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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046529
UUCD1 version UUC-HoS-00177
Ensembl Protein ID ENSP00000452732.1
UniProt Accession Q6ZNA4; C9JUS4; H0YN55; Q6P9A4; Q6ZMU2; Q7L428; Q7Z346; Q8N1P9; Q8WUA3; Q9NSR1; RN111_HUMAN
Genbank Protein ID BAC04531.1; BAD18471.1; BAD18633.1; CAB75669.2; CAD98031.1; EAW77561.1; AAH10369.1; AAH20984.1; AAH60862.1
Protein Name E3 ubiquitin-protein ligase Arkadia; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia
Genbank Nucleotide ID AK095327; AK131304; AK131488; AL157474; BX538130; BX647259; BC010369; BC020984; BC060862
Gene Name RNF111
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000157450.15 ENST00000348370.8 ENSP00000288199.5
ENSG00000157450.15 ENST00000559160.1 ENSP00000452842.1
ENSG00000157450.15 ENST00000559209.5 ENSP00000453872.1
ENSG00000157450.15 ENST00000557998.5 ENSP00000452732.1
ENSG00000157450.15 ENST00000561186.5 ENSP00000453015.1
ENSG00000157450.15 ENST00000559592.1 ENSP00000453248.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 14657019; 18451154; 17341133
UBD/SIM/SIM SIM 23086935
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.10e-06 30.6 942 983
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+ +++g  ++ lpC H+fh+ C+ +w        ++ +CP+Cr
   Q: 942  CTICLSILEEGedVRRLPCMHLFHQVCVDQW------LITNKKCPICR 983
           9*****9944444******************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
 E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (PubMed:23751493). Catalyzes 'Lys-63'-linked ubiquitination of sumoylated XPC in response to UV irradiation, promoting nucleotide excision repair (PubMed:23751493). Mediates ubiquitination and degradation of sumoylated PML (By similarity). The regulation of the BMP-SMAD signaling is however independent of sumoylation and is not dependent of SUMO interaction motifs (SIMs) (By similarity).
Protein Sequence
(Fasta)
MSQWTPEYNE LYTLKVDMKS EIPSDAPKTQ ESLKGILLHP EPIGAAKSFP AGVEMINSKV 60
GNEFSHLCDD SQKQEKEMNG NQQEQEKSLV VRKKRKSQQA GPSYVQNCVK ENQGILGLRQ 120
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Protein Fasta Sequence


>IUUC-Hsa-046529|E3,RING;UBD,SIM|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGCAGATGCT GGAGCTGCTG GTGCTGGAGC AGTTTCTGAG CGCGCTGCCA GCCGACACGC 60
AGGCCTGGGT GTGCAGCCGT CAGCCGCTAA GCTGGGAGGA GGCGGTGGCC CTGCTGGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046529|E3,RING;UBD,SIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029306--RNF111_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF15303--RNF111_N
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0043234--C:protein complex
GO:0032184--F:SUMO polymer binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0070911--P:global genome nucleotide-excision repair
GO:0007389--P:pattern specification process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
KEGG hsa:54778
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000605 Aegilops tauschii 50.94 9.00e-14 70.10
IUUC-Aml-001378 Ailuropoda melanoleuca 95.51 0.00e+00 1467.00
IUUC-Apl-003634 Anas platyrhynchos 84.75 0.00e+00 1283.00
IUUC-Aca-004574 Anolis carolinensis 75.48 4.00e-126 444.00
IUUC-Ath-007520 Arabidopsis thaliana 35.51 3.00e-15 75.90
IUUC-Acl-008067 Aspergillus clavatus 44.64 3.00e-10 61.20
IUUC-Ang-009544 Aspergillus niger 53.33 3.00e-10 60.80
IUUC-Ate-010250 Aspergillus terreus 51.11 7.00e-10 59.70
IUUC-Bta-012823 Bos taurus 95.78 0.00e+00 1489.00
IUUC-Bdi-014777 Brachypodium distachyon 59.09 4.00e-13 68.20
IUUC-Cja-018850 Callithrix jacchus 94.68 0.00e+00 1361.00
IUUC-Cfa-021062 Canis familiaris 95.98 0.00e+00 1469.00
IUUC-Cpo-021467 Cavia porcellus 89.44 0.00e+00 1363.00
IUUC-Csa-024048 Chlorocebus sabaeus 98.19 0.00e+00 1494.00
IUUC-Cho-024278 Choloepus hoffmanni 88.10 7.00e-143 501.00
IUUC-Dre-028323 Danio rerio 51.50 7.00e-159 555.00
IUUC-Dno-028850 Dasypus novemcinctus 90.67 0.00e+00 1362.00
IUUC-Dme-031973 Drosophila melanogaster 38.24 3.00e-25 111.00
IUUC-Ete-032985 Echinops telfairi 91.88 2.00e-118 420.00
IUUC-Eca-033659 Equus caballus 96.48 0.00e+00 1520.00
IUUC-Eeu-034773 Erinaceus europaeus 84.55 0.00e+00 760.00
IUUC-Fca-035560 Felis catus 96.08 0.00e+00 1422.00
IUUC-Fal-037598 Ficedula albicollis 82.15 0.00e+00 1267.00
IUUC-Gmo-038696 Gadus morhua 70.77 1.00e-65 244.00
IUUC-Gga-040900 Gallus gallus 84.05 0.00e+00 1272.00
IUUC-Gac-041830 Gasterosteus aculeatus 53.45 2.00e-171 596.00
IUUC-Gma-043396 Glycine max 50.00 7.00e-14 70.10
IUUC-Ggo-044921 Gorilla gorilla 98.90 0.00e+00 1583.00
IUUC-Itr-048765 Ictidomys tridecemlineatus 97.28 0.00e+00 1453.00
IUUC-Lch-049512 Latimeria chalumnae 72.05 0.00e+00 1012.00
IUUC-Lpe-050764 Leersia perrieri 52.94 1.00e-12 66.20
IUUC-Loc-052174 Lepisosteus oculatus 56.95 0.00e+00 694.00
IUUC-Laf-053804 Loxodonta africana 93.46 0.00e+00 1339.00
IUUC-Mcc-055297 Macaca mulatta 98.09 0.00e+00 1525.00
IUUC-Meu-056052 Macropus eugenii 82.56 3.00e-121 429.00
IUUC-Mtr-058136 Medicago truncatula 55.32 4.00e-13 67.40
IUUC-Mga-059350 Meleagris gallopavo 84.75 0.00e+00 1295.00
IUUC-Mmr-061666 Microcebus murinus 96.48 0.00e+00 1495.00
IUUC-Mdo-061958 Monodelphis domestica 87.45 0.00e+00 1328.00
IUUC-Mmu-063900 Mus musculus 88.93 0.00e+00 1337.00
IUUC-Mac-065281 Musa acuminata 31.71 8.00e-11 59.30
IUUC-Mpu-066492 Mustela putorius furo 95.77 0.00e+00 1472.00
IUUC-Mlu-067464 Myotis lucifugus 94.48 0.00e+00 1412.00
IUUC-Nfi-068528 Neosartorya fischeri 51.11 8.00e-10 59.70
IUUC-Nle-070038 Nomascus leucogenys 98.21 0.00e+00 1575.00
IUUC-Opr-070924 Ochotona princeps 82.78 0.00e+00 795.00
IUUC-Ont-072297 Oreochromis niloticus 53.12 9.00e-100 358.00
IUUC-Oan-072897 Ornithorhynchus anatinus 66.74 0.00e+00 887.00
IUUC-Ocu-074713 Oryctolagus cuniculus 95.01 0.00e+00 1470.00
IUUC-Oba-074994 Oryza barthii 32.46 5.00e-13 69.30
IUUC-Obr-076337 Oryza brachyantha 32.11 4.00e-13 70.10
IUUC-Ogl-077817 Oryza glaberrima 32.46 5.00e-13 69.30
IUUC-Ogu-077954 Oryza glumaepatula 32.46 6.00e-13 69.30
IUUC-Oin-079127 Oryza indica 34.62 8.00e-13 69.30
IUUC-Olo-080304 Oryza longistaminata 32.46 6.00e-13 69.30
IUUC-Ome-081451 Oryza meridionalis 34.62 8.00e-13 69.30
IUUC-Oni-082765 Oryza nivara 32.46 6.00e-13 69.30
IUUC-Opu-084108 Oryza punctata 34.62 6.00e-13 69.70
IUUC-Oru-084289 Oryza rufipogon 32.46 7.00e-13 69.30
IUUC-Osa-085712 Oryza sativa 32.46 6.00e-13 69.30
IUUC-Ola-087455 Oryzias latipes 52.76 4.00e-177 615.00
IUUC-Oga-088809 Otolemur garnettii 96.39 0.00e+00 1528.00
IUUC-Oar-090286 Ovis aries 94.77 0.00e+00 1491.00
IUUC-Ptr-091451 Pan troglodytes 98.90 0.00e+00 1577.00
IUUC-Pan-092593 Papio anubis 98.69 0.00e+00 1511.00
IUUC-Psi-093662 Pelodiscus sinensis 81.33 0.00e+00 888.00
IUUC-Pma-094624 Petromyzon marinus 59.07 3.00e-66 246.00
IUUC-Pfo-096611 Poecilia formosa 51.52 1.00e-177 617.00
IUUC-Pab-097885 Pongo abelii 98.49 0.00e+00 1539.00
IUUC-Pca-100561 Procavia capensis 80.87 0.00e+00 744.00
IUUC-Pva-102891 Pteropus vampyrus 95.98 0.00e+00 1552.00
IUUC-Rno-105327 Rattus norvegicus 90.04 0.00e+00 1372.00
IUUC-Sha-107401 Sarcophilus harrisii 87.74 0.00e+00 1338.00
IUUC-Sar-113238 Sorex araneus 88.14 0.00e+00 881.00
IUUC-Sbi-114185 Sorghum bicolor 50.94 3.00e-14 71.20
IUUC-Ssc-116436 Sus scrofa 95.78 0.00e+00 1510.00
IUUC-Tgu-116470 Taeniopygia guttata 82.70 0.00e+00 1204.00
IUUC-Tru-118054 Takifugu rubripes 49.81 5.00e-160 558.00
IUUC-Tni-120063 Tetraodon nigroviridis 52.19 3.00e-178 619.00
IUUC-Tae-125027 Triticum aestivum 58.33 2.00e-14 72.40
IUUC-Tur-126415 Triticum urartu 53.70 4.00e-14 71.20
IUUC-Tbe-128026 Tupaia belangeri 90.47 0.00e+00 1273.00
IUUC-Ttr-128623 Tursiops truncatus 92.16 0.00e+00 1393.00
IUUC-Uma-129481 Ustilago maydis 35.53 5.00e-10 61.60
IUUC-Vpa-130662 Vicugna pacos 92.66 0.00e+00 1478.00
Created Date 25-Jun-2017

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