iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000042303.16	ENSMUST00000139517.7	ENSMUSP00000122543.1
ENSMUSG00000042303.16	ENSMUST00000143147.7	ENSMUSP00000115920.1
ENSMUSG00000042303.16	ENSMUST00000154904.2	ENSMUSP00000118050.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.70e-10	40.4	483	538

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ ++l d+e  +ddeL ++k d++++i   ++de  ++g  el+g rG fP+ Fve l+
   Q: 483  RRAKALLDFERHDDDELGFRKNDIITII--SQKDEHCWVG--ELNGLRGWFPAKFVEVLD 538
           56799***********************..777888888*..9**************987 PP

Organism

Mus musculus

Functional Description
(View)

May play a cooperative role in NF2-mediated growth suppression of cells.

Protein Sequence
(Fasta)

MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV DKEGSEPGCS 60
QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS LPRSEKLRSL VLAGIPHGMR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCTGCGG CCCGCGCGTG CGCAGAAGGG CAGCAGTGCG CGCCGACTAG GAGGCAGCTG 60
CTAGCCTGAC CTGCCGAGGT GCTGAGGTGG CCGCGAGACA GGTGAGCGGT GCGCGAGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0338--Growth arrest
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000195--Rab-GTPase-TBC_dom
IPR004012--Run_dom
IPR001452--SH3_domain

PROSITE

PS50826--RUN
PS50002--SH3
PS50086--TBC_RABGAP

Pfam

PF00566--RabGAP-TBC
PF02759--RUN
PF00018--SH3_1

SMART

SM00593--RUN
SM00326--SH3
SM00164--TBC

Gene Ontology

GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005921--C:gap junction
GO:0005622--C:intracellular
GO:0005096--F:GTPase activator activity
GO:0030695--F:GTPase regulator activity
GO:0017137--F:Rab GTPase binding
GO:0090630--P:activation of GTPase activity
GO:0007050--P:cell cycle arrest
GO:0006886--P:intracellular protein transport
GO:0048227--P:plasma membrane to endosome transport
GO:0045732--P:positive regulation of protein catabolic process
GO:0032486--P:Rap protein signal transduction
GO:0032483--P:regulation of Rab protein signal transduction
GO:0031338--P:regulation of vesicle fusion

KEGG

mmu:105835

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004863	Anolis carolinensis	87.37	0.00e+00	1317.00
IUUC-Cja-019526	Callithrix jacchus	93.44	0.00e+00	893.00
IUUC-Cfa-021075	Canis familiaris	95.21	0.00e+00	1407.00
IUUC-Dno-029715	Dasypus novemcinctus	92.66	0.00e+00	1373.00
IUUC-Dme-031891	Drosophila melanogaster	64.94	0.00e+00	991.00
IUUC-Eca-033476	Equus caballus	94.79	0.00e+00	1397.00
IUUC-Fca-035397	Felis catus	97.24	0.00e+00	833.00
IUUC-Laf-054163	Loxodonta africana	72.82	0.00e+00	1015.00
IUUC-Mcc-055074	Macaca mulatta	96.93	5.00e-152	530.00
IUUC-Mpu-065920	Mustela putorius furo	94.66	0.00e+00	1398.00
IUUC-Psi-093779	Pelodiscus sinensis	88.05	0.00e+00	1331.00
IUUC-Rno-105265	Rattus norvegicus	98.53	0.00e+00	1439.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence