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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063610
UUCD1 version UUC-MuM-00001
Ensembl Protein ID ENSMUSP00000103306.1
UniProt Accession D3YUA5; D3YUA5_MOUSE
Genbank Protein ID ENSMUSP00000103305
Protein Name F-box/WD repeat-containing protein 7
Genbank Nucleotide ID AC124496
Gene Name Fbxw7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028086.15 ENSMUST00000107679.7 ENSMUSP00000103306.1
ENSMUSG00000028086.15 ENSMUST00000107675.7 ENSMUSP00000103302.1
ENSMUSG00000028086.15 ENSMUST00000029727.7 ENSMUSP00000029727.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
iRefIndexHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 15103331; 20101214; 25670854
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 20101214; 25670854; 26983463
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00014 23.0 280 327
E3 adaptor/Cullin RING/DCX/DWD 5.60e-60 197.7 626 659
UBD/Beta-Prp 2.60e-101 339.8 377 659
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 99   daglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           +++ ++ lp+e+ + +l++l++++ll+aa++cr w+ la+++ lw++ 
   Q: 280  QRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREK 327
           5677899*********************************9****975 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 626  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 659
           9*********449******************976 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 377  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 461
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 462  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 544
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++ ++ ++
   Q: 545  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSA 629
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 630  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 659
           *************************98776 PP
   
Organism Mus musculus
Protein Sequence
(Fasta)
MNQELLSVGS KRRRTGGSLR GNASSSQVDE GQMNRVVEED PQQQARHQEE EHTARNGELV 60
GANPRPGDQN DTQQGQVEEN NNRFISVDED SSGNQEEQEE DEEHAGEQEE EEEEEEEEEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063610|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGCCGCTG TCCTCTCCTT CCCCTCCCCT CCCCTCCACC CCCTCTGGGG GGGCTTCTCT 60
TTGGGCCTGC CGCCGCACCC CGGCTCCTCG GCGGGACTCC AGGAGTTCTC GGCGCCCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063610|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 98.57 0.00e+00 1133.00
IUUC-Apl-003489 Anas platyrhynchos 90.70 0.00e+00 1190.00
IUUC-Aca-005318 Anolis carolinensis 97.46 0.00e+00 1098.00
IUUC-Ago-007794 Ashbya gossypii 31.07 7.00e-62 231.00
IUUC-Acl-008123 Aspergillus clavatus 32.40 4.00e-75 276.00
IUUC-Afl-008730 Aspergillus flavus 31.33 5.00e-74 272.00
IUUC-Afu-009014 Aspergillus fumigatus 32.33 2.00e-75 277.00
IUUC-Ani-009332 Aspergillus nidulans 33.47 2.00e-80 293.00
IUUC-Ang-009529 Aspergillus niger 34.07 1.00e-75 278.00
IUUC-Aor-010215 Aspergillus oryzae 30.71 9.00e-75 274.00
IUUC-Ate-010535 Aspergillus terreus 32.09 4.00e-75 276.00
IUUC-Ame-010898 Astyanax mexicanus 93.98 0.00e+00 1047.00
IUUC-Bgr-012075 Blumeria graminis 33.47 1.00e-79 291.00
IUUC-Bta-012391 Bos taurus 98.19 0.00e+00 1102.00
IUUC-Bci-013725 Botrytis cinerea 33.20 2.00e-78 286.00
IUUC-Cel-018495 Caenorhabditis elegans 48.82 1.00e-131 463.00
IUUC-Cja-018902 Callithrix jacchus 99.28 0.00e+00 1135.00
IUUC-Cfa-020237 Canis familiaris 98.93 0.00e+00 1136.00
IUUC-Cpo-022234 Cavia porcellus 98.19 0.00e+00 1103.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.54 6.00e-49 188.00
IUUC-Csa-023532 Chlorocebus sabaeus 99.28 0.00e+00 1137.00
IUUC-Cho-025026 Choloepus hoffmanni 82.98 0.00e+00 768.00
IUUC-Cin-025516 Ciona intestinalis 70.34 3.00e-141 494.00
IUUC-Csv-026312 Ciona savignyi 75.47 0.00e+00 754.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 34.82 3.00e-85 309.00
IUUC-Cne-027018 Cryptococcus neoformans 33.08 2.00e-73 271.00
IUUC-Cme-027168 Cyanidioschyzon merolae 31.10 4.00e-31 130.00
IUUC-Dre-028303 Danio rerio 93.90 0.00e+00 1049.00
IUUC-Dno-029576 Dasypus novemcinctus 96.96 0.00e+00 1117.00
IUUC-Dor-030196 Dipodomys ordii 90.58 0.00e+00 1207.00
IUUC-Dse-031558 Dothistroma septosporum 38.98 9.00e-71 261.00
IUUC-Dme-031702 Drosophila melanogaster 76.41 0.00e+00 801.00
IUUC-Ete-032791 Echinops telfairi 90.37 0.00e+00 1001.00
IUUC-Eca-033424 Equus caballus 98.19 0.00e+00 1101.00
IUUC-Eeu-034996 Erinaceus europaeus 96.05 0.00e+00 1095.00
IUUC-Fca-036422 Felis catus 98.93 0.00e+00 1138.00
IUUC-Fal-037267 Ficedula albicollis 97.81 0.00e+00 1094.00
IUUC-Fox-037800 Fusarium oxysporum 34.07 1.00e-84 307.00
IUUC-Fso-038258 Fusarium solani 34.21 9.00e-84 304.00
IUUC-Gmo-039119 Gadus morhua 80.87 0.00e+00 903.00
IUUC-Ggr-039781 Gaeumannomyces graminis 34.46 3.00e-85 309.00
IUUC-Gga-040667 Gallus gallus 89.01 0.00e+00 1182.00
IUUC-Gac-042423 Gasterosteus aculeatus 74.45 0.00e+00 802.00
IUUC-Ggo-044422 Gorilla gorilla 98.93 0.00e+00 1137.00
IUUC-Hsa-045898 Homo sapiens 98.93 0.00e+00 1137.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 99.36 0.00e+00 972.00
IUUC-Kpa-049097 Komagataella pastoris 31.92 1.00e-76 281.00
IUUC-Lch-050414 Latimeria chalumnae 93.68 0.00e+00 1087.00
IUUC-Loc-052348 Lepisosteus oculatus 95.64 0.00e+00 1072.00
IUUC-Lma-053185 Leptosphaeria maculans 31.80 5.00e-70 259.00
IUUC-Laf-054054 Loxodonta africana 99.10 0.00e+00 1136.00
IUUC-Mcc-055056 Macaca mulatta 99.28 0.00e+00 1137.00
IUUC-Meu-056778 Macropus eugenii 89.50 0.00e+00 730.00
IUUC-Mor-057133 Magnaporthe oryzae 39.13 2.00e-74 274.00
IUUC-Mpo-057542 Magnaporthe poae 39.13 2.00e-74 274.00
IUUC-Mla-059081 Melampsora laricipopulina 32.76 4.00e-75 276.00
IUUC-Mga-059255 Meleagris gallopavo 89.72 0.00e+00 1179.00
IUUC-Mvi-060490 Microbotryum violaceum 38.75 1.00e-67 251.00
IUUC-Mmr-061292 Microcebus murinus 99.28 0.00e+00 1136.00
IUUC-Mdo-062304 Monodelphis domestica 89.80 0.00e+00 1209.00
IUUC-Mpu-065931 Mustela putorius furo 98.93 0.00e+00 1136.00
IUUC-Mlu-066976 Myotis lucifugus 93.25 0.00e+00 1245.00
IUUC-Nfi-068428 Neosartorya fischeri 31.67 3.00e-75 276.00
IUUC-Ncr-068688 Neurospora crassa 35.97 9.00e-88 317.00
IUUC-Nle-070174 Nomascus leucogenys 98.93 0.00e+00 1137.00
IUUC-Opr-070851 Ochotona princeps 86.05 0.00e+00 652.00
IUUC-Ont-071997 Oreochromis niloticus 93.28 0.00e+00 1071.00
IUUC-Oan-072936 Ornithorhynchus anatinus 92.96 0.00e+00 1240.00
IUUC-Ocu-074742 Oryctolagus cuniculus 99.10 0.00e+00 1134.00
IUUC-Obr-076806 Oryza brachyantha 31.52 8.00e-30 126.00
IUUC-Oin-079809 Oryza indica 31.52 5.00e-30 127.00
IUUC-Ola-087098 Oryzias latipes 93.90 0.00e+00 1060.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.47 7.00e-38 150.00
IUUC-Oga-088884 Otolemur garnettii 99.47 0.00e+00 783.00
IUUC-Oar-090220 Ovis aries 92.86 0.00e+00 1191.00
IUUC-Ptr-090492 Pan troglodytes 98.93 0.00e+00 1137.00
IUUC-Pan-091770 Papio anubis 99.28 0.00e+00 1137.00
IUUC-Psi-093207 Pelodiscus sinensis 98.19 0.00e+00 1102.00
IUUC-Pma-094749 Petromyzon marinus 83.30 0.00e+00 942.00
IUUC-Pno-095026 Phaeosphaeria nodorum 38.83 4.00e-71 263.00
IUUC-Pfo-096493 Poecilia formosa 94.01 0.00e+00 1058.00
IUUC-Pab-098141 Pongo abelii 98.19 0.00e+00 1102.00
IUUC-Pca-100571 Procavia capensis 98.74 0.00e+00 808.00
IUUC-Pva-102988 Pteropus vampyrus 99.10 0.00e+00 1130.00
IUUC-Pgr-103612 Puccinia graminis 35.66 4.00e-62 233.00
IUUC-Ptt-103698 Puccinia triticina 35.55 1.00e-41 165.00
IUUC-Pte-104275 Pyrenophora teres 32.56 1.00e-73 271.00
IUUC-Pyt-104635 Pyrenophora triticirepentis 39.03 6.00e-72 266.00
IUUC-Rno-105706 Rattus norvegicus 94.67 0.00e+00 1248.00
IUUC-Sce-106314 Saccharomyces cerevisiae 29.39 1.00e-60 228.00
IUUC-Sha-107653 Sarcophilus harrisii 92.97 0.00e+00 1241.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 33.83 4.00e-79 289.00
IUUC-Spo-108115 Schizosaccharomyces pombe 32.14 5.00e-63 235.00
IUUC-Sar-113600 Sorex araneus 92.82 0.00e+00 1040.00
IUUC-Sre-114901 Sporisorium reilianum 48.13 7.00e-68 252.00
IUUC-Ssc-115787 Sus scrofa 97.49 0.00e+00 1108.00
IUUC-Tgu-117510 Taeniopygia guttata 89.72 0.00e+00 1181.00
IUUC-Tru-117819 Takifugu rubripes 93.97 0.00e+00 1082.00
IUUC-Tsy-118828 Tarsius syrichta 99.10 0.00e+00 1134.00
IUUC-Tni-120468 Tetraodon nigroviridis 93.65 0.00e+00 1072.00
IUUC-Tre-122193 Trichoderma reesei 36.25 2.00e-85 310.00
IUUC-Tvi-122615 Trichoderma virens 35.03 4.00e-84 305.00
IUUC-Tme-127021 Tuber melanosporum 34.89 6.00e-84 305.00
IUUC-Tbe-127925 Tupaia belangeri 99.44 0.00e+00 1103.00
IUUC-Ttr-128899 Tursiops truncatus 98.92 0.00e+00 1133.00
IUUC-Uma-129449 Ustilago maydis 46.89 4.00e-67 250.00
IUUC-Vda-129802 Verticillium dahliae 36.40 4.00e-88 319.00
IUUC-Vpa-130082 Vicugna pacos 99.36 0.00e+00 958.00
IUUC-Xtr-132213 Xenopus tropicalis 85.67 0.00e+00 1155.00
IUUC-Xma-133646 Xiphophorus maculatus 93.84 0.00e+00 1053.00
IUUC-Yli-134429 Yarrowia lipolytica 34.07 1.00e-86 314.00
Created Date 25-Jun-2017

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