iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	5.20e-07	31.1	10	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 6    ksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekk 73
           ++l   +++l+v+p+    ++K   e +  +p+e++++i   ++L ed+++L++yglkdg+ ++ll+k+
   Q: 10   RDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLiEDHCSLGSYGLKDGDIVVLLQKD 78
           45555589999****************************5555555********************997 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM ERLLIEDHCS 60
LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA VPGTSSSRPQ HPGQQQQRTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATGGAC TTTGGAACAC AACGTGCTAC CTCAAGGCTC CACCTGGCCA CACAGCAGGC 60
ACTGAGGCTG GGAGACAGCC CCCAGACAGA TGAGTGTCCG CGCCTCTCTG AGAGGTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR033882--DDI1_N
IPR019103--Peptidase_aspartic_DDI1-type
IPR021109--Peptidase_aspartic_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF09668--Asp_protease
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0004190--F:aspartic-type endopeptidase activity

KEGG

hsa:414301

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001903	Ailuropoda melanoleuca	79.55	1.00e-172	598.00
IUUC-Bta-012745	Bos taurus	77.86	1.00e-155	542.00
IUUC-Cja-019839	Callithrix jacchus	84.92	1.00e-178	619.00
IUUC-Cfa-020256	Canis familiaris	82.09	1.00e-150	526.00
IUUC-Cpo-022103	Cavia porcellus	81.31	4.00e-166	577.00
IUUC-Csa-023164	Chlorocebus sabaeus	96.46	0.00e+00	709.00
IUUC-Cin-025396	Ciona intestinalis	57.60	4.00e-38	150.00
IUUC-Cme-027324	Cyanidioschyzon merolae	49.66	2.00e-37	150.00
IUUC-Dno-028935	Dasypus novemcinctus	83.08	3.00e-155	541.00
IUUC-Ete-032664	Echinops telfairi	76.26	6.00e-150	523.00
IUUC-Eca-034133	Equus caballus	83.83	3.00e-157	548.00
IUUC-Eeu-035148	Erinaceus europaeus	78.30	1.00e-152	532.00
IUUC-Fal-037492	Ficedula albicollis	26.32	5.00e-09	54.70
IUUC-Ggo-044472	Gorilla gorilla	98.74	0.00e+00	723.00
IUUC-Itr-048710	Ictidomys tridecemlineatus	78.57	9.00e-162	563.00
IUUC-Laf-054347	Loxodonta africana	81.59	7.00e-169	586.00
IUUC-Mcc-055289	Macaca mulatta	96.21	0.00e+00	707.00
IUUC-Mmr-061679	Microcebus murinus	78.14	5.00e-159	553.00
IUUC-Mmu-064298	Mus musculus	79.17	2.00e-163	568.00
IUUC-Mpu-066770	Mustela putorius furo	72.32	2.00e-135	475.00
IUUC-Mlu-067295	Myotis lucifugus	77.11	1.00e-137	483.00
IUUC-Nle-069088	Nomascus leucogenys	96.97	0.00e+00	687.00
IUUC-Opr-070199	Ochotona princeps	81.59	7.00e-172	596.00
IUUC-Ocu-074510	Oryctolagus cuniculus	83.17	3.00e-173	601.00
IUUC-Oga-089146	Otolemur garnettii	80.99	6.00e-152	530.00
IUUC-Oar-089778	Ovis aries	77.86	2.00e-154	538.00
IUUC-Pan-092815	Papio anubis	94.46	0.00e+00	654.00
IUUC-Pab-098087	Pongo abelii	96.97	0.00e+00	707.00
IUUC-Pca-100554	Procavia capensis	78.61	1.00e-152	532.00
IUUC-Pgr-103310	Puccinia graminis	60.00	2.00e-14	71.60
IUUC-Sar-113702	Sorex araneus	25.53	6.00e-10	57.00
IUUC-Ssc-115331	Sus scrofa	83.08	3.00e-156	545.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence