iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046540

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase NEURL3; Lung-inducible neuralized-related C3CH4 RING domain protein; Neuralized-like protein 3; RING-type E3 ubiquitin transferase NEURL3

Genbank Nucleotide ID

AC013270

Gene Name

NEURL3; LINCR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163121.9	ENST00000451794.5	ENSP00000478591.1
ENSG00000163121.9	ENST00000310865.7	ENSP00000479456.1

Annotation

Cancer Mutation
ICGC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
AREsite	miRTarBase	TRANSFAC	RepTar
Protein-protein Interaction
Mentha
Disease-associated Variation
OMIM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-06	30.5	202	241

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           CaiC+++  + ++++pCgH  f++ C   w    ++ s +++CP+Cr
   Q: 202  CAICFYHAAN-TRLVPCGHtYFCRYCA--W----RVFSDTAKCPVCR 241
           **********.********557****6..9....889*********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation.

Protein Sequence
(Fasta)

MGAQLCFEAN AKAPREALRF HAEAKGAQVR LDTRGCIAHR RTTFHDGIVF SQRPVRLGER 60
VALRVLREES GWCGGLRVGF TRLDPACVSV PSLPPFLCPD LEEQSPTWAA VLPEGCALTG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCAACCT GACACTCAGC AGCAAGTTAG GCCTATCTAC AAATCTCCTG CTCTGTGCCC 60
GCGCAGTCCA GTGGAGGAGA TATTCCTAAT TAGGGGGCAC TTCCAAGGGG CGGAGTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR006573--NHR_dom
IPR001841--Znf_RING

PROSITE

PS51065--NHR
PS50089--ZF_RING_2

Pfam

PF07177--Neuralized

SMART

SM00588--NEUZ
SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding

KEGG

hsa:93082

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004857	Anolis carolinensis	35.40	7.00e-45	174.00
IUUC-Dno-029996	Dasypus novemcinctus	71.37	5.00e-88	317.00
IUUC-Eca-034278	Equus caballus	59.17	8.00e-64	236.00
IUUC-Ggo-045041	Gorilla gorilla	98.47	4.00e-150	523.00
IUUC-Lma-053195	Leptosphaeria maculans	37.66	6.00e-06	46.20
IUUC-Mpu-066853	Mustela putorius furo	69.20	2.00e-95	342.00
IUUC-Nle-069399	Nomascus leucogenys	95.74	1.00e-143	501.00
IUUC-Pab-098639	Pongo abelii	96.18	6.00e-146	509.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence