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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063843
UUCD1 version UUC-MuM-01234
Ensembl Protein ID ENSMUSP00000147654.1
UniProt Accession Q80TQ2; Q80VB3; Q8BXZ3; Q8BYL9; Q8CGB0; CYLD_MOUSE
Genbank Protein ID BAC65671.1; BAC30222.1; BAC31357.1; AAH42438.1; AAH49879.1
Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD
Genbank Nucleotide ID AK122389; AK039054; AK042764; BC042438; BC049879
Gene Name Cyld; Cyld1; Kiaa0849
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000036712.15 ENSMUST00000211554.1 ENSMUSP00000148037.1
ENSMUSG00000036712.15 ENSMUST00000209532.1 ENSMUSP00000147654.1
ENSMUSG00000036712.15 ENSMUST00000209206.1 ENSMUSP00000147904.1
ENSMUSG00000036712.15 ENSMUST00000043526.14 ENSMUSP00000039834.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDABioGRIDmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 1.30e-23 84.8 592 948
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL+++++  + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 592  GIQGHYNSCYLDSTLFCLFAFSSALDTVLLRPKEKNDIEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 678
           999*************************999999999999999999999*******9887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ ++++  ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 679  KDPEEFLNILFHDILRVE--PLLKIRSAGQKVQDCNFYQIFMEKNEKVGVPTIQQLLEWSFINSnLKfaeAPSCLIIQmPRFGKDFKLF 765
           ****************99..8899999999999***************************9854144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh  R          ++    v++p+
   Q: 766  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcstQVHLHPRRL---------NHSYHPVSLPK 841
           ****99998...***************987655********9985544.67777762212455555565.........45667888886 PP
   S: 258  eL...dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg 327
            L   d ++ c+        ++k eL+av++ +      HYva+vk  k++  Wl fd               +Vt+++e  e l+++ 
   Q: 842  DLpdwDWRHGCIP-------CQKMELFAVLCIET----SHYVAFVKYGKDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSL 919
           6511144444444.......9**********999....9********777788*****9999*******99999999976678888776 PP
   S: 328  ...................staYvlfYkr 337
                              ++aY+++Y++
   Q: 920  edlhsldsrriqgcarrllCDAYMCMYQS 948
           899999999999999************85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (PubMed:25134987). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity).
 Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B (By similarity). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (PubMed:25134987). Also able to remove linear ('Met-1'-linked) polyubiquitin chains to regulate innate immunity: recruited to the LUBAC complex and, together with OTULIN, restricts linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity).
Protein Sequence
(Fasta)
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRV 60
PSTKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERL SLFRNRLRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063843|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTCGGAGG CGGGGCAGGT GGGGGCGGGC CCAGGTAGCA GGTTCGGCTG CGCGGGGGCC 60
CGCGCGCCTG AGGTAAATAC TGGGGTGGTG GGTGTGGGGC GCCCGGCCGG CCCGGGACGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063843|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0378--Hydrolase
KW-0391--Immunity
KW-0399--Innate immunity
KW-0472--Membrane
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0048471--C:perinuclear region of cytoplasm
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0070064--F:proline-rich region binding
GO:0019901--F:protein kinase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:0016579--P:protein deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG mmu:74256
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 95.08 0.00e+00 1872.00
IUUC-Apl-003356 Anas platyrhynchos 86.00 0.00e+00 1647.00
IUUC-Aca-004402 Anolis carolinensis 79.65 0.00e+00 1469.00
IUUC-Ame-011581 Astyanax mexicanus 67.08 0.00e+00 1204.00
IUUC-Bta-012359 Bos taurus 94.67 0.00e+00 1847.00
IUUC-Cel-018528 Caenorhabditis elegans 34.55 1.00e-55 211.00
IUUC-Cja-018797 Callithrix jacchus 93.93 0.00e+00 1844.00
IUUC-Cfa-020264 Canis familiaris 94.77 0.00e+00 1861.00
IUUC-Cpo-022057 Cavia porcellus 95.82 0.00e+00 1875.00
IUUC-Csa-023093 Chlorocebus sabaeus 94.35 0.00e+00 1843.00
IUUC-Cho-024486 Choloepus hoffmanni 81.00 1.00e-173 603.00
IUUC-Cin-025179 Ciona intestinalis 43.48 3.00e-115 408.00
IUUC-Dre-028233 Danio rerio 66.91 0.00e+00 1247.00
IUUC-Dno-029496 Dasypus novemcinctus 94.14 0.00e+00 1845.00
IUUC-Dor-030919 Dipodomys ordii 89.23 0.00e+00 1728.00
IUUC-Dme-032159 Drosophila melanogaster 45.94 7.00e-123 434.00
IUUC-Ete-032734 Echinops telfairi 88.70 0.00e+00 1721.00
IUUC-Eca-033350 Equus caballus 95.08 0.00e+00 1863.00
IUUC-Eeu-034566 Erinaceus europaeus 96.77 3.00e-113 403.00
IUUC-Fca-035632 Felis catus 93.82 0.00e+00 1290.00
IUUC-Fal-037313 Ficedula albicollis 80.77 0.00e+00 1534.00
IUUC-Gmo-039239 Gadus morhua 66.53 0.00e+00 1180.00
IUUC-Gga-040668 Gallus gallus 86.21 0.00e+00 1646.00
IUUC-Gac-042630 Gasterosteus aculeatus 67.53 0.00e+00 1183.00
IUUC-Ggo-044462 Gorilla gorilla 94.67 0.00e+00 1858.00
IUUC-Hsa-045846 Homo sapiens 94.77 0.00e+00 1859.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 94.01 0.00e+00 820.00
IUUC-Lch-050303 Latimeria chalumnae 70.02 0.00e+00 1275.00
IUUC-Loc-052190 Lepisosteus oculatus 68.78 0.00e+00 1258.00
IUUC-Laf-054480 Loxodonta africana 90.73 0.00e+00 748.00
IUUC-Mcc-055849 Macaca mulatta 94.67 0.00e+00 1856.00
IUUC-Meu-056755 Macropus eugenii 81.84 0.00e+00 849.00
IUUC-Mga-059561 Meleagris gallopavo 85.62 0.00e+00 1638.00
IUUC-Mmr-060942 Microcebus murinus 95.40 0.00e+00 1862.00
IUUC-Mdo-062618 Monodelphis domestica 91.11 0.00e+00 1799.00
IUUC-Mpu-066919 Mustela putorius furo 94.87 0.00e+00 1861.00
IUUC-Mlu-066983 Myotis lucifugus 90.17 0.00e+00 1744.00
IUUC-Nle-069893 Nomascus leucogenys 94.77 0.00e+00 1859.00
IUUC-Opr-071181 Ochotona princeps 86.03 0.00e+00 1548.00
IUUC-Ont-071697 Oreochromis niloticus 66.91 0.00e+00 1182.00
IUUC-Oan-073658 Ornithorhynchus anatinus 88.81 0.00e+00 1735.00
IUUC-Ocu-074954 Oryctolagus cuniculus 94.98 0.00e+00 1860.00
IUUC-Ola-086523 Oryzias latipes 66.02 0.00e+00 1169.00
IUUC-Oga-089003 Otolemur garnettii 94.98 0.00e+00 1865.00
IUUC-Oar-090376 Ovis aries 94.69 0.00e+00 1860.00
IUUC-Ptr-090520 Pan troglodytes 92.99 0.00e+00 1812.00
IUUC-Pan-092281 Papio anubis 94.35 0.00e+00 1843.00
IUUC-Psi-093047 Pelodiscus sinensis 86.71 0.00e+00 1563.00
IUUC-Pma-094575 Petromyzon marinus 54.59 8.00e-66 243.00
IUUC-Pfo-096358 Poecilia formosa 65.40 0.00e+00 1120.00
IUUC-Pab-097740 Pongo abelii 94.25 0.00e+00 1850.00
IUUC-Pca-100461 Procavia capensis 85.25 0.00e+00 1502.00
IUUC-Pva-102134 Pteropus vampyrus 85.13 0.00e+00 1644.00
IUUC-Rno-105807 Rattus norvegicus 96.65 0.00e+00 1852.00
IUUC-Sha-107236 Sarcophilus harrisii 91.37 0.00e+00 1758.00
IUUC-Sar-113366 Sorex araneus 97.11 0.00e+00 927.00
IUUC-Tgu-117201 Taeniopygia guttata 82.69 0.00e+00 1566.00
IUUC-Tru-117953 Takifugu rubripes 67.63 0.00e+00 1180.00
IUUC-Tsy-119610 Tarsius syrichta 93.20 0.00e+00 1822.00
IUUC-Tni-120743 Tetraodon nigroviridis 53.27 4.00e-136 479.00
IUUC-Tbe-128155 Tupaia belangeri 77.97 0.00e+00 753.00
IUUC-Ttr-128942 Tursiops truncatus 90.17 0.00e+00 1750.00
IUUC-Vpa-130281 Vicugna pacos 84.62 0.00e+00 1610.00
IUUC-Xtr-132627 Xenopus tropicalis 75.64 0.00e+00 1394.00
Created Date 25-Jun-2017

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