• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063090
UUCD1 version UUC-MuM-00907
Ensembl Protein ID ENSMUSP00000108138.2
UniProt Accession Q810L3; Q3TFD8; Q3U233; Q3U4U9; Q3UGJ9; Q8BJZ9; Q8BWH4; CHFR_MOUSE
Genbank Protein ID BAC35008.2; BAC36912.1; BAE28209.1; BAE32331.1; BAE33172.1; BAE33309.1; BAE40960.1; BAE40969.1; EDL20040.1; AAH49792.1
Protein Name E3 ubiquitin-protein ligase CHFR; Checkpoint with forkhead and RING finger domains protein; RING-type E3 ubiquitin transferase CHFR
Genbank Nucleotide ID AK052473; AK077629; AK147892; AK154038; AK155295; AK155525; AK169182; AK169193; CH466529; BC049792
Gene Name Chfr
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000014668.15 ENSMUST00000200038.1 ENSMUSP00000142354.1
ENSMUSG00000014668.15 ENSMUST00000199672.4 ENSMUSP00000143310.1
ENSMUSG00000014668.15 ENSMUST00000112519.8 ENSMUSP00000108138.2
ENSMUSG00000014668.15 ENSMUST00000199557.4 ENSMUSP00000143113.1
ENSMUSG00000014668.15 ENSMUST00000198633.4 ENSMUSP00000143480.1
ENSMUSG00000014668.15 ENSMUST00000014812.12 ENSMUSP00000014812.8
ENSMUSG00000014668.15 ENSMUST00000199283.1 ENSMUSP00000143389.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 82.98 0.00e+00 1012.00 IUUC-Hsa-046851
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
 E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
Protein Sequence
(Fasta)
MELHGEEQPP PPQEPWGRLL RLGAEEDEPQ ILLWKREWTI GRRRGCDLSF PSNKLVSGDH 60
CKLTVDEISG EVTLEDTSTN GTVINKLQVV KKQTYPLQSG DIIYLVYRKN EPEHNVAYLY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063090|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCTCCCGTG GATCAGCTGG GGTACCCGAG ATGTCTGTTG ACAGCGGTGG CGGCGACTGT 60
AAGGCCGGTT CCGGGATCCG CGCAGGGCGT GGGGTAAGCT GGCCGGCGGG TGGGGTCCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063090|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0013--ADP-ribosylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00498--FHA
SMART

SM00240--FHA
SM00184--RING
Gene Ontology

GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0000166--F:nucleotide binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0000278--P:mitotic cell cycle
GO:0007093--P:mitotic cell cycle checkpoint
GO:0007067--P:mitotic nuclear division
GO:0019941--P:modification-dependent protein catabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:231600
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001235 Ailuropoda melanoleuca 79.87 0.00e+00 951.00
IUUC-Apl-003848 Anas platyrhynchos 73.82 0.00e+00 917.00
IUUC-Aca-004525 Anolis carolinensis 67.61 0.00e+00 838.00
IUUC-Aly-005401 Arabidopsis lyrata 27.08 2.00e-27 117.00
IUUC-Afl-008661 Aspergillus flavus 28.10 2.00e-09 58.50
IUUC-Ang-009542 Aspergillus niger 30.61 4.00e-09 57.40
IUUC-Aor-010000 Aspergillus oryzae 28.10 1.00e-09 59.30
IUUC-Ate-010344 Aspergillus terreus 29.13 1.00e-08 55.50
IUUC-Ame-011701 Astyanax mexicanus 94.44 1.00e-37 147.00
IUUC-Bgr-012082 Blumeria graminis 30.77 3.00e-09 57.80
IUUC-Bta-012623 Bos taurus 79.79 0.00e+00 959.00
IUUC-Bci-013931 Botrytis cinerea 27.27 5.00e-10 60.50
IUUC-Bdi-014581 Brachypodium distachyon 26.24 3.00e-27 116.00
IUUC-Cfa-020239 Canis familiaris 79.91 0.00e+00 986.00
IUUC-Cpo-021431 Cavia porcellus 80.75 0.00e+00 997.00
IUUC-Cre-022788 Chlamydomonas reinhardtii 27.93 2.00e-08 53.50
IUUC-Csa-023886 Chlorocebus sabaeus 82.42 0.00e+00 952.00
IUUC-Cho-025103 Choloepus hoffmanni 64.35 0.00e+00 736.00
IUUC-Cgl-026521 Colletotrichum gloeosporioides 29.27 1.00e-11 65.50
IUUC-Dno-030027 Dasypus novemcinctus 76.66 0.00e+00 877.00
IUUC-Dor-030283 Dipodomys ordii 88.96 7.00e-160 557.00
IUUC-Dse-031151 Dothistroma septosporum 33.96 3.00e-11 63.90
IUUC-Ete-032539 Echinops telfairi 71.12 0.00e+00 843.00
IUUC-Eca-033261 Equus caballus 81.08 0.00e+00 1001.00
IUUC-Eeu-034729 Erinaceus europaeus 57.23 4.00e-84 305.00
IUUC-Fca-035722 Felis catus 74.15 0.00e+00 883.00
IUUC-Fal-037014 Ficedula albicollis 71.88 0.00e+00 906.00
IUUC-Ggr-039814 Gaeumannomyces graminis 33.64 2.00e-13 71.60
IUUC-Gga-040342 Gallus gallus 62.20 2.00e-124 438.00
IUUC-Ggo-045266 Gorilla gorilla 73.57 0.00e+00 773.00
IUUC-Hsa-046851 Homo sapiens 82.82 0.00e+00 972.00
IUUC-Itr-049059 Ictidomys tridecemlineatus 83.51 0.00e+00 1024.00
IUUC-Loc-052356 Lepisosteus oculatus 59.76 0.00e+00 771.00
IUUC-Lma-053260 Leptosphaeria maculans 28.21 2.00e-09 57.80
IUUC-Laf-053663 Loxodonta africana 76.15 0.00e+00 922.00
IUUC-Mcc-054606 Macaca mulatta 80.86 0.00e+00 968.00
IUUC-Meu-056164 Macropus eugenii 86.90 0.00e+00 647.00
IUUC-Mor-056977 Magnaporthe oryzae 29.73 3.00e-10 61.20
IUUC-Mtr-058792 Medicago truncatula 25.86 2.00e-27 117.00
IUUC-Mga-059744 Meleagris gallopavo 73.78 0.00e+00 922.00
IUUC-Mmr-061346 Microcebus murinus 82.84 0.00e+00 1026.00
IUUC-Mdo-061834 Monodelphis domestica 73.77 0.00e+00 912.00
IUUC-Mpu-066200 Mustela putorius furo 76.81 0.00e+00 909.00
IUUC-Mlu-067417 Myotis lucifugus 76.12 0.00e+00 912.00
IUUC-Nfi-068546 Neosartorya fischeri 26.67 7.00e-08 53.10
IUUC-Ncr-068857 Neurospora crassa 29.55 3.00e-12 68.20
IUUC-Nle-069154 Nomascus leucogenys 76.69 0.00e+00 858.00
IUUC-Opr-070317 Ochotona princeps 74.67 0.00e+00 794.00
IUUC-Ont-071760 Oreochromis niloticus 55.76 0.00e+00 672.00
IUUC-Oan-073419 Ornithorhynchus anatinus 72.08 0.00e+00 879.00
IUUC-Ocu-074763 Oryctolagus cuniculus 83.77 0.00e+00 1008.00
IUUC-Obr-076345 Oryza brachyantha 25.77 7.00e-27 115.00
IUUC-Ogl-077562 Oryza glaberrima 26.55 2.00e-28 120.00
IUUC-Oin-080164 Oryza indica 34.00 5.00e-15 74.30
IUUC-Opu-083277 Oryza punctata 23.82 2.00e-26 114.00
IUUC-Osa-086171 Oryza sativa 26.55 1.00e-28 121.00
IUUC-Oga-088680 Otolemur garnettii 82.38 0.00e+00 1025.00
IUUC-Oar-089757 Ovis aries 79.57 0.00e+00 956.00
IUUC-Ptr-090909 Pan troglodytes 85.59 0.00e+00 695.00
IUUC-Pan-092235 Papio anubis 80.56 0.00e+00 929.00
IUUC-Psi-093106 Pelodiscus sinensis 70.07 0.00e+00 803.00
IUUC-Pab-098261 Pongo abelii 81.83 0.00e+00 919.00
IUUC-Pca-100392 Procavia capensis 83.95 4.00e-118 418.00
IUUC-Pva-102435 Pteropus vampyrus 73.69 0.00e+00 897.00
IUUC-Pte-104339 Pyrenophora teres 32.04 4.00e-11 63.50
IUUC-Pyt-104522 Pyrenophora triticirepentis 31.09 2.00e-11 65.10
IUUC-Rno-105158 Rattus norvegicus 93.98 0.00e+00 1185.00
IUUC-Sha-106696 Sarcophilus harrisii 56.53 0.00e+00 648.00
IUUC-Ssl-108645 Sclerotinia sclerotiorum 27.27 9.00e-11 62.80
IUUC-Sar-113392 Sorex araneus 64.92 0.00e+00 684.00
IUUC-Ssc-115596 Sus scrofa 78.96 0.00e+00 936.00
IUUC-Tgu-117207 Taeniopygia guttata 73.31 0.00e+00 914.00
IUUC-Tsy-119248 Tarsius syrichta 63.95 2.00e-111 396.00
IUUC-Tvi-122458 Trichoderma virens 30.19 2.00e-08 54.70
IUUC-Tur-126062 Triticum urartu 24.13 9.00e-19 88.60
IUUC-Tme-126931 Tuber melanosporum 32.35 5.00e-10 59.30
IUUC-Ttr-128219 Tursiops truncatus 70.35 0.00e+00 817.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved