iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046786

UUCD1 version

UUC-HoS-01242

Ensembl Protein ID

ENSP00000328287.6

UniProt Accession

Q5XPI4; A1L4Q3; A6NLS5; Q5I022; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2; RN123_HUMAN

Genbank Protein ID

AAU93470.1; AAH41145.1; AAH57392.2; AAH88801.1; AAI30633.1; AAQ15203.1; BAB14139.1; BAB15607.1; CAB66663.2

Protein Name

E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123; RING-type E3 ubiquitin transferase RNF123

Genbank Nucleotide ID

AY744152; AC099668; BC057392; BC088801; BC130632; AF370367; AK022627; AK026968; AL136729

Gene Name

RNF123; KPC1; FP1477

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164068.15	ENST00000327697.10	ENSP00000328287.6
ENSG00000164068.15	ENST00000432042.5	ENSP00000392443.1
ENSG00000164068.15	ENST00000457726.5	ENSP00000394369.1
ENSG00000164068.15	ENST00000443204.3	ENSP00000390856.1
ENSG00000164068.15	ENST00000433785.1	ENSP00000416156.1
ENSG00000164068.15	ENST00000444689.1	ENSP00000413794.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15531880

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.3	10.5	1254	1292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+ ++    ++ pCgH  ++ C+++        +++  C  C+
   Q: 1254 CPICYAHPIS-AVFQPCGHKSCKACINQH------LMNNKDCFFCK 1292
           ******9988.555************666......67777798885 PP

Organism

Homo sapiens

Functional Description
(View)

Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Protein Sequence
(Fasta)

MASKGAGMSF SRKSYRLTSD AEKSRVTGIV QEKLLNDYLN RIFSSSEHAP PAATSRKPLN 60
FQNLPEHLDQ LLQVDNEEEE SQGQVEGRLG PSTVVLDHTG GFEGLLLVDD DLLGVIGHSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGAGGCT CAGCGCGCAA GCGTGCGCGT GATTTGGCCC TGAACGGACG CCGTAGCCAA 60
GAGGTTGGGC GGATGTTGTG AGCCGGGTCG CTGCGGCCGA GGCTCCGGGT GAGTGAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011989--ARM-like
IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50089--ZF_RING_2

Pfam

PF00622--SPRY

SMART

SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:63891

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002334	Ailuropoda melanoleuca	94.50	0.00e+00	2313.00
IUUC-Atr-002731	Amborella trichopoda	27.74	7.00e-47	183.00
IUUC-Apl-003337	Anas platyrhynchos	79.48	0.00e+00	2016.00
IUUC-Aca-005266	Anolis carolinensis	78.97	0.00e+00	1617.00
IUUC-Aly-005720	Arabidopsis lyrata	34.07	2.00e-46	182.00
IUUC-Ath-007453	Arabidopsis thaliana	28.60	1.00e-49	192.00
IUUC-Ame-011173	Astyanax mexicanus	67.70	0.00e+00	1431.00
IUUC-Bta-012466	Bos taurus	92.41	0.00e+00	2326.00
IUUC-Bol-016281	Brassica oleracea	26.14	3.00e-97	350.00
IUUC-Bra-016892	Brassica rapa	26.38	2.00e-97	351.00
IUUC-Cja-019535	Callithrix jacchus	97.16	0.00e+00	2417.00
IUUC-Cfa-020260	Canis familiaris	94.70	0.00e+00	2357.00
IUUC-Cpo-021921	Cavia porcellus	93.53	0.00e+00	2397.00
IUUC-Cre-022617	Chlamydomonas reinhardtii	52.47	8.00e-48	186.00
IUUC-Csa-024158	Chlorocebus sabaeus	98.94	0.00e+00	2449.00
IUUC-Cho-025093	Choloepus hoffmanni	82.17	0.00e+00	902.00
IUUC-Cin-025392	Ciona intestinalis	37.88	4.00e-112	398.00
IUUC-Csv-026271	Ciona savignyi	35.37	2.00e-39	155.00
IUUC-Dre-027457	Danio rerio	78.69	0.00e+00	1220.00
IUUC-Dor-030129	Dipodomys ordii	87.85	0.00e+00	2160.00
IUUC-Dme-032022	Drosophila melanogaster	29.69	6.00e-158	552.00
IUUC-Ete-032681	Echinops telfairi	84.25	0.00e+00	820.00
IUUC-Eca-033488	Equus caballus	93.89	0.00e+00	2441.00
IUUC-Eeu-035141	Erinaceus europaeus	95.07	0.00e+00	989.00
IUUC-Fca-036540	Felis catus	95.04	0.00e+00	2338.00
IUUC-Fal-036716	Ficedula albicollis	80.28	0.00e+00	1995.00
IUUC-Gmo-038827	Gadus morhua	72.14	0.00e+00	842.00
IUUC-Gga-040227	Gallus gallus	79.85	0.00e+00	1986.00
IUUC-Gac-041611	Gasterosteus aculeatus	78.69	0.00e+00	919.00
IUUC-Gma-043507	Glycine max	25.31	8.00e-88	319.00
IUUC-Ggo-045274	Gorilla gorilla	99.47	0.00e+00	2461.00
IUUC-Itr-047988	Ictidomys tridecemlineatus	94.65	0.00e+00	2459.00
IUUC-Lch-050613	Latimeria chalumnae	81.49	0.00e+00	1081.00
IUUC-Lpe-050692	Leersia perrieri	26.21	6.00e-87	316.00
IUUC-Loc-052484	Lepisosteus oculatus	76.10	0.00e+00	1920.00
IUUC-Laf-053359	Loxodonta africana	94.02	0.00e+00	2336.00
IUUC-Mcc-054643	Macaca mulatta	98.86	0.00e+00	2445.00
IUUC-Meu-056856	Macropus eugenii	78.47	0.00e+00	1748.00
IUUC-Mtr-058494	Medicago truncatula	25.12	1.00e-88	322.00
IUUC-Mga-060198	Meleagris gallopavo	65.77	0.00e+00	1291.00
IUUC-Mmr-061762	Microcebus murinus	95.17	0.00e+00	2383.00
IUUC-Mdo-062049	Monodelphis domestica	81.59	0.00e+00	2054.00
IUUC-Mmu-064274	Mus musculus	93.84	0.00e+00	2454.00
IUUC-Mac-064561	Musa acuminata	44.62	2.00e-45	178.00
IUUC-Mpu-066413	Mustela putorius furo	94.65	0.00e+00	2340.00
IUUC-Mlu-067411	Myotis lucifugus	83.52	0.00e+00	2065.00
IUUC-Nle-069644	Nomascus leucogenys	98.86	0.00e+00	2446.00
IUUC-Opr-070465	Ochotona princeps	90.63	0.00e+00	2240.00
IUUC-Ont-072552	Oreochromis niloticus	73.74	0.00e+00	1690.00
IUUC-Ocu-074740	Oryctolagus cuniculus	92.74	0.00e+00	2318.00
IUUC-Oba-075088	Oryza barthii	33.05	6.00e-44	173.00
IUUC-Obr-076657	Oryza brachyantha	31.72	3.00e-43	171.00
IUUC-Ogl-077313	Oryza glaberrima	27.98	1.00e-31	130.00
IUUC-Ogu-078672	Oryza glumaepatula	33.33	9.00e-45	176.00
IUUC-Oin-079756	Oryza indica	33.33	6.00e-45	176.00
IUUC-Olo-080369	Oryza longistaminata	33.62	2.00e-45	178.00
IUUC-Oni-082996	Oryza nivara	33.33	6.00e-45	176.00
IUUC-Opu-083892	Oryza punctata	27.38	3.00e-14	72.00
IUUC-Oru-084434	Oryza rufipogon	33.24	4.00e-47	184.00
IUUC-Osa-085595	Oryza sativa	31.14	1.00e-27	116.00
IUUC-Ola-086405	Oryzias latipes	76.44	0.00e+00	1294.00
IUUC-Oga-088794	Otolemur garnettii	94.28	0.00e+00	2350.00
IUUC-Oar-089775	Ovis aries	85.26	0.00e+00	2135.00
IUUC-Pan-092845	Papio anubis	98.86	0.00e+00	2446.00
IUUC-Psi-093521	Pelodiscus sinensis	78.29	2.00e-118	418.00
IUUC-Ppa-095501	Physcomitrella patens	28.25	4.00e-101	363.00
IUUC-Pfo-097083	Poecilia formosa	74.90	0.00e+00	1910.00
IUUC-Pab-098302	Pongo abelii	97.76	0.00e+00	2404.00
IUUC-Pop-099033	Populus trichocarpa	29.73	4.00e-50	194.00
IUUC-Pca-100742	Procavia capensis	85.10	0.00e+00	2057.00
IUUC-Ppe-101476	Prunus persica	29.40	2.00e-46	182.00
IUUC-Pva-103045	Pteropus vampyrus	92.15	0.00e+00	2243.00
IUUC-Rno-105433	Rattus norvegicus	93.71	0.00e+00	2384.00
IUUC-Sha-107441	Sarcophilus harrisii	82.37	0.00e+00	2072.00
IUUC-Smo-109606	Selaginella moellendorffii	27.79	2.00e-102	367.00
IUUC-Sit-110792	Setaria italica	32.51	4.00e-44	174.00
IUUC-Sly-110982	Solanum lycopersicum	25.22	7.00e-88	319.00
IUUC-Stu-112003	Solanum tuberosum	24.75	8.00e-67	249.00
IUUC-Sar-113146	Sorex araneus	92.80	0.00e+00	1087.00
IUUC-Sbi-113941	Sorghum bicolor	32.68	2.00e-38	154.00
IUUC-Ssc-115635	Sus scrofa	94.40	0.00e+00	2381.00
IUUC-Tgu-116688	Taeniopygia guttata	80.26	0.00e+00	1866.00
IUUC-Tsy-119023	Tarsius syrichta	97.31	0.00e+00	669.00
IUUC-Tca-121219	Theobroma cacao	35.23	1.00e-51	199.00
IUUC-Tbe-127542	Tupaia belangeri	72.60	0.00e+00	1241.00
IUUC-Ttr-128241	Tursiops truncatus	91.76	0.00e+00	2228.00
IUUC-Vvi-131629	Vitis vinifera	34.92	4.00e-51	197.00
IUUC-Xtr-132790	Xenopus tropicalis	77.72	0.00e+00	1995.00
IUUC-Xma-133302	Xiphophorus maculatus	72.91	0.00e+00	1284.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence