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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046702
UUCD1 version UUC-HoS-00007
Ensembl Protein ID ENSP00000261464.5
UniProt Accession O00463; B4DIS9; B4E0A2; Q6FHY1; TRAF5_HUMAN
Genbank Protein ID BAA25262.1; BAG58591.1; BAG64364.1; CAG38794.1; CAH72434.1; EAW93420.1; EAW93422.1; AAH29600.1; AAC51329.1
Protein Name TNF receptor-associated factor 5; RING finger protein 84
Genbank Nucleotide ID AB000509; AK295766; AK303286; CR536557; AL590101; CH471100; CH471100; BC029600; U69108
Gene Name TRAF5; RNF84
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000082512.14 ENST00000261464.9 ENSP00000261464.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20161788; 19893571
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0013 20.9 45 84
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C++ + + p+ ++CgH f+++C+  +    ++ ++  +CP++
   Q: 45   CAFCHSVLHN-PHQTGCGHRFCQHCILSL----RELNTVPICPVD 84
           ********99.**************9777....999*******97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
 Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Protein Sequence
(Fasta)
MAYSEEHKGM PCGFIRQNSG NSISLDFEPS IEYQFVERLE ERYKCAFCHS VLHNPHQTGC 60
GHRFCQHCIL SLRELNTVPI CPVDKEVIKS QEVFKDNCCK REVLNLYVYC SNAPGCNAKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046702|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGACGCACGT GAGGGAAATC AGATGACTGG ACTTGTAGAT ACTAACGGTT CTGAAGCGGG 60
TAGGTTAGCT TTCCAACCGC CTGGATGACG GTCTCAGCCT CCTCCCGACC CCTTCCTGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046702|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027130--TRAF5
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF
PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF
Pfam

PF00097--zf-C3HC4
PF02176--zf-TRAF
SMART

SM00061--MATH
SM00184--RING
Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005813--C:centrosome
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0042802--F:identical protein binding
GO:0031996--F:thioesterase binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042981--P:regulation of apoptotic process
GO:0007165--P:signal transduction
KEGG hsa:7188
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000797 Aegilops tauschii 30.83 2.00e-09 57.00
IUUC-Aml-001288 Ailuropoda melanoleuca 87.35 0.00e+00 1015.00
IUUC-Atr-003147 Amborella trichopoda 27.78 6.00e-07 48.10
IUUC-Aca-004687 Anolis carolinensis 68.49 0.00e+00 801.00
IUUC-Aly-006415 Arabidopsis lyrata 24.84 3.00e-08 53.90
IUUC-Ath-007062 Arabidopsis thaliana 24.84 1.00e-08 55.10
IUUC-Acl-008349 Aspergillus clavatus 26.48 9.00e-16 78.20
IUUC-Afu-008782 Aspergillus fumigatus 25.83 1.00e-12 68.20
IUUC-Ani-009190 Aspergillus nidulans 26.70 3.00e-14 72.80
IUUC-Ang-009779 Aspergillus niger 23.91 4.00e-17 82.80
IUUC-Bgr-012191 Blumeria graminis 26.80 1.00e-16 80.90
IUUC-Bta-012558 Bos taurus 87.81 0.00e+00 1009.00
IUUC-Bdi-014466 Brachypodium distachyon 25.15 3.00e-09 55.80
IUUC-Bol-015913 Brassica oleracea 23.74 1.00e-08 55.50
IUUC-Bra-017948 Brassica rapa 23.74 7.00e-09 56.20
IUUC-Cja-019589 Callithrix jacchus 92.65 0.00e+00 1079.00
IUUC-Cfa-020639 Canis familiaris 83.18 0.00e+00 934.00
IUUC-Cpo-021878 Cavia porcellus 86.56 0.00e+00 1010.00
IUUC-Csa-024172 Chlorocebus sabaeus 97.49 0.00e+00 1130.00
IUUC-Cho-024532 Choloepus hoffmanni 79.57 0.00e+00 921.00
IUUC-Cgl-026455 Colletotrichum gloeosporioides 25.30 4.00e-17 82.80
IUUC-Dno-029746 Dasypus novemcinctus 76.53 0.00e+00 769.00
IUUC-Dor-030469 Dipodomys ordii 86.38 0.00e+00 997.00
IUUC-Dse-031478 Dothistroma septosporum 23.45 1.00e-10 61.60
IUUC-Ete-032910 Echinops telfairi 75.63 0.00e+00 879.00
IUUC-Eca-033786 Equus caballus 87.46 0.00e+00 1027.00
IUUC-Fca-036026 Felis catus 88.17 0.00e+00 1013.00
IUUC-Fal-036842 Ficedula albicollis 72.38 0.00e+00 849.00
IUUC-Gga-040519 Gallus gallus 71.48 0.00e+00 848.00
IUUC-Gma-042951 Glycine max 29.49 3.00e-08 52.80
IUUC-Ggo-044762 Gorilla gorilla 96.65 0.00e+00 1132.00
IUUC-Hvu-047127 Hordeum vulgare 31.46 2.00e-07 50.40
IUUC-Itr-048986 Ictidomys tridecemlineatus 83.18 0.00e+00 944.00
IUUC-Lch-049962 Latimeria chalumnae 47.77 6.00e-146 510.00
IUUC-Lpe-051100 Leersia perrieri 30.25 3.00e-08 53.10
IUUC-Loc-052170 Lepisosteus oculatus 49.73 4.00e-165 574.00
IUUC-Laf-053476 Loxodonta africana 87.53 0.00e+00 789.00
IUUC-Mcc-054878 Macaca mulatta 97.67 0.00e+00 1135.00
IUUC-Mga-060145 Meleagris gallopavo 70.40 0.00e+00 837.00
IUUC-Mmr-061719 Microcebus murinus 83.90 0.00e+00 905.00
IUUC-Mdo-063077 Monodelphis domestica 75.86 0.00e+00 897.00
IUUC-Mmu-064169 Mus musculus 75.45 0.00e+00 880.00
IUUC-Mpu-065801 Mustela putorius furo 88.17 0.00e+00 1013.00
IUUC-Mlu-067192 Myotis lucifugus 86.92 0.00e+00 1008.00
IUUC-Nfi-068511 Neosartorya fischeri 28.90 7.00e-18 85.10
IUUC-Ncr-068632 Neurospora crassa 22.84 7.00e-17 82.40
IUUC-Nle-069250 Nomascus leucogenys 98.38 0.00e+00 1140.00
IUUC-Opr-071122 Ochotona princeps 75.09 0.00e+00 833.00
IUUC-Oan-072905 Ornithorhynchus anatinus 76.37 0.00e+00 892.00
IUUC-Ocu-073755 Oryctolagus cuniculus 87.63 0.00e+00 1003.00
IUUC-Oba-075263 Oryza barthii 28.57 7.00e-10 58.20
IUUC-Obr-076500 Oryza brachyantha 27.03 2.00e-10 60.10
IUUC-Ogl-077708 Oryza glaberrima 28.02 2.00e-09 57.00
IUUC-Ogu-078582 Oryza glumaepatula 28.02 2.00e-09 57.00
IUUC-Oin-079499 Oryza indica 28.02 2.00e-09 57.00
IUUC-Ome-081269 Oryza meridionalis 28.02 1.00e-09 57.40
IUUC-Oni-083040 Oryza nivara 31.93 3.00e-09 55.80
IUUC-Opu-083468 Oryza punctata 28.57 2.00e-10 60.10
IUUC-Oru-084662 Oryza rufipogon 27.27 1.00e-09 57.80
IUUC-Osa-085740 Oryza sativa 31.93 9.00e-09 54.30
IUUC-Ola-086783 Oryzias latipes 36.35 6.00e-102 364.00
IUUC-Oga-089077 Otolemur garnettii 82.24 0.00e+00 925.00
IUUC-Oar-090003 Ovis aries 83.83 0.00e+00 952.00
IUUC-Ptr-091465 Pan troglodytes 98.92 0.00e+00 1147.00
IUUC-Pan-092301 Papio anubis 97.85 0.00e+00 1136.00
IUUC-Psi-093956 Pelodiscus sinensis 70.97 0.00e+00 851.00
IUUC-Pab-097604 Pongo abelii 98.38 0.00e+00 1142.00
IUUC-Pop-099898 Populus trichocarpa 26.88 6.00e-08 52.00
IUUC-Pca-100433 Procavia capensis 68.53 0.00e+00 660.00
IUUC-Ppe-101547 Prunus persica 28.88 7.00e-09 56.20
IUUC-Pva-102112 Pteropus vampyrus 89.25 0.00e+00 1023.00
IUUC-Rno-105077 Rattus norvegicus 77.42 0.00e+00 916.00
IUUC-Sha-107492 Sarcophilus harrisii 77.50 0.00e+00 918.00
IUUC-Ssl-108580 Sclerotinia sclerotiorum 23.30 8.00e-13 68.60
IUUC-Sit-109710 Setaria italica 28.49 6.00e-11 61.60
IUUC-Sbi-113900 Sorghum bicolor 29.17 2.00e-09 57.00
IUUC-Ssc-116427 Sus scrofa 86.92 0.00e+00 1001.00
IUUC-Tgu-117408 Taeniopygia guttata 70.58 0.00e+00 829.00
IUUC-Tsy-119571 Tarsius syrichta 77.78 0.00e+00 876.00
IUUC-Tur-126067 Triticum urartu 30.83 2.00e-09 56.20
IUUC-Tbe-127412 Tupaia belangeri 87.98 0.00e+00 856.00
IUUC-Ttr-128492 Tursiops truncatus 86.34 0.00e+00 645.00
IUUC-Vpa-130751 Vicugna pacos 76.99 0.00e+00 701.00
IUUC-Vvi-131070 Vitis vinifera 29.03 1.00e-10 60.80
IUUC-Xtr-132721 Xenopus tropicalis 56.05 0.00e+00 654.00
Created Date 25-Jun-2017

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