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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064017
UUCD1 version UUC-MuM-00064
Ensembl Protein ID ENSMUSP00000132224.1
UniProt Accession Q9DBH0; Q8BTG4; Q923F6; WWP2_MOUSE
Genbank Protein ID BAB23702.1; BAC40661.1; BAC41195.1; AAH04712.1; AAH39921.1; AAH48184.1
Protein Name NEDD4-like E3 ubiquitin-protein ligase WWP2; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2
Genbank Nucleotide ID AK004962; AK088936; AK090392; BC004712; BC039921; BC048184
Gene Name Wwp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000031930.11 ENSMUST00000166615.2 ENSMUSP00000132224.1
ENSMUSG00000031930.11 ENSMUST00000212205.1 ENSMUSP00000148679.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 17496161; 17526739
Classification
Family E-value Score Start End
E3 activity/HECT 9.70e-135 450.4 537 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGeni+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELFFIQDMEILGKVTTHELKEGGENIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k++ y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNAIYRH-YTKSSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i + +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 799  TGTCRLPVGGFAELIgsngPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 869
           *********************************************************************96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Protein Sequence
(Fasta)
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IVLNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064017|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGTGACCCG GCCCGAGTGC GGGCGCTGGA AGGCGGAAGT GGAGCGGAGT TAGGCGCCGC 60
TGGTGTGGCC GCGGCAGGTA GGTGGCGCGG GGGCACTGGG GGGCTCGGCA GCGAGCGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064017|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0008134--F:transcription factor binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0010629--P:negative regulation of gene expression
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0032410--P:negative regulation of transporter activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0034765--P:regulation of ion transmembrane transport
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
KEGG mmu:66894
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 94.84 0.00e+00 1641.00
IUUC-Apl-003912 Anas platyrhynchos 76.20 0.00e+00 1240.00
IUUC-Aca-004291 Anolis carolinensis 80.90 0.00e+00 1434.00
IUUC-Bta-013231 Bos taurus 94.25 0.00e+00 1599.00
IUUC-Cja-019455 Callithrix jacchus 95.63 0.00e+00 1683.00
IUUC-Cfa-021017 Canis familiaris 95.29 0.00e+00 1630.00
IUUC-Cpo-021988 Cavia porcellus 95.29 0.00e+00 1664.00
IUUC-Csa-023549 Chlorocebus sabaeus 95.52 0.00e+00 1691.00
IUUC-Dre-028513 Danio rerio 91.59 0.00e+00 1138.00
IUUC-Dno-028976 Dasypus novemcinctus 94.72 0.00e+00 1655.00
IUUC-Dor-030176 Dipodomys ordii 93.03 0.00e+00 1513.00
IUUC-Eca-033949 Equus caballus 95.17 0.00e+00 1644.00
IUUC-Eeu-034529 Erinaceus europaeus 86.81 0.00e+00 1360.00
IUUC-Fca-036236 Felis catus 95.06 0.00e+00 1667.00
IUUC-Fal-036948 Ficedula albicollis 78.21 0.00e+00 1332.00
IUUC-Gmo-038842 Gadus morhua 88.89 0.00e+00 1067.00
IUUC-Gga-040617 Gallus gallus 79.89 0.00e+00 1437.00
IUUC-Gac-041338 Gasterosteus aculeatus 69.44 0.00e+00 1253.00
IUUC-Ggo-045278 Gorilla gorilla 95.98 0.00e+00 1696.00
IUUC-Hsa-046148 Homo sapiens 95.98 0.00e+00 1697.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 97.94 0.00e+00 1122.00
IUUC-Lch-050663 Latimeria chalumnae 78.03 0.00e+00 1390.00
IUUC-Loc-052604 Lepisosteus oculatus 76.22 0.00e+00 1321.00
IUUC-Laf-053944 Loxodonta africana 94.83 0.00e+00 1664.00
IUUC-Mcc-055655 Macaca mulatta 95.63 0.00e+00 1692.00
IUUC-Meu-055953 Macropus eugenii 79.47 0.00e+00 1385.00
IUUC-Mga-060190 Meleagris gallopavo 80.50 0.00e+00 1434.00
IUUC-Mmr-060896 Microcebus murinus 96.42 0.00e+00 1649.00
IUUC-Mdo-062536 Monodelphis domestica 90.60 0.00e+00 1613.00
IUUC-Mpu-066608 Mustela putorius furo 92.89 0.00e+00 1584.00
IUUC-Mlu-067623 Myotis lucifugus 92.08 0.00e+00 1591.00
IUUC-Nle-069496 Nomascus leucogenys 94.03 0.00e+00 1649.00
IUUC-Opr-071054 Ochotona princeps 83.51 0.00e+00 1423.00
IUUC-Ont-071279 Oreochromis niloticus 74.36 0.00e+00 1282.00
IUUC-Oan-073512 Ornithorhynchus anatinus 86.33 0.00e+00 1492.00
IUUC-Ocu-074271 Oryctolagus cuniculus 94.98 0.00e+00 1624.00
IUUC-Ola-087237 Oryzias latipes 69.43 0.00e+00 1228.00
IUUC-Oga-088164 Otolemur garnettii 96.09 0.00e+00 1678.00
IUUC-Oar-089698 Ovis aries 94.60 0.00e+00 1613.00
IUUC-Ptr-091306 Pan troglodytes 94.71 0.00e+00 1667.00
IUUC-Pan-092814 Papio anubis 92.09 0.00e+00 1601.00
IUUC-Pfo-096709 Poecilia formosa 72.89 0.00e+00 1283.00
IUUC-Pab-098494 Pongo abelii 90.39 0.00e+00 1602.00
IUUC-Pca-100596 Procavia capensis 83.10 0.00e+00 1379.00
IUUC-Pva-103154 Pteropus vampyrus 90.37 0.00e+00 1559.00
IUUC-Rno-104954 Rattus norvegicus 97.49 0.00e+00 1440.00
IUUC-Sha-106781 Sarcophilus harrisii 90.71 0.00e+00 1644.00
IUUC-Ssc-116307 Sus scrofa 83.63 0.00e+00 1436.00
IUUC-Tgu-116530 Taeniopygia guttata 75.74 0.00e+00 1185.00
IUUC-Tru-118287 Takifugu rubripes 89.63 0.00e+00 1068.00
IUUC-Tsy-119097 Tarsius syrichta 82.97 0.00e+00 1231.00
IUUC-Tni-120801 Tetraodon nigroviridis 68.29 0.00e+00 1151.00
IUUC-Tbe-127793 Tupaia belangeri 83.91 0.00e+00 1435.00
IUUC-Ttr-128275 Tursiops truncatus 90.34 0.00e+00 1548.00
IUUC-Xtr-132866 Xenopus tropicalis 82.70 0.00e+00 1134.00
Created Date 25-Jun-2017

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