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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105990
Ensembl Protein ID ENSRNOP00000001476.3
UniProt Accession Q6AY57; WIPI2_RAT
Genbank Protein ID AAH79184.1
Protein Name WD repeat domain phosphoinositide-interacting protein 2
Genbank Nucleotide ID BC079184
Gene Name Wipi2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000001114.5 ENSRNOT00000001476.5 ENSRNOP00000001476.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.50e-07 30.1 183 217
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlrtg 33
           H ++  +laf  s+t l+++s  gt i+v+++ +g
   Q: 183  HDSPLAALAFdaSGTKLATASEKGTvIRVFSIPEG 217
           9999999***9877***********9999987665 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.
 Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.
Protein Sequence
(Fasta)
MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 60
VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105990|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGAGGGTGGG CGGGACCGCG CAAGCGCGCA GCCCGTCCCG GCTCTGGAGC ATAAACAAGA 60
GTGGGGACGG TATGAGGCGG CAGTTGGTCC CCGCGCAGCG AGAGGGGGCG AGCGGGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105990|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032911--WIPI2
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0000045--P:autophagosome assembly
KEGG rno:288498
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001842 Ailuropoda melanoleuca 91.90 0.00e+00 759.00
IUUC-Apl-003390 Anas platyrhynchos 91.67 0.00e+00 802.00
IUUC-Aca-004975 Anolis carolinensis 91.24 0.00e+00 841.00
IUUC-Ago-007948 Ashbya gossypii 42.57 8.00e-27 115.00
IUUC-Acl-008148 Aspergillus clavatus 44.15 2.00e-55 209.00
IUUC-Afl-008562 Aspergillus flavus 44.53 2.00e-56 212.00
IUUC-Afu-008936 Aspergillus fumigatus 35.39 2.00e-58 219.00
IUUC-Ani-009254 Aspergillus nidulans 44.53 2.00e-56 212.00
IUUC-Ang-009798 Aspergillus niger 35.24 2.00e-63 236.00
IUUC-Aor-010066 Aspergillus oryzae 44.53 2.00e-56 212.00
IUUC-Ate-010266 Aspergillus terreus 35.01 6.00e-59 221.00
IUUC-Ame-010727 Astyanax mexicanus 83.60 0.00e+00 776.00
IUUC-Bta-012655 Bos taurus 91.46 0.00e+00 816.00
IUUC-Bci-013627 Botrytis cinerea 34.11 1.00e-62 233.00
IUUC-Cel-018503 Caenorhabditis elegans 42.39 2.00e-84 306.00
IUUC-Cja-018829 Callithrix jacchus 90.50 0.00e+00 820.00
IUUC-Cfa-020858 Canis familiaris 88.65 0.00e+00 815.00
IUUC-Cpo-022235 Cavia porcellus 95.96 0.00e+00 845.00
IUUC-Cre-022613 Chlamydomonas reinhardtii 31.85 6.00e-32 131.00
IUUC-Csa-023963 Chlorocebus sabaeus 89.20 0.00e+00 806.00
IUUC-Cho-024328 Choloepus hoffmanni 81.66 0.00e+00 653.00
IUUC-Cin-025343 Ciona intestinalis 58.19 4.00e-138 484.00
IUUC-Csv-025920 Ciona savignyi 70.56 8.00e-152 529.00
IUUC-Cgl-026425 Colletotrichum gloeosporioides 46.45 2.00e-29 123.00
IUUC-Cne-026947 Cryptococcus neoformans 36.34 2.00e-62 233.00
IUUC-Dre-027490 Danio rerio 83.15 0.00e+00 771.00
IUUC-Dno-030057 Dasypus novemcinctus 85.50 0.00e+00 754.00
IUUC-Dor-030472 Dipodomys ordii 88.98 0.00e+00 801.00
IUUC-Dse-031215 Dothistroma septosporum 31.22 3.00e-52 199.00
IUUC-Ete-032362 Echinops telfairi 80.52 0.00e+00 747.00
IUUC-Eca-034362 Equus caballus 93.57 0.00e+00 816.00
IUUC-Fca-036230 Felis catus 93.06 0.00e+00 757.00
IUUC-Fal-036782 Ficedula albicollis 91.67 0.00e+00 802.00
IUUC-Fox-037797 Fusarium oxysporum 42.32 3.00e-53 202.00
IUUC-Fso-038174 Fusarium solani 43.07 3.00e-54 205.00
IUUC-Gmo-039706 Gadus morhua 57.14 1.00e-134 472.00
IUUC-Ggr-040113 Gaeumannomyces graminis 42.44 3.00e-53 202.00
IUUC-Gga-040690 Gallus gallus 91.24 0.00e+00 847.00
IUUC-Gac-041360 Gasterosteus aculeatus 83.15 0.00e+00 746.00
IUUC-Gma-043876 Glycine max 35.92 4.00e-39 155.00
IUUC-Hsa-046782 Homo sapiens 91.79 0.00e+00 838.00
IUUC-Itr-048693 Ictidomys tridecemlineatus 93.09 0.00e+00 847.00
IUUC-Kpa-049378 Komagataella pastoris 41.81 4.00e-55 209.00
IUUC-Lch-050413 Latimeria chalumnae 79.33 0.00e+00 711.00
IUUC-Lma-052948 Leptosphaeria maculans 33.86 5.00e-61 228.00
IUUC-Laf-054007 Loxodonta africana 95.06 0.00e+00 882.00
IUUC-Mor-057125 Magnaporthe oryzae 41.95 6.00e-52 198.00
IUUC-Mga-059795 Meleagris gallopavo 89.47 0.00e+00 812.00
IUUC-Mvi-060219 Microbotryum violaceum 39.93 4.00e-46 178.00
IUUC-Mmr-061096 Microcebus murinus 89.20 0.00e+00 842.00
IUUC-Mdo-061815 Monodelphis domestica 88.15 0.00e+00 837.00
IUUC-Mmu-063787 Mus musculus 99.55 0.00e+00 923.00
IUUC-Mpu-066019 Mustela putorius furo 86.44 0.00e+00 757.00
IUUC-Mlu-068016 Myotis lucifugus 92.58 0.00e+00 825.00
IUUC-Nfi-068424 Neosartorya fischeri 35.25 2.00e-59 223.00
IUUC-Ncr-068833 Neurospora crassa 34.55 2.00e-60 226.00
IUUC-Opr-070933 Ochotona princeps 78.62 0.00e+00 636.00
IUUC-Ont-072495 Oreochromis niloticus 83.37 0.00e+00 748.00
IUUC-Oan-073084 Ornithorhynchus anatinus 83.26 0.00e+00 759.00
IUUC-Ocu-074689 Oryctolagus cuniculus 94.31 0.00e+00 824.00
IUUC-Oba-075601 Oryza barthii 30.30 6.00e-31 128.00
IUUC-Oga-088894 Otolemur garnettii 92.74 0.00e+00 783.00
IUUC-Oar-089850 Ovis aries 91.67 0.00e+00 801.00
IUUC-Ptr-090456 Pan troglodytes 89.63 0.00e+00 813.00
IUUC-Pan-092111 Papio anubis 97.30 0.00e+00 872.00
IUUC-Psi-094095 Pelodiscus sinensis 92.14 0.00e+00 804.00
IUUC-Pno-095015 Phaeosphaeria nodorum 34.44 3.00e-54 205.00
IUUC-Pfo-096987 Poecilia formosa 82.10 0.00e+00 737.00
IUUC-Pab-097754 Pongo abelii 95.48 0.00e+00 800.00
IUUC-Pva-103047 Pteropus vampyrus 81.64 0.00e+00 756.00
IUUC-Pte-104139 Pyrenophora teres 34.32 2.00e-56 213.00
IUUC-Pyt-104488 Pyrenophora triticirepentis 33.94 2.00e-56 213.00
IUUC-Sha-106581 Sarcophilus harrisii 91.90 0.00e+00 803.00
IUUC-Sja-107913 Schizosaccharomyces japonicus 35.52 3.00e-52 198.00
IUUC-Spo-108068 Schizosaccharomyces pombe 37.50 3.00e-49 189.00
IUUC-Ssl-108418 Sclerotinia sclerotiorum 35.87 1.00e-67 249.00
IUUC-Sre-115219 Sporisorium reilianum 42.11 3.00e-49 189.00
IUUC-Ssc-116360 Sus scrofa 92.58 0.00e+00 800.00
IUUC-Tgu-116951 Taeniopygia guttata 92.14 0.00e+00 810.00
IUUC-Tru-117889 Takifugu rubripes 80.22 0.00e+00 737.00
IUUC-Tre-121895 Trichoderma reesei 41.95 1.00e-56 213.00
IUUC-Tvi-122311 Trichoderma virens 41.57 1.00e-56 213.00
IUUC-Uma-129438 Ustilago maydis 44.69 3.00e-44 172.00
IUUC-Vda-129782 Verticillium dahliae 46.28 6.00e-38 151.00
IUUC-Xma-133370 Xiphophorus maculatus 82.10 0.00e+00 737.00
IUUC-Yli-134337 Yarrowia lipolytica 38.10 4.00e-57 215.00
Created Date 25-Jun-2017

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