iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-58	198.1	2672	2943

Active Site

Position(s)	Description	Evidence
2913	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 61   glknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLk 157
           g+  p +l  ++ +Gr++g++l +g + +l++s+++++ +l+ ++ + dl   dp l+++l  + +      +el+ d+++  +++  g++ +++Lk
   Q: 2672 GNGAPMRLAAYRTVGRIMGICLSQGDIFPLRFSRHIFSYILKLPICWLDLGFYDPVLFNNLRALFKA---HPSELDTDFSIV-EQSADGKAVTVNLK 2764
           334568999******************************************************9977...677777777775.555668888888** PP
   S: 158  pgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFw 250
           p+G+++ V+++N  eYv +++e  l  +    +ea+reG+ +vip+++l  +t+e+l+l+icG e+++++ l+++t + ++  ++++++    qwFw
   Q: 2765 PNGDEVLVNKDNVIEYVYKYAERVLVGKRIITFEAIREGILDVIPESMLFGLTPEDLRLIICGIESVSISVLQENTGFLDESRASQETLnrfkQWFW 2861
           ***************************9999***********************************************8888888888888899*** PP
   S: 251  evleefsseerkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +v+e+f+++e+++++ F+Tgs+ lP++G  + +  ++++r  ++d  lP++nTC+++L +P Yssk +l+ kLl+Ai+  k+F++
   Q: 2862 QVIESFTQQEKQELVFFWTGSPALPAAGKWPTS-ASVMLRP-QEDVFLPTANTCISRLYVPVYSSKRVLRTKLLLAIKA-KNFGF 2943
           ******************************999.5566676.899*********************************9.88875 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MSGHSVDGEE QSSSAPARNH TLTHVLYAQE AVGDEKKDSA IIDLIVDQFK QENIGNILAN 60
PAIASLGPSR IRQVVLGPKH VGVLLDDATV CRIPYHVLQI QSGEVKEAEA VKGEPSSRLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGTAAACC TTTAAAACAA ATTGGTGAAG CATACGAAAA GAAAAGGACG GAAACACCGT 60
CGTCAAACAC CAGGTGAGAA TATTTTATCT CTTGAAAGTT ATTAACTTTT TTTTTCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR016024--ARM-type_fold
IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT

SMART

SM00119--HECTc
SM00396--ZnF_UBR1

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

cel:CELE_F36A2.13

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	35.73	2.00e-71	264.00
IUUC-Apl-004165	Anas platyrhynchos	35.52	1.00e-68	255.00
IUUC-Aca-004577	Anolis carolinensis	35.50	4.00e-68	253.00
IUUC-Ame-010702	Astyanax mexicanus	42.62	2.00e-55	211.00
IUUC-Bta-012313	Bos taurus	35.73	2.00e-71	264.00
IUUC-Cja-019858	Callithrix jacchus	35.73	2.00e-71	264.00
IUUC-Cfa-020973	Canis familiaris	35.73	2.00e-71	264.00
IUUC-Cpo-022065	Cavia porcellus	43.62	4.00e-58	218.00
IUUC-Csa-023985	Chlorocebus sabaeus	35.73	2.00e-71	264.00
IUUC-Cho-025034	Choloepus hoffmanni	36.02	3.00e-63	237.00
IUUC-Cin-025715	Ciona intestinalis	44.06	3.00e-66	247.00
IUUC-Csv-026131	Ciona savignyi	44.52	1.00e-56	213.00
IUUC-Dre-027730	Danio rerio	36.02	1.00e-69	258.00
IUUC-Dno-029123	Dasypus novemcinctus	35.81	6.00e-70	259.00
IUUC-Dor-030757	Dipodomys ordii	35.73	1.00e-71	265.00
IUUC-Dme-032192	Drosophila melanogaster	30.51	1.00e-74	275.00
IUUC-Ete-032292	Echinops telfairi	35.52	2.00e-69	258.00
IUUC-Eca-034347	Equus caballus	35.52	1.00e-69	258.00
IUUC-Eeu-034873	Erinaceus europaeus	35.94	7.00e-72	265.00
IUUC-Fca-036485	Felis catus	43.29	3.00e-55	210.00
IUUC-Fal-037071	Ficedula albicollis	35.52	9.00e-69	255.00
IUUC-Gmo-039589	Gadus morhua	35.96	8.00e-69	255.00
IUUC-Gga-041195	Gallus gallus	35.68	3.00e-68	253.00
IUUC-Gac-042538	Gasterosteus aculeatus	35.53	1.00e-69	258.00
IUUC-Ggo-045351	Gorilla gorilla	35.73	6.00e-71	262.00
IUUC-Hsa-045941	Homo sapiens	35.73	9.00e-71	262.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	35.73	7.00e-72	266.00
IUUC-Lch-050480	Latimeria chalumnae	35.23	4.00e-66	246.00
IUUC-Loc-052664	Lepisosteus oculatus	35.65	1.00e-68	254.00
IUUC-Laf-053960	Loxodonta africana	43.62	6.00e-58	218.00
IUUC-Mcc-054703	Macaca mulatta	35.73	2.00e-71	264.00
IUUC-Meu-056431	Macropus eugenii	45.19	6.00e-43	169.00
IUUC-Mga-059289	Meleagris gallopavo	35.52	9.00e-69	255.00
IUUC-Mmr-061737	Microcebus murinus	35.73	3.00e-71	264.00
IUUC-Mdo-062499	Monodelphis domestica	35.52	1.00e-67	251.00
IUUC-Mmu-063273	Mus musculus	35.73	2.00e-71	264.00
IUUC-Mpu-066907	Mustela putorius furo	35.73	3.00e-71	263.00
IUUC-Mlu-067942	Myotis lucifugus	35.73	2.00e-71	264.00
IUUC-Nle-069527	Nomascus leucogenys	35.73	2.00e-71	264.00
IUUC-Opr-070626	Ochotona princeps	37.61	5.00e-56	213.00
IUUC-Ont-071951	Oreochromis niloticus	35.94	3.00e-69	257.00
IUUC-Oan-072958	Ornithorhynchus anatinus	35.73	5.00e-67	249.00
IUUC-Ocu-074503	Oryctolagus cuniculus	35.73	1.00e-71	265.00
IUUC-Ola-086757	Oryzias latipes	35.24	5.00e-69	256.00
IUUC-Oga-088781	Otolemur garnettii	35.52	7.00e-69	255.00
IUUC-Oar-089274	Ovis aries	35.73	2.00e-71	264.00
IUUC-Ptr-090669	Pan troglodytes	35.73	9.00e-71	261.00
IUUC-Pan-092226	Papio anubis	35.73	2.00e-71	264.00
IUUC-Psi-093502	Pelodiscus sinensis	35.58	5.00e-68	253.00
IUUC-Pma-094454	Petromyzon marinus	34.11	5.00e-63	235.00
IUUC-Pfo-096173	Poecilia formosa	35.97	1.00e-68	255.00
IUUC-Pab-098355	Pongo abelii	35.73	3.00e-71	263.00
IUUC-Pca-100570	Procavia capensis	35.31	4.00e-68	253.00
IUUC-Pva-102572	Pteropus vampyrus	35.91	7.00e-70	259.00
IUUC-Rno-104916	Rattus norvegicus	35.73	3.00e-72	266.00
IUUC-Sha-106653	Sarcophilus harrisii	35.52	2.00e-67	251.00
IUUC-Sar-113517	Sorex araneus	32.14	1.00e-55	211.00
IUUC-Ssc-115470	Sus scrofa	43.62	5.00e-58	219.00
IUUC-Tgu-116932	Taeniopygia guttata	35.31	1.00e-66	248.00
IUUC-Tru-117682	Takifugu rubripes	35.82	2.00e-69	256.00
IUUC-Tsy-119417	Tarsius syrichta	41.95	7.00e-53	202.00
IUUC-Tni-120442	Tetraodon nigroviridis	41.60	3.00e-65	244.00
IUUC-Ttr-128606	Tursiops truncatus	35.73	2.00e-71	264.00
IUUC-Vpa-130112	Vicugna pacos	35.73	2.00e-71	264.00
IUUC-Xtr-131929	Xenopus tropicalis	36.08	9.00e-72	265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence