iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.00e-27	93.5	705	742
UBD/Beta-Prp	3.00e-44	151.8	563	777

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H + vt+la  ++  +l sGs+D++i++W+l + ++++
   Q: 705  HLEAVTSLAVdPNgLYLMSGSHDCSIRLWNLESKTCIQ 742
           8899*******77799***************9999987 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvls......lsfspsgdklvsGshdrtirvwdletgqc 128
             l gh+++v+ + +s   + l+++s D+t+++w      +  t+ + ++++        +s++p  +++v+  +  +  ++++et+q 
   Q: 563  GPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWTTTEVAPALTVFNDNQELGIpasvdlVSSDP--SHMVASFSKGYTSIFNMETQQR 649
           5689******************************8887777777776666665443411155555..8888888899************ PP
   S: 129  lee......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqt 211
           + +        +  +  +n v +hp+  + ++++ Dr ++++d +tgkl++ +   h ++v+sl++d+ng +l+sgs+d +++lw+l++
   Q: 650  ILTlesnvdSTASSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVA-HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
           **9888866444445557778899999**************************98.********************************* PP
   S: 212  gecvrtlnght....dnvksvrfspnderlvsgssDgsir 247
           ++c++++++h+    + + +v+f+p + +++s+++D   +
   Q: 738  KTCIQEFTAHRkkfeESIHDVAFHPSKCYIASAGADALAK 777
           ***********999999******************97655 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDEQAGPGVF FSNNHPGAGG AKGLGPLAEA AAAGDGAAAA GAARAQYSLP GILHFLQHEW 60
ARFEVERAQW EVERAELQAQ IAFLQGERKG QENLKKDLVR RIKMLEYALK QERAKYHKLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGGAGGAGG CAGAGCTGGC CGCCGCAGTT TGCCGCCGCT GCTGGGCGCC TAGGCAGAGC 60
TCCCCGGGGT TCGTGCGGCC GCCATGGACG AGCAGGCGGG GCCCGGCGTC TTCTTCAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR013258--Striatin_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08232--Striatin
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0000159--C:protein phosphatase type 2A complex
GO:0008285--P:negative regulation of cell proliferation
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001899	Ailuropoda melanoleuca	96.05	0.00e+00	1340.00
IUUC-Apl-003927	Anas platyrhynchos	87.09	0.00e+00	1111.00
IUUC-Aca-004933	Anolis carolinensis	79.84	0.00e+00	1147.00
IUUC-Ate-010457	Aspergillus terreus	26.24	2.00e-28	120.00
IUUC-Ame-010997	Astyanax mexicanus	73.15	0.00e+00	1064.00
IUUC-Bta-013077	Bos taurus	96.41	0.00e+00	1368.00
IUUC-Cja-018973	Callithrix jacchus	96.92	0.00e+00	1375.00
IUUC-Cfa-020988	Canis familiaris	93.03	0.00e+00	1217.00
IUUC-Cpo-022496	Cavia porcellus	96.54	0.00e+00	1375.00
IUUC-Csa-023829	Chlorocebus sabaeus	96.29	0.00e+00	1366.00
IUUC-Dre-028560	Danio rerio	69.55	0.00e+00	969.00
IUUC-Dno-029742	Dasypus novemcinctus	90.51	0.00e+00	1300.00
IUUC-Dor-030721	Dipodomys ordii	89.49	0.00e+00	1262.00
IUUC-Eca-033760	Equus caballus	96.16	0.00e+00	1269.00
IUUC-Eeu-034953	Erinaceus europaeus	96.09	0.00e+00	747.00
IUUC-Fca-036530	Felis catus	95.73	0.00e+00	1270.00
IUUC-Fal-037353	Ficedula albicollis	81.49	0.00e+00	881.00
IUUC-Gga-040132	Gallus gallus	87.21	0.00e+00	1127.00
IUUC-Gac-041713	Gasterosteus aculeatus	73.33	0.00e+00	1056.00
IUUC-Ggo-045455	Gorilla gorilla	84.95	0.00e+00	1172.00
IUUC-Hsa-046415	Homo sapiens	96.79	0.00e+00	1369.00
IUUC-Lch-050475	Latimeria chalumnae	80.25	0.00e+00	1167.00
IUUC-Loc-051859	Lepisosteus oculatus	76.46	0.00e+00	1118.00
IUUC-Laf-053537	Loxodonta africana	95.64	0.00e+00	1374.00
IUUC-Mcc-055817	Macaca mulatta	96.05	0.00e+00	1365.00
IUUC-Meu-055946	Macropus eugenii	69.14	0.00e+00	895.00
IUUC-Mga-059694	Meleagris gallopavo	87.36	0.00e+00	1107.00
IUUC-Mmr-060768	Microcebus murinus	96.79	0.00e+00	1394.00
IUUC-Mdo-061901	Monodelphis domestica	85.70	0.00e+00	1294.00
IUUC-Mmu-064154	Mus musculus	97.82	0.00e+00	1385.00
IUUC-Mpu-065827	Mustela putorius furo	91.59	0.00e+00	1356.00
IUUC-Mlu-067102	Myotis lucifugus	95.65	0.00e+00	1332.00
IUUC-Ncr-068831	Neurospora crassa	39.60	6.00e-22	99.80
IUUC-Nle-070008	Nomascus leucogenys	96.16	0.00e+00	1275.00
IUUC-Opr-071067	Ochotona princeps	61.47	1.00e-178	619.00
IUUC-Ont-072025	Oreochromis niloticus	73.16	0.00e+00	1047.00
IUUC-Oan-072950	Ornithorhynchus anatinus	91.02	0.00e+00	1162.00
IUUC-Ocu-074316	Oryctolagus cuniculus	95.45	0.00e+00	1255.00
IUUC-Ola-087279	Oryzias latipes	71.32	0.00e+00	1025.00
IUUC-Oga-088284	Otolemur garnettii	96.03	0.00e+00	1364.00
IUUC-Oar-090304	Ovis aries	97.05	0.00e+00	1375.00
IUUC-Ptr-091052	Pan troglodytes	96.92	0.00e+00	1372.00
IUUC-Pan-092270	Papio anubis	90.79	0.00e+00	1321.00
IUUC-Psi-093907	Pelodiscus sinensis	87.30	0.00e+00	1035.00
IUUC-Pfo-097042	Poecilia formosa	71.93	0.00e+00	1126.00
IUUC-Pab-098110	Pongo abelii	96.92	0.00e+00	1372.00
IUUC-Pca-100266	Procavia capensis	84.79	0.00e+00	987.00
IUUC-Pva-102824	Pteropus vampyrus	94.23	0.00e+00	1345.00
IUUC-Pgr-103483	Puccinia graminis	36.99	7.00e-57	216.00
IUUC-Sha-107004	Sarcophilus harrisii	86.85	0.00e+00	1106.00
IUUC-Ssc-115280	Sus scrofa	97.18	0.00e+00	1382.00
IUUC-Tgu-116759	Taeniopygia guttata	87.64	0.00e+00	1129.00
IUUC-Tru-117944	Takifugu rubripes	72.91	0.00e+00	1051.00
IUUC-Tsy-119405	Tarsius syrichta	85.04	0.00e+00	1065.00
IUUC-Tni-120571	Tetraodon nigroviridis	72.22	0.00e+00	1057.00
IUUC-Uma-129659	Ustilago maydis	34.70	3.00e-64	239.00
IUUC-Vpa-130294	Vicugna pacos	95.58	0.00e+00	1254.00
IUUC-Xma-134233	Xiphophorus maculatus	67.83	0.00e+00	903.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence