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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045749
UUCD1 version UUC-HoS-00435
Ensembl Protein ID ENSP00000358247.1
UniProt Accession Q9UKA2; B2R7Q5; E1P530; O95919; Q5BJH0; Q9UJU0; FBXL4_HUMAN
Genbank Protein ID AAF03699.1; AAF04511.1; AAF09247.1; BAG35902.1; CAB37981.1; EAW48489.1; EAW48490.1; AAH55010.1; AAH91484.1
Protein Name F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5
Genbank Nucleotide ID AF176699; AF174590; AF199355; AK313076; AL022395; CH471051; CH471051; BC055010; BC091484
Gene Name FBXL4; FBL4; FBL5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000112234.8 ENST00000369244.6 ENSP00000358247.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 21757720
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00089 21.0 273 317
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 96   egpdaglldrlpeeilveilklldkeellraarvcrrwq.elasqk 140
           egp++g +d+lp+e+++ il++l+ ++l+r+a++c+ ++ ++++ +
   Q: 273  EGPNNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSqHCCD-P 317
           9***********************************99966665.4 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MSPVFPMLTV LTMFYYICLR RRARTATRGE MMNTHRAIES NSQTSPLNAE VVQYAKEVVD 60
FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA SLPFKRTPPN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045749|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCCTCCCCG GCTCCGCCCC GCCTCCCCGG GCCCGCCGCT CCTCGCGGCC TCCGCGTCTT 60
CCTTCCGGGT CGCGCTAGGC CGGGCTTGCG GCGGTTGTGC CGCATCTAGA GAGTCGGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045749|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0433--Leucine-rich repeat
KW-0488--Methylation
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF00646--F-box
SMART

SM00367--LRR_CC
Gene Ontology

GO:0005829--C:cytosol
GO:0005758--C:mitochondrial intermembrane space
GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:26235
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001706 Ailuropoda melanoleuca 95.33 0.00e+00 1212.00
IUUC-Apl-004115 Anas platyrhynchos 86.63 0.00e+00 1100.00
IUUC-Aca-004482 Anolis carolinensis 81.96 0.00e+00 1020.00
IUUC-Ame-010656 Astyanax mexicanus 65.22 0.00e+00 806.00
IUUC-Bta-013498 Bos taurus 77.33 0.00e+00 943.00
IUUC-Cja-019838 Callithrix jacchus 97.58 0.00e+00 1239.00
IUUC-Cfa-020456 Canis familiaris 95.33 0.00e+00 1215.00
IUUC-Csa-024014 Chlorocebus sabaeus 97.58 0.00e+00 1237.00
IUUC-Cho-024333 Choloepus hoffmanni 96.05 8.00e-141 494.00
IUUC-Cin-025800 Ciona intestinalis 41.38 5.00e-118 418.00
IUUC-Csv-026119 Ciona savignyi 39.52 8.00e-117 414.00
IUUC-Dre-027364 Danio rerio 68.06 0.00e+00 872.00
IUUC-Dno-029258 Dasypus novemcinctus 93.08 0.00e+00 1160.00
IUUC-Dor-030963 Dipodomys ordii 81.48 0.00e+00 957.00
IUUC-Dme-031781 Drosophila melanogaster 32.60 6.00e-72 265.00
IUUC-Ete-032619 Echinops telfairi 86.53 0.00e+00 757.00
IUUC-Eca-033869 Equus caballus 94.52 0.00e+00 1211.00
IUUC-Eeu-034752 Erinaceus europaeus 85.01 0.00e+00 647.00
IUUC-Fca-036554 Felis catus 95.65 0.00e+00 1215.00
IUUC-Fal-036695 Ficedula albicollis 86.47 0.00e+00 1088.00
IUUC-Gmo-039192 Gadus morhua 67.46 0.00e+00 830.00
IUUC-Gga-040713 Gallus gallus 86.47 0.00e+00 1094.00
IUUC-Gac-041952 Gasterosteus aculeatus 69.39 0.00e+00 838.00
IUUC-Ggo-044425 Gorilla gorilla 98.39 0.00e+00 1267.00
IUUC-Itr-047877 Ictidomys tridecemlineatus 94.82 0.00e+00 695.00
IUUC-Lch-049424 Latimeria chalumnae 76.80 0.00e+00 986.00
IUUC-Loc-052577 Lepisosteus oculatus 73.23 0.00e+00 902.00
IUUC-Laf-054305 Loxodonta africana 95.18 0.00e+00 1171.00
IUUC-Mcc-055258 Macaca mulatta 89.37 0.00e+00 1107.00
IUUC-Meu-056888 Macropus eugenii 89.78 0.00e+00 833.00
IUUC-Mga-059700 Meleagris gallopavo 86.31 0.00e+00 1103.00
IUUC-Mmr-061712 Microcebus murinus 93.24 0.00e+00 1161.00
IUUC-Mdo-062098 Monodelphis domestica 89.21 0.00e+00 1137.00
IUUC-Mmu-063505 Mus musculus 93.40 0.00e+00 1194.00
IUUC-Mpu-066263 Mustela putorius furo 95.17 0.00e+00 1212.00
IUUC-Mlu-067327 Myotis lucifugus 93.89 0.00e+00 1152.00
IUUC-Nle-069478 Nomascus leucogenys 98.25 0.00e+00 1148.00
IUUC-Opr-070497 Ochotona princeps 94.71 1.00e-90 327.00
IUUC-Ont-071391 Oreochromis niloticus 68.51 0.00e+00 830.00
IUUC-Oan-073721 Ornithorhynchus anatinus 81.10 0.00e+00 1002.00
IUUC-Ocu-073821 Oryctolagus cuniculus 93.88 0.00e+00 1192.00
IUUC-Ola-087182 Oryzias latipes 68.64 0.00e+00 850.00
IUUC-Oga-088018 Otolemur garnettii 93.57 0.00e+00 1187.00
IUUC-Oar-090339 Ovis aries 92.91 0.00e+00 1160.00
IUUC-Ptr-090776 Pan troglodytes 98.55 0.00e+00 1269.00
IUUC-Pan-092203 Papio anubis 97.91 0.00e+00 1241.00
IUUC-Psi-093022 Pelodiscus sinensis 85.99 0.00e+00 1090.00
IUUC-Pfo-097500 Poecilia formosa 67.42 0.00e+00 845.00
IUUC-Pab-097943 Pongo abelii 97.91 0.00e+00 1240.00
IUUC-Pca-100898 Procavia capensis 93.24 0.00e+00 1142.00
IUUC-Pva-102663 Pteropus vampyrus 94.52 0.00e+00 1212.00
IUUC-Rno-105570 Rattus norvegicus 92.91 0.00e+00 1186.00
IUUC-Sha-106688 Sarcophilus harrisii 89.21 0.00e+00 1139.00
IUUC-Sar-113608 Sorex araneus 93.58 0.00e+00 695.00
IUUC-Ssc-115444 Sus scrofa 93.88 0.00e+00 1204.00
IUUC-Tgu-117129 Taeniopygia guttata 90.45 0.00e+00 626.00
IUUC-Tru-118101 Takifugu rubripes 68.39 0.00e+00 808.00
IUUC-Tsy-119589 Tarsius syrichta 94.85 0.00e+00 1204.00
IUUC-Tni-120420 Tetraodon nigroviridis 68.06 0.00e+00 830.00
IUUC-Tbe-128069 Tupaia belangeri 93.66 8.00e-142 497.00
IUUC-Ttr-128566 Tursiops truncatus 84.22 0.00e+00 1047.00
IUUC-Vpa-130059 Vicugna pacos 93.40 0.00e+00 1194.00
IUUC-Xtr-132488 Xenopus tropicalis 69.82 0.00e+00 818.00
Created Date 25-Jun-2017

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