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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046680
UUCD1 version UUC-HoS-01134
Ensembl Protein ID ENSP00000263202.9
UniProt Accession Q92890; A8MW31; Q9Y5N0; UFD1_HUMAN
Genbank Protein ID AAD08720.1; AAD28788.1; CAG30493.1; AAH01049.1; AAH05087.1
Protein Name Ubiquitin fusion degradation protein 1 homolog
Genbank Nucleotide ID U64444; AF141201; CR456607; AK225877; BC005087
Gene Name UFD1L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000070010.18 ENST00000263202.14 ENSP00000263202.9
ENSG00000070010.18 ENST00000447868.5 ENSP00000402136.1
ENSG00000070010.18 ENST00000421968.6 ENSP00000406680.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/Other DUB/Other 20061341
UBD/Other/Other UBD/Other/Other 24248593
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/Other/Other 37.35 8.00e-52 198.00 IUUC-Sce-106174
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).
Protein Sequence
(Fasta)
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN 60
ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046680|DUB,DUB/Other;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTCCGGTG AGCCTCTGGG GCGTACCGGC TTGGCGCGGC GGCAGCGGCA GCGGCGGCTG 60
GGAGAGCGGT CGGCGGGGTT TCTTCGTTGC ATTGCCTGAG AGGAGCGGAG TCTGCCAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046680|DUB,DUB/Other;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004854--UFD1

Pfam

PF03152--UFD1

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036501--C:UFD1-NPL4 complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0070987--P:error-free translesion synthesis
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0001501--P:skeletal system development
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG hsa:7353
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000441 Aegilops tauschii 51.80 5.00e-66 244.00
IUUC-Aml-001398 Ailuropoda melanoleuca 100.00 2.00e-178 617.00
IUUC-Atr-002449 Amborella trichopoda 48.84 7.00e-56 210.00
IUUC-Apl-004065 Anas platyrhynchos 92.75 2.00e-142 498.00
IUUC-Aca-004973 Anolis carolinensis 93.16 7.00e-173 599.00
IUUC-Aly-005501 Arabidopsis lyrata 52.14 1.00e-67 249.00
IUUC-Ath-007324 Arabidopsis thaliana 52.61 1.00e-67 249.00
IUUC-Ago-007918 Ashbya gossypii 38.51 1.00e-53 203.00
IUUC-Acl-008362 Aspergillus clavatus 42.64 5.00e-67 248.00
IUUC-Afl-008690 Aspergillus flavus 54.17 2.00e-64 239.00
IUUC-Afu-008787 Aspergillus fumigatus 43.54 9.00e-66 243.00
IUUC-Ani-009385 Aspergillus nidulans 56.57 5.00e-57 215.00
IUUC-Ang-009709 Aspergillus niger 56.22 5.00e-64 238.00
IUUC-Aor-010240 Aspergillus oryzae 54.17 2.00e-64 239.00
IUUC-Ate-010551 Aspergillus terreus 56.31 1.00e-64 240.00
IUUC-Ame-011417 Astyanax mexicanus 88.96 4.00e-159 553.00
IUUC-Bgr-011986 Blumeria graminis 56.25 9.00e-62 230.00
IUUC-Bta-012559 Bos taurus 97.36 2.00e-128 451.00
IUUC-Bci-013767 Botrytis cinerea 56.08 5.00e-58 218.00
IUUC-Bdi-014336 Brachypodium distachyon 52.00 2.00e-65 242.00
IUUC-Bol-015824 Brassica oleracea 44.41 2.00e-66 245.00
IUUC-Bra-016732 Brassica rapa 44.09 3.00e-66 245.00
IUUC-Cel-018590 Caenorhabditis elegans 40.47 2.00e-49 189.00
IUUC-Cja-019487 Callithrix jacchus 99.35 1.00e-178 618.00
IUUC-Cfa-020497 Canis familiaris 99.67 1.00e-178 618.00
IUUC-Cpo-022150 Cavia porcellus 99.67 1.00e-177 615.00
IUUC-Cre-023007 Chlamydomonas reinhardtii 50.66 3.00e-58 218.00
IUUC-Csa-023602 Chlorocebus sabaeus 100.00 4.00e-179 620.00
IUUC-Cin-025594 Ciona intestinalis 57.72 4.00e-93 334.00
IUUC-Csv-026040 Ciona savignyi 55.59 1.00e-94 339.00
IUUC-Cgl-026460 Colletotrichum gloeosporioides 48.15 7.00e-52 197.00
IUUC-Cne-026990 Cryptococcus neoformans 42.49 3.00e-39 156.00
IUUC-Cme-027323 Cyanidioschyzon merolae 33.55 3.00e-43 168.00
IUUC-Dre-027987 Danio rerio 86.69 8.00e-154 536.00
IUUC-Dor-030294 Dipodomys ordii 97.39 4.00e-174 603.00
IUUC-Dse-031411 Dothistroma septosporum 38.24 5.00e-57 214.00
IUUC-Dme-031798 Drosophila melanogaster 56.01 4.00e-93 334.00
IUUC-Ete-032432 Echinops telfairi 98.05 1.00e-175 608.00
IUUC-Eca-034427 Equus caballus 100.00 4.00e-179 620.00
IUUC-Eeu-034917 Erinaceus europaeus 70.68 2.00e-111 395.00
IUUC-Fca-035380 Felis catus 99.67 1.00e-178 618.00
IUUC-Fal-037659 Ficedula albicollis 94.04 5.00e-168 583.00
IUUC-Fox-038062 Fusarium oxysporum 44.90 5.00e-21 94.00
IUUC-Fso-038111 Fusarium solani 35.96 2.00e-53 202.00
IUUC-Gmo-039298 Gadus morhua 86.73 1.00e-146 512.00
IUUC-Ggr-039771 Gaeumannomyces graminis 51.03 3.00e-56 212.00
IUUC-Gga-040313 Gallus gallus 94.79 5.00e-172 596.00
IUUC-Gac-042009 Gasterosteus aculeatus 85.81 1.00e-147 515.00
IUUC-Gma-043844 Glycine max 52.28 2.00e-67 249.00
IUUC-Ggo-044639 Gorilla gorilla 89.21 4.00e-173 600.00
IUUC-Hvu-047860 Hordeum vulgare 52.44 1.00e-65 243.00
IUUC-Itr-047987 Ictidomys tridecemlineatus 100.00 2.00e-178 617.00
IUUC-Kpa-049136 Komagataella pastoris 36.57 3.00e-55 208.00
IUUC-Lch-050607 Latimeria chalumnae 88.41 9.00e-156 542.00
IUUC-Lpe-050726 Leersia perrieri 50.23 2.00e-61 229.00
IUUC-Loc-051848 Lepisosteus oculatus 89.32 4.00e-161 560.00
IUUC-Lma-053187 Leptosphaeria maculans 41.64 3.00e-65 241.00
IUUC-Laf-053569 Loxodonta africana 98.06 8.00e-175 605.00
IUUC-Mcc-055275 Macaca mulatta 99.67 2.00e-178 617.00
IUUC-Mor-056967 Magnaporthe oryzae 37.94 9.00e-57 214.00
IUUC-Mpo-057399 Magnaporthe poae 51.55 1.00e-56 213.00
IUUC-Mtr-058353 Medicago truncatula 51.30 3.00e-65 241.00
IUUC-Mla-058830 Melampsora laricipopulina 44.56 2.00e-42 167.00
IUUC-Mga-059803 Meleagris gallopavo 93.89 9.00e-144 502.00
IUUC-Mvi-060456 Microbotryum violaceum 46.81 3.00e-45 176.00
IUUC-Mmr-060573 Microcebus murinus 99.67 1.00e-178 618.00
IUUC-Mdo-062831 Monodelphis domestica 96.74 1.00e-174 605.00
IUUC-Mmu-064302 Mus musculus 98.70 6.00e-177 612.00
IUUC-Mac-064745 Musa acuminata 51.72 7.00e-66 244.00
IUUC-Mpu-065922 Mustela putorius furo 99.67 6.00e-179 619.00
IUUC-Mlu-068236 Myotis lucifugus 98.71 1.00e-176 611.00
IUUC-Nfi-068417 Neosartorya fischeri 43.54 1.00e-65 243.00
IUUC-Ncr-068747 Neurospora crassa 40.75 5.00e-54 204.00
IUUC-Nle-069948 Nomascus leucogenys 89.24 3.00e-174 604.00
IUUC-Opr-070919 Ochotona princeps 84.05 2.00e-140 491.00
IUUC-Ont-071467 Oreochromis niloticus 86.41 2.00e-152 531.00
IUUC-Oan-073436 Ornithorhynchus anatinus 76.36 2.00e-69 254.00
IUUC-Ocu-074427 Oryctolagus cuniculus 98.05 5.00e-168 583.00
IUUC-Oba-075440 Oryza barthii 51.27 3.00e-66 245.00
IUUC-Obr-076275 Oryza brachyantha 51.15 8.00e-60 224.00
IUUC-Ogl-077237 Oryza glaberrima 51.27 2.00e-66 245.00
IUUC-Ogu-078934 Oryza glumaepatula 51.27 2.00e-66 245.00
IUUC-Oin-079475 Oryza indica 51.69 8.00e-67 247.00
IUUC-Olo-080285 Oryza longistaminata 59.64 7.00e-57 213.00
IUUC-Ome-081887 Oryza meridionalis 50.64 4.00e-66 244.00
IUUC-Oni-082064 Oryza nivara 51.69 1.00e-66 246.00
IUUC-Opu-083610 Oryza punctata 50.64 6.00e-66 244.00
IUUC-Oru-084911 Oryza rufipogon 44.27 6.00e-67 247.00
IUUC-Osa-085366 Oryza sativa 51.27 3.00e-66 245.00
IUUC-Ola-086846 Oryzias latipes 76.15 1.00e-138 486.00
IUUC-Olu-087879 Ostreococcus lucimarinus 45.82 6.00e-57 214.00
IUUC-Oga-089017 Otolemur garnettii 98.38 2.00e-175 608.00
IUUC-Oar-089970 Ovis aries 94.44 1.00e-167 582.00
IUUC-Ptr-091147 Pan troglodytes 90.61 4.00e-163 566.00
IUUC-Pan-091757 Papio anubis 92.21 2.00e-159 554.00
IUUC-Psi-093931 Pelodiscus sinensis 95.11 2.00e-172 598.00
IUUC-Pno-094775 Phaeosphaeria nodorum 48.62 3.00e-59 222.00
IUUC-Ppa-095156 Physcomitrella patens 51.79 1.00e-63 236.00
IUUC-Pfo-097295 Poecilia formosa 85.53 8.00e-152 529.00
IUUC-Pab-098537 Pongo abelii 100.00 4.00e-179 620.00
IUUC-Pop-099436 Populus trichocarpa 49.60 3.00e-67 248.00
IUUC-Pca-100631 Procavia capensis 86.67 5.00e-166 577.00
IUUC-Ppe-101259 Prunus persica 50.87 1.00e-66 246.00
IUUC-Pva-102679 Pteropus vampyrus 90.97 6.00e-160 556.00
IUUC-Pgr-103475 Puccinia graminis 45.59 8.00e-45 174.00
IUUC-Ptt-104012 Puccinia triticina 38.73 3.00e-32 132.00
IUUC-Pte-104071 Pyrenophora teres 51.43 7.00e-62 231.00
IUUC-Pyt-104501 Pyrenophora triticirepentis 51.43 7.00e-62 231.00
IUUC-Rno-104858 Rattus norvegicus 98.70 7.00e-177 612.00
IUUC-Sce-106174 Saccharomyces cerevisiae 39.02 3.00e-54 206.00
IUUC-Sha-107075 Sarcophilus harrisii 96.73 2.00e-174 604.00
IUUC-Sja-107663 Schizosaccharomyces japonicus 44.00 1.00e-60 226.00
IUUC-Spo-108259 Schizosaccharomyces pombe 45.92 5.00e-52 197.00
IUUC-Ssl-108473 Sclerotinia sclerotiorum 39.03 2.00e-51 196.00
IUUC-Smo-109290 Selaginella moellendorffii 53.28 7.00e-66 244.00
IUUC-Sit-109992 Setaria italica 51.06 2.00e-65 242.00
IUUC-Sly-110858 Solanum lycopersicum 51.57 3.00e-63 234.00
IUUC-Stu-112129 Solanum tuberosum 51.13 8.00e-64 237.00
IUUC-Sar-113061 Sorex araneus 99.02 9.00e-177 612.00
IUUC-Sbi-114882 Sorghum bicolor 44.27 5.00e-66 244.00
IUUC-Sre-115104 Sporisorium reilianum 47.12 2.00e-44 172.00
IUUC-Ssc-115403 Sus scrofa 99.02 1.00e-177 615.00
IUUC-Tgu-117013 Taeniopygia guttata 94.44 4.00e-171 593.00
IUUC-Tru-118307 Takifugu rubripes 86.69 1.00e-148 518.00
IUUC-Tsy-119309 Tarsius syrichta 89.44 5.00e-69 254.00
IUUC-Tni-120209 Tetraodon nigroviridis 86.08 1.00e-146 512.00
IUUC-Tca-121421 Theobroma cacao 51.30 4.00e-67 248.00
IUUC-Tre-122235 Trichoderma reesei 45.88 1.00e-51 197.00
IUUC-Tvi-122421 Trichoderma virens 45.81 3.00e-52 199.00
IUUC-Tae-124587 Triticum aestivum 51.80 3.00e-66 245.00
IUUC-Tur-126353 Triticum urartu 37.50 4.00e-25 109.00
IUUC-Tme-126918 Tuber melanosporum 53.65 6.00e-59 221.00
IUUC-Ttr-129286 Tursiops truncatus 89.32 4.00e-161 560.00
IUUC-Uma-129404 Ustilago maydis 48.17 1.00e-45 177.00
IUUC-Vda-129746 Verticillium dahliae 48.47 4.00e-53 201.00
IUUC-Vpa-130648 Vicugna pacos 100.00 2.00e-24 105.00
IUUC-Vvi-131301 Vitis vinifera 52.17 3.00e-66 245.00
IUUC-Xtr-132583 Xenopus tropicalis 90.88 5.00e-164 570.00
IUUC-Xma-133129 Xiphophorus maculatus 85.85 7.00e-152 529.00
IUUC-Yli-134515 Yarrowia lipolytica 46.43 4.00e-51 195.00
IUUC-Zma-135266 Zea mays 43.53 9.00e-66 243.00
Created Date 25-Jun-2017

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