• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045947
UUCD1 version UUC-HoS-00018
Ensembl Protein ID ENSP00000370156.1
UniProt Accession O15344; B2RCG2; O75361; Q9BZX5; TRI18_HUMAN
Genbank Protein ID CAA74018.1; AAB99951.1; AAC32998.1; AAC32999.1; AAC33000.1; AAC33001.1; AAC33002.1; AAG50191.1; AAG50192.1; AAG33130.1; BAG37559.1; EAW98780.1; AAH53626.1
Protein Name E3 ubiquitin-protein ligase Midline-1; Midin; Putative transcription factor XPRF; RING finger protein 59; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18
Genbank Nucleotide ID Y13667; AF035360; AF041206; AF041207; AF041208; AF041209; AF041210; AF230976; AF230977; AF269101; AK315095; CH471074; BC053626
Gene Name MID1; FXY; RNF59; TRIM18; XPRF
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101871.14 ENST00000380779.5 ENSP00000370156.1
ENSG00000101871.14 ENST00000610939.1 ENSP00000483707.1
ENSG00000101871.14 ENST00000616003.4 ENSP00000484712.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18949047
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.20e-07 32.9 10 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       + + +s ++f+CP+Cr
   Q: 10   CPICLELFED-PLLLPCAHSLCFNCAHRIlvshcaTNESVESITAFQCPTCR 60
           **********.999************999999999888889**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
 Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
Protein Sequence
(Fasta)
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNESVES ITAFQCPTCR 60
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MTSAEKVLCQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045947|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTGCCCCA GCCCAGCCTG CTTGAAGGAC CTACAGGTTT GTCTCTTCCA GATCAGAACT 60
GAGGAACAAA AACCCCCATC CTGGGAAAAA TGGGGAAGCT GGTGAGTCTT ACCACTCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045947|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027727--MID1
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005819--C:spindle
GO:0042802--F:identical protein binding
GO:0008017--F:microtubule binding
GO:0051219--F:phosphoprotein binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0000226--P:microtubule cytoskeleton organization
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0007389--P:pattern specification process
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0035372--P:protein localization to microtubule
KEGG hsa:4281
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001734 Ailuropoda melanoleuca 96.70 0.00e+00 1319.00
IUUC-Apl-004060 Anas platyrhynchos 95.50 0.00e+00 1313.00
IUUC-Aca-005182 Anolis carolinensis 95.65 0.00e+00 1323.00
IUUC-Ame-010973 Astyanax mexicanus 81.36 0.00e+00 1134.00
IUUC-Bta-013266 Bos taurus 98.80 0.00e+00 1352.00
IUUC-Cja-019993 Callithrix jacchus 99.85 0.00e+00 1360.00
IUUC-Cfa-020747 Canis familiaris 98.80 0.00e+00 1353.00
IUUC-Cpo-021998 Cavia porcellus 99.40 0.00e+00 1359.00
IUUC-Csa-023229 Chlorocebus sabaeus 100.00 0.00e+00 1366.00
IUUC-Cin-025118 Ciona intestinalis 41.89 5.00e-157 548.00
IUUC-Csv-026320 Ciona savignyi 41.90 3.00e-157 548.00
IUUC-Dre-027831 Danio rerio 76.33 0.00e+00 1095.00
IUUC-Dno-028977 Dasypus novemcinctus 98.65 0.00e+00 1352.00
IUUC-Dor-030720 Dipodomys ordii 90.25 0.00e+00 1215.00
IUUC-Ete-032898 Echinops telfairi 90.70 0.00e+00 1214.00
IUUC-Eca-033732 Equus caballus 98.80 0.00e+00 1353.00
IUUC-Eeu-034564 Erinaceus europaeus 91.60 0.00e+00 1234.00
IUUC-Fca-036267 Felis catus 98.80 0.00e+00 1353.00
IUUC-Fal-037274 Ficedula albicollis 95.65 0.00e+00 1313.00
IUUC-Gga-040837 Gallus gallus 95.35 0.00e+00 1306.00
IUUC-Gac-041958 Gasterosteus aculeatus 81.48 0.00e+00 1170.00
IUUC-Ggo-044572 Gorilla gorilla 89.84 0.00e+00 1239.00
IUUC-Lch-049502 Latimeria chalumnae 88.93 0.00e+00 1043.00
IUUC-Loc-052454 Lepisosteus oculatus 89.82 0.00e+00 1231.00
IUUC-Laf-053708 Loxodonta africana 96.48 0.00e+00 1340.00
IUUC-Mcc-055664 Macaca mulatta 99.85 0.00e+00 1364.00
IUUC-Meu-056180 Macropus eugenii 92.20 0.00e+00 1259.00
IUUC-Mga-059764 Meleagris gallopavo 94.76 0.00e+00 1290.00
IUUC-Mmr-060771 Microcebus murinus 99.40 0.00e+00 1362.00
IUUC-Mdo-062566 Monodelphis domestica 97.15 0.00e+00 1335.00
IUUC-Mmu-063950 Mus musculus 93.38 0.00e+00 1303.00
IUUC-Mpu-065690 Mustela putorius furo 98.50 0.00e+00 1350.00
IUUC-Mlu-067067 Myotis lucifugus 93.96 0.00e+00 1330.00
IUUC-Nle-069446 Nomascus leucogenys 99.85 0.00e+00 1366.00
IUUC-Ont-072567 Oreochromis niloticus 83.63 0.00e+00 1156.00
IUUC-Oan-073348 Ornithorhynchus anatinus 96.40 0.00e+00 1326.00
IUUC-Ola-087138 Oryzias latipes 79.59 0.00e+00 1123.00
IUUC-Oga-088162 Otolemur garnettii 99.25 0.00e+00 1360.00
IUUC-Oar-090200 Ovis aries 94.40 0.00e+00 1332.00
IUUC-Ptr-091126 Pan troglodytes 99.85 0.00e+00 1361.00
IUUC-Pan-091898 Papio anubis 100.00 0.00e+00 1366.00
IUUC-Psi-093184 Pelodiscus sinensis 95.05 0.00e+00 1315.00
IUUC-Pma-094517 Petromyzon marinus 26.03 7.00e-54 205.00
IUUC-Pfo-097477 Poecilia formosa 82.34 0.00e+00 1155.00
IUUC-Pab-098582 Pongo abelii 99.85 0.00e+00 1365.00
IUUC-Pca-100517 Procavia capensis 91.15 0.00e+00 1230.00
IUUC-Pva-103254 Pteropus vampyrus 99.46 0.00e+00 1110.00
IUUC-Rno-105259 Rattus norvegicus 99.10 0.00e+00 1350.00
IUUC-Sha-107060 Sarcophilus harrisii 97.28 0.00e+00 1324.00
IUUC-Sar-113538 Sorex araneus 96.85 0.00e+00 1332.00
IUUC-Ssc-115887 Sus scrofa 98.20 0.00e+00 1349.00
IUUC-Tgu-116818 Taeniopygia guttata 95.65 0.00e+00 1313.00
IUUC-Tru-117868 Takifugu rubripes 80.53 0.00e+00 1104.00
IUUC-Tsy-119648 Tarsius syrichta 100.00 0.00e+00 1366.00
IUUC-Tni-120841 Tetraodon nigroviridis 81.25 0.00e+00 1134.00
IUUC-Tbe-127963 Tupaia belangeri 94.30 0.00e+00 1304.00
IUUC-Ttr-129089 Tursiops truncatus 98.50 0.00e+00 1348.00
IUUC-Vpa-130092 Vicugna pacos 94.90 0.00e+00 1282.00
IUUC-Xtr-132778 Xenopus tropicalis 87.63 0.00e+00 1037.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved