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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031577
UUCD1 version UUC-DrM-00381
Ensembl Protein ID FBpp0306829
UniProt Accession Q9VQ67; Q9VQ67_DROME
Genbank Protein ID AAF51314.2; AGB92433.1
Protein Name CG4238, isoform D; CG4238, isoform I
Genbank Nucleotide ID AE014134; AE014134
Gene Name CG4238; Dmel_CG4238
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0031384 FBtr0334773 FBpp0306829
FBgn0031384 FBtr0301067 FBpp0290289
FBgn0031384 FBtr0301068 FBpp0290290
FBgn0031384 FBtr0330672 FBpp0303522
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.30e-94 316.6 636 976
Active Site
Position(s) Description Evidence
944 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg.......rlldlpl 92
           sd+  ++ev+f+gE+g+d+gG+ re+++l++++l+++  glf +++++ ++ ++pnp++  +   +lk+Fef+G+++gk+l+++       +l+++++
   Q: 636  SDWCGNFEVTFQGEQGIDWGGLRREWFELVCSALFDARGGLFcTFHDKHQALVHPNPTRPAH--LKLKHFEFAGKMVGKCLFESalggtyrQLVRARF 731
           789999************************************888888***********975..9******************99999999******* PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           s+sf+ +l+g +++++ +e+ dp+ly s +k+i++ +  d +++ l+l f     ++++ +  k+ eL+p+G++++Vtn+ k++Y +++++ rl++++
   Q: 732  SRSFLAQLIGLRVHYKYFEQDDPDLYLSkIKYILDTDL-DATDT-LELYFVeemYDSSSGQLSKTIELIPNGAKTRVTNATKNQYLDALAQQRLCNNV 827
           ****************************9*****9954.66665.7777774444555577778889******************************* PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkp 284
           k +v++f +G+n++ip +lls+F+e+elell+cG+ e++++d+k+++  +g+  e  +++ wFw  +++fs++e +++LqF+Tg+s+lP+gGf+el+p
   Q: 828  KDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHHIANGNSAEFRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPGGFQELNP 925
           *************************************************************************************************9 PP
   S: 285  rlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           + f+i  + +  +lP+++TCfn+L+LP+Y+s+e++++ Ll+Ai+e+ +gF++
   Q: 926  Q-FQITAAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGsEGFGM 976
           9.999998999***************************************97 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MGQMHCSPED ASLRSDLVLI RSFVVYKGRP PDHATRFDIS MLVSHINVGG VMHAATGGKT 60
FPTLKVKLCF GESMGISSLS SCGDPERLPE LPPLDEQRLQ RAALHLQQKL ILREWLKDHR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031577|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGCAGCAAA AATCGAAGAA GAAGCAGCGC AGTGCATTTA TTTTGCTCTC GCTGCATTTT 60
TGCACTCTGC GCTTTTTTCT GCATAAATCA TTCGGCAAAA GTAACTTAAT ACTTGAAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031577|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT
Pfam

PF00630--Filamin
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001308 Ailuropoda melanoleuca 47.95 0.00e+00 735.00
IUUC-Apl-004071 Anas platyrhynchos 47.23 0.00e+00 719.00
IUUC-Aca-005218 Anolis carolinensis 46.77 0.00e+00 723.00
IUUC-Ame-011871 Astyanax mexicanus 43.88 0.00e+00 754.00
IUUC-Bta-012978 Bos taurus 47.60 0.00e+00 734.00
IUUC-Cja-019081 Callithrix jacchus 47.48 0.00e+00 736.00
IUUC-Cfa-020736 Canis familiaris 46.92 0.00e+00 712.00
IUUC-Cpo-021581 Cavia porcellus 47.83 0.00e+00 735.00
IUUC-Csa-024189 Chlorocebus sabaeus 34.65 9.00e-69 253.00
IUUC-Cho-024751 Choloepus hoffmanni 47.35 0.00e+00 727.00
IUUC-Cin-025773 Ciona intestinalis 42.61 2.00e-141 495.00
IUUC-Csv-026090 Ciona savignyi 41.88 1.00e-178 619.00
IUUC-Dre-027788 Danio rerio 43.82 0.00e+00 762.00
IUUC-Dno-030022 Dasypus novemcinctus 47.66 0.00e+00 734.00
IUUC-Ete-032402 Echinops telfairi 45.96 0.00e+00 700.00
IUUC-Eca-033908 Equus caballus 47.54 0.00e+00 735.00
IUUC-Eeu-034869 Erinaceus europaeus 61.62 2.00e-164 572.00
IUUC-Fca-036023 Felis catus 47.66 0.00e+00 734.00
IUUC-Fal-037477 Ficedula albicollis 47.41 0.00e+00 728.00
IUUC-Gmo-039197 Gadus morhua 48.31 0.00e+00 728.00
IUUC-Gga-040704 Gallus gallus 47.04 0.00e+00 726.00
IUUC-Gac-041511 Gasterosteus aculeatus 47.87 0.00e+00 731.00
IUUC-Ggo-044527 Gorilla gorilla 45.50 0.00e+00 677.00
IUUC-Hsa-046082 Homo sapiens 47.48 0.00e+00 736.00
IUUC-Itr-048168 Ictidomys tridecemlineatus 47.36 0.00e+00 734.00
IUUC-Lch-049772 Latimeria chalumnae 40.71 0.00e+00 679.00
IUUC-Loc-052541 Lepisosteus oculatus 43.09 0.00e+00 739.00
IUUC-Laf-053852 Loxodonta africana 47.66 0.00e+00 733.00
IUUC-Mcc-054759 Macaca mulatta 32.88 1.00e-55 209.00
IUUC-Meu-056247 Macropus eugenii 33.39 1.00e-84 306.00
IUUC-Mga-060161 Meleagris gallopavo 47.11 0.00e+00 721.00
IUUC-Mmr-061447 Microcebus murinus 47.42 0.00e+00 733.00
IUUC-Mdo-062110 Monodelphis domestica 47.30 0.00e+00 717.00
IUUC-Mmu-064349 Mus musculus 47.66 0.00e+00 739.00
IUUC-Mpu-065824 Mustela putorius furo 47.66 0.00e+00 735.00
IUUC-Mlu-067729 Myotis lucifugus 47.42 0.00e+00 729.00
IUUC-Nle-069721 Nomascus leucogenys 47.48 0.00e+00 734.00
IUUC-Opr-070189 Ochotona princeps 47.63 0.00e+00 734.00
IUUC-Ont-072122 Oreochromis niloticus 49.05 0.00e+00 739.00
IUUC-Oan-072700 Ornithorhynchus anatinus 58.95 5.00e-165 573.00
IUUC-Ocu-074057 Oryctolagus cuniculus 47.37 0.00e+00 733.00
IUUC-Ola-087492 Oryzias latipes 48.31 0.00e+00 743.00
IUUC-Oga-088084 Otolemur garnettii 47.41 0.00e+00 735.00
IUUC-Oar-090354 Ovis aries 47.07 0.00e+00 717.00
IUUC-Ptr-091456 Pan troglodytes 47.36 0.00e+00 735.00
IUUC-Pan-092596 Papio anubis 46.71 0.00e+00 712.00
IUUC-Psi-092942 Pelodiscus sinensis 46.42 0.00e+00 728.00
IUUC-Pma-094662 Petromyzon marinus 47.63 6.00e-161 560.00
IUUC-Pfo-096838 Poecilia formosa 43.39 0.00e+00 734.00
IUUC-Pab-097849 Pongo abelii 47.24 0.00e+00 734.00
IUUC-Pca-100498 Procavia capensis 35.25 1.00e-72 267.00
IUUC-Pva-102599 Pteropus vampyrus 47.42 0.00e+00 731.00
IUUC-Rno-105776 Rattus norvegicus 47.36 0.00e+00 739.00
IUUC-Sha-106699 Sarcophilus harrisii 48.12 0.00e+00 723.00
IUUC-Sar-113621 Sorex araneus 47.44 0.00e+00 728.00
IUUC-Ssc-115742 Sus scrofa 47.36 0.00e+00 734.00
IUUC-Tgu-116490 Taeniopygia guttata 47.53 0.00e+00 731.00
IUUC-Tru-117679 Takifugu rubripes 49.06 0.00e+00 736.00
IUUC-Tsy-119607 Tarsius syrichta 51.91 2.00e-166 578.00
IUUC-Tni-120376 Tetraodon nigroviridis 47.15 0.00e+00 699.00
IUUC-Tbe-127348 Tupaia belangeri 65.03 7.00e-65 240.00
IUUC-Ttr-128786 Tursiops truncatus 62.62 2.00e-162 565.00
IUUC-Vpa-130180 Vicugna pacos 43.31 4.00e-147 514.00
IUUC-Xtr-132631 Xenopus tropicalis 46.59 0.00e+00 706.00
Created Date 25-Jun-2017

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