• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063870
UUCD1 version UUC-MuM-01225
Ensembl Protein ID ENSMUSP00000047467.5
UniProt Accession Q5I043; Q6NZP3; Q6ZPP1; Q8BWI1; UBP28_MOUSE
Genbank Protein ID AAH66033.1; AAH88733.1; BAC34993.1; BAC98190.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28
Genbank Nucleotide ID BC066033; BC088733; AK052442; AK129380
Gene Name Usp28; Kiaa1515
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032267.8 ENSMUST00000215788.1 ENSMUSP00000150005.1
ENSMUSG00000032267.8 ENSMUST00000213874.1 ENSMUSP00000149207.1
ENSMUSG00000032267.8 ENSMUST00000047349.7 ENSMUSP00000047467.5
ENSMUSG00000032267.8 ENSMUST00000215856.1 ENSMUSP00000150707.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 9.20e-58 197.1 162 653
Active Site
Position(s) Description Evidence
171 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
605 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ l+ s++k v+p++ l+ lk + ++ 
   Q: 162  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSynlpqNILENCRSH-TEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRS- 248
           6******************************96665444455433.378888*******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           s+ +qqD++Ef++ lld le+++                 +l  + +++  +k+++++++lF g++ ++ + +        +e+f +++
   Q: 249  SEEQQQDVSEFTHKLLDWLEDAF-----------------QLAVNVNSHLRNKSENPMVQLFYGTFLTEGVREGKPFC--NNETFGQYP 318
           99*********************.................55666778899****************99998665555..5899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe      ++eg+ ++  +    +++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 319  LQVNGYH-----NLDECLEG----AMVEGDIALLPSDR--SVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 396
           *******.....99***965....56666666666654..56678899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 397  RYMYKskelirskresvrklkeeiqvlqqkleryvkygsgpsrfplpdmlkyviefastkpasesclsgsaehvtlplpsvhcpisdlt 485
           **999778888777777777777777777777777777777777777777777777777666666666666666666666666666666 PP
   S: 268  ......peekqke............................................................................ 274
                 p     e                                                                            
   Q: 486  pkesssP-----Escsqnagstfsspedalpssegmngpftsphssletpappaprtvtdeemnfvktclqrwrseieqdiqdlkncis 569
           6555551.....05555566666666666666666677777777777777777777777777888888888888888888888889999 PP
   S: 275  ................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                           ++ Y+L+av+vH+G++s GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 570  sstkaieqmycdpllrQVPYRLHAVLVHEGQASAGHYWAYIYNQPRQtWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 653
           9999999999999999***************************88888*******************8879************6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.
 Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.
Protein Sequence
(Fasta)
MTAELQQDDS AGAADGHGSS CQMLLNQLRE ITGIQDPSFL HEALKASNGD ITQAVSLLTD 60
QRVKEPSHDT TAAEPSEVEE SATSKDLLAK VIDLTHDNKD DLQAAIALSL LESPNIQADN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063870|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTGCCTCCC GGTGCTCCCG GGCTTCGGGG GCGGTGGTGG TGGCGGTGGC GACCGCGGCG 60
AAGACGACAA CGAGAGTGGG GCTACACGCG GAGGGACACC ACGGCCATGA CTGCGGAGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063870|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0006281--P:DNA repair
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:235323
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001836 Ailuropoda melanoleuca 87.22 0.00e+00 1868.00
IUUC-Apl-004010 Anas platyrhynchos 65.02 0.00e+00 1361.00
IUUC-Aca-004741 Anolis carolinensis 56.89 0.00e+00 841.00
IUUC-Acl-008164 Aspergillus clavatus 24.18 1.00e-12 69.30
IUUC-Afu-008871 Aspergillus fumigatus 31.96 8.00e-09 56.60
IUUC-Ani-009503 Aspergillus nidulans 36.19 2.00e-11 65.10
IUUC-Ang-009577 Aspergillus niger 36.36 3.00e-11 65.10
IUUC-Ate-010275 Aspergillus terreus 23.39 6.00e-17 83.60
IUUC-Ame-011910 Astyanax mexicanus 49.70 1.00e-127 451.00
IUUC-Bta-013377 Bos taurus 85.41 0.00e+00 1793.00
IUUC-Cja-019977 Callithrix jacchus 87.72 0.00e+00 1852.00
IUUC-Cfa-020378 Canis familiaris 86.55 0.00e+00 1295.00
IUUC-Cpo-021817 Cavia porcellus 84.96 0.00e+00 1807.00
IUUC-Csa-023446 Chlorocebus sabaeus 87.86 0.00e+00 1311.00
IUUC-Cho-024717 Choloepus hoffmanni 75.81 0.00e+00 1091.00
IUUC-Csv-025911 Ciona savignyi 35.43 9.00e-143 501.00
IUUC-Cme-027167 Cyanidioschyzon merolae 33.83 3.00e-16 81.30
IUUC-Dno-029559 Dasypus novemcinctus 89.61 0.00e+00 1469.00
IUUC-Dor-030955 Dipodomys ordii 84.58 0.00e+00 1795.00
IUUC-Ete-032828 Echinops telfairi 74.48 0.00e+00 1051.00
IUUC-Eca-034300 Equus caballus 86.27 0.00e+00 1779.00
IUUC-Eeu-034458 Erinaceus europaeus 82.21 0.00e+00 1563.00
IUUC-Fca-035753 Felis catus 87.12 0.00e+00 1870.00
IUUC-Fal-037062 Ficedula albicollis 62.52 0.00e+00 854.00
IUUC-Gga-040878 Gallus gallus 65.52 0.00e+00 1313.00
IUUC-Gac-041867 Gasterosteus aculeatus 53.28 0.00e+00 1065.00
IUUC-Ggo-045384 Gorilla gorilla 87.44 0.00e+00 1850.00
IUUC-Hsa-046277 Homo sapiens 87.53 0.00e+00 1847.00
IUUC-Itr-048276 Ictidomys tridecemlineatus 87.75 0.00e+00 1147.00
IUUC-Lch-049692 Latimeria chalumnae 62.89 0.00e+00 1294.00
IUUC-Loc-052636 Lepisosteus oculatus 60.00 0.00e+00 859.00
IUUC-Laf-053808 Loxodonta africana 86.36 0.00e+00 1783.00
IUUC-Mcc-055473 Macaca mulatta 88.11 0.00e+00 1314.00
IUUC-Meu-056416 Macropus eugenii 69.23 0.00e+00 1389.00
IUUC-Mga-060011 Meleagris gallopavo 63.17 0.00e+00 1305.00
IUUC-Mmr-060720 Microcebus murinus 85.31 0.00e+00 1748.00
IUUC-Mdo-061955 Monodelphis domestica 81.57 0.00e+00 1264.00
IUUC-Mpu-066454 Mustela putorius furo 86.42 0.00e+00 1264.00
IUUC-Mlu-067487 Myotis lucifugus 81.31 0.00e+00 1713.00
IUUC-Nfi-068458 Neosartorya fischeri 34.91 6.00e-11 63.90
IUUC-Nle-070044 Nomascus leucogenys 87.53 0.00e+00 1844.00
IUUC-Opr-070888 Ochotona princeps 95.67 5.00e-159 555.00
IUUC-Ont-072386 Oreochromis niloticus 53.67 0.00e+00 731.00
IUUC-Ocu-074523 Oryctolagus cuniculus 84.30 0.00e+00 1772.00
IUUC-Ola-086393 Oryzias latipes 52.75 0.00e+00 1065.00
IUUC-Oga-088618 Otolemur garnettii 85.90 0.00e+00 1798.00
IUUC-Oar-089848 Ovis aries 84.57 0.00e+00 1233.00
IUUC-Ptr-091630 Pan troglodytes 86.27 0.00e+00 1383.00
IUUC-Pan-092882 Papio anubis 85.19 0.00e+00 778.00
IUUC-Psi-093422 Pelodiscus sinensis 66.96 0.00e+00 999.00
IUUC-Pma-094250 Petromyzon marinus 49.22 3.00e-64 238.00
IUUC-Pno-095093 Phaeosphaeria nodorum 31.45 3.00e-11 64.70
IUUC-Pfo-096466 Poecilia formosa 56.87 0.00e+00 756.00
IUUC-Pab-098337 Pongo abelii 87.44 0.00e+00 1841.00
IUUC-Pca-100901 Procavia capensis 71.65 0.00e+00 1466.00
IUUC-Pva-102226 Pteropus vampyrus 80.66 0.00e+00 1578.00
IUUC-Pte-104300 Pyrenophora teres 21.03 8.00e-13 70.10
IUUC-Pyt-104434 Pyrenophora triticirepentis 21.25 1.00e-11 65.90
IUUC-Rno-105735 Rattus norvegicus 95.23 0.00e+00 1442.00
IUUC-Sha-107489 Sarcophilus harrisii 81.71 0.00e+00 1739.00
IUUC-Sre-115145 Sporisorium reilianum 25.08 2.00e-11 65.90
IUUC-Tgu-116609 Taeniopygia guttata 65.04 0.00e+00 1307.00
IUUC-Tru-117807 Takifugu rubripes 52.52 0.00e+00 1029.00
IUUC-Tsy-118971 Tarsius syrichta 79.97 0.00e+00 1130.00
IUUC-Tni-119983 Tetraodon nigroviridis 52.67 0.00e+00 1049.00
IUUC-Ttr-128887 Tursiops truncatus 80.79 0.00e+00 1681.00
IUUC-Uma-129338 Ustilago maydis 24.31 3.00e-13 72.00
IUUC-Vpa-130614 Vicugna pacos 84.04 0.00e+00 1352.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved