	33	105

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           ++ + s++g++++l+v+ ++tV  L+++++++l++p e+ +L+ k++ L  + +L+++g+ dgs++ l+++++ 
   Q: 33   SLAIHSTTGTRYDLSVPHDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSG-KLQEFGVGDGSKLTLVPTVEA 105
           6778999********88888*****************************999.*****************9875 PP

Organism

Mus musculus

Functional Description
(View)

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4 (PubMed:27326929). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity).

Protein Sequence
(Fasta)

MEPQPGGARS CRRGAPGGAC ELNTATESAA PMSLAIHSTT GTRYDLSVPH DETVEGLRKR 60
LSQRLKVPKE RLALLHKDTR LSSGKLQEFG VGDGSKLTLV PTVEAGLMSQ ASRPEQSVMQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACCGGCAC GGCCACCTCT TGCCAGGACC CATACGCAGG TCATCTGGAG CAGTGGTGAC 60
CCAGGACCTA CGGAGCCGGT GAGTAGGGGC GGGACCGCAC GAAACGGAGA GGGGCCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0019900--F:kinase binding
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion

KEGG

mmu:59090

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001211	Ailuropoda melanoleuca	85.37	8.00e-84	303.00
IUUC-Aca-004280	Anolis carolinensis	65.12	9.00e-45	174.00
IUUC-Aly-006539	Arabidopsis lyrata	34.09	7.00e-03	33.10
IUUC-Ath-006838	Arabidopsis thaliana	31.91	7.00e-03	33.50
IUUC-Ame-011299	Astyanax mexicanus	66.97	2.00e-61	230.00
IUUC-Bta-013082	Bos taurus	70.50	3.00e-149	521.00
IUUC-Bol-015166	Brassica oleracea	29.89	3.00e-03	35.80
IUUC-Bra-016943	Brassica rapa	31.03	3.00e-03	36.20
IUUC-Cel-018301	Caenorhabditis elegans	26.83	2.00e-03	36.60
IUUC-Cja-019102	Callithrix jacchus	80.86	8.00e-172	596.00
IUUC-Cfa-020096	Canis familiaris	80.39	3.00e-169	588.00
IUUC-Cpo-022290	Cavia porcellus	69.51	1.00e-150	525.00
IUUC-Csa-023581	Chlorocebus sabaeus	80.54	8.00e-167	580.00
IUUC-Cin-025582	Ciona intestinalis	38.92	1.00e-29	124.00
IUUC-Csv-025994	Ciona savignyi	38.42	7.00e-30	125.00
IUUC-Dre-027459	Danio rerio	69.41	8.00e-67	248.00
IUUC-Dor-030604	Dipodomys ordii	80.00	1.00e-136	479.00
IUUC-Dme-031978	Drosophila melanogaster	37.78	1.00e-22	102.00
IUUC-Eca-034126	Equus caballus	84.62	9.00e-79	286.00
IUUC-Fal-037190	Ficedula albicollis	71.90	5.00e-62	231.00
IUUC-Fso-038183	Fusarium solani	33.90	3.90e-01	31.60
IUUC-Gmo-039292	Gadus morhua	62.80	3.00e-60	225.00
IUUC-Gga-040242	Gallus gallus	58.27	1.00e-114	406.00
IUUC-Gac-042379	Gasterosteus aculeatus	60.95	2.00e-58	219.00
IUUC-Gma-043175	Glycine max	37.33	3.00e-06	43.10
IUUC-Ggo-045533	Gorilla gorilla	94.63	1.00e-83	303.00
IUUC-Hsa-045827	Homo sapiens	80.54	9.00e-165	573.00
IUUC-Itr-048112	Ictidomys tridecemlineatus	72.19	3.00e-124	438.00
IUUC-Lch-050469	Latimeria chalumnae	60.40	5.00e-131	461.00
IUUC-Loc-051781	Lepisosteus oculatus	62.44	7.00e-54	204.00
IUUC-Mcc-055441	Macaca mulatta	75.78	2.00e-135	475.00
IUUC-Meu-056379	Macropus eugenii	58.95	2.00e-109	389.00
IUUC-Mtr-057978	Medicago truncatula	31.17	6.00e-05	38.90
IUUC-Mdo-061920	Monodelphis domestica	83.95	1.00e-59	224.00
IUUC-Mac-065611	Musa acuminata	32.43	1.20e-02	35.40
IUUC-Mpu-066091	Mustela putorius furo	80.00	7.00e-166	576.00
IUUC-Mlu-067919	Myotis lucifugus	91.30	1.00e-19	90.10
IUUC-Nle-069450	Nomascus leucogenys	68.76	5.00e-82	298.00
IUUC-Opr-070444	Ochotona princeps	66.88	7.00e-90	323.00
IUUC-Ont-071842	Oreochromis niloticus	65.30	1.00e-58	221.00
IUUC-Ola-087286	Oryzias latipes	62.50	9.00e-56	211.00
IUUC-Oga-088735	Otolemur garnettii	77.04	1.00e-163	569.00
IUUC-Oar-089367	Ovis aries	77.96	9.00e-89	320.00
IUUC-Pan-092335	Papio anubis	90.08	2.00e-179	622.00
IUUC-Psi-093850	Pelodiscus sinensis	37.98	6.00e-47	181.00
IUUC-Pfo-096547	Poecilia formosa	66.51	1.00e-59	224.00
IUUC-Pab-097811	Pongo abelii	77.85	1.00e-125	442.00
IUUC-Pop-099759	Populus trichocarpa	33.33	1.00e-04	37.70
IUUC-Pca-100261	Procavia capensis	76.47	1.00e-90	327.00
IUUC-Pva-102408	Pteropus vampyrus	79.02	4.00e-163	567.00
IUUC-Rno-105442	Rattus norvegicus	96.85	0.00e+00	710.00
IUUC-Sly-110979	Solanum lycopersicum	32.05	2.00e-05	40.80
IUUC-Stu-112279	Solanum tuberosum	34.67	2.00e-05	40.80
IUUC-Ssc-115388	Sus scrofa	74.50	2.00e-120	425.00
IUUC-Tgu-116546	Taeniopygia guttata	54.57	7.00e-85	307.00
IUUC-Tru-118322	Takifugu rubripes	63.93	3.00e-58	219.00
IUUC-Tni-120877	Tetraodon nigroviridis	70.00	2.00e-62	233.00
IUUC-Ttr-128596	Tursiops truncatus	74.63	9.00e-131	459.00
IUUC-Xtr-132534	Xenopus tropicalis	54.44	3.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence