iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046093

Ensembl Protein ID

ENSP00000300589.2

UniProt Accession

Q9HC29; E2JEQ6; Q96RH5; Q96RH6; Q96RH8; NOD2_HUMAN

Genbank Protein ID

AAG33677.1; AAK70867.1; AAK70868.1; CAC42117.1; ADN95581.1

Protein Name

Nucleotide-binding oligomerization domain-containing protein 2; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1

Genbank Nucleotide ID

AF178930; AF385089; AF385090; AJ303140; HQ204571

Gene Name

NOD2; CARD15; IBD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167207.11	ENST00000300589.6	ENSP00000300589.2
ENSG00000167207.11	ENST00000527070.5	ENSP00000435149.1
ENSG00000167207.11	ENST00000534057.1	ENSP00000437246.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/CARD	CARD	23300079

Classification

Family	E-value	Score	Start	End
UBD/CARD	2.30e-23	84.2	168	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaae 56
           +e+rl+++t+++r+r+lLd+++v++++l++fll++++el+++ a + +++++++
   Q: 168  DEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKK 221
           8***************************************************93 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Protein Sequence
(Fasta)

MGEEGGSASH DEEERASVLL GHSPGCEMCS QEAFQAQRSQ LVELLVSGSL EGFESVLDWL 60
LSWEVLSWED YEGFHLLGQP LSHLARRLLD TVWNKGTWAC QKLIAAAQEA QADSQSPKLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGAGCCG GGAGTCGTGG CCCGGAGTGG GCCTTGGAGT CGGCGCGCAG GCGGCTCGCG 60
GTGAGTGCTG TGCCCAGCGC CTGGGGGTGG GCTGGGGGGA GACTGTGGGC GCCGAGGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0031982--C:vesicle
GO:0003779--F:actin binding
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0019899--F:enzyme binding
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0019901--F:protein kinase binding
GO:0000187--P:activation of MAPK activity
GO:0035419--P:activation of MAPK activity involved in innate immune response
GO:0071225--P:cellular response to muramyl dipeptide
GO:0071407--P:cellular response to organic cyclic compound
GO:0002367--P:cytokine production involved in immune response
GO:0002374--P:cytokine secretion involved in immune response
GO:0006952--P:defense response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0009595--P:detection of biotic stimulus
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0007254--P:JNK cascade
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:2000110--P:negative regulation of macrophage apoptotic process
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0002732--P:positive regulation of dendritic cell cytokine production
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0046645--P:positive regulation of gamma-delta T cell activation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032733--P:positive regulation of interleukin-10 production
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051770--P:positive regulation of nitric-oxide synthase biosynthetic process
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000363--P:positive regulation of prostaglandin-E synthase activity
GO:0060585--P:positive regulation of prostaglandin-endoperoxide synthase activity
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0050727--P:regulation of inflammatory response
GO:0032495--P:response to muramyl dipeptide
GO:0007584--P:response to nutrient

KEGG

hsa:64127

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.73	0.00e+00	1496.00
IUUC-Ame-011021	Astyanax mexicanus	46.06	0.00e+00	879.00
IUUC-Bta-013241	Bos taurus	81.24	0.00e+00	1621.00
IUUC-Cja-019633	Callithrix jacchus	91.41	0.00e+00	1394.00
IUUC-Cfa-020039	Canis familiaris	83.42	0.00e+00	1636.00
IUUC-Cpo-022337	Cavia porcellus	79.98	0.00e+00	1541.00
IUUC-Csa-023906	Chlorocebus sabaeus	95.75	0.00e+00	1910.00
IUUC-Dre-027568	Danio rerio	48.32	0.00e+00	833.00
IUUC-Dno-029098	Dasypus novemcinctus	80.58	0.00e+00	1514.00
IUUC-Dor-031102	Dipodomys ordii	73.55	0.00e+00	699.00
IUUC-Ete-032943	Echinops telfairi	77.31	0.00e+00	1124.00
IUUC-Eca-034310	Equus caballus	84.48	0.00e+00	1626.00
IUUC-Eeu-034589	Erinaceus europaeus	83.78	2.00e-164	573.00
IUUC-Fca-036252	Felis catus	79.22	0.00e+00	817.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.50	0.00e+00	820.00
IUUC-Ggo-044861	Gorilla gorilla	98.94	0.00e+00	1924.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	81.37	0.00e+00	1476.00
IUUC-Lch-049454	Latimeria chalumnae	53.53	0.00e+00	919.00
IUUC-Laf-053553	Loxodonta africana	83.50	0.00e+00	1512.00
IUUC-Mcc-055772	Macaca mulatta	95.87	0.00e+00	1852.00
IUUC-Meu-056785	Macropus eugenii	68.44	2.00e-114	407.00
IUUC-Mmr-060596	Microcebus murinus	83.38	0.00e+00	1624.00
IUUC-Mdo-062983	Monodelphis domestica	68.02	0.00e+00	1126.00
IUUC-Mmu-063951	Mus musculus	77.58	0.00e+00	1523.00
IUUC-Mpu-066412	Mustela putorius furo	83.02	0.00e+00	1627.00
IUUC-Mlu-067601	Myotis lucifugus	80.73	0.00e+00	1446.00
IUUC-Nle-069913	Nomascus leucogenys	97.57	0.00e+00	1557.00
IUUC-Opr-070999	Ochotona princeps	84.42	0.00e+00	993.00
IUUC-Ont-072512	Oreochromis niloticus	46.60	0.00e+00	883.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.30	0.00e+00	1103.00
IUUC-Ocu-074837	Oryctolagus cuniculus	86.44	0.00e+00	1645.00
IUUC-Ola-086555	Oryzias latipes	45.73	0.00e+00	814.00
IUUC-Oga-088909	Otolemur garnettii	84.23	0.00e+00	1627.00
IUUC-Oar-089315	Ovis aries	80.57	0.00e+00	1555.00
IUUC-Ptr-090542	Pan troglodytes	98.94	0.00e+00	1925.00
IUUC-Pan-092545	Papio anubis	95.38	0.00e+00	1875.00
IUUC-Pma-094167	Petromyzon marinus	34.44	1.00e-64	241.00
IUUC-Ppa-095344	Physcomitrella patens	32.63	2.00e-06	48.50
IUUC-Pfo-096976	Poecilia formosa	44.73	0.00e+00	828.00
IUUC-Pab-098481	Pongo abelii	98.17	0.00e+00	1904.00
IUUC-Pca-100135	Procavia capensis	76.65	0.00e+00	1295.00
IUUC-Pva-102127	Pteropus vampyrus	81.21	0.00e+00	1455.00
IUUC-Rno-105783	Rattus norvegicus	80.00	0.00e+00	1511.00
IUUC-Sce-106163	Saccharomyces cerevisiae	25.96	2.90e-02	35.00
IUUC-Sar-113448	Sorex araneus	74.12	0.00e+00	922.00
IUUC-Tru-118708	Takifugu rubripes	44.64	0.00e+00	780.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.95	2.00e-33	136.00
IUUC-Tbe-127661	Tupaia belangeri	86.96	0.00e+00	855.00
IUUC-Ttr-128318	Tursiops truncatus	77.57	0.00e+00	1447.00
IUUC-Vpa-130502	Vicugna pacos	75.26	1.00e-161	564.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence