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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045756
UUCD1 version UUC-HoS-00004
Ensembl Protein ID ENSP00000237455.4
UniProt Accession O00237; A6NFV6; B2RAG4; Q53SU6; Q8IVB9; RN103_HUMAN
Genbank Protein ID BAA19739.1; BAB20900.1; BAG36861.1; AAX93079.1; AAH35053.1; AAI10334.1
Protein Name E3 ubiquitin-protein ligase RNF103; KF-1; RING finger protein 103; RING-type E3 ubiquitin transferase RNF103; Zinc finger protein 103 homolog
Genbank Nucleotide ID D76444; AB052743; AK314180; AC015971; BC035053; BC110333
Gene Name RNF103; ZFP103
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000239305.6 ENST00000237455.4 ENSP00000237455.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21455683; 19753093
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.50e-07 31.7 621 663
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplv..lpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle f++g l+  lpCgHvfh++C+ +w     ++ ++  CP+Cr
   Q: 621  CVVCLENFENGCLLmgLPCGHVFHQNCIVMW-----LAGGRHCCPVCR 663
           **********87776688*************.....89*********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
 Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
Protein Sequence
(Fasta)
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS 60
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045756|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTTATGTCT CGGCTCCGGC CGCGGCCGCC GCTGATACAC GGTTGTGGAG GGTACGGCCG 60
CGGTCTCCGG AGGTGGCGGG GGTGTTGGGG ACGGGTGCTG CGACCGGCAC TGCCCATCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045756|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012336--Thioredoxin-like_fold
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007417--P:central nervous system development
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:7844
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002130 Ailuropoda melanoleuca 97.59 0.00e+00 1262.00
IUUC-Apl-004099 Anas platyrhynchos 86.85 0.00e+00 1102.00
IUUC-Aca-004500 Anolis carolinensis 85.16 0.00e+00 1106.00
IUUC-Ame-011513 Astyanax mexicanus 70.69 0.00e+00 920.00
IUUC-Bta-012824 Bos taurus 97.29 0.00e+00 1264.00
IUUC-Bdi-014038 Brachypodium distachyon 54.35 3.00e-10 58.50
IUUC-Cja-019429 Callithrix jacchus 97.89 0.00e+00 1296.00
IUUC-Cfa-020110 Canis familiaris 97.74 0.00e+00 1299.00
IUUC-Cpo-021413 Cavia porcellus 83.21 0.00e+00 1050.00
IUUC-Csa-023111 Chlorocebus sabaeus 99.34 0.00e+00 1176.00
IUUC-Dre-027675 Danio rerio 71.71 0.00e+00 925.00
IUUC-Dno-029645 Dasypus novemcinctus 94.55 0.00e+00 1148.00
IUUC-Dor-030871 Dipodomys ordii 95.06 0.00e+00 801.00
IUUC-Ete-032670 Echinops telfairi 94.52 0.00e+00 649.00
IUUC-Eca-033322 Equus caballus 97.74 0.00e+00 1261.00
IUUC-Eeu-035071 Erinaceus europaeus 96.77 9.00e-151 527.00
IUUC-Fca-036356 Felis catus 97.29 0.00e+00 1272.00
IUUC-Fal-036861 Ficedula albicollis 85.91 0.00e+00 1130.00
IUUC-Gmo-039251 Gadus morhua 60.85 0.00e+00 740.00
IUUC-Gga-040659 Gallus gallus 86.97 0.00e+00 1142.00
IUUC-Gac-042187 Gasterosteus aculeatus 63.25 0.00e+00 777.00
IUUC-Ggo-044883 Gorilla gorilla 99.70 0.00e+00 1377.00
IUUC-Hvu-047185 Hordeum vulgare 47.17 3.00e-10 57.40
IUUC-Itr-048705 Ictidomys tridecemlineatus 87.46 0.00e+00 1101.00
IUUC-Lch-049872 Latimeria chalumnae 80.76 0.00e+00 976.00
IUUC-Lpe-051679 Leersia perrieri 60.00 9.00e-11 62.40
IUUC-Loc-051795 Lepisosteus oculatus 76.35 0.00e+00 963.00
IUUC-Laf-053807 Loxodonta africana 96.68 0.00e+00 1282.00
IUUC-Mcc-054842 Macaca mulatta 98.04 0.00e+00 1280.00
IUUC-Meu-056570 Macropus eugenii 87.38 0.00e+00 1068.00
IUUC-Mga-059758 Meleagris gallopavo 87.42 0.00e+00 1014.00
IUUC-Mvi-060247 Microbotryum violaceum 52.27 1.00e-10 61.60
IUUC-Mmr-061620 Microcebus murinus 94.51 0.00e+00 637.00
IUUC-Mdo-062398 Monodelphis domestica 84.64 0.00e+00 1111.00
IUUC-Mmu-064279 Mus musculus 95.32 0.00e+00 1230.00
IUUC-Mac-064686 Musa acuminata 37.50 1.00e-11 62.40
IUUC-Mpu-065770 Mustela putorius furo 98.04 0.00e+00 1269.00
IUUC-Mlu-067764 Myotis lucifugus 93.84 0.00e+00 1254.00
IUUC-Nle-069363 Nomascus leucogenys 99.40 0.00e+00 1317.00
IUUC-Opr-070664 Ochotona princeps 95.17 0.00e+00 1243.00
IUUC-Ont-072466 Oreochromis niloticus 63.44 0.00e+00 815.00
IUUC-Oan-073047 Ornithorhynchus anatinus 92.98 0.00e+00 836.00
IUUC-Ocu-074240 Oryctolagus cuniculus 93.30 0.00e+00 1240.00
IUUC-Oba-075208 Oryza barthii 49.06 3.00e-11 61.60
IUUC-Ogl-077486 Oryza glaberrima 49.06 3.00e-11 61.60
IUUC-Olo-080618 Oryza longistaminata 49.06 3.00e-11 61.60
IUUC-Ome-081540 Oryza meridionalis 45.45 3.00e-11 61.20
IUUC-Oru-084388 Oryza rufipogon 49.06 3.00e-11 61.60
IUUC-Osa-086245 Oryza sativa 49.06 3.00e-11 61.60
IUUC-Ola-086352 Oryzias latipes 62.16 0.00e+00 750.00
IUUC-Oga-088582 Otolemur garnettii 98.04 0.00e+00 1302.00
IUUC-Oar-090324 Ovis aries 96.26 0.00e+00 1255.00
IUUC-Pan-092792 Papio anubis 99.10 0.00e+00 1311.00
IUUC-Psi-092964 Pelodiscus sinensis 90.50 0.00e+00 1147.00
IUUC-Pma-094186 Petromyzon marinus 52.85 0.00e+00 671.00
IUUC-Pfo-097169 Poecilia formosa 61.85 0.00e+00 792.00
IUUC-Pab-098549 Pongo abelii 99.70 0.00e+00 1318.00
IUUC-Pca-100113 Procavia capensis 91.63 0.00e+00 1045.00
IUUC-Pva-102543 Pteropus vampyrus 93.83 0.00e+00 786.00
IUUC-Rno-105676 Rattus norvegicus 95.50 0.00e+00 1193.00
IUUC-Sha-106596 Sarcophilus harrisii 91.84 0.00e+00 710.00
IUUC-Sit-109739 Setaria italica 50.00 2.00e-09 55.10
IUUC-Sly-111354 Solanum lycopersicum 52.17 2.00e-12 64.30
IUUC-Sar-113147 Sorex araneus 97.04 0.00e+00 1145.00
IUUC-Ssc-115585 Sus scrofa 96.38 0.00e+00 1247.00
IUUC-Tgu-117258 Taeniopygia guttata 86.21 0.00e+00 1129.00
IUUC-Tsy-119127 Tarsius syrichta 95.23 0.00e+00 1125.00
IUUC-Tbe-128054 Tupaia belangeri 97.03 0.00e+00 1068.00
IUUC-Ttr-128931 Tursiops truncatus 98.88 0.00e+00 857.00
IUUC-Vpa-130826 Vicugna pacos 96.50 0.00e+00 1155.00
IUUC-Xtr-132828 Xenopus tropicalis 81.74 0.00e+00 1087.00
Created Date 25-Jun-2017

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