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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046754
UUCD1 version UUC-HoS-01089
Ensembl Protein ID ENSP00000366819.3
UniProt Accession P15374; B2R970; Q5TBK8; Q6IBE9; UCHL3_HUMAN
Genbank Protein ID AAA36791.1; AAV38166.1; CAG33136.1; BAG36417.1; CAI12419.1; EAW80542.1; AAH18125.1
Protein Name Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin thioesterase L3
Genbank Nucleotide ID M30496; BT019359; CR456855; AK313665; AL137244; CH471093; BC018125
Gene Name UCHL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000118939.17 ENST00000377595.7 ENSP00000366819.3
ENSG00000118939.17 ENST00000419068.1 ENSP00000398189.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/UCH UCH 20622874
UBD/Other/Other UBD/Other/Other 19154770; 20042598
Classification
Family E-value Score Start End
DUB/UCH 2.80e-72 245.6 3 230
Active Site
Position(s) Description Evidence
95 Nucleophile {ECO:0000269|PubMed:19154770,
ECO:0000269|PubMed:20380862,
ECO:0000269|PubMed:9790970}
169 Proton donor ECO:0000305}
Domain Profile

   DUB/UCH
   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvig 96
           +++wl+Le++P++ +++++++g++ ++q+ ++y++dpe l+++++pv+++lllF+i+ek+e +r+++   ++++++++d++++++f+kq+i+
   Q: 3    GQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEE--EEKIKSQGQDVTSSVYFMKQTIS 92
           589*************************************************************766..5589******************* PP
   S: 97   NsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvnin 187
           N+C+t++l+++++n++dk+ ++ G+tl++++e++ ++spe++a+ l+n ++++++h++ a+++++++p+ +       +k  +hf+++v+++
   Q: 93   NACGTIGLIHAIANNKDKMhFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSID-------EKVDLHFIALVHVD 177
           ********************************************************************888.......8899********** PP
   S: 188  grlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivad 244
           g+lyeldg+kpfP+++g++++++ l+d+++v+++f+er    + de+rfn++a++a+
   Q: 178  GHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMER----DPDELRFNAIALSAA 230
           **************************************....***********9875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
 Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
Protein Sequence
(Fasta)
MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE 60
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046754|DUB,UCH;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGCATGCG TAGAACGCGA GCGCTCGGCA AGGCTCGGCT CGGAAGAGTC CAAGCGTGAG 60
GGGAGAGGGC TGTGGATTCA GATACTGTTT TTCTCCCGAA ATAGGAAATT GGCTTATTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046754|DUB,UCH;UBD,UBD/Other/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001578--Peptidase_C12_UCH
PROSITE

PS00140--UCH_1
Pfam

PF01088--Peptidase_C12
PRINTS

PR00707--UBCTHYDRLASE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0008233--F:peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0043130--F:ubiquitin binding
GO:0030163--P:protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:7347
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000360 Aegilops tauschii 44.07 2.00e-53 202.00
IUUC-Aml-001344 Ailuropoda melanoleuca 100.00 2.00e-137 481.00
IUUC-Atr-002931 Amborella trichopoda 47.49 3.00e-48 184.00
IUUC-Apl-003949 Anas platyrhynchos 87.32 9.00e-105 372.00
IUUC-Aca-004924 Anolis carolinensis 82.68 3.00e-115 407.00
IUUC-Aly-005721 Arabidopsis lyrata 50.22 4.00e-60 224.00
IUUC-Ath-006827 Arabidopsis thaliana 50.88 2.00e-60 225.00
IUUC-Ago-007950 Ashbya gossypii 35.14 2.00e-27 115.00
IUUC-Acl-008305 Aspergillus clavatus 39.56 3.00e-40 158.00
IUUC-Afl-008611 Aspergillus flavus 40.25 1.00e-43 169.00
IUUC-Afu-008945 Aspergillus fumigatus 40.68 2.00e-43 169.00
IUUC-Ani-009339 Aspergillus nidulans 40.51 5.00e-44 171.00
IUUC-Ang-009691 Aspergillus niger 38.72 3.00e-43 168.00
IUUC-Aor-009961 Aspergillus oryzae 40.25 1.00e-43 169.00
IUUC-Ate-010316 Aspergillus terreus 40.85 2.00e-44 172.00
IUUC-Ame-011157 Astyanax mexicanus 73.04 2.00e-101 362.00
IUUC-Bgr-012125 Blumeria graminis 36.71 1.00e-39 156.00
IUUC-Bta-012673 Bos taurus 99.13 2.00e-136 478.00
IUUC-Bci-013734 Botrytis cinerea 37.61 2.00e-42 165.00
IUUC-Bdi-014330 Brachypodium distachyon 45.81 2.00e-56 212.00
IUUC-Bol-015214 Brassica oleracea 52.86 1.00e-63 235.00
IUUC-Bra-017491 Brassica rapa 53.30 3.00e-63 234.00
IUUC-Cel-018302 Caenorhabditis elegans 40.09 1.00e-35 142.00
IUUC-Cfa-020371 Canis familiaris 97.37 2.00e-107 381.00
IUUC-Cpo-022036 Cavia porcellus 96.52 2.00e-131 461.00
IUUC-Cre-022599 Chlamydomonas reinhardtii 44.19 3.00e-38 151.00
IUUC-Csa-023854 Chlorocebus sabaeus 99.13 1.00e-135 475.00
IUUC-Cin-025545 Ciona intestinalis 49.78 8.00e-67 246.00
IUUC-Cgl-026409 Colletotrichum gloeosporioides 34.47 3.00e-32 132.00
IUUC-Cne-026914 Cryptococcus neoformans 35.19 2.00e-30 125.00
IUUC-Cme-027216 Cyanidioschyzon merolae 37.39 3.00e-28 118.00
IUUC-Dre-028356 Danio rerio 74.35 3.00e-103 367.00
IUUC-Dse-031461 Dothistroma septosporum 40.51 4.00e-39 154.00
IUUC-Dme-032146 Drosophila melanogaster 50.67 4.00e-62 231.00
IUUC-Eca-033220 Equus caballus 99.57 2.00e-136 477.00
IUUC-Fca-036421 Felis catus 100.00 2.00e-137 481.00
IUUC-Fal-036773 Ficedula albicollis 87.10 2.00e-106 378.00
IUUC-Fox-037830 Fusarium oxysporum 36.80 3.00e-41 161.00
IUUC-Fso-038259 Fusarium solani 36.68 2.00e-39 157.00
IUUC-Gmo-039468 Gadus morhua 68.70 3.00e-84 304.00
IUUC-Ggr-039832 Gaeumannomyces graminis 37.12 2.00e-37 149.00
IUUC-Gga-041205 Gallus gallus 85.65 7.00e-112 396.00
IUUC-Gac-041629 Gasterosteus aculeatus 68.42 6.00e-88 316.00
IUUC-Gma-043057 Glycine max 49.78 9.00e-54 203.00
IUUC-Ggo-044533 Gorilla gorilla 99.57 4.00e-136 476.00
IUUC-Hvu-047176 Hordeum vulgare 41.05 7.00e-44 170.00
IUUC-Itr-047992 Ictidomys tridecemlineatus 97.47 8.00e-91 325.00
IUUC-Kpa-049123 Komagataella pastoris 37.09 7.00e-33 133.00
IUUC-Lch-049685 Latimeria chalumnae 78.51 6.00e-110 389.00
IUUC-Lpe-051377 Leersia perrieri 45.32 3.00e-47 181.00
IUUC-Loc-051988 Lepisosteus oculatus 76.52 6.00e-106 376.00
IUUC-Lma-053316 Leptosphaeria maculans 40.26 1.00e-42 166.00
IUUC-Laf-053985 Loxodonta africana 98.27 1.00e-134 471.00
IUUC-Mcc-055888 Macaca mulatta 97.83 2.00e-132 464.00
IUUC-Mor-057271 Magnaporthe oryzae 37.12 2.00e-41 162.00
IUUC-Mpo-057343 Magnaporthe poae 32.19 3.00e-22 98.20
IUUC-Mtr-057713 Medicago truncatula 48.67 1.00e-53 202.00
IUUC-Mla-058942 Melampsora laricipopulina 45.37 2.00e-47 182.00
IUUC-Mga-059702 Meleagris gallopavo 86.85 3.00e-104 370.00
IUUC-Mvi-060249 Microbotryum violaceum 44.30 5.00e-42 164.00
IUUC-Mmr-061284 Microcebus murinus 100.00 3.00e-92 331.00
IUUC-Mdo-062639 Monodelphis domestica 79.85 1.00e-122 432.00
IUUC-Mmu-063299 Mus musculus 98.26 1.00e-135 474.00
IUUC-Mac-065075 Musa acuminata 45.85 5.00e-54 204.00
IUUC-Mpu-066769 Mustela putorius furo 100.00 2.00e-137 481.00
IUUC-Mlu-066937 Myotis lucifugus 96.96 1.00e-132 465.00
IUUC-Nfi-068320 Neosartorya fischeri 40.76 2.00e-44 172.00
IUUC-Ncr-068673 Neurospora crassa 38.96 1.00e-45 176.00
IUUC-Nle-069175 Nomascus leucogenys 100.00 2.00e-124 437.00
IUUC-Opr-070652 Ochotona princeps 100.00 3.00e-64 238.00
IUUC-Ont-072170 Oreochromis niloticus 70.61 2.00e-89 321.00
IUUC-Oan-073247 Ornithorhynchus anatinus 93.81 2.00e-59 220.00
IUUC-Ocu-074422 Oryctolagus cuniculus 98.26 8.00e-136 475.00
IUUC-Oba-075098 Oryza barthii 42.04 3.00e-50 191.00
IUUC-Obr-076041 Oryza brachyantha 45.18 6.00e-55 206.00
IUUC-Ogl-076980 Oryza glaberrima 45.61 1.00e-54 206.00
IUUC-Ogu-078978 Oryza glumaepatula 38.74 9.00e-48 183.00
IUUC-Oin-079285 Oryza indica 41.59 2.00e-49 189.00
IUUC-Olo-080671 Oryza longistaminata 42.04 1.00e-49 189.00
IUUC-Ome-081428 Oryza meridionalis 41.15 2.00e-48 185.00
IUUC-Oni-082406 Oryza nivara 42.04 3.00e-50 191.00
IUUC-Opu-083305 Oryza punctata 42.04 9.00e-49 186.00
IUUC-Oru-084969 Oryza rufipogon 42.04 3.00e-50 191.00
IUUC-Osa-085830 Oryza sativa 45.61 1.00e-54 206.00
IUUC-Ola-086893 Oryzias latipes 68.42 1.00e-85 309.00
IUUC-Olu-087858 Ostreococcus lucimarinus 44.93 1.00e-52 199.00
IUUC-Oga-088055 Otolemur garnettii 99.57 4.00e-136 476.00
IUUC-Oar-090319 Ovis aries 98.70 6.00e-136 476.00
IUUC-Pan-092714 Papio anubis 98.70 9.00e-135 472.00
IUUC-Psi-094036 Pelodiscus sinensis 86.64 4.00e-106 377.00
IUUC-Pma-094412 Petromyzon marinus 64.94 4.00e-55 206.00
IUUC-Pno-094997 Phaeosphaeria nodorum 36.22 8.00e-35 140.00
IUUC-Ppa-095519 Physcomitrella patens 51.11 3.00e-64 238.00
IUUC-Pfo-096182 Poecilia formosa 67.83 2.00e-88 318.00
IUUC-Pab-098216 Pongo abelii 100.00 4.00e-83 299.00
IUUC-Pop-099282 Populus trichocarpa 49.12 8.00e-54 203.00
IUUC-Ppe-101332 Prunus persica 48.23 6.00e-56 210.00
IUUC-Pgr-103430 Puccinia graminis 47.48 7.00e-51 193.00
IUUC-Ptt-103955 Puccinia triticina 49.14 2.00e-51 195.00
IUUC-Pte-104414 Pyrenophora teres 38.89 1.00e-39 156.00
IUUC-Pyt-104753 Pyrenophora triticirepentis 34.03 8.00e-35 140.00
IUUC-Rno-105096 Rattus norvegicus 97.39 2.00e-134 471.00
IUUC-Sce-106412 Saccharomyces cerevisiae 36.08 4.00e-28 118.00
IUUC-Sha-106677 Sarcophilus harrisii 94.01 1.00e-121 428.00
IUUC-Sja-107753 Schizosaccharomyces japonicus 30.95 3.00e-26 111.00
IUUC-Spo-108322 Schizosaccharomyces pombe 31.00 4.00e-26 111.00
IUUC-Ssl-108641 Sclerotinia sclerotiorum 37.61 1.00e-38 153.00
IUUC-Smo-108914 Selaginella moellendorffii 49.14 4.00e-54 204.00
IUUC-Sit-110163 Setaria italica 47.41 1.00e-55 209.00
IUUC-Sly-111613 Solanum lycopersicum 49.78 2.00e-62 231.00
IUUC-Stu-112526 Solanum tuberosum 50.88 7.00e-58 216.00
IUUC-Sbi-114545 Sorghum bicolor 46.72 2.00e-53 202.00
IUUC-Sre-114961 Sporisorium reilianum 42.49 2.00e-40 159.00
IUUC-Ssc-115255 Sus scrofa 97.64 7.00e-123 432.00
IUUC-Tgu-117003 Taeniopygia guttata 86.09 3.00e-111 394.00
IUUC-Tru-118330 Takifugu rubripes 62.84 8.00e-69 254.00
IUUC-Tsy-119488 Tarsius syrichta 98.25 3.00e-63 234.00
IUUC-Tni-120042 Tetraodon nigroviridis 64.13 1.00e-70 261.00
IUUC-Tca-120976 Theobroma cacao 47.79 4.00e-56 211.00
IUUC-Tre-122149 Trichoderma reesei 38.70 2.00e-43 169.00
IUUC-Tvi-122450 Trichoderma virens 38.70 2.00e-43 168.00
IUUC-Tae-122693 Triticum aestivum 45.22 7.00e-54 204.00
IUUC-Tur-126250 Triticum urartu 44.07 4.00e-53 201.00
IUUC-Tme-126961 Tuber melanosporum 37.02 4.00e-36 144.00
IUUC-Uma-129382 Ustilago maydis 41.38 3.00e-43 168.00
IUUC-Vda-129678 Verticillium dahliae 32.07 6.00e-32 130.00
IUUC-Vpa-130783 Vicugna pacos 99.13 1.00e-63 236.00
IUUC-Vvi-131661 Vitis vinifera 48.03 3.00e-57 214.00
IUUC-Xtr-132428 Xenopus tropicalis 74.35 8.00e-107 379.00
IUUC-Xma-134245 Xiphophorus maculatus 67.11 3.00e-88 317.00
IUUC-Yli-134570 Yarrowia lipolytica 35.90 1.00e-36 146.00
IUUC-Zma-134740 Zea mays 45.85 4.00e-55 207.00
Created Date 25-Jun-2017

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